And his AI girlfriend needs a DoD IL6 wipe.
July 7, 2025 at 5:34 PM
And his AI girlfriend needs a DoD IL6 wipe.
Dominique de Villepin : l’homme de droite préféré de la gauche entretient le flou autour de ses positions et intentions présidentielles
➡️ https://l.humanite.fr/iL6
➡️ https://l.humanite.fr/iL6
April 23, 2025 at 9:30 AM
Dominique de Villepin : l’homme de droite préféré de la gauche entretient le flou autour de ses positions et intentions présidentielles
➡️ https://l.humanite.fr/iL6
➡️ https://l.humanite.fr/iL6
Widerlegung von Kleinschnitz' zweiter Long-Covid-Studie:
Comment on: Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 - Matthias Kohl, 2024
doi.org
August 31, 2024 at 2:44 PM
Widerlegung von Kleinschnitz' zweiter Long-Covid-Studie:
Le Collectif citoyen JOP 2030 a saisi la justice administrative le 15 septembre pour exiger la mise en place d’un « véritable débat public » sur les Jeux olympiques et paralympiques d’hiver 2030 qui doivent se dérouler dans les Alpes françaises.
Lire l'article ➡️ https://l.reporterre.net/iL6
Lire l'article ➡️ https://l.reporterre.net/iL6
September 15, 2025 at 5:56 PM
Le Collectif citoyen JOP 2030 a saisi la justice administrative le 15 septembre pour exiger la mise en place d’un « véritable débat public » sur les Jeux olympiques et paralympiques d’hiver 2030 qui doivent se dérouler dans les Alpes françaises.
Lire l'article ➡️ https://l.reporterre.net/iL6
Lire l'article ➡️ https://l.reporterre.net/iL6
it’s real interesting how jain doesn’t mention that casten won IL6 by 8 in 2024 when it only went for harris by 6!
December 20, 2025 at 11:22 PM
it’s real interesting how jain doesn’t mention that casten won IL6 by 8 in 2024 when it only went for harris by 6!
Researchers found that IL6 suppresses mitochondrial function via the JAK1/STAT1/3-HIF1α/ERRα pathway.
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
Xu et al. show that IL6, not TNF-α, suppresses mitochondrial function. When PGC1 is
low, IL6 increases HIF1A transcription and stabilizes HIF1α protein via ERRα. HIF1α
reciprocally suppresses ERRα, co...
www.cell.com
March 8, 2025 at 12:25 AM
Researchers found that IL6 suppresses mitochondrial function via the JAK1/STAT1/3-HIF1α/ERRα pathway.
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
teaching points on ICANS:
🧊 ICANS often follows CRS (cytokine release syndrome); watch for it carefully
🧊 toci may worsen ICANS (it blocks IL-6R in the body but toci doesn't penetrate CNS. This elevates IL6 levels. IL6 spills into the brain)
🧊 ICANS can be harder to treat than CRS #EMIMCC
🧊 ICANS often follows CRS (cytokine release syndrome); watch for it carefully
🧊 toci may worsen ICANS (it blocks IL-6R in the body but toci doesn't penetrate CNS. This elevates IL6 levels. IL6 spills into the brain)
🧊 ICANS can be harder to treat than CRS #EMIMCC
June 6, 2025 at 7:19 PM
teaching points on ICANS:
🧊 ICANS often follows CRS (cytokine release syndrome); watch for it carefully
🧊 toci may worsen ICANS (it blocks IL-6R in the body but toci doesn't penetrate CNS. This elevates IL6 levels. IL6 spills into the brain)
🧊 ICANS can be harder to treat than CRS #EMIMCC
🧊 ICANS often follows CRS (cytokine release syndrome); watch for it carefully
🧊 toci may worsen ICANS (it blocks IL-6R in the body but toci doesn't penetrate CNS. This elevates IL6 levels. IL6 spills into the brain)
🧊 ICANS can be harder to treat than CRS #EMIMCC
Herr Kleinschnitz sollte seine letzte Studie zurückziehen, alles andere wäre peinlich!!
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Comment on: Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 - Matthias Kohl, 2024
journals.sagepub.com
May 31, 2024 at 12:35 PM
Herr Kleinschnitz sollte seine letzte Studie zurückziehen, alles andere wäre peinlich!!
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
aww my oldest nephew just spent 90min info dumping on me about failed IL6 clinical trials, which means
a) I have been a good influence and
b) lil sperglet got the juice
a) I have been a good influence and
b) lil sperglet got the juice
January 31, 2026 at 11:52 PM
aww my oldest nephew just spent 90min info dumping on me about failed IL6 clinical trials, which means
a) I have been a good influence and
b) lil sperglet got the juice
a) I have been a good influence and
b) lil sperglet got the juice
Vascularize #hiPSC-derived Retinal #Organoid with dissociated #EndothelialCell + #MuralCell from #BloodVesselOrganoid
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
March 18, 2025 at 11:05 AM
Vascularize #hiPSC-derived Retinal #Organoid with dissociated #EndothelialCell + #MuralCell from #BloodVesselOrganoid
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
D-IL6
In 1776, Americans went to war rather than send more of their money to Britain every time they drank a cup of tea.
In 2026, Donald Trump started a war with Iran and then forced Americans to send more of their money to Iran every time they buy gasoline. www.washingtonpost.com/business/202...
In 2026, Donald Trump started a war with Iran and then forced Americans to send more of their money to Iran every time they buy gasoline. www.washingtonpost.com/business/202...
Trump administration lifts sanctions on millions of barrels of Iranian oil
The Treasury Department’s authorization of the sale of Iranian crude already at sea is likely to provide revenue for Iran’s war effort against the U.S.
www.washingtonpost.com
March 21, 2026 at 1:36 PM
D-IL6
Also, cytokines like TNFa and IL6 can also cause intermittent insulin resistance.
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
[Medical fatmisia]
Drs explaining insulin resistance: it's because you're a fat person who eats too much sugar. Try the fad diet of the day
But like... Insulin is like a key that lets glucose into your cells
If that key isn't working well, your cells are not getting enough energy from glucose
Drs explaining insulin resistance: it's because you're a fat person who eats too much sugar. Try the fad diet of the day
But like... Insulin is like a key that lets glucose into your cells
If that key isn't working well, your cells are not getting enough energy from glucose
July 14, 2025 at 3:58 PM
Also, cytokines like TNFa and IL6 can also cause intermittent insulin resistance.
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41... @natimmunol.nature.com
June 16, 2025 at 2:25 PM
The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41... @natimmunol.nature.com
Eine erhöhte IL6-, Komplement- und Cortisol-Signalisierung während einer akuten Infektion korrelierte mit der späteren Entwicklung von Long COVID.
„Zusammenfassend zeigen unsere Daten, dass Long Covid durch anhaltende chronische Entzündungen und eine Erschöpfung des Immunsystems gekennzeichnet ist.
„Zusammenfassend zeigen unsere Daten, dass Long Covid durch anhaltende chronische Entzündungen und eine Erschöpfung des Immunsystems gekennzeichnet ist.
May 14, 2024 at 2:48 PM
Eine erhöhte IL6-, Komplement- und Cortisol-Signalisierung während einer akuten Infektion korrelierte mit der späteren Entwicklung von Long COVID.
„Zusammenfassend zeigen unsere Daten, dass Long Covid durch anhaltende chronische Entzündungen und eine Erschöpfung des Immunsystems gekennzeichnet ist.
„Zusammenfassend zeigen unsere Daten, dass Long Covid durch anhaltende chronische Entzündungen und eine Erschöpfung des Immunsystems gekennzeichnet ist.
Very exciting talk on how VWF activity is dysregulated, as IL6 inhibits ADAMTS13 in ischemic stroke. After clot formation the vessels can reverses blood flow to protect the brain cells. @frederikdenorme.bsky.social #ISTH2025
June 23, 2025 at 1:56 PM
Very exciting talk on how VWF activity is dysregulated, as IL6 inhibits ADAMTS13 in ischemic stroke. After clot formation the vessels can reverses blood flow to protect the brain cells. @frederikdenorme.bsky.social #ISTH2025
#Autophagy #Senescence #MitralValveDisease
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
June 23, 2025 at 7:07 PM
#Autophagy #Senescence #MitralValveDisease
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
Eva from my la will be speaking today about our newest work on how RanBP2, a component of the nuclear pore, regulates the translation of IL6 mRNA into the IL6 cytokine protein.
Our next meeting will take place on Wednesday, May 14th from 4:00 to 5:00 pm, in CCBR Black Room. We have the pleasure of hosting:
Dr. Katerina Kiriakopulos
and
Yifan (Eva) Wang
Pizza will be provided after the session. Please see the attached poster and pass along the info to anyone interested!
Dr. Katerina Kiriakopulos
and
Yifan (Eva) Wang
Pizza will be provided after the session. Please see the attached poster and pass along the info to anyone interested!
May 14, 2025 at 1:33 PM
Eva from my la will be speaking today about our newest work on how RanBP2, a component of the nuclear pore, regulates the translation of IL6 mRNA into the IL6 cytokine protein.
Microvessel (purified from rat adipose) - #hiPSC-cardiomyocyte cotransplantation🫀
👉>100-fold⏫hiPSC-CM engraftment
👉⏫heart functional recovery
in Diabetic rat MI #T2D
A potential role of #Angiocrine IL6🤠
@saravasconcelos.bsky.social @stemcellreports.bsky.social 2025
www.cell.com/stem-cell-re...
👉>100-fold⏫hiPSC-CM engraftment
👉⏫heart functional recovery
in Diabetic rat MI #T2D
A potential role of #Angiocrine IL6🤠
@saravasconcelos.bsky.social @stemcellreports.bsky.social 2025
www.cell.com/stem-cell-re...
March 11, 2025 at 9:39 PM
Microvessel (purified from rat adipose) - #hiPSC-cardiomyocyte cotransplantation🫀
👉>100-fold⏫hiPSC-CM engraftment
👉⏫heart functional recovery
in Diabetic rat MI #T2D
A potential role of #Angiocrine IL6🤠
@saravasconcelos.bsky.social @stemcellreports.bsky.social 2025
www.cell.com/stem-cell-re...
👉>100-fold⏫hiPSC-CM engraftment
👉⏫heart functional recovery
in Diabetic rat MI #T2D
A potential role of #Angiocrine IL6🤠
@saravasconcelos.bsky.social @stemcellreports.bsky.social 2025
www.cell.com/stem-cell-re...
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 3, 2025 at 6:09 PM
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway
www.nature.com/articles/s41...
www.nature.com/articles/s41...
if its just one il6 gear youll be ok unless the healer starts whispering their bitching in yo ear
September 16, 2026 at 5:25 PM
if its just one il6 gear youll be ok unless the healer starts whispering their bitching in yo ear
Very very cool and lovely anatomical work!
I wonder if this is at all modulated by GLP1? GLP1 neurons are activated by IL6 and sit in the nearby NTS.
Excited to give this a thorough read!
I wonder if this is at all modulated by GLP1? GLP1 neurons are activated by IL6 and sit in the nearby NTS.
Excited to give this a thorough read!
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
doi.org
April 12, 2025 at 12:26 PM
Very very cool and lovely anatomical work!
I wonder if this is at all modulated by GLP1? GLP1 neurons are activated by IL6 and sit in the nearby NTS.
Excited to give this a thorough read!
I wonder if this is at all modulated by GLP1? GLP1 neurons are activated by IL6 and sit in the nearby NTS.
Excited to give this a thorough read!
Entzündungswege wie IL6 und JAK-STAT sowie Wege, die mit T-Zell-Dysfunktion in Verbindung stehen. Klinische Versuche mit entzündungshemmenden Medikamenten, die auf diese Signalwege abzielen, sind geplant.“
www.biorxiv.org/content/10.1...
#LongCovid #MECFS #COVID19 #SARSCoV2 #Coronavirus
www.biorxiv.org/content/10.1...
#LongCovid #MECFS #COVID19 #SARSCoV2 #Coronavirus
Persistent Activation of Chronic Inflammatory Pathways in Long Covid
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
May 14, 2024 at 2:53 PM
Entzündungswege wie IL6 und JAK-STAT sowie Wege, die mit T-Zell-Dysfunktion in Verbindung stehen. Klinische Versuche mit entzündungshemmenden Medikamenten, die auf diese Signalwege abzielen, sind geplant.“
www.biorxiv.org/content/10.1...
#LongCovid #MECFS #COVID19 #SARSCoV2 #Coronavirus
www.biorxiv.org/content/10.1...
#LongCovid #MECFS #COVID19 #SARSCoV2 #Coronavirus
How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪
buff.ly/GDBusEN
#Respirometry #Metabolism #CVD #HFD
buff.ly/GDBusEN
#Respirometry #Metabolism #CVD #HFD
An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice - npj Metabolic Health and Disease
npj Metabolic Health and Disease - An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice
buff.ly
April 1, 2026 at 5:40 PM
How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪
buff.ly/GDBusEN
#Respirometry #Metabolism #CVD #HFD
buff.ly/GDBusEN
#Respirometry #Metabolism #CVD #HFD
Eternal Strands looks to bring the magic. Jeff is certainly digging it so far. New episode segment video up: youtu.be/IL6-0pnXDh8?...
Eternal Strands looks to bring the magic: As featured in DLC Episode 584
YouTube video by DLC Pod
youtu.be
January 31, 2025 at 6:50 PM
Eternal Strands looks to bring the magic. Jeff is certainly digging it so far. New episode segment video up: youtu.be/IL6-0pnXDh8?...