New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The molecular basis of force selectivity by PIEZO2
Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
www.nature.com
March 4, 2026 at 5:19 PM
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PIEZO2 ion channels come to the fore yet again, now as a key sensor for adipose tissue www.cell.com/cell-metabol... @ardemp.bskyverified.social @scripps.edu
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation
Wang et al. identified that the mechanoreceptor PIEZO2 is abundantly expressed in
fat-innervating sensory neurons and plays a crucial role in mediating the adipose
afferent pathway.
www.cell.com
March 6, 2025 at 5:47 PM
PIEZO2 ion channels come to the fore yet again, now as a key sensor for adipose tissue www.cell.com/cell-metabol... @ardemp.bskyverified.social @scripps.edu
A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...
Renal PIEZO2 is an essential regulator of renin
The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone
system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney
cells that produce...
www.cell.com
December 4, 2025 at 11:27 PM
A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...
Very excited to share our new manuscript – published today!
Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why.
www.nature.com/articles/s41...
An overview of the results below ⬇️ ⬇️
Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why.
www.nature.com/articles/s41...
An overview of the results below ⬇️ ⬇️
The molecular basis of force selectivity by PIEZO2 - Nature
PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
www.nature.com
March 5, 2026 at 12:51 AM
Very excited to share our new manuscript – published today!
Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why.
www.nature.com/articles/s41...
An overview of the results below ⬇️ ⬇️
Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why.
www.nature.com/articles/s41...
An overview of the results below ⬇️ ⬇️
Preliminary Valentine's data from my postdoc work with @ardemp.bskyverified.social - RNAscope of Piezo2 transcript (green) and a nociceptor marker (magenta) in a mouse dorsal root ganglion 💜
February 14, 2026 at 3:08 AM
Preliminary Valentine's data from my postdoc work with @ardemp.bskyverified.social - RNAscope of Piezo2 transcript (green) and a nociceptor marker (magenta) in a mouse dorsal root ganglion 💜
So proud of my lab mate @ericmulhall.bsky.social and honored to help with this amazing project he led using MINFLUX to study why PIEZO2 behaves differently than PIEZO1 from the lab of @ardemp.bskyverified.social share.google/2Uln5O5OyqhM...
The molecular basis of force selectivity by PIEZO2 - Nature
PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
share.google
March 4, 2026 at 8:51 PM
So proud of my lab mate @ericmulhall.bsky.social and honored to help with this amazing project he led using MINFLUX to study why PIEZO2 behaves differently than PIEZO1 from the lab of @ardemp.bskyverified.social share.google/2Uln5O5OyqhM...
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol... @ardemp.bskyverified.social
www.cell.com/cell-metabol... @ardemp.bskyverified.social
March 6, 2025 at 7:33 PM
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol... @ardemp.bskyverified.social
www.cell.com/cell-metabol... @ardemp.bskyverified.social
A novel mechanism behind episodic neuropathic pain—the interaction between dynamic blood vessel movements and Piezo2 mechanoreceptors in sensory neurons #piezo2 #neuropathicpain #nociceptors buff.ly/e5os312 @tbertalab.bsky.social
buff.ly
March 29, 2025 at 4:03 PM
A novel mechanism behind episodic neuropathic pain—the interaction between dynamic blood vessel movements and Piezo2 mechanoreceptors in sensory neurons #piezo2 #neuropathicpain #nociceptors buff.ly/e5os312 @tbertalab.bsky.social
It is well known that the genitals are unusually sensitive, and that genital touch is crucial for mating and associated pleasure.
Why?
www.science.org/doi/10.1126/...
Why?
www.science.org/doi/10.1126/...
PIEZO2 and perineal mechanosensation are essential for sexual function
A select set of perineal mechanosensors provide exquisite behavioral sensitivity, require Piezo2, and control sexual function in mice and humans.
www.science.org
December 30, 2024 at 12:08 AM
It is well known that the genitals are unusually sensitive, and that genital touch is crucial for mating and associated pleasure.
Why?
www.science.org/doi/10.1126/...
Why?
www.science.org/doi/10.1126/...
Preprint dropped! Excited about this study by Yu Wang, a PhD student from Li Ye's lab and mine, now a postdoc in @deisseroth.bsky.social lab. It unveils an unexpected role for PIEZO2/mechanosensation in sensory neurons that innervate fat! What is it sensing in fat?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 20, 2024 at 2:40 AM
Preprint dropped! Excited about this study by Yu Wang, a PhD student from Li Ye's lab and mine, now a postdoc in @deisseroth.bsky.social lab. It unveils an unexpected role for PIEZO2/mechanosensation in sensory neurons that innervate fat! What is it sensing in fat?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proud of this collab! At first, we wondered—why would PIEZO2-positive neurons innervate soft tissue like fat? Turns out, mechanosensation plays a role in unexpected places. Studying PIEZOs keeps revealing surprises in biology and disease! 1/2
PIEZO2 ion channels come to the fore yet again, now as a key sensor for adipose tissue www.cell.com/cell-metabol... @ardemp.bskyverified.social @scripps.edu
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation
Wang et al. identified that the mechanoreceptor PIEZO2 is abundantly expressed in
fat-innervating sensory neurons and plays a crucial role in mediating the adipose
afferent pathway.
www.cell.com
March 6, 2025 at 7:12 PM
Proud of this collab! At first, we wondered—why would PIEZO2-positive neurons innervate soft tissue like fat? Turns out, mechanosensation plays a role in unexpected places. Studying PIEZOs keeps revealing surprises in biology and disease! 1/2
"Here, we measure the sensitivity of the force-gated ion channel Piezo2 and demonstrate that it is modulated by alternative splicing."
New preprint: www.biorxiv.org/content/10.6...
New preprint: www.biorxiv.org/content/10.6...
February 18, 2026 at 1:47 PM
"Here, we measure the sensitivity of the force-gated ion channel Piezo2 and demonstrate that it is modulated by alternative splicing."
New preprint: www.biorxiv.org/content/10.6...
New preprint: www.biorxiv.org/content/10.6...
New pre-print form the lab, led by @rem7106.bsky.social Targeting piezo2 to alleviate osteoarthritis pain
Check out our latest preprint showing promise for treating joint pain @jointsintheworld.bsky.social
FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes https://www.biorxiv.org/content/10.1101/2025.03.17.643683v1
March 23, 2025 at 4:00 PM
New pre-print form the lab, led by @rem7106.bsky.social Targeting piezo2 to alleviate osteoarthritis pain
New #MINFLUX paper investigating protein #structuraldynamics:
@ericmulhall.bsky.social @rose-hill.bsky.social @ardemp.bskyverified.social et al used abberior MINFLUX + #DNAPAINT +electrophysiology to investigate ion channel PIEZO2's mechanosensory selectivity.
link.abberior.rocks/piezo2
@scripps.edu
@ericmulhall.bsky.social @rose-hill.bsky.social @ardemp.bskyverified.social et al used abberior MINFLUX + #DNAPAINT +electrophysiology to investigate ion channel PIEZO2's mechanosensory selectivity.
link.abberior.rocks/piezo2
@scripps.edu
The molecular basis of force selectivity by PIEZO2 - Nature
PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
www.nature.com
March 9, 2026 at 8:12 AM
New #MINFLUX paper investigating protein #structuraldynamics:
@ericmulhall.bsky.social @rose-hill.bsky.social @ardemp.bskyverified.social et al used abberior MINFLUX + #DNAPAINT +electrophysiology to investigate ion channel PIEZO2's mechanosensory selectivity.
link.abberior.rocks/piezo2
@scripps.edu
@ericmulhall.bsky.social @rose-hill.bsky.social @ardemp.bskyverified.social et al used abberior MINFLUX + #DNAPAINT +electrophysiology to investigate ion channel PIEZO2's mechanosensory selectivity.
link.abberior.rocks/piezo2
@scripps.edu
The prominence of the pervasive PIEZO ion channels keeps showing up, now for regulating adipose tissue glucose uptake and energy storage
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism
Systemic metabolism ensures energy homeostasis through inter-organ crosstalk regulating thermogenic adipose tissue. Unlike the well-described inductiv…
www.sciencedirect.com
February 6, 2025 at 5:36 PM
The prominence of the pervasive PIEZO ion channels keeps showing up, now for regulating adipose tissue glucose uptake and energy storage
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
BOOM! Identification of a PIEZO2+, KIT+, and TRPM8+ A fiber nociceptor subtype that is responsible for human hair pull pain: www.researchsquare.com/article/rs-5... @saadnagi.bsky.social and colleagues, well done!
PIEZO2-dependent rapid pain system in humans.
The diversity of mechanical pain sensations in humans cannot be explained based on our current understanding of pain-sensing neural classes in the skin. To begin to bridge this gap, we dissected the n...
www.researchsquare.com
December 9, 2024 at 12:53 AM
BOOM! Identification of a PIEZO2+, KIT+, and TRPM8+ A fiber nociceptor subtype that is responsible for human hair pull pain: www.researchsquare.com/article/rs-5... @saadnagi.bsky.social and colleagues, well done!
Piezo2 has ~40 domains
April 16, 2026 at 5:23 PM
Piezo2 has ~40 domains
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.biorxiv.org
September 18, 2025 at 3:23 PM
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PIEZO2—unlike PIEZO1—is tethered to the actin cytoskeleton, enabling sensory neurons to detect localized mechanical forces such as light touch.
Findings reported in @nature.com by @ericmulhall.bsky.social from @ardemp.bskyverified.social's lab link nanometer-scale imaging to sensory function.
Findings reported in @nature.com by @ericmulhall.bsky.social from @ardemp.bskyverified.social's lab link nanometer-scale imaging to sensory function.
A new clue to how the body detects physical force
www.scripps.edu
March 5, 2026 at 11:07 PM
PIEZO2—unlike PIEZO1—is tethered to the actin cytoskeleton, enabling sensory neurons to detect localized mechanical forces such as light touch.
Findings reported in @nature.com by @ericmulhall.bsky.social from @ardemp.bskyverified.social's lab link nanometer-scale imaging to sensory function.
Findings reported in @nature.com by @ericmulhall.bsky.social from @ardemp.bskyverified.social's lab link nanometer-scale imaging to sensory function.
Beautiful new work on the force-gated ion channel Piezo2.
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The molecular basis of force selectivity by PIEZO2
Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
www.nature.com
March 4, 2026 at 6:28 PM
Beautiful new work on the force-gated ion channel Piezo2.
Mechanically evoked neuronal activity via Piezo2 and Nav channels is essential for the development and structural maturation of mechanosensory end-organs underlying gentle touch. #Mechanotransduction #Piezo2 www.cell.com/neuron/fullt...
Activity-dependent development of the body’s touch receptors
Santiago et al. report that the mechanosensitive ion channel Piezo2 is required for
the transcriptional and structural maturation of the primary sensory neurons that
detect gentle touch and that Piezo...
www.cell.com
August 12, 2025 at 1:40 PM
Mechanically evoked neuronal activity via Piezo2 and Nav channels is essential for the development and structural maturation of mechanosensory end-organs underlying gentle touch. #Mechanotransduction #Piezo2 www.cell.com/neuron/fullt...
I have to be honest. I never thought I would read a manuscript that discusses PIEZO2, the Big Bang, and wormholes in the same place. But here we are:
www.researchgate.net/profile/Bala...
www.researchgate.net/profile/Bala...
December 29, 2025 at 6:52 PM
I have to be honest. I never thought I would read a manuscript that discusses PIEZO2, the Big Bang, and wormholes in the same place. But here we are:
www.researchgate.net/profile/Bala...
www.researchgate.net/profile/Bala...
🧠💩 Pain in the Gut: Fusobacterium varium bacteria triggers IBS symptoms by hijacking Piezo2 signaling #GutMicrobiome #Piezo2 #VisceralHypersensitivity #Neurogastroenterology pmc.ncbi.nlm.nih.gov/articles/PMC...
Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility
The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation o...
pmc.ncbi.nlm.nih.gov
June 13, 2025 at 7:24 PM
🧠💩 Pain in the Gut: Fusobacterium varium bacteria triggers IBS symptoms by hijacking Piezo2 signaling #GutMicrobiome #Piezo2 #VisceralHypersensitivity #Neurogastroenterology pmc.ncbi.nlm.nih.gov/articles/PMC...
Nice way to end the year being part of this paper in Cell showing that PIEZO2 is an essential regulator of renin by @rose-hill.bsky.social and top scientists including @ardemp.bskyverified.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social
December 26, 2025 at 9:30 PM
Nice way to end the year being part of this paper in Cell showing that PIEZO2 is an essential regulator of renin by @rose-hill.bsky.social and top scientists including @ardemp.bskyverified.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social