How did our ancestors turn lumps of rock into pure, shining fragments of metal? 🔥 The technology transformed ancient societies through the use of metal tools and weapons.
Butser team member Fergus takes us through the magical process of smelting metal ore:
www.youtube.com/watch?v=PLD1...
Butser team member Fergus takes us through the magical process of smelting metal ore:
www.youtube.com/watch?v=PLD1...
How to Turn Rock into Metal | The Smelting Technique
YouTube video by Butser Ancient Farm
www.youtube.com
May 21, 2026 at 10:59 AM
How did our ancestors turn lumps of rock into pure, shining fragments of metal? 🔥 The technology transformed ancient societies through the use of metal tools and weapons.
Butser team member Fergus takes us through the magical process of smelting metal ore:
www.youtube.com/watch?v=PLD1...
Butser team member Fergus takes us through the magical process of smelting metal ore:
www.youtube.com/watch?v=PLD1...
Bu yöntem kanser hücrelerinin büyümesini durdururken hastanın T-hücreli bağışıklık sistemini de harekete geçiriyor. Ayrıca ekip, nüksetmeye yol açan dirençli kök hücreleri engellemek için PLD1 inhibitörünü keşfederek patent başvurusunda bulundu.
June 12, 2026 at 2:38 PM
Bu yöntem kanser hücrelerinin büyümesini durdururken hastanın T-hücreli bağışıklık sistemini de harekete geçiriyor. Ayrıca ekip, nüksetmeye yol açan dirençli kök hücreleri engellemek için PLD1 inhibitörünü keşfederek patent başvurusunda bulundu.
👀 In case you missed our most recent #lipidmatters #blog is titled: 'Something New Regarding PLD1 Activation: PLD1 Activation by Arf11 '. Click the link to read it NOW!! - lipidmaps.org/updates/lipi...
September 4, 2026 at 3:01 PM
👀 In case you missed our most recent #lipidmatters #blog is titled: 'Something New Regarding PLD1 Activation: PLD1 Activation by Arf11 '. Click the link to read it NOW!! - lipidmaps.org/updates/lipi...
Gut microbiota and bile acids changes in MASLD mice model with hepatic PLD1 knockout https://www.biorxiv.org/content/10.1101/2025.07.13.663496v1
July 14, 2025 at 3:46 AM
Gut microbiota and bile acids changes in MASLD mice model with hepatic PLD1 knockout https://www.biorxiv.org/content/10.1101/2025.07.13.663496v1
The authors included RRIDs in their in Experimental & Molecular Medicine paper! We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #RRID
PLD1 and PLD2 promote an immunosuppressive tumor microenvironment via CCL19-dependent macrophage polarization and PD-L1 induction - Experimental & Molecular Medicine
This study explores the role of phospholipase D (PLD) isoforms, PLD1 and PLD2, in melanoma, focusing on their impact on the tumor microenvironment (TME). The authors reveal that PLD1/2 are upregulated in melanoma, promoting tumor growth and immune evasion by modulating macrophage polarization and PD-L1 expression. Using CRISPR–Cas9 knockout models and pharmacological inhibition, they demonstrate that PLD1/2 deficiency shifts macrophages from an M2-like to an M1-like phenotype, enhancing T cell-mediated antitumor immunity. PLD1/2 deficiency reduces secretion of CCL19, which functions as an upstream regulator of immunosuppressive macrophage polarization and PD-L1 expression via the PI3K–Akt–NF-κB pathway. The findings suggest that targeting PLD1/2 could enhance cancer immunotherapy by reprogramming the immune landscape, highlighting the potential of PLD inhibitors as therapeutic agents. Future research could explore the applicability of these findings across differ
doi.org
June 12, 2026 at 7:01 AM
The authors included RRIDs in their in Experimental & Molecular Medicine paper! We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #RRID
RRIDs were included in this paper. Thanks for making your methods matter! #reproducibility #OpenScience #reproducibility
PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer’s Disease Pathogenesis
doi.org
December 26, 2025 at 8:00 AM
RRIDs were included in this paper. Thanks for making your methods matter! #reproducibility #OpenScience #reproducibility
New exclusive video content posted for YouTube! Check it out and give us some ideas on what you'd like to see us do next! www.youtube.com/watch?v=Pld1...
#WWE2K25 #WWE2K #WWE #WWE2K26 @wwegames2k.bsky.social #RoyalRumble
#WWE2K25 #WWE2K #WWE #WWE2K26 @wwegames2k.bsky.social #RoyalRumble
May 22, 2026 at 2:39 AM
New exclusive video content posted for YouTube! Check it out and give us some ideas on what you'd like to see us do next! www.youtube.com/watch?v=Pld1...
#WWE2K25 #WWE2K #WWE #WWE2K26 @wwegames2k.bsky.social #RoyalRumble
#WWE2K25 #WWE2K #WWE #WWE2K26 @wwegames2k.bsky.social #RoyalRumble
#ffxiv I have a serious question, because I had a dream.
How is damage calculated, if PLD1 is covering a teammate, then mitigates and that PLD is then again covered by PLD2 who ALSO mitigates?
Does that even work?🤔
How is damage calculated, if PLD1 is covering a teammate, then mitigates and that PLD is then again covered by PLD2 who ALSO mitigates?
Does that even work?🤔
February 8, 2026 at 1:53 PM
#ffxiv I have a serious question, because I had a dream.
How is damage calculated, if PLD1 is covering a teammate, then mitigates and that PLD is then again covered by PLD2 who ALSO mitigates?
Does that even work?🤔
How is damage calculated, if PLD1 is covering a teammate, then mitigates and that PLD is then again covered by PLD2 who ALSO mitigates?
Does that even work?🤔
Great talk from my previous PI @TGO_lab on some of the work I was involved with at @icvs_uminho during my MSc. #PLD1 #lipidomics #neuroscience
x.com/TGO_lab/status…
x.com/TGO_lab/status…
January 20, 2025 at 7:47 PM
Great talk from my previous PI @TGO_lab on some of the work I was involved with at @icvs_uminho during my MSc. #PLD1 #lipidomics #neuroscience
x.com/TGO_lab/status…
x.com/TGO_lab/status…
We explored the impact in the #hippocampus of ablating phospoholipases D1 and D2 (PLD1 & PLD2) with PLD1 leading to disruption of dorsal-ventral lipid signatures & hippocampal-dependent behavioural deficits.
January 20, 2025 at 7:42 PM
We explored the impact in the #hippocampus of ablating phospoholipases D1 and D2 (PLD1 & PLD2) with PLD1 leading to disruption of dorsal-ventral lipid signatures & hippocampal-dependent behavioural deficits.
February 17, 2026 at 8:26 AM
Dual Role for Pld1 in Klebsiella pneumoniae Virulence: Transcriptomics and Proteomics Provide Insights into Direct and Indirect Effects pubmed.ncbi.nlm.nih.gov/40396329/
May 23, 2025 at 2:58 AM
Dual Role for Pld1 in Klebsiella pneumoniae Virulence: Transcriptomics and Proteomics Provide Insights into Direct and Indirect Effects pubmed.ncbi.nlm.nih.gov/40396329/
Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion https://www.biorxiv.org/content/10.1101/2023.12.07.570684v1
Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion https://www.biorxiv.org/content/10.1101/2023.12.07.570684v1
Phospholipase D1 (PLD1) activity is essential for the stimulated exocytosis of secretory vesicles wh
www.biorxiv.org
December 12, 2023 at 7:30 AM
Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion https://www.biorxiv.org/content/10.1101/2023.12.07.570684v1
Gut microbiota and bile acids changes in MASLD mice model with hepatic PLD1 knockout https://www.biorxiv.org/content/10.1101/2025.07.13.663496v1
July 14, 2025 at 3:46 AM
Gut microbiota and bile acids changes in MASLD mice model with hepatic PLD1 knockout https://www.biorxiv.org/content/10.1101/2025.07.13.663496v1
[BioRxiv] PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis
https://doi.org/10.64898/2025.12.08.692971
#neurodegeneration #biorxiv #Dementia #Alzheimers
https://doi.org/10.64898/2025.12.08.692971
#neurodegeneration #biorxiv #Dementia #Alzheimers
BioRxiv Article
doi.org
December 12, 2025 at 12:26 AM
[BioRxiv] PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis
https://doi.org/10.64898/2025.12.08.692971
#neurodegeneration #biorxiv #Dementia #Alzheimers
https://doi.org/10.64898/2025.12.08.692971
#neurodegeneration #biorxiv #Dementia #Alzheimers
PLD1: another interesting one: Opus 4.6 just guesses the right formula based on empirical checks rather than deriving it.
I suppose the formula is pretty simple?
P_i = (n - i - 1)/(2(n - i + 1))
Opus 4.6 transcript: logs.epoch.ai/inspect-vie...
I suppose the formula is pretty simple?
P_i = (n - i - 1)/(2(n - i + 1))
Opus 4.6 transcript: logs.epoch.ai/inspect-vie...
February 12, 2026 at 10:54 PM
PLD1: another interesting one: Opus 4.6 just guesses the right formula based on empirical checks rather than deriving it.
I suppose the formula is pretty simple?
P_i = (n - i - 1)/(2(n - i + 1))
Opus 4.6 transcript: logs.epoch.ai/inspect-vie...
I suppose the formula is pretty simple?
P_i = (n - i - 1)/(2(n - i + 1))
Opus 4.6 transcript: logs.epoch.ai/inspect-vie...
Exploring the PLD1-tau interaction in Frontotemporal Dementia. https://www.biorxiv.org/content/10.64898/2026.02.12.705569v1
February 14, 2026 at 8:17 AM
Exploring the PLD1-tau interaction in Frontotemporal Dementia. https://www.biorxiv.org/content/10.64898/2026.02.12.705569v1
PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis https://www.biorxiv.org/content/10.64898/2025.12.08.692971v1
December 11, 2025 at 3:16 PM
PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis https://www.biorxiv.org/content/10.64898/2025.12.08.692971v1
Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion https://www.biorxiv.org/content/10.1101/2023.12.07.570684v1
Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion https://www.biorxiv.org/content/10.1101/2023.12.07.570684v1
Phospholipase D1 (PLD1) activity is essential for the stimulated exocytosis of secretory vesicles wh
www.biorxiv.org
December 12, 2023 at 7:30 AM
Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion https://www.biorxiv.org/content/10.1101/2023.12.07.570684v1
Exploring the PLD1-tau interaction in Frontotemporal Dementia. https://www.biorxiv.org/content/10.64898/2026.02.12.705569v1
February 14, 2026 at 8:17 AM
Exploring the PLD1-tau interaction in Frontotemporal Dementia. https://www.biorxiv.org/content/10.64898/2026.02.12.705569v1
PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis https://www.biorxiv.org/content/10.64898/2025.12.08.692971v1
December 11, 2025 at 3:16 PM
PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis https://www.biorxiv.org/content/10.64898/2025.12.08.692971v1