Why Mendelian Randomization Unveils Poly(ADP ribose) Polymerase 1 as Causal Plasma Protein matters more than you think.
#mendelianrandomization #cellular #molecule #coherance #dna #quantum #joedispenza #fyp #energy #logic #science #people
#mendelianrandomization #cellular #molecule #coherance #dna #quantum #joedispenza #fyp #energy #logic #science #people
September 21, 2026 at 4:02 AM
Why Mendelian Randomization Unveils Poly(ADP ribose) Polymerase 1 as Causal Plasma Protein matters more than you think.
#mendelianrandomization #cellular #molecule #coherance #dna #quantum #joedispenza #fyp #energy #logic #science #people
#mendelianrandomization #cellular #molecule #coherance #dna #quantum #joedispenza #fyp #energy #logic #science #people
Here practical considerations for examining and reducing biases in #MendelianRandomization analyses #Genetics @mendelrandom.bsky.social academic.oup.com/jcem/advance...
No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods
Abstract. Mendelian randomization (MR) is increasingly used in epidemiological studies to investigate causal relationships. MR depends on 3 fundamental ins
academic.oup.com
June 13, 2025 at 9:24 AM
Here practical considerations for examining and reducing biases in #MendelianRandomization analyses #Genetics @mendelrandom.bsky.social academic.oup.com/jcem/advance...
Beauty of an #MendelianRandomization study 👏
This part's my favorite: "This study suggests that IL-6 antagonists do not increase the risk of tuberculosis but rather should be investigated as therapeutic adjuncts in its treatment."
This part's my favorite: "This study suggests that IL-6 antagonists do not increase the risk of tuberculosis but rather should be investigated as therapeutic adjuncts in its treatment."
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower
risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This
study suggests that IL-6 antago...
www.thelancet.com
November 21, 2024 at 7:25 PM
Beauty of an #MendelianRandomization study 👏
This part's my favorite: "This study suggests that IL-6 antagonists do not increase the risk of tuberculosis but rather should be investigated as therapeutic adjuncts in its treatment."
This part's my favorite: "This study suggests that IL-6 antagonists do not increase the risk of tuberculosis but rather should be investigated as therapeutic adjuncts in its treatment."
A practical guide for nephrologist peer reviewers: understanding and appraising Mendelian randomization studies
#Nephrology #MedEd #MendelianRandomization @wisit661.bsky.social
www.tandfonline.com/doi/full/10....
#Nephrology #MedEd #MendelianRandomization @wisit661.bsky.social
www.tandfonline.com/doi/full/10....
A practical guide for nephrologist peer reviewers: understanding and appraising Mendelian randomization studies
Identifying risk factors for disease onset and progression has been a core focus in nephrology research. Mendelian Randomization (MR) has emerged as a powerful genetic epidemiological approach, uti...
www.tandfonline.com
January 15, 2025 at 2:51 AM
A practical guide for nephrologist peer reviewers: understanding and appraising Mendelian randomization studies
#Nephrology #MedEd #MendelianRandomization @wisit661.bsky.social
www.tandfonline.com/doi/full/10....
#Nephrology #MedEd #MendelianRandomization @wisit661.bsky.social
www.tandfonline.com/doi/full/10....
🧪 After some hype based on poorly designed observational research.. new preprint awaiting feedback!
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
PDE5 inhibition and Alzheimer's disease risk: a mendelian randomisation study
Introduction: While preclinical studies suggest that Phosphodiesterase 5 (PDE5) inhibition may reduce cognitive impairment, findings from observational studies on whether PDE5 inhibitors reduce Alzhei...
www.medrxiv.org
November 18, 2024 at 9:19 PM
🧪 After some hype based on poorly designed observational research.. new preprint awaiting feedback!
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
Genetic evidence on the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada)
www.medrxiv.org/content/10.1...
(1/4) INVITATION: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍Online, download the calendar invite here: healtheconomics.org/event/applyi...
🗓️ Tues 16 Sept
⏰8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍Online, download the calendar invite here: healtheconomics.org/event/applyi...
Applying Mendelian Randomization in Health Economics – Bridging Genomics and Cost-Effectiveness – International Health Economics Association
healtheconomics.org
August 14, 2025 at 8:26 AM
(1/4) INVITATION: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍Online, download the calendar invite here: healtheconomics.org/event/applyi...
🗓️ Tues 16 Sept
⏰8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍Online, download the calendar invite here: healtheconomics.org/event/applyi...
Association between age-related cardiovascular disease and systemic lupus erythematosus: a Mendelian randomization analysis
#OpenAccess in #AgingAdvances: doi.org/10.4103/AGIN...
#MendelianRandomization #SLE #Lupus #CardiovascularDisease #HeartHealth #GWAS #Autoimmune #MedicalResearch
#OpenAccess in #AgingAdvances: doi.org/10.4103/AGIN...
#MendelianRandomization #SLE #Lupus #CardiovascularDisease #HeartHealth #GWAS #Autoimmune #MedicalResearch
December 2, 2025 at 6:21 AM
Association between age-related cardiovascular disease and systemic lupus erythematosus: a Mendelian randomization analysis
#OpenAccess in #AgingAdvances: doi.org/10.4103/AGIN...
#MendelianRandomization #SLE #Lupus #CardiovascularDisease #HeartHealth #GWAS #Autoimmune #MedicalResearch
#OpenAccess in #AgingAdvances: doi.org/10.4103/AGIN...
#MendelianRandomization #SLE #Lupus #CardiovascularDisease #HeartHealth #GWAS #Autoimmune #MedicalResearch
🚨Our latest paper is out on the Br J Dermatol 🚨Using #MendelianRandomization, we identify OX40 as a likely disease mediator in palmoplantar pustulosis. Given OX40 inhibitors are in clinical development (for #eczema), this is exciting news!
#skin, #inflammation tinyurl.com/mtezcub3
#skin, #inflammation tinyurl.com/mtezcub3
Validate User
tinyurl.com
July 22, 2025 at 8:57 PM
🚨Our latest paper is out on the Br J Dermatol 🚨Using #MendelianRandomization, we identify OX40 as a likely disease mediator in palmoplantar pustulosis. Given OX40 inhibitors are in clinical development (for #eczema), this is exciting news!
#skin, #inflammation tinyurl.com/mtezcub3
#skin, #inflammation tinyurl.com/mtezcub3
(1/4) TOMORROW: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite (incl. the Zoom link) here: healtheconomics.org/event/applyi...
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite (incl. the Zoom link) here: healtheconomics.org/event/applyi...
Applying Mendelian Randomization in Health Economics – Bridging Genomics and Cost-Effectiveness – International Health Economics Association
healtheconomics.org
September 15, 2025 at 8:51 AM
(1/4) TOMORROW: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite (incl. the Zoom link) here: healtheconomics.org/event/applyi...
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite (incl. the Zoom link) here: healtheconomics.org/event/applyi...
Again! Another amazing investigation on the genetic basis of #T2D by Eli Zeggini lab
#gwas #MendelianRandomization
www.nature.com/articles/s42...
#gwas #MendelianRandomization
www.nature.com/articles/s42...
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues - Nature Metabolism
Analysing the causal links of gene expression and protein abundance on type 2 diabetes risk in blood and seven tissues related to the disease from individuals of four ancestries, the authors advance o...
www.nature.com
June 4, 2026 at 4:04 PM
Again! Another amazing investigation on the genetic basis of #T2D by Eli Zeggini lab
#gwas #MendelianRandomization
www.nature.com/articles/s42...
#gwas #MendelianRandomization
www.nature.com/articles/s42...
(1/4) NEXT WEEK: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite here: healtheconomics.org/event/applyi...
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite here: healtheconomics.org/event/applyi...
Applying Mendelian Randomization in Health Economics – Bridging Genomics and Cost-Effectiveness – International Health Economics Association
healtheconomics.org
September 9, 2025 at 8:40 AM
(1/4) NEXT WEEK: Applying #MendelianRandomization in #HealthEconomics - Bridging #Genomics & #CostEffectiveness
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite here: healtheconomics.org/event/applyi...
🗓️ Tues 16 Sept
⏰ 8-9 AM UTC / 9-10 AM BST / 6-7 PM AEST
📍 Online, download the calendar invite here: healtheconomics.org/event/applyi...
#MendelianRandomization (MR) and mediation analysis reveals a complex yet strong relationship between #ImmuneCells and blood metabolites both in promoting and preventing #Urolithiasis. #KidneyStones #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
July 3, 2025 at 5:30 PM
#MendelianRandomization (MR) and mediation analysis reveals a complex yet strong relationship between #ImmuneCells and blood metabolites both in promoting and preventing #Urolithiasis. #KidneyStones #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Immune cells produce various chemokines and cytokines, affecting the stability and excitability of neurons and thus influencing seizures.
doi.org/10.1002/epi4...
#epilepsy #epilepsia #ILAE #gutmicrobiota #immunecells #Mendelianrandomization
doi.org/10.1002/epi4...
#epilepsy #epilepsia #ILAE #gutmicrobiota #immunecells #Mendelianrandomization
July 24, 2025 at 2:05 PM
Immune cells produce various chemokines and cytokines, affecting the stability and excitability of neurons and thus influencing seizures.
doi.org/10.1002/epi4...
#epilepsy #epilepsia #ILAE #gutmicrobiota #immunecells #Mendelianrandomization
doi.org/10.1002/epi4...
#epilepsy #epilepsia #ILAE #gutmicrobiota #immunecells #Mendelianrandomization
New study finds valvular heart disease, hypertensive heart disease, and endocarditis increase risk of systemic lupus erythematosus, reveals shared genetic links.
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch
January 27, 2026 at 5:20 AM
New study finds valvular heart disease, hypertensive heart disease, and endocarditis increase risk of systemic lupus erythematosus, reveals shared genetic links.
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch
High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study. Read more in #JCEM: https://bit.ly/44pCMd6 #BMI #VascularRelatedDementia #MendelianRandomization @endocrinesociety.bsky.social
June 30, 2026 at 9:21 PM
High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study. Read more in #JCEM: https://bit.ly/44pCMd6 #BMI #VascularRelatedDementia #MendelianRandomization @endocrinesociety.bsky.social
🌟🌟🌟 Methodology Highlight
🔗https://bit.ly/3QC0xLS
🧬 This review highlights why biologically informed variant selection is key to credible MR, with practical examples from CRP, alcohol, vitamin D, estradiol, and caffeine.
#MendelianRandomization #CausalInference #GeneticEpidemiology
🔗https://bit.ly/3QC0xLS
🧬 This review highlights why biologically informed variant selection is key to credible MR, with practical examples from CRP, alcohol, vitamin D, estradiol, and caffeine.
#MendelianRandomization #CausalInference #GeneticEpidemiology
June 12, 2026 at 6:04 AM
🌟🌟🌟 Methodology Highlight
🔗https://bit.ly/3QC0xLS
🧬 This review highlights why biologically informed variant selection is key to credible MR, with practical examples from CRP, alcohol, vitamin D, estradiol, and caffeine.
#MendelianRandomization #CausalInference #GeneticEpidemiology
🔗https://bit.ly/3QC0xLS
🧬 This review highlights why biologically informed variant selection is key to credible MR, with practical examples from CRP, alcohol, vitamin D, estradiol, and caffeine.
#MendelianRandomization #CausalInference #GeneticEpidemiology
The recording from this event is now available! #mendelianrandomisation #mendelianrandomization #genomics #healtheconomics #costeffectiveness #CEA
www.youtube.com/watch?v=ui0n...
www.youtube.com/watch?v=ui0n...
September 23, 2025 at 8:58 AM
The recording from this event is now available! #mendelianrandomisation #mendelianrandomization #genomics #healtheconomics #costeffectiveness #CEA
www.youtube.com/watch?v=ui0n...
www.youtube.com/watch?v=ui0n...
📄 Read the paper here: link.springer.com/article/10.1...
#BMCMedicine #Genetics #SensoryScience #Nutrition #SensoryNutrition #FoodScience #MendelianRandomization #PrecisionNutrition #Taste #Smell
#BMCMedicine #Genetics #SensoryScience #Nutrition #SensoryNutrition #FoodScience #MendelianRandomization #PrecisionNutrition #Taste #Smell
A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics
rdcu.be
June 18, 2026 at 1:43 AM
These findings suggest that suicide behaviors may be mediated by different brain processes across adults and older children, and thus may require different screening and diagnostic considerations. #suicide #MendelianRandomization #ABCD study #Brain Structure
3/3
3/3
September 17, 2025 at 8:31 PM
These findings suggest that suicide behaviors may be mediated by different brain processes across adults and older children, and thus may require different screening and diagnostic considerations. #suicide #MendelianRandomization #ABCD study #Brain Structure
3/3
3/3
🚨JUST PUBLISHED!🚨 Latest #Study drops a game-changer in #ALS research 🎯🧠💥 Using proteomics+#MendelianRandomization we reveal that high #SHBG & low bioavailable #Tstosterone = key risk factors for #ALS⚠️@mdpiopenaccess.bsky.social
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
www.mdpi.com
March 31, 2025 at 7:21 AM
🚨JUST PUBLISHED!🚨 Latest #Study drops a game-changer in #ALS research 🎯🧠💥 Using proteomics+#MendelianRandomization we reveal that high #SHBG & low bioavailable #Tstosterone = key risk factors for #ALS⚠️@mdpiopenaccess.bsky.social
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
Targeted vitamin D supplementation may lower depression risk for deficient individuals, study finds 🧬🔬📝 www.news-medical.net/news/2024070... #VitaminD #Depression #MentalHealth #ChronicPain #Research #HealthStudy #MendelianRandomization #Supplements #Wellbeing #Science
Targeted vitamin D supplementation may lower depression risk for deficient individuals, study finds
Targeted vitamin D supplementation for those with low levels can reduce the risk of depression, but shows no significant impact on chronic pain or other conditions.
www.news-medical.net
July 8, 2024 at 1:23 AM
Targeted vitamin D supplementation may lower depression risk for deficient individuals, study finds 🧬🔬📝 www.news-medical.net/news/2024070... #VitaminD #Depression #MentalHealth #ChronicPain #Research #HealthStudy #MendelianRandomization #Supplements #Wellbeing #Science
Inflammatory proteins linked to higher risk of endometrial cancer 🔬🧬📊 www.news-medical.net/news/2024100... #EndometrialCancer #Inflammation #CancerRisk #IL6 #HSD11B1 #CancerResearch #Immunology #MendelianRandomization #Biomarkers #Health
Inflammatory proteins linked to higher risk of endometrial cancer
Study identifies key inflammatory and immune response proteins linked to endometrial cancer risk through both observational and Mendelian Randomization analyses, revealing the roles of IL-6 and HSD11B...
www.news-medical.net
October 1, 2024 at 10:49 PM
Inflammatory proteins linked to higher risk of endometrial cancer 🔬🧬📊 www.news-medical.net/news/2024100... #EndometrialCancer #Inflammation #CancerRisk #IL6 #HSD11B1 #CancerResearch #Immunology #MendelianRandomization #Biomarkers #Health
📌Open Postdoc position in biostats @ Eurac Research Institute for Biomedicine
🕓Call open until 16/7/2026
🔭We look for researchers passionate of #Statgen #CausalInference in molecular biol #MendelianRandomization #GeneNetworks #Triangulation #BigData
Applications to be sent through the website below
🕓Call open until 16/7/2026
🔭We look for researchers passionate of #Statgen #CausalInference in molecular biol #MendelianRandomization #GeneNetworks #Triangulation #BigData
Applications to be sent through the website below
📢 We are hiring!
✴️ We're looking for a PostDoctoral Researcher who would like to develop causal inference models for molecular traits in large datasets
✴️The position is for nearly 3 yrs in the ❤️ of the beautiful Dolomites with a fantastic group of colleagues!
eurac.onboard.org/jobs/KmZ2WEm...
✴️ We're looking for a PostDoctoral Researcher who would like to develop causal inference models for molecular traits in large datasets
✴️The position is for nearly 3 yrs in the ❤️ of the beautiful Dolomites with a fantastic group of colleagues!
eurac.onboard.org/jobs/KmZ2WEm...
Postdoctoral Researcher in Multi-Omics and Causal inference
Eurac Research · Bozen/Bolzano
eurac.onboard.org
June 24, 2026 at 7:52 AM
📌Open Postdoc position in biostats @ Eurac Research Institute for Biomedicine
🕓Call open until 16/7/2026
🔭We look for researchers passionate of #Statgen #CausalInference in molecular biol #MendelianRandomization #GeneNetworks #Triangulation #BigData
Applications to be sent through the website below
🕓Call open until 16/7/2026
🔭We look for researchers passionate of #Statgen #CausalInference in molecular biol #MendelianRandomization #GeneNetworks #Triangulation #BigData
Applications to be sent through the website below
#antibody #idiopathicpulmonaryfibrosis #Mendelianrandomization #herpesvirus #infection
www.archivesofmedicalscience.com/Epstein-Barr...
www.archivesofmedicalscience.com/Epstein-Barr...
Epstein-Barr virus infection is causally associated with idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization study
Introduction: Previous studies suggest an association between herpes virus infections and idiopathic pulmonary fibrosis (IPF), but the causal relationship remains largely unclear. We used bidirection...
www.archivesofmedicalscience.com
April 3, 2026 at 5:54 AM
Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Skin Research and Technology: Vol 31, No 10
Click on the title to browse this issue
onlinelibrary.wiley.com
October 9, 2025 at 2:01 PM
Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...
Unclear biological rationale supporting valid application of MR to the research question 😶
Decision by journal+publisher. Authors disagree
onlinelibrary.wiley.com/toc/16000846...