America's women should make it crystal clear to SCOTUS that prohibiting "birth control pills" and/or "Mifepristone" will mean outlawing all prescription medications primarily used to treat erectile dysfunction (ED) a/k/a PDE5 (phosphodiesterase type 5) inhibitors.
May 15, 2026 at 10:31 PM
America's women should make it crystal clear to SCOTUS that prohibiting "birth control pills" and/or "Mifepristone" will mean outlawing all prescription medications primarily used to treat erectile dysfunction (ED) a/k/a PDE5 (phosphodiesterase type 5) inhibitors.
Dadurch wird eine Erektion nicht nur ermöglicht, sondern auch aufrechterhalten.
Um wirken zu können, muss allerdings eine sexuelle Stimulation vorliegen.
Sildenafil gehört zu den PDE-5-Hemmer und hemmt folglich die Phosphodiesterase-5.
#DerApotheker 🥷 2
Um wirken zu können, muss allerdings eine sexuelle Stimulation vorliegen.
Sildenafil gehört zu den PDE-5-Hemmer und hemmt folglich die Phosphodiesterase-5.
#DerApotheker 🥷 2
July 13, 2024 at 5:18 PM
Dadurch wird eine Erektion nicht nur ermöglicht, sondern auch aufrechterhalten.
Um wirken zu können, muss allerdings eine sexuelle Stimulation vorliegen.
Sildenafil gehört zu den PDE-5-Hemmer und hemmt folglich die Phosphodiesterase-5.
#DerApotheker 🥷 2
Um wirken zu können, muss allerdings eine sexuelle Stimulation vorliegen.
Sildenafil gehört zu den PDE-5-Hemmer und hemmt folglich die Phosphodiesterase-5.
#DerApotheker 🥷 2
They really should have used "Revatio" to prevent all the jokes from non- #medical people (Revatio is the version of #sildenefil used for #pulmonaryhypertension, a phosphodiesterase-5 (PDE-5) inhibitor which widens blood vessels in the lungs
Difference is dosing. PH doses are smaller
Difference is dosing. PH doses are smaller
BREAKING: England players are reportedly permitted to use Viagra to help manage World Cup altitude conditions in Mexico City.
July 3, 2026 at 8:42 PM
They really should have used "Revatio" to prevent all the jokes from non- #medical people (Revatio is the version of #sildenefil used for #pulmonaryhypertension, a phosphodiesterase-5 (PDE-5) inhibitor which widens blood vessels in the lungs
Difference is dosing. PH doses are smaller
Difference is dosing. PH doses are smaller
Investigation of the pleiotropic effects of #Phosphodiesterase-5 #inhibitors on the #skeletalmuscle #proteome and #transcriptome and #serum #metabolome in middle-age adults reports systemic #antiinflammatory effects, with no immunohistochemical changes in 1 month.
doi.org/10.14814/phy...
doi.org/10.14814/phy...
Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study
Phosphodiesterase-5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were…
doi.org
September 24, 2026 at 9:15 AM
Investigation of the pleiotropic effects of #Phosphodiesterase-5 #inhibitors on the #skeletalmuscle #proteome and #transcriptome and #serum #metabolome in middle-age adults reports systemic #antiinflammatory effects, with no immunohistochemical changes in 1 month.
doi.org/10.14814/phy...
doi.org/10.14814/phy...
The study has been published in Alzheimer’s Research and Therapy. YES, it is PEER-REVIEWED.
• alzres.biomedcentral.com/articles/10....
🧪🧵⬇️
• alzres.biomedcentral.com/articles/10....
🧪🧵⬇️
![Results
Among the 80 candidates that were nominated by the expert panel, seven underwent review, with only three candidates meeting the following consensus criteria of relevant mechanisms for targeting neurodegenerative pathways, non-clinical efficacy, and tolerability in older individuals. The three agents were: [1] the live attenuated herpes zoster (HZ) vaccine (Zostavax) [2], sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, and
[3] riluzole, a glutamate antagonist. The HZ vaccine additionally offers potential for population-level dementia risk reduction.
Conclusion
This Delphi consensus identified three high-priority drug repurposing candidates for AD with favourable safety profiles and mechanistic plausibility, which are considered suitable for pragmatic clinical trials, including remote or hybrid designs. The PROTECT platform, which supports international cohorts in the UK, Norway, and Canada, offers a well-established means to conduct such trials effectively, thus helping to accelerate the evaluation and potential deployment of these drug candidates to benefit individuals with or at risk for AD.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:llgfbjvsqkaicezsf7mzjxr3/bafkreibftu3m77jme2o3u3mzpu6g3qabpb2o6ngvemrmwfudtkb5nqmo6m)
November 20, 2025 at 5:03 PM
The study has been published in Alzheimer’s Research and Therapy. YES, it is PEER-REVIEWED.
• alzres.biomedcentral.com/articles/10....
🧪🧵⬇️
• alzres.biomedcentral.com/articles/10....
🧪🧵⬇️
AlvaDesc has been used in "Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer" doi.org/10.1039/D4MD...
Check #alvaDesc at: alvascience.com/alvadesc/
#compchem #cheminformatics
Check #alvaDesc at: alvascience.com/alvadesc/
#compchem #cheminformatics
Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer
Phosphodiesterase 5 (PDE5), an enzyme responsible for catalyzing the degradation of cyclic guanosine monophosphate (cGMP), has been linked to the development of cancer. PDE5 inhibitors (PDE5i), such a...
doi.org
December 18, 2024 at 12:57 PM
AlvaDesc has been used in "Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer" doi.org/10.1039/D4MD...
Check #alvaDesc at: alvascience.com/alvadesc/
#compchem #cheminformatics
Check #alvaDesc at: alvascience.com/alvadesc/
#compchem #cheminformatics
🧪 After some hype based on poorly designed observational research.. new preprint awaiting feedback!
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
PDE5 inhibition and Alzheimer's disease risk: a mendelian randomisation study
Introduction: While preclinical studies suggest that Phosphodiesterase 5 (PDE5) inhibition may reduce cognitive impairment, findings from observational studies on whether PDE5 inhibitors reduce Alzhei...
www.medrxiv.org
November 18, 2024 at 9:19 PM
🧪 After some hype based on poorly designed observational research.. new preprint awaiting feedback!
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
Good dogs like you deserve rewards (boot fucking) and treats (psychoactive serotonin inhibitors mixed with aphrodisiacs and a phosphodiesterase type 5 inhibitor) <3
May 12, 2026 at 10:20 AM
Good dogs like you deserve rewards (boot fucking) and treats (psychoactive serotonin inhibitors mixed with aphrodisiacs and a phosphodiesterase type 5 inhibitor) <3
Ophthopedia Update: Phosphodiesterase 5 inhibitor use and incident diabetic retinopathy in men with erectile dysfunction and type 2 diabetes: a propensity-matched cohort study: Eye, Published online: 25 September 2026;… #Ophthalmology #Eye #Ophthotwitter
Phosphodiesterase 5 inhibitor use and incident diabetic retinopathy in men with erectile dysfunction and type 2 diabetes: a propensity-matched cohort study
Eye, Published online: 25 September 2026; doi:10.1038/s41433-026-04893-4Phosphodiesterase 5 inhibitor use and incident diabetic retinopathy in men with erectile dysfunction and type 2 diabetes: a propensity-matched cohort study
dlvr.it
September 26, 2026 at 3:16 AM
Ophthopedia Update: Phosphodiesterase 5 inhibitor use and incident diabetic retinopathy in men with erectile dysfunction and type 2 diabetes: a propensity-matched cohort study: Eye, Published online: 25 September 2026;… #Ophthalmology #Eye #Ophthotwitter
'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration'
#TumorImmunology
#TumorImmunology
Rescuing dendritic cell interstitial motility sustains antitumour immunity - Nature
Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.
www.nature.com
July 2, 2025 at 12:29 AM
'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration'
#TumorImmunology
#TumorImmunology
Study finds erectile dysfunction drugs linked to lower Alzheimer's risk news-medical.net/news/2024021...
#erectiledysfunction #Alzheimers #AD #menshealth #health
#erectiledysfunction #Alzheimers #AD #menshealth #health
Study finds erectile dysfunction drugs linked to lower Alzheimer's risk
Researchers evaluated the effect of phosphodiesterase-5 inhibitor (PDE5I) initiation compared to non-use and Alzheimer's disease development risk among males suffering from erectile dysfunction.
news-medical.net
February 12, 2024 at 10:29 PM
Study finds erectile dysfunction drugs linked to lower Alzheimer's risk news-medical.net/news/2024021...
#erectiledysfunction #Alzheimers #AD #menshealth #health
#erectiledysfunction #Alzheimers #AD #menshealth #health
In preliminary findings, Omar Saeed, M.D., and colleague have observed that #sildenafil (Viagra)—a phosphodiesterase-5 inhibitor prescribed to certain LVAD patients because of high lung pressure —appears to be linked to reduced stroke and death among those patients. #MedSky #research
Testing Whether Viagra Can Benefit Heart-Failure Patients
bit.ly
January 29, 2025 at 3:58 PM
In preliminary findings, Omar Saeed, M.D., and colleague have observed that #sildenafil (Viagra)—a phosphodiesterase-5 inhibitor prescribed to certain LVAD patients because of high lung pressure —appears to be linked to reduced stroke and death among those patients. #MedSky #research
doi.org/10.7326/M21-... no clue if you have academic access as it is not on anna's archive but you can still see the conclusion. even if you take the limitations at face value [and, most of our patients are bad at following instructions] you'd presumably see Something.
Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease: A Case-Crossover Study: Annals of Internal ...
Background: Concomitant use of oral organic nitrates (nitrates) and phosphodiesterase type 5 (PDE5) inhibitors is contraindicated. Objective: To measure temporal trends in the coprescription of nitrat...
doi.org
December 1, 2024 at 2:53 AM
doi.org/10.7326/M21-... no clue if you have academic access as it is not on anna's archive but you can still see the conclusion. even if you take the limitations at face value [and, most of our patients are bad at following instructions] you'd presumably see Something.
Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation
Fear generalization, a lack of discrimination between safe and unsafe cues, is a hallmark of posttraumatic stress disorder. The phosphodiesterase 5 (P…
www.sciencedirect.com
January 27, 2025 at 10:41 AM
Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The Blue Journal thanks Athiththan Yogeswaran, MD, for his contribution to the October issue
Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in ILD: A PVRI GoDeep Meta-Registry Analysis
www.atsjournals.org/doi/full/10....
Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in ILD: A PVRI GoDeep Meta-Registry Analysis
www.atsjournals.org/doi/full/10....
October 9, 2025 at 3:52 PM
The Blue Journal thanks Athiththan Yogeswaran, MD, for his contribution to the October issue
Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in ILD: A PVRI GoDeep Meta-Registry Analysis
www.atsjournals.org/doi/full/10....
Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in ILD: A PVRI GoDeep Meta-Registry Analysis
www.atsjournals.org/doi/full/10....
El reconocimiento premia el trabajo titulado “Vitamin D as an add-on therapy to phosphodiesterase-5 inhibitor in experimental pulmonary arterial hypertension”, seleccionado por su relevancia científica en fisiología pulmonar y cardiovascular
Premian una investigación española que apunta a la vitamina D como aliada frente a la hipertensión pulmonar
La investigación de la Facultad de Medicina de la Universidad Complutense de Madrid ha sido galardonada con el premio “Best Short Report Article” por la revista American Journal of Physiolog ...
mlibr.es
May 17, 2026 at 8:01 PM
El reconocimiento premia el trabajo titulado “Vitamin D as an add-on therapy to phosphodiesterase-5 inhibitor in experimental pulmonary arterial hypertension”, seleccionado por su relevancia científica en fisiología pulmonar y cardiovascular
Patients with diabetes often also have erectile dysfunction, which is nothing more than endothelial dysfunction, and in such patients, the use of phosphodiesterase-5 (PDE5) inhibitors is recommended to treat erectile dysfunction. ...
November 23, 2024 at 10:50 AM
Patients with diabetes often also have erectile dysfunction, which is nothing more than endothelial dysfunction, and in such patients, the use of phosphodiesterase-5 (PDE5) inhibitors is recommended to treat erectile dysfunction. ...
RRIDs were included in this in Science Advances paper. Thanks for making your methods matter! #methodsmatter #reproducibility #STMpublishing
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
Read the full paper: Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
doi.org
April 11, 2026 at 7:01 AM
RRIDs were included in this in Science Advances paper. Thanks for making your methods matter! #methodsmatter #reproducibility #STMpublishing
Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in Interstitial Lung Disease: A PVRI GoDeep Meta-Registry Analysis
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/yeu6f7tv
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/yeu6f7tv
October 13, 2025 at 3:13 PM
Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in Interstitial Lung Disease: A PVRI GoDeep Meta-Registry Analysis
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/yeu6f7tv
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/yeu6f7tv
A 10,000-Foot View at Survival and Treatment with Phosphodiesterase-5 Inhibitors in Interstitial Lung Disease Pulmonary Hypertension
@atscommunity.bsky.social #medsky
🔓 Open Access
🔗 tinyurl.com/32xvxtpf
@atscommunity.bsky.social #medsky
🔓 Open Access
🔗 tinyurl.com/32xvxtpf
October 13, 2025 at 3:16 PM
A 10,000-Foot View at Survival and Treatment with Phosphodiesterase-5 Inhibitors in Interstitial Lung Disease Pulmonary Hypertension
@atscommunity.bsky.social #medsky
🔓 Open Access
🔗 tinyurl.com/32xvxtpf
@atscommunity.bsky.social #medsky
🔓 Open Access
🔗 tinyurl.com/32xvxtpf
Men On Viagra Found To have 18% Lower Risk Of Alzheimer’s Disease
Depositphotos Phosphodiesterase type 5 inhibitors such as Viagra are, of course, best known for effectively treating erectile dysfunction, but a study of nearly 270,000 men has added to the growing body of evidence that they may…
Depositphotos Phosphodiesterase type 5 inhibitors such as Viagra are, of course, best known for effectively treating erectile dysfunction, but a study of nearly 270,000 men has added to the growing body of evidence that they may…
Men On Viagra Found To have 18% Lower Risk Of Alzheimer’s Disease
Depositphotos Phosphodiesterase type 5 inhibitors such as Viagra are, of course, best known for effectively treating erectile dysfunction, but a study of nearly 270,000 men has added to the growing body of evidence that they may also lower the risk of developing Alzheimer’s disease. University College London (UCL) researchers looked at 269,725 male participants in the UK, with an average age of 59, with no evidence of cognitive impairment, who had recently been diagnosed with erectile dysfunction…….
onlinemarketingscoops.com
August 19, 2026 at 5:28 PM
Men On Viagra Found To have 18% Lower Risk Of Alzheimer’s Disease
Depositphotos Phosphodiesterase type 5 inhibitors such as Viagra are, of course, best known for effectively treating erectile dysfunction, but a study of nearly 270,000 men has added to the growing body of evidence that they may…
Depositphotos Phosphodiesterase type 5 inhibitors such as Viagra are, of course, best known for effectively treating erectile dysfunction, but a study of nearly 270,000 men has added to the growing body of evidence that they may…
RRID:AB_3668997, was just reported to be used in "Phosphodiesterase 5 expression in photoreceptors rescues retinal degeneration induced by deregulation of membrane guanylyl cyclas…". RRIDs like this improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch
doi.org
February 16, 2025 at 8:02 AM
RRID:AB_3668997, was just reported to be used in "Phosphodiesterase 5 expression in photoreceptors rescues retinal degeneration induced by deregulation of membrane guanylyl cyclas…". RRIDs like this improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch
It helped people survive covid
pmc.ncbi.nlm.nih.gov/articles/PMC...
And it's in trials for long covid
clinicaltrials.gov/study/NCT043...
pmc.ncbi.nlm.nih.gov/articles/PMC...
And it's in trials for long covid
clinicaltrials.gov/study/NCT043...
Efficacy of Sildenafil in Patients with Severe COVID-19 and Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is common in severe coronavirus disease 2019 (COVID-19) and worsens the prognosis. Sildenafil, a phosphodiesterase-5 inhibitor, is approved for PAH treatment but little is known about its efficacy in cases of ...
pmc.ncbi.nlm.nih.gov
April 1, 2026 at 2:03 AM
It helped people survive covid
pmc.ncbi.nlm.nih.gov/articles/PMC...
And it's in trials for long covid
clinicaltrials.gov/study/NCT043...
pmc.ncbi.nlm.nih.gov/articles/PMC...
And it's in trials for long covid
clinicaltrials.gov/study/NCT043...