Nature research paper: A methanogen hydrolase reveals the structure of archaeal peptidoglycan
go.nature.com/4xN3B7j
go.nature.com/4xN3B7j
A methanogen hydrolase reveals the structure of archaeal peptidoglycan - Nature
ArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleaving the cell wall of methanogens, revealing an unsuspected chemical structure of archaeal peptidoglycan that includes a previously unidentified sugar.
go.nature.com
September 30, 2026 at 9:47 AM
Nature research paper: A methanogen hydrolase reveals the structure of archaeal peptidoglycan
go.nature.com/4xN3B7j
go.nature.com/4xN3B7j
Out Now! Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae #MicroSky
Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae
Nature Microbiology, Published online: 07 April 2026; doi:10.1038/s41564-026-02322-6Sequential peptidoglycan carboxylase activity of DacA and DacB generates a local peptidoglycan signature that recruits MapZ and establishes the division site at the Streptococcus pneumoniae cell equator.
go.nature.com
April 7, 2026 at 6:41 PM
Out Now! Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae #MicroSky
OUT NOW: Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation
by Knut Drescher & co
www.nature.com/articles/s41...
by Knut Drescher & co
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 3, 2025 at 4:23 PM
OUT NOW: Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation
by Knut Drescher & co
www.nature.com/articles/s41...
by Knut Drescher & co
www.nature.com/articles/s41...
Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it?
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Archaea produce peptidoglycan hydrolases that kill bacteria
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...
journals.plos.org
August 14, 2025 at 6:50 PM
Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it?
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation.
Details here 👇
www.nature.com/articles/s41...
Details here 👇
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 6, 2025 at 10:13 AM
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation.
Details here 👇
www.nature.com/articles/s41...
Details here 👇
www.nature.com/articles/s41...
This first-author publication is my… first! Archaea kill bacteria by targeting their Achilles’ heel: peptidoglycan. Big shoutout to @ahocher.bsky.social, @valeriesoo.bsky.social, Pauline Misson, @tobiaswarnecke.bsky.social and MRC LMS Proteomics. A thread 🔽
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Archaea produce peptidoglycan hydrolases that kill bacteria
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...
journals.plos.org
August 15, 2025 at 11:19 AM
This first-author publication is my… first! Archaea kill bacteria by targeting their Achilles’ heel: peptidoglycan. Big shoutout to @ahocher.bsky.social, @valeriesoo.bsky.social, Pauline Misson, @tobiaswarnecke.bsky.social and MRC LMS Proteomics. A thread 🔽
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness | Science Translational Medicine www.science.org/doi/10.1126/...
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness
Polymeric Borrelia burgdorferi peptidoglycan cell wall can persist in murine livers for weeks to months after direct injection or infection.
www.science.org
June 26, 2025 at 8:18 AM
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness | Science Translational Medicine www.science.org/doi/10.1126/...
#microsky
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology
Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.
www.nature.com
July 29, 2025 at 1:23 PM
#microsky
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.
Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.
📄 www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation
#Vibriocholerae
@naturemicrobiol.bsky.social from @knutdrescher.bsky.social
www.nature.com/articles/s41...
#Vibriocholerae
@naturemicrobiol.bsky.social from @knutdrescher.bsky.social
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 4, 2025 at 4:57 PM
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation
#Vibriocholerae
@naturemicrobiol.bsky.social from @knutdrescher.bsky.social
www.nature.com/articles/s41...
#Vibriocholerae
@naturemicrobiol.bsky.social from @knutdrescher.bsky.social
www.nature.com/articles/s41...
So happy to see this paper finally out 🥳 it took only seven years after the first purification of archaeal peptidoglycan 🤣 Congrats to all the people involved 🥂🍾
And here is the story behind the paper: communities.springernature.com/posts/cracki...
And here is the story behind the paper: communities.springernature.com/posts/cracki...
September 23, 2026 at 4:06 PM
So happy to see this paper finally out 🥳 it took only seven years after the first purification of archaeal peptidoglycan 🤣 Congrats to all the people involved 🥂🍾
And here is the story behind the paper: communities.springernature.com/posts/cracki...
And here is the story behind the paper: communities.springernature.com/posts/cracki...
Peptidoglycan as danger signal promotes biofilm formation - great article by the Drescher lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 4, 2025 at 2:21 PM
Peptidoglycan as danger signal promotes biofilm formation - great article by the Drescher lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interested in #archaea, #methane, #cell-envelopes?
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
www.nature.com
September 23, 2026 at 3:19 PM
Interested in #archaea, #methane, #cell-envelopes?
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
Bacterial peptidoglycan recycling www.cell.com/trends/micro... #jcampubs
Bacterial peptidoglycan recycling
During growth and division, the bacterial cell wall is remodeled, resulting in the
liberation of peptidoglycan (PG) fragments which are typically reinternalized and
recycled. Recycling of PG has been ...
www.cell.com
December 2, 2024 at 5:26 PM
Bacterial peptidoglycan recycling www.cell.com/trends/micro... #jcampubs
Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi
Exciting new research from @jutraslab.bsky.social
journals.plos.org/plospathogen...
#MicroSky
Exciting new research from @jutraslab.bsky.social
journals.plos.org/plospathogen...
#MicroSky
Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi
Author summary Many of the pathogenic mechanisms by which Borrelia burgdorferi causes disease involve cell envelope interactions with host components. To further elucidate the role of peptidoglycan in...
journals.plos.org
January 29, 2026 at 8:25 PM
Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi
Exciting new research from @jutraslab.bsky.social
journals.plos.org/plospathogen...
#MicroSky
Exciting new research from @jutraslab.bsky.social
journals.plos.org/plospathogen...
#MicroSky
Check out our exciting new paper out now in @plos.org where Dr Ahmad manipulated #peptidoglycan chemistry to understand Lyme disease and arthritis 👇👏
#Microsky
#glycotime
journals.plos.org/plospathogen...
#Microsky
#glycotime
journals.plos.org/plospathogen...
Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi
Author summary Many of the pathogenic mechanisms by which Borrelia burgdorferi causes disease involve cell envelope interactions with host components. To further elucidate the role of peptidoglycan in...
journals.plos.org
January 20, 2026 at 7:34 PM
Check out our exciting new paper out now in @plos.org where Dr Ahmad manipulated #peptidoglycan chemistry to understand Lyme disease and arthritis 👇👏
#Microsky
#glycotime
journals.plos.org/plospathogen...
#Microsky
#glycotime
journals.plos.org/plospathogen...
New paper alert-outstanding postdoc Mecaila McClune has deeply enriched our understanding of #Lymedisease pathogenesis through live, real-time peptidoglycan #glycotime tracking. Her work draws curious parallels to #LongCovid & infection associated chronic illness
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness
Polymeric Borrelia burgdorferi peptidoglycan cell wall can persist in murine livers for weeks to months after direct injection or infection.
www.science.org
April 23, 2025 at 6:33 PM
New paper alert-outstanding postdoc Mecaila McClune has deeply enriched our understanding of #Lymedisease pathogenesis through live, real-time peptidoglycan #glycotime tracking. Her work draws curious parallels to #LongCovid & infection associated chronic illness
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
cool! peptidoglycan triggers biofilm formation in various Gram-pos. and Gram-neg. bacteria.
also cool - but well known: peptidoglycan fragments trigger spore germination in 𝘉. 𝘴𝘶𝘣𝘵𝘪𝘭𝘪𝘴
#MicroSky
also cool - but well known: peptidoglycan fragments trigger spore germination in 𝘉. 𝘴𝘶𝘣𝘵𝘪𝘭𝘪𝘴
#MicroSky
January 4, 2025 at 12:58 AM
cool! peptidoglycan triggers biofilm formation in various Gram-pos. and Gram-neg. bacteria.
also cool - but well known: peptidoglycan fragments trigger spore germination in 𝘉. 𝘴𝘶𝘣𝘵𝘪𝘭𝘪𝘴
#MicroSky
also cool - but well known: peptidoglycan fragments trigger spore germination in 𝘉. 𝘴𝘶𝘣𝘵𝘪𝘭𝘪𝘴
#MicroSky
𝘚𝘤𝘪 𝘛𝘳𝘢𝘯𝘴𝘭 𝘔𝘦𝘥
Weeks after 𝘉. 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪
is cleared, its peptidoglycan lingers in the liver in polymeric form—resisting degradation, rewiring mononuclear cell metabolism, and triggering low grade inflammation
Structural basis to long-lasting symptoms that affect 5-10% of people with Lyme disease?
Weeks after 𝘉. 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪
is cleared, its peptidoglycan lingers in the liver in polymeric form—resisting degradation, rewiring mononuclear cell metabolism, and triggering low grade inflammation
Structural basis to long-lasting symptoms that affect 5-10% of people with Lyme disease?
The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness
Polymeric Borrelia burgdorferi peptidoglycan cell wall can persist in murine livers for weeks to months after direct injection or infection.
www.science.org
May 5, 2025 at 1:35 PM
𝘚𝘤𝘪 𝘛𝘳𝘢𝘯𝘴𝘭 𝘔𝘦𝘥
Weeks after 𝘉. 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪
is cleared, its peptidoglycan lingers in the liver in polymeric form—resisting degradation, rewiring mononuclear cell metabolism, and triggering low grade inflammation
Structural basis to long-lasting symptoms that affect 5-10% of people with Lyme disease?
Weeks after 𝘉. 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪
is cleared, its peptidoglycan lingers in the liver in polymeric form—resisting degradation, rewiring mononuclear cell metabolism, and triggering low grade inflammation
Structural basis to long-lasting symptoms that affect 5-10% of people with Lyme disease?
A methanogen hydrolase reveals the structure of archaeal peptidoglycan www.nature.com/articles/s41... #jcampubs
A methanogen hydrolase reveals the structure of archaeal peptidoglycan - Nature
ArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleaving the cell wall of methanogens, reveali...
www.nature.com
September 24, 2026 at 1:58 PM
A methanogen hydrolase reveals the structure of archaeal peptidoglycan www.nature.com/articles/s41... #jcampubs
Our new paper on FtsN is out! Now there are three tracks for organized cell wall constriction-- the old, boring E. coli always manages to surprise us.
A special shout-out to all the people who made this work possible, especially Dr. Jason Lyu, and Dr. David Weiss.
www.nature.com/articles/s41...
A special shout-out to all the people who made this work possible, especially Dr. Jason Lyu, and Dr. David Weiss.
www.nature.com/articles/s41...
Third track model for coordination of septal peptidoglycan synthesis and degradation by FtsN in Escherichia coli - Nature Microbiology
Partitioning of FtsN and the septal peptidoglycan synthesis complex between an active synthesis track and an inactive denuded glycan track coordinates opposing peptidoglycan synthesis and degradation ...
www.nature.com
May 27, 2025 at 5:13 PM
Our new paper on FtsN is out! Now there are three tracks for organized cell wall constriction-- the old, boring E. coli always manages to surprise us.
A special shout-out to all the people who made this work possible, especially Dr. Jason Lyu, and Dr. David Weiss.
www.nature.com/articles/s41...
A special shout-out to all the people who made this work possible, especially Dr. Jason Lyu, and Dr. David Weiss.
www.nature.com/articles/s41...
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 4:01 PM
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
What is better than one? Two connected papers!
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
December 19, 2025 at 2:06 PM
What is better than one? Two connected papers!
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
Agata Starosta @agatastarosta.bsky.social on Ribosomes translocation into the spore of Bacillus subtilis is highly organised and requires peptidoglycan rearrangements
#EMBOBacNet
#EMBOBacNet
September 15, 2026 at 9:04 AM
Agata Starosta @agatastarosta.bsky.social on Ribosomes translocation into the spore of Bacillus subtilis is highly organised and requires peptidoglycan rearrangements
#EMBOBacNet
#EMBOBacNet
The reason why gram positive bacteria stain purple is because of PEPTIDOGLYCAN 🗣️
(I’m studying)
(I’m studying)
September 10, 2025 at 4:00 PM
The reason why gram positive bacteria stain purple is because of PEPTIDOGLYCAN 🗣️
(I’m studying)
(I’m studying)
Out Now! Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis #MicroSky
Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis
Nature Microbiology, Published online: 26 May 2026; doi:10.1038/s41564-026-02368-6Wall teichoic acids confer rod shape in the Gram-positive model organism Bacillus subtilis by occluding pores in the cell wall, thereby preventing runaway isotropic (non-oriented) peptidoglycan synthesis.
go.nature.com
May 26, 2026 at 12:18 PM
Out Now! Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis #MicroSky