Maria Corina Machado wins Nobel Peace Prize!
First FELON loses!
#DefendersOfDemocracy
#NobelPeacePrize
www.npr.org/2025/10/10/n...
First FELON loses!
#DefendersOfDemocracy
#NobelPeacePrize
www.npr.org/2025/10/10/n...
Venezuela's opposition leader María Corina Machado wins 2025 Nobel Peace Prize
Venezuela's opposition leader María Corina Machado has won this year's Nobel Peace Prize for her tireless work promoting democratic rights for the people of Venezuela.
www.npr.org
October 10, 2025 at 4:16 PM
My response to someone still in dismay about everything that has gone on with politics after the election, and to the present day!
bsky.app/profile/ppat...
bsky.app/profile/ppat...
I get what you're saying. The disappointment is unreal.
I do think that grassroots people and organizations are showing up, showing out, and getting in "good trouble!"
That, is the very essence of change.
I do think that grassroots people and organizations are showing up, showing out, and getting in "good trouble!"
That, is the very essence of change.
April 3, 2025 at 10:00 PM
My response to someone still in dismay about everything that has gone on with politics after the election, and to the present day!
bsky.app/profile/ppat...
bsky.app/profile/ppat...
When purine-nucleotide levels are low, PPAT remains active, enabling cells to produce more nucleotides. But when these levels rise, the nucleotides themselves drive assembly of the PPAT–NUDT5 complex, inhibiting PPAT and shutting down further production.'
Nucleotides act as ‘molecular glue’ and can sense their own abundance
Some nucleotides have been shown to control metabolism by ‘gluing’ proteins together. Could other small molecules made naturally by cells have similar capabilities?
www.nature.com
July 17, 2026 at 3:25 AM
When purine-nucleotide levels are low, PPAT remains active, enabling cells to produce more nucleotides. But when these levels rise, the nucleotides themselves drive assembly of the PPAT–NUDT5 complex, inhibiting PPAT and shutting down further production.'
Yes, because LOVE is greater than hate! ❤️
#BadBunnyBowl
#Woke
#SheShed
#DefendersofDemocracy
(Courtesy DannieD
YouTube)
#BadBunnyBowl
#Woke
#SheShed
#DefendersofDemocracy
(Courtesy DannieD
YouTube)
February 9, 2026 at 3:33 AM
🔥Texas Rep. James Talerico gets to the heart of what's wrong with Christian Nationalism.🔥
Special note: Evening if you're not particularly spiritual, agnostic or atheist, you can appreciate him calling this out.
youtube.com/shorts/mu7Sv...
Special note: Evening if you're not particularly spiritual, agnostic or atheist, you can appreciate him calling this out.
youtube.com/shorts/mu7Sv...
Trump vs Jesus
YouTube video by James Talarico
youtube.com
March 5, 2025 at 8:29 PM
PPAT
i have a pen... i have an apple... UH... applepen...
i have a pen... i have an apple... UH... applepen...
February 7, 2025 at 4:13 AM
PPAT
i have a pen... i have an apple... UH... applepen...
i have a pen... i have an apple... UH... applepen...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 7:35 AM
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
It's been a long time coming and I'm super excited to share our new preprint is out: "A novel transgenic reporter to study vertebrate epigenetics". We generated a zebrafish epigenetic reporter and found a fatty liver disease mutant with weird epigenetic phenotypes 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 24, 2025 at 10:42 PM
It's been a long time coming and I'm super excited to share our new preprint is out: "A novel transgenic reporter to study vertebrate epigenetics". We generated a zebrafish epigenetic reporter and found a fatty liver disease mutant with weird epigenetic phenotypes 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PRPP amidotransferase (PPAT) is rate-limiting in purine synthesis. This study shows that PPAT forms intracellular #condensates in response to high purine demand via #PhaseSeparation (driven by TORC1-mediated macromolecular crowding of cytoplasm) @plosbiology.org 🧪 plos.io/3Yw2VVb
April 14, 2025 at 11:51 AM
PRPP amidotransferase (PPAT) is rate-limiting in purine synthesis. This study shows that PPAT forms intracellular #condensates in response to high purine demand via #PhaseSeparation (driven by TORC1-mediated macromolecular crowding of cytoplasm) @plosbiology.org 🧪 plos.io/3Yw2VVb
🔊 Uusi jakso ulkona: Siirtomaavallan purkautuminen Afrikassa.
Afrikan dekolonisaatio alkoi 2. maailmansodan jälkeen.
Osa maista vapautui rauhallisesti, osa ajautui verisiin vapaus- ja sisällissotiin, osa diktatuuriin, korruptioon ja kleptokratiaan.
youtube.com/watch?v=pPaT...
Afrikan dekolonisaatio alkoi 2. maailmansodan jälkeen.
Osa maista vapautui rauhallisesti, osa ajautui verisiin vapaus- ja sisällissotiin, osa diktatuuriin, korruptioon ja kleptokratiaan.
youtube.com/watch?v=pPaT...
Afrikan dekolonisaatio
YouTube video by Peter & Peter
youtube.com
April 26, 2026 at 10:00 AM
🔊 Uusi jakso ulkona: Siirtomaavallan purkautuminen Afrikassa.
Afrikan dekolonisaatio alkoi 2. maailmansodan jälkeen.
Osa maista vapautui rauhallisesti, osa ajautui verisiin vapaus- ja sisällissotiin, osa diktatuuriin, korruptioon ja kleptokratiaan.
youtube.com/watch?v=pPaT...
Afrikan dekolonisaatio alkoi 2. maailmansodan jälkeen.
Osa maista vapautui rauhallisesti, osa ajautui verisiin vapaus- ja sisällissotiin, osa diktatuuriin, korruptioon ja kleptokratiaan.
youtube.com/watch?v=pPaT...
March 18, 2025 at 10:04 PM
Hallo #piraten #ppat
Hallo Welt! 🏴☠️
October 1, 2023 at 5:14 PM
Hallo #piraten #ppat
Datakeskusyhtiöt ovat kykeneviä ostamaan kokonaisia tuotantolaitoksia. Tai siis isot PPAt joissa ostetaan kokonaisen uuden tuotantolaitoksen koko tuotanto >10 vuotta ennalta sovitulla hinnalla joka riittää kattamaan investointikustannukset. Eikös Google ole jo aloittanut ydinvoimahankkeita?
January 14, 2025 at 10:38 AM
Datakeskusyhtiöt ovat kykeneviä ostamaan kokonaisia tuotantolaitoksia. Tai siis isot PPAt joissa ostetaan kokonaisen uuden tuotantolaitoksen koko tuotanto >10 vuotta ennalta sovitulla hinnalla joka riittää kattamaan investointikustannukset. Eikös Google ole jo aloittanut ydinvoimahankkeita?
11/The NUDT5-PPAT complex seems to hold PPAT into an inactive oligomer (likely a tetramer) that suppresses DNPB. In vitro, NUDT5 reduces PPAT enzymatic activity, much better than purine nucleotides alone. But this requires that NUDT5 associate with PPAT.
November 6, 2025 at 7:05 PM
11/The NUDT5-PPAT complex seems to hold PPAT into an inactive oligomer (likely a tetramer) that suppresses DNPB. In vitro, NUDT5 reduces PPAT enzymatic activity, much better than purine nucleotides alone. But this requires that NUDT5 associate with PPAT.
September 24, 2026 at 8:48 PM
It appears we have a winner: bsky.app/profile/ppat...
November 25, 2024 at 9:24 PM
It appears we have a winner: bsky.app/profile/ppat...
Hauptsache die PPat und Wohlhabenden werden weder mit höherer Einkommenssteuer, noch Vermögenssteuer auf grosse Vermögen, noch Erbschaftssteuer auf hohe Erbschaften herangezogen um das Gemeinwohl zu stutzen. Es wird ununterbrochen von unten nach oben umverteilt, die so immer stärker Verarmten auch
May 9, 2026 at 8:07 AM
Hauptsache die PPat und Wohlhabenden werden weder mit höherer Einkommenssteuer, noch Vermögenssteuer auf grosse Vermögen, noch Erbschaftssteuer auf hohe Erbschaften herangezogen um das Gemeinwohl zu stutzen. Es wird ununterbrochen von unten nach oben umverteilt, die so immer stärker Verarmten auch
Meine Mutter,92! ist für zwei Tage im Krhs für einen Minieingriff. (Alter u PPat) sie wollte ihre Maske aufsetzen um im Haus transportiert zu werden. OÄrztin hat ihr erklärt, sie brauche keine Maske, gäbe soviele Viren u C sei harmlos, sie wollten nicht, dass Pat Maske tragen.
Sie glaubt das jetzt.😡
Sie glaubt das jetzt.😡
September 26, 2024 at 9:43 AM
Meine Mutter,92! ist für zwei Tage im Krhs für einen Minieingriff. (Alter u PPat) sie wollte ihre Maske aufsetzen um im Haus transportiert zu werden. OÄrztin hat ihr erklärt, sie brauche keine Maske, gäbe soviele Viren u C sei harmlos, sie wollten nicht, dass Pat Maske tragen.
Sie glaubt das jetzt.😡
Sie glaubt das jetzt.😡
10/Mutating a single NUDT5 residue from the interface with PPAT eliminated NUDT5’s ability to bind PPAT and confer sensitivity to 6TG, both in cultured cells and xenografted tumors.
November 6, 2025 at 7:04 PM
10/Mutating a single NUDT5 residue from the interface with PPAT eliminated NUDT5’s ability to bind PPAT and confer sensitivity to 6TG, both in cultured cells and xenografted tumors.
Ha, das kenne ich noch aus meiner Kindheit. Sowohl d Hausarzt als auch der HNO hatten ein extra Wartezimmer f Privatpatienten. So konnten d Kassenpat nicht meckern über die schnellere Abfertigung v Ppat. Das beim HNO war mir als Kind wg riesiger dunkler Bilder immer unheimlich.
January 31, 2026 at 6:05 AM
Ha, das kenne ich noch aus meiner Kindheit. Sowohl d Hausarzt als auch der HNO hatten ein extra Wartezimmer f Privatpatienten. So konnten d Kassenpat nicht meckern über die schnellere Abfertigung v Ppat. Das beim HNO war mir als Kind wg riesiger dunkler Bilder immer unheimlich.
Actually just so yaknow you probably took the Puppy-adjusted Preschool Aptitude Test (PPAT) and it's wayyyyyy easier so don't like, compare yourself to wolves or foxes or cats or anything.
February 10, 2025 at 7:18 PM
Actually just so yaknow you probably took the Puppy-adjusted Preschool Aptitude Test (PPAT) and it's wayyyyyy easier so don't like, compare yourself to wolves or foxes or cats or anything.
December 2, 2024 at 1:45 AM
The Supreme Court will decide if they wish to take up the case of overturning marriage rights for the gay community this fall.
Kim Davis, the hypocrite, wants you to think she is the moral center of the universe.
Fun facts are below:
#SheShed
#DefendersofDemocracy
Kim Davis, the hypocrite, wants you to think she is the moral center of the universe.
Fun facts are below:
#SheShed
#DefendersofDemocracy
August 12, 2025 at 6:28 PM