Immunofluorescence of Parvalbumin-positive interneurons. The brain surely is a work of art
#neuroskyence #neuroscience #queerinstem #stem
#neuroskyence #neuroscience #queerinstem #stem
December 21, 2024 at 12:20 PM
Immunofluorescence of Parvalbumin-positive interneurons. The brain surely is a work of art
#neuroskyence #neuroscience #queerinstem #stem
#neuroskyence #neuroscience #queerinstem #stem
Couldn't wait for #FluorescenceFriday to share our cover image @SfNJournals Article is pretty cool too #keepCA2weird #PNNs www.jneurosci.org/content/45/6...
Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory
Perineuronal nets (PNNs) are a specialized extracellular matrix that surrounds certain populations of neurons, including (inhibitory) parvalbumin (PV)-expressing interneurons throughout the brain and ...
www.jneurosci.org
February 5, 2025 at 8:18 PM
Couldn't wait for #FluorescenceFriday to share our cover image @SfNJournals Article is pretty cool too #keepCA2weird #PNNs www.jneurosci.org/content/45/6...
The most beautiful neurons in the brain (fact), and also my villain origin story - #FluorescenceFriday
🧡 biocytin patched and filled Purkinje cell
💚 parvalbumin
💜 AnkG for axon initial segments
🧡 biocytin patched and filled Purkinje cell
💚 parvalbumin
💜 AnkG for axon initial segments
January 24, 2025 at 1:22 PM
The most beautiful neurons in the brain (fact), and also my villain origin story - #FluorescenceFriday
🧡 biocytin patched and filled Purkinje cell
💚 parvalbumin
💜 AnkG for axon initial segments
🧡 biocytin patched and filled Purkinje cell
💚 parvalbumin
💜 AnkG for axon initial segments
Excited to share our new paper!
Our new paper in
@NatureComms
reveals how parvalbumin (PV) interneurons regulate stroke recovery by enhancing network synchronization.
Read here: nature.com/articles/s41...
#Neuroscience #StrokeRecovery #BrainPlasticity
Our new paper in
@NatureComms
reveals how parvalbumin (PV) interneurons regulate stroke recovery by enhancing network synchronization.
Read here: nature.com/articles/s41...
#Neuroscience #StrokeRecovery #BrainPlasticity
Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug - Nature Communications
The biological mechanisms of rehabilitation after stroke are not fully understood. Here authors identify parvalbumin interneurons as a key mediator of rehabilitation-induced stroke recovery and a drug...
nature.com
March 18, 2025 at 8:58 PM
Excited to share our new paper!
Our new paper in
@NatureComms
reveals how parvalbumin (PV) interneurons regulate stroke recovery by enhancing network synchronization.
Read here: nature.com/articles/s41...
#Neuroscience #StrokeRecovery #BrainPlasticity
Our new paper in
@NatureComms
reveals how parvalbumin (PV) interneurons regulate stroke recovery by enhancing network synchronization.
Read here: nature.com/articles/s41...
#Neuroscience #StrokeRecovery #BrainPlasticity
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
www.sciencedirect.com
June 11, 2025 at 11:34 AM
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
April 30, 2025 at 3:12 PM
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
🚨New paper from the Epp and Sargin Labs!🚨
We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis
www.science.org/doi/10.1126/...
Simplified highlights below:
🧵/15
We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis
www.science.org/doi/10.1126/...
Simplified highlights below:
🧵/15
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease
Altered function, connectivity, and survival of parvalbumin-expressing neurons in the retrosplenial cortex in Alzheimer’s disease.
www.science.org
April 30, 2025 at 6:34 PM
🚨New paper from the Epp and Sargin Labs!🚨
We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis
www.science.org/doi/10.1126/...
Simplified highlights below:
🧵/15
We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis
www.science.org/doi/10.1126/...
Simplified highlights below:
🧵/15
Female brain holds the key to understanding Alzheimer’s disease. Epp-Sargin lab collaboration led by @dterstege.bsky.social featuring @liisagalea.bsky.social is out in Science Advances. We uncover the mechanisms that make females more vulnerable to Alzheimer’s - in mouse models and human brains 🧠
April 30, 2025 at 6:55 PM
Female brain holds the key to understanding Alzheimer’s disease. Epp-Sargin lab collaboration led by @dterstege.bsky.social featuring @liisagalea.bsky.social is out in Science Advances. We uncover the mechanisms that make females more vulnerable to Alzheimer’s - in mouse models and human brains 🧠
Mild stress/PTSD research... pmc.ncbi.nlm.nih.gov/articles/PMC...
Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation
A rising concern in autism spectrum disorder (ASD) is the heightened sensitivity to trauma, the potential consequences of which have been overlooked, particularly upon the severity of the ASD traits. ...
pmc.ncbi.nlm.nih.gov
June 26, 2025 at 1:37 PM
Mild stress/PTSD research... pmc.ncbi.nlm.nih.gov/articles/PMC...
Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner
www.nature.com/articles/s41...
#neuroscience
www.nature.com/articles/s41...
#neuroscience
Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner - Nature Communications
There has been conflicting evidence on the role of parvalbumin expressing neurons (PVNs) in the prefrontal cortex in working memory. Here, the authors show that prefrontal PVN activity scales with tas...
www.nature.com
June 15, 2026 at 9:30 PM
Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner
www.nature.com/articles/s41...
#neuroscience
www.nature.com/articles/s41...
#neuroscience
Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes.
https://go.nature.com/4lWkesG
https://go.nature.com/4lWkesG
Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.
go.nature.com
May 5, 2025 at 9:27 AM
Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes.
https://go.nature.com/4lWkesG
https://go.nature.com/4lWkesG
A unique type of parvalbumin-expressing inhibitory neurons in the basal forebrain enhances sustained attention, revealing a new neural circuit beyond cholinergic neurons. #Attention PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S009286742600646X
No description available
www.cell.com
October 4, 2026 at 7:00 PM
A unique type of parvalbumin-expressing inhibitory neurons in the basal forebrain enhances sustained attention, revealing a new neural circuit beyond cholinergic neurons. #Attention PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪
We now have #NeuroSkyence manuscript 3 of 2025 on BioRxiv. I had a relatively small role in this molecular project, which was led by my colleague Brian Morris and our student, Liang Yue. 1/2
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Glucocorticoids modulate expression of perineuronal net component genes and parvalbumin during development of mouse cortical neurons
Severe prenatal maternal stress is a risk factor for schizophrenia in offspring. Since parvalbumin-containing GABAergic interneuron function in cortex and hippocampus is compromised in schizophrenia, ...
www.biorxiv.org
February 15, 2025 at 12:25 PM
We now have #NeuroSkyence manuscript 3 of 2025 on BioRxiv. I had a relatively small role in this molecular project, which was led by my colleague Brian Morris and our student, Liang Yue. 1/2
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
April 30, 2025 at 3:41 PM
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
This recent 🔥 Hot Topic 🔥 examines how prefrontal cortex parvalbumin-expressing interneurons contribute to sex differences in psychiatric disorders, w/ sex differences in glutamate receptor activity likely shaped by estrogen receptor signaling
Parvalbumin interneurons mediate sex differences in prefrontal cortex function
Neuropsychopharmacology - Parvalbumin interneurons mediate sex differences in prefrontal cortex function
www.nature.com
September 26, 2025 at 5:29 PM
This recent 🔥 Hot Topic 🔥 examines how prefrontal cortex parvalbumin-expressing interneurons contribute to sex differences in psychiatric disorders, w/ sex differences in glutamate receptor activity likely shaped by estrogen receptor signaling
Textbook neuroscience teaches that anatomy dictates function. But which aspects of anatomy determine differences in function between species? We think neuroscience is now well-placed to tackle this question. Here is our attempt at one piece of the puzzle: www.nature.com/articles/s42...
Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques - Communications Biology
Integrative anatomical, molecular, behavioral, and modeling evidence suggests that higher dopamine D1 receptor expression in prefrontal cortical parvalbumin neurons in marmosets likely contributes to ...
www.nature.com
July 1, 2025 at 3:40 PM
Textbook neuroscience teaches that anatomy dictates function. But which aspects of anatomy determine differences in function between species? We think neuroscience is now well-placed to tackle this question. Here is our attempt at one piece of the puzzle: www.nature.com/articles/s42...
GAD65 GFP and parvalbumin.
November 25, 2025 at 6:40 PM
GAD65 GFP and parvalbumin.
Basket cells, parvalbumin expressing or fast-spiking neurons, names that emphasize different properties of the same type. However they are not all the same, like these in the mouse barrel cortex: one has axon in its layer; the other sends axon to other layers
Both are very beautiful
#neuroskyence
Both are very beautiful
#neuroskyence
September 24, 2025 at 1:04 PM
Basket cells, parvalbumin expressing or fast-spiking neurons, names that emphasize different properties of the same type. However they are not all the same, like these in the mouse barrel cortex: one has axon in its layer; the other sends axon to other layers
Both are very beautiful
#neuroskyence
Both are very beautiful
#neuroskyence
Link to the study for reference...
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation
A rising concern in autism spectrum disorder (ASD) is the heightened sensitivity to trauma, the potential consequences of which have been overlooked, particularly upon the severity of the ASD traits. ...
pmc.ncbi.nlm.nih.gov
May 22, 2025 at 11:58 PM
Link to the study for reference...
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug www.nature.com/articles/s41...
Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug - Nature Communications
The biological mechanisms of rehabilitation after stroke are not fully understood. Here authors identify parvalbumin interneurons as a key mediator of rehabilitation-induced stroke recovery and a drug...
www.nature.com
March 17, 2025 at 10:20 AM
Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug www.nature.com/articles/s41...
Tend to agree. Work by us & @kdmicheva.bsky.social showed that a strangely high fraction (~50%) of myelin in upper layers of cortex wraps short lengths of fast-spiking, parvalbumin-positive basket cells. We suggested it was to support their axons, rather than to speed up spike time arrival.
May 30, 2026 at 7:18 PM
Tend to agree. Work by us & @kdmicheva.bsky.social showed that a strangely high fraction (~50%) of myelin in upper layers of cortex wraps short lengths of fast-spiking, parvalbumin-positive basket cells. We suggested it was to support their axons, rather than to speed up spike time arrival.
Ryan’s paper out in Neuron (bit.ly/3IICGFX). He derived bona fide parvalbumin (PV+) cortical interneurons from hPSCs, one the slowest developing neurons, and could capturing interneuron-related disease phenotypes linked to schizophrenia - including impaired gamma-oscillations - in his assembloids.
Redirecting
bit.ly
July 22, 2025 at 5:59 PM
Ryan’s paper out in Neuron (bit.ly/3IICGFX). He derived bona fide parvalbumin (PV+) cortical interneurons from hPSCs, one the slowest developing neurons, and could capturing interneuron-related disease phenotypes linked to schizophrenia - including impaired gamma-oscillations - in his assembloids.
The 2025 Association for Research in Otolaryngology Midwinter Meeting is in the books, and my Parvalbumin arbors have been potentiated.
February 27, 2025 at 2:48 AM
The 2025 Association for Research in Otolaryngology Midwinter Meeting is in the books, and my Parvalbumin arbors have been potentiated.
🧠 Fluoxetine and brain flexibility
A new study found that long-term fluoxetine changes how brain cells in the prefrontal cortex use energy and form connections, keeping the adult brain adaptable.
🔗 www.nature.com/articles/s41...
#SciComm #Neuroscience 🧪
A new study found that long-term fluoxetine changes how brain cells in the prefrontal cortex use energy and form connections, keeping the adult brain adaptable.
🔗 www.nature.com/articles/s41...
#SciComm #Neuroscience 🧪
Chronic treatment with fluoxetine regulates mitochondrial features and plasticity-associated transcriptomic pathways in parvalbumin-positive interneurons of prefrontal cortex - Neuropsychopharmacology
Neuropsychopharmacology - Chronic treatment with fluoxetine regulates mitochondrial features and plasticity-associated transcriptomic pathways in parvalbumin-positive interneurons of prefrontal cortex
www.nature.com
September 29, 2025 at 12:03 PM
🧠 Fluoxetine and brain flexibility
A new study found that long-term fluoxetine changes how brain cells in the prefrontal cortex use energy and form connections, keeping the adult brain adaptable.
🔗 www.nature.com/articles/s41...
#SciComm #Neuroscience 🧪
A new study found that long-term fluoxetine changes how brain cells in the prefrontal cortex use energy and form connections, keeping the adult brain adaptable.
🔗 www.nature.com/articles/s41...
#SciComm #Neuroscience 🧪
For #FluorescenceFriday - image credit to JHU Neuro grad student Suhaas Adiraju - parvalbumin 🟢, somatostatin 🔴, vGlut1 (Cyan). 🟣 marks cells activated by amphetamine using the Fos-TRAP activity-dependent tagging system. 🔬🧪🧠
August 29, 2025 at 5:45 PM
For #FluorescenceFriday - image credit to JHU Neuro grad student Suhaas Adiraju - parvalbumin 🟢, somatostatin 🔴, vGlut1 (Cyan). 🟣 marks cells activated by amphetamine using the Fos-TRAP activity-dependent tagging system. 🔬🧪🧠