Here is our very own @mattwengler.bsky.social talking about his phosphoproteomic analysis of TOR signalling. #CMINorwich26
March 4, 2026 at 1:48 PM
Here is our very own @mattwengler.bsky.social talking about his phosphoproteomic analysis of TOR signalling. #CMINorwich26
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation - Nature
Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underl...
www.nature.com
September 30, 2026 at 6:01 PM
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
Redirecting
doi.org
May 27, 2025 at 7:15 PM
Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science
doi.org/10.1016/j.ce...
End-of-year read! The work of Melvin Bérard in the @sophiemartinlab.bsky.social is now out in @plosbiology.org.
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast
doi.org/10.1371/jour...
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast
doi.org/10.1371/jour...
December 23, 2024 at 10:11 AM
End-of-year read! The work of Melvin Bérard in the @sophiemartinlab.bsky.social is now out in @plosbiology.org.
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast
doi.org/10.1371/jour...
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast
doi.org/10.1371/jour...
Nature research paper: A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation
go.nature.com/4hvQV05
go.nature.com/4hvQV05
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation - Nature
Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in follicular lymphoma.
go.nature.com
October 2, 2026 at 7:15 AM
Nature research paper: A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation
go.nature.com/4hvQV05
go.nature.com/4hvQV05
Our phosphoproteomic analysis of appressorium morphogenesis expertly presented by Frank Menke, a tour de force from Neftaly Cruz-Mireles and our teams. @TheSainsburyLab #ECFG17
March 5, 2025 at 4:12 PM
Our phosphoproteomic analysis of appressorium morphogenesis expertly presented by Frank Menke, a tour de force from Neftaly Cruz-Mireles and our teams. @TheSainsburyLab #ECFG17
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissue www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
December 8, 2024 at 6:40 PM
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissue www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
A new #ScienceSignaling study offers insights into the KOLF2.IJ cell line, which is derived from induced pluripotent stem cells and has been proposed as a neuronal model for Alzheimer’s disease and related #dementia research. https://scim.ag/4aFNY9O
Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J
Trace protein and phosphoprotein dynamics during neuronal differentiation in the iPSC-derived cell line model are described.
scim.ag
February 27, 2026 at 4:00 PM
A new #ScienceSignaling study offers insights into the KOLF2.IJ cell line, which is derived from induced pluripotent stem cells and has been proposed as a neuronal model for Alzheimer’s disease and related #dementia research. https://scim.ag/4aFNY9O
SPARCE is out!🎉 A new workflow for Multiplexed phosphoproteomics of low cell numbers rdcu.be/ejrte, co-led by @emgaiz.bsky.social and Xiuyuan Chen. Also see Behind the Paper go.nature.com/3RYwsDz for main take aways. Thanks to @uclmedsci.bsky.social and @cruk-cityoflondon.bsky.social for support.
Multiplexed phosphoproteomics of low cell numbers using SPARCE
Communications Biology - Streamlined Phosphoproteomic Analysis of Rare CElls (SPARCE) enables robust quantification of proteomes and phosphoproteomes from just 1,000 FACS-sorted cells, advancing...
rdcu.be
April 29, 2025 at 3:27 PM
SPARCE is out!🎉 A new workflow for Multiplexed phosphoproteomics of low cell numbers rdcu.be/ejrte, co-led by @emgaiz.bsky.social and Xiuyuan Chen. Also see Behind the Paper go.nature.com/3RYwsDz for main take aways. Thanks to @uclmedsci.bsky.social and @cruk-cityoflondon.bsky.social for support.
PrEditR takes mass spectrometry–based phosphoproteomic data outputs (and other PTMs) and designs sgRNA sequences to introduce site-specific amino acid substitutions in endogenous genes for functional evaluation using CRISPR-mediated base editing. Try it and let us know what you think.
May 17, 2026 at 5:35 PM
PrEditR takes mass spectrometry–based phosphoproteomic data outputs (and other PTMs) and designs sgRNA sequences to introduce site-specific amino acid substitutions in endogenous genes for functional evaluation using CRISPR-mediated base editing. Try it and let us know what you think.
Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in Dictyostelium discoideum in Response to two different chemorepellents https://www.biorxiv.org/content/10.1101/2025.10.21.683751v1
October 22, 2025 at 9:30 PM
Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in Dictyostelium discoideum in Response to two different chemorepellents https://www.biorxiv.org/content/10.1101/2025.10.21.683751v1
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues www.sciencedirect.co...
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#proteomics #prot-paper
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#proteomics #prot-paper
July 30, 2025 at 3:20 PM
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues www.sciencedirect.co...
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#proteomics #prot-paper
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#proteomics #prot-paper
Alright bsky. Looking to expand my analysis toolbox - any fun examples of niche or slightly unconventional phosphoproteomic analyses/figures? 🧪🖥️🧬
November 9, 2023 at 11:23 AM
Alright bsky. Looking to expand my analysis toolbox - any fun examples of niche or slightly unconventional phosphoproteomic analyses/figures? 🧪🖥️🧬
Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation of iPSC
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 26, 2026 at 2:45 AM
Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation of iPSC
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Quantitative phosphoproteomic analysis of chicken DF-1 cells infected with Eimeria tenella, using tandem mass tag (TMT) and parallel reaction monitoring (PRM) mass spectrometry
doi.org/10.1051/para...
doi.org/10.1051/para...
December 16, 2024 at 9:49 AM
Quantitative phosphoproteomic analysis of chicken DF-1 cells infected with Eimeria tenella, using tandem mass tag (TMT) and parallel reaction monitoring (PRM) mass spectrometry
doi.org/10.1051/para...
doi.org/10.1051/para...
The article also includes a full phosphoproteomic dataset, provided as open-source data, mapping downstream signaling of the GNAQ p.R183Q mutation in endothelial cells. www.ebi.ac.uk/pride/archiv...
PRIDE - PRoteomics IDEntifications Database
EMBL-EBI
www.ebi.ac.uk
February 4, 2026 at 9:41 PM
The article also includes a full phosphoproteomic dataset, provided as open-source data, mapping downstream signaling of the GNAQ p.R183Q mutation in endothelial cells. www.ebi.ac.uk/pride/archiv...
Metal ion-enhanced ZIC-cHILIC StageTip for N-Glycoproteomic and Phosphoproteomic Profiling in EGFR-mutated Lung Cancer Cells #MCP #MassSpec www.mcponline.org/article/S153...
Metal ion-enhanced ZIC-cHILIC StageTip for N-Glycoproteomic and Phosphoproteomic Profiling in EGFR-mutated Lung Cancer Cells
Surface glycosylation and intracellular phosphorylation regulates the cell-cell communication
and signaling cascades. Due to complex glycosylation and dynamic phosphorylation,
exploring their interpla...
www.mcponline.org
March 26, 2025 at 7:41 PM
Metal ion-enhanced ZIC-cHILIC StageTip for N-Glycoproteomic and Phosphoproteomic Profiling in EGFR-mutated Lung Cancer Cells #MCP #MassSpec www.mcponline.org/article/S153...
OsFCA Regulates Brassinosteroid Signaling and Rice Architecture through Phase Separation
Zhang et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
Zhang et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
June 9, 2026 at 1:45 AM
OsFCA Regulates Brassinosteroid Signaling and Rice Architecture through Phase Separation
Zhang et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
Zhang et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric #oocyte divisions. New study from Ivan Avilov, Peter Lenart (@plenart.bsky.social) and colleagues @maxplanck.de: rupress.org/jcb/article/...
#Cytoskeleton #CellCycle #CellDivision #Physiology #Meiosis
#Cytoskeleton #CellCycle #CellDivision #Physiology #Meiosis
October 29, 2025 at 3:15 PM
Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric #oocyte divisions. New study from Ivan Avilov, Peter Lenart (@plenart.bsky.social) and colleagues @maxplanck.de: rupress.org/jcb/article/...
#Cytoskeleton #CellCycle #CellDivision #Physiology #Meiosis
#Cytoskeleton #CellCycle #CellDivision #Physiology #Meiosis
Nitrogen-starvation of #FissionYeast inactivates growth pathways (incl TORC1) & can trigger sexual reproduction. @sophiemartinlab.bsky.social use proteomic & phosphoproteomic changes during sexual development to show that TORC1 is reactivated by pheromone signaling 🧪 @plosbiology.org plos.io/4h3OUVO
January 7, 2025 at 9:35 AM
Nitrogen-starvation of #FissionYeast inactivates growth pathways (incl TORC1) & can trigger sexual reproduction. @sophiemartinlab.bsky.social use proteomic & phosphoproteomic changes during sexual development to show that TORC1 is reactivated by pheromone signaling 🧪 @plosbiology.org plos.io/4h3OUVO
News in Proteomics Research blog post | Phosphoproteomic analysis of different CHO - Antibody producing cell lines! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
March 1, 2025 at 4:20 PM
News in Proteomics Research blog post | Phosphoproteomic analysis of different CHO - Antibody producing cell lines! proteomicsnews.blogs...
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#proteomics #prot-other
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#proteomics #prot-other
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissue https://www.biorxiv.org/content/10.1101/2024.11.17.624038v1
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissue https://www.biorxiv.org/content/10.1101/2024.11.17.624038v1
Formalin-fixed paraffin-embedded FFPE patient tissues are a valuable resource for proteomic studies
www.biorxiv.org
November 19, 2024 at 1:04 AM
High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissue https://www.biorxiv.org/content/10.1101/2024.11.17.624038v1
Multi-omics (transcriptomic, proteomic, phosphoproteomic) analyses mapping signaling networks + key host factors in HPAI infection in duck lungs: activation of RIG-I-like receptor, toll-like receptor, NOD-like receptor, NF-κB, and JAK/STAT signaling pathways ciritical.
👉 www.mdpi.com/1422-0067/27...
👉 www.mdpi.com/1422-0067/27...
April 8, 2026 at 6:51 AM
Multi-omics (transcriptomic, proteomic, phosphoproteomic) analyses mapping signaling networks + key host factors in HPAI infection in duck lungs: activation of RIG-I-like receptor, toll-like receptor, NOD-like receptor, NF-κB, and JAK/STAT signaling pathways ciritical.
👉 www.mdpi.com/1422-0067/27...
👉 www.mdpi.com/1422-0067/27...