Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice
Piperacillin, an FDA-approved beta-lactam, is effective at killing the Lyme disease–causing agent Borrelia burgdorferi.
scim.ag
May 16, 2025 at 7:20 PM
Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
piperacillin/tazobactam
December 4, 2024 at 10:14 PM
piperacillin/tazobactam
Kaum etwas sagt deutlicher "Ich habe keine Ahnung von Antiinfektiva" als Meropenem und Piperacillin/Tazobactam zu kombinieren.
Ich schreule.
Ich schreule.
November 12, 2024 at 7:42 PM
Kaum etwas sagt deutlicher "Ich habe keine Ahnung von Antiinfektiva" als Meropenem und Piperacillin/Tazobactam zu kombinieren.
Ich schreule.
Ich schreule.
Cefepime should be used instead of piperacillin-tazobactam.
Piperacillin-tazobactam should be used instead of cefepime.
No, you're killing people, you monster!
Or, are you? Or do we even know? #FOAMed #medsky #nephsky
www.acepnow.com/article/sett...
Piperacillin-tazobactam should be used instead of cefepime.
No, you're killing people, you monster!
Or, are you? Or do we even know? #FOAMed #medsky #nephsky
www.acepnow.com/article/sett...
Settling the Cefepime versus Piperacillin-Tazobactam Debate - ACEP Now
ACEP Now offers real-time clinical news, news from the American College of Emergency Physicians, and news on practice trends and health care reform for the emergency medicine physician. ACEP Now is an...
www.acepnow.com
November 17, 2024 at 7:01 PM
Cefepime should be used instead of piperacillin-tazobactam.
Piperacillin-tazobactam should be used instead of cefepime.
No, you're killing people, you monster!
Or, are you? Or do we even know? #FOAMed #medsky #nephsky
www.acepnow.com/article/sett...
Piperacillin-tazobactam should be used instead of cefepime.
No, you're killing people, you monster!
Or, are you? Or do we even know? #FOAMed #medsky #nephsky
www.acepnow.com/article/sett...
The ALLIUM trial
Novel antibiotic cefepime -enmetazobactam is non inferior vs piperacillin-tazobactam for pyelonephritis
#escmidglobal2026
Novel antibiotic cefepime -enmetazobactam is non inferior vs piperacillin-tazobactam for pyelonephritis
#escmidglobal2026
April 18, 2026 at 9:46 AM
The ALLIUM trial
Novel antibiotic cefepime -enmetazobactam is non inferior vs piperacillin-tazobactam for pyelonephritis
#escmidglobal2026
Novel antibiotic cefepime -enmetazobactam is non inferior vs piperacillin-tazobactam for pyelonephritis
#escmidglobal2026
The Christmas cocktail no one wants:
22 Dec: Piperacillin/Tazobactam
26 Dec: Meropenem+Linezolid
28 Dec: Negative cultures→ Meropenem+Soltrim +Fluconazole
A nightmare—we need faster & better #diagnostics
#AMR #fungi #bacteria #fungalinfections #science #GlobalHealth #SciComm #MedSky #publichealth
22 Dec: Piperacillin/Tazobactam
26 Dec: Meropenem+Linezolid
28 Dec: Negative cultures→ Meropenem+Soltrim +Fluconazole
A nightmare—we need faster & better #diagnostics
#AMR #fungi #bacteria #fungalinfections #science #GlobalHealth #SciComm #MedSky #publichealth
December 30, 2024 at 2:55 PM
The Christmas cocktail no one wants:
22 Dec: Piperacillin/Tazobactam
26 Dec: Meropenem+Linezolid
28 Dec: Negative cultures→ Meropenem+Soltrim +Fluconazole
A nightmare—we need faster & better #diagnostics
#AMR #fungi #bacteria #fungalinfections #science #GlobalHealth #SciComm #MedSky #publichealth
22 Dec: Piperacillin/Tazobactam
26 Dec: Meropenem+Linezolid
28 Dec: Negative cultures→ Meropenem+Soltrim +Fluconazole
A nightmare—we need faster & better #diagnostics
#AMR #fungi #bacteria #fungalinfections #science #GlobalHealth #SciComm #MedSky #publichealth
piperacillin TAZOBACTAM!!
August 7, 2023 at 5:09 PM
piperacillin TAZOBACTAM!!
Der Galaktomannan-Test liefert häufig falsch positive Ergebnisse, wenn der Patient Piperacillin/Tazobacatam oder andere ẞ-Laktam-Antibiotika erhält.
Grund sind Kreuzantigene gegen Penicilline.
#FOAMed #Intensivstation #ABS
Grund sind Kreuzantigene gegen Penicilline.
#FOAMed #Intensivstation #ABS
January 26, 2025 at 2:44 PM
Der Galaktomannan-Test liefert häufig falsch positive Ergebnisse, wenn der Patient Piperacillin/Tazobacatam oder andere ẞ-Laktam-Antibiotika erhält.
Grund sind Kreuzantigene gegen Penicilline.
#FOAMed #Intensivstation #ABS
Grund sind Kreuzantigene gegen Penicilline.
#FOAMed #Intensivstation #ABS
Examples of common IV antibiotics and their sodium content:
- Ampicillin: 731 mg/dose → 2,924 mg/day
- Ceftriaxone: 55 mg/dose → 110 mg/day
- Metronidazole: 324 mg/dose → 973 mg/day
- Piperacillin-Tazobactam: 556 mg/dose → 1,668 mg/day
- Vancomycin: 885 mg/dose → 1,770 mg/day
- Ampicillin: 731 mg/dose → 2,924 mg/day
- Ceftriaxone: 55 mg/dose → 110 mg/day
- Metronidazole: 324 mg/dose → 973 mg/day
- Piperacillin-Tazobactam: 556 mg/dose → 1,668 mg/day
- Vancomycin: 885 mg/dose → 1,770 mg/day
December 8, 2025 at 9:28 AM
Examples of common IV antibiotics and their sodium content:
- Ampicillin: 731 mg/dose → 2,924 mg/day
- Ceftriaxone: 55 mg/dose → 110 mg/day
- Metronidazole: 324 mg/dose → 973 mg/day
- Piperacillin-Tazobactam: 556 mg/dose → 1,668 mg/day
- Vancomycin: 885 mg/dose → 1,770 mg/day
- Ampicillin: 731 mg/dose → 2,924 mg/day
- Ceftriaxone: 55 mg/dose → 110 mg/day
- Metronidazole: 324 mg/dose → 973 mg/day
- Piperacillin-Tazobactam: 556 mg/dose → 1,668 mg/day
- Vancomycin: 885 mg/dose → 1,770 mg/day
New hope for LYME DISEASE, right under our eyes?
Unbiased screen surprisingly shows PIPERACILLIN can wipe out 𝘉𝘰𝘳𝘳𝘦𝘭𝘪𝘢 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪 in mice at tiny doses — 100 times lower than doxycycline — while leaving gut bacteria intact
Jutras Lab Northwestern Sci Transl Med
www.science.org/doi/10.1126/...
Unbiased screen surprisingly shows PIPERACILLIN can wipe out 𝘉𝘰𝘳𝘳𝘦𝘭𝘪𝘢 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪 in mice at tiny doses — 100 times lower than doxycycline — while leaving gut bacteria intact
Jutras Lab Northwestern Sci Transl Med
www.science.org/doi/10.1126/...
April 26, 2025 at 8:11 AM
New hope for LYME DISEASE, right under our eyes?
Unbiased screen surprisingly shows PIPERACILLIN can wipe out 𝘉𝘰𝘳𝘳𝘦𝘭𝘪𝘢 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪 in mice at tiny doses — 100 times lower than doxycycline — while leaving gut bacteria intact
Jutras Lab Northwestern Sci Transl Med
www.science.org/doi/10.1126/...
Unbiased screen surprisingly shows PIPERACILLIN can wipe out 𝘉𝘰𝘳𝘳𝘦𝘭𝘪𝘢 𝘣𝘶𝘳𝘨𝘥𝘰𝘳𝘧𝘦𝘳𝘪 in mice at tiny doses — 100 times lower than doxycycline — while leaving gut bacteria intact
Jutras Lab Northwestern Sci Transl Med
www.science.org/doi/10.1126/...
Stoked to share this coverage of @jutraslab.bsky.social and colleagues’ recent work on piperacillin and its ability to treat Lyme disease by our intrepid virologist @jessicaoros.bsky.social. Please check it out! #scicomm 🧪
In our latest Fixations post, we discuss a recently published study characterizing the antibiotic piperacillin as a potentially more effective treatment for Lyme disease, a promising development given that tickborne diseases are on the rise in the US. Read it here: open.substack.com/pub/isabella...
A New T(r)ick Up Our Sleeve: Piperacillin as a Novel Treatment for Lyme Disease (Fixations #4)
In our latest post, we discuss a study published this past April identifying a new and more effective drug against Lyme disease.
open.substack.com
June 2, 2025 at 5:55 PM
Stoked to share this coverage of @jutraslab.bsky.social and colleagues’ recent work on piperacillin and its ability to treat Lyme disease by our intrepid virologist @jessicaoros.bsky.social. Please check it out! #scicomm 🧪
Piperacillin Kills Lyme Bacteria in Mice, Leaves Gut Microbiome Alone.
Already FDA-approved for pneumonia, the antibiotic shows promising results for Lyme disease. www.lymedisease.org/members/lyme...
Already FDA-approved for pneumonia, the antibiotic shows promising results for Lyme disease. www.lymedisease.org/members/lyme...
Piperacillin Kills Lyme Bacteria in Mice, Leaves Gut Microbiome Alone - LymeDisease.org Member Community
Already FDA-approved for pneumonia, the antibiotic shows promising results for Lyme disease
www.lymedisease.org
July 12, 2025 at 6:03 PM
Piperacillin Kills Lyme Bacteria in Mice, Leaves Gut Microbiome Alone.
Already FDA-approved for pneumonia, the antibiotic shows promising results for Lyme disease. www.lymedisease.org/members/lyme...
Already FDA-approved for pneumonia, the antibiotic shows promising results for Lyme disease. www.lymedisease.org/members/lyme...
Vancomycin and piperacillin tazobactam friends or foes?!
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
November 18, 2024 at 3:49 AM
Vancomycin and piperacillin tazobactam friends or foes?!
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
Piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment. Northwestern University.
Published April 23 in the journal Science Translational Medicine.
Published April 23 in the journal Science Translational Medicine.
April 25, 2025 at 3:49 PM
Piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment. Northwestern University.
Published April 23 in the journal Science Translational Medicine.
Published April 23 in the journal Science Translational Medicine.
🆕✨Systematic Review of the Literature
Evaluation of the Efficacy of Piperacillin/Tazobactam in Extended-Spectrum Beta-
Lactamase-Producing(ESBL) Enterobacteriaceae Urinary Tract Infections #idsky #medsky #EMIMCC #AMSsky #utisky
journals.sagepub.com/doi/abs/10.1...
Evaluation of the Efficacy of Piperacillin/Tazobactam in Extended-Spectrum Beta-
Lactamase-Producing(ESBL) Enterobacteriaceae Urinary Tract Infections #idsky #medsky #EMIMCC #AMSsky #utisky
journals.sagepub.com/doi/abs/10.1...
Evaluation of the Efficacy of Piperacillin/Tazobactam in Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Urinary Tract Infections: A Systematic Review of the Literature - Samantha P. Sut...
Objective: To evaluate the efficacy of piperacillin/tazobactam (PTZ) for the treatment of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL-PE...
journals.sagepub.com
December 9, 2024 at 11:02 AM
🆕🔥ROAD Study🔥🆕
Resistance Optimised Antibiotic Dosing
A pilot study by Prof.Jason Roberts #cmicomm
Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? #idsky #medsky
www.sciencedirect.com/science/arti...
Resistance Optimised Antibiotic Dosing
A pilot study by Prof.Jason Roberts #cmicomm
Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? #idsky #medsky
www.sciencedirect.com/science/arti...
Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A ...
Pre-clinical data suggest that resistance to beta-lactam antibiotics can be suppressed with higher than conventional antibiotic exposures. The objecti…
www.sciencedirect.com
November 27, 2024 at 8:42 AM
🆕🔥ROAD Study🔥🆕
Resistance Optimised Antibiotic Dosing
A pilot study by Prof.Jason Roberts #cmicomm
Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? #idsky #medsky
www.sciencedirect.com/science/arti...
Resistance Optimised Antibiotic Dosing
A pilot study by Prof.Jason Roberts #cmicomm
Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? #idsky #medsky
www.sciencedirect.com/science/arti...
Ampicillin
Trimethoprim
Piperacillin
Trimethoprim
Piperacillin
December 25, 2025 at 10:46 PM
Ampicillin
Trimethoprim
Piperacillin
Trimethoprim
Piperacillin
My entire blood volume is this (Zosyn) and Rocephin now, so hopefully I can go home tomorrow and and stay home 🤞🏼
March 8, 2026 at 5:17 PM
My entire blood volume is this (Zosyn) and Rocephin now, so hopefully I can go home tomorrow and and stay home 🤞🏼
🆕️🔥Systematic review and network meta-analysis
70 studies (76 638 patients)
Vancomycin + piperacillin/tazobactam significantly increased the risk of AKI and severe Stage 2–3 AKI compared with vancomycin + other anti-pseudomonal beta-lactams #idsky
academic.oup.com/jac/advance-...
70 studies (76 638 patients)
Vancomycin + piperacillin/tazobactam significantly increased the risk of AKI and severe Stage 2–3 AKI compared with vancomycin + other anti-pseudomonal beta-lactams #idsky
academic.oup.com/jac/advance-...
Vancomycin combined with piperacillin/tazobactam increases the risk of acute kidney injury compared with vancomycin plus other anti-pseudomonal beta-lactams: a systematic review and network meta-analy...
AbstractObjective. To explore whether vancomycin plus piperacillin/tazobactam actually increases nephrotoxicity compared with other anti-pseudomonal beta-l
academic.oup.com
November 13, 2024 at 1:31 PM
🆕️🔥Systematic review and network meta-analysis
70 studies (76 638 patients)
Vancomycin + piperacillin/tazobactam significantly increased the risk of AKI and severe Stage 2–3 AKI compared with vancomycin + other anti-pseudomonal beta-lactams #idsky
academic.oup.com/jac/advance-...
70 studies (76 638 patients)
Vancomycin + piperacillin/tazobactam significantly increased the risk of AKI and severe Stage 2–3 AKI compared with vancomycin + other anti-pseudomonal beta-lactams #idsky
academic.oup.com/jac/advance-...
Interesting , and as an ID doc in a Lyme hotbed love to see other treatments, but major caveats here:
This is in mice
Press releases invariably > actual findings
Piperacillin is given IV
Already have an oral penicillin (amoxicillin) approved for Lyme
Doxy better tolerated than piperacillin in humans
This is in mice
Press releases invariably > actual findings
Piperacillin is given IV
Already have an oral penicillin (amoxicillin) approved for Lyme
Doxy better tolerated than piperacillin in humans
May 6, 2025 at 1:57 PM
Interesting , and as an ID doc in a Lyme hotbed love to see other treatments, but major caveats here:
This is in mice
Press releases invariably > actual findings
Piperacillin is given IV
Already have an oral penicillin (amoxicillin) approved for Lyme
Doxy better tolerated than piperacillin in humans
This is in mice
Press releases invariably > actual findings
Piperacillin is given IV
Already have an oral penicillin (amoxicillin) approved for Lyme
Doxy better tolerated than piperacillin in humans
Just don't give out low doses of piperacillin willy nilly and undermine the ability to treat patients with zosyn when they're really sick.
An antibiotic that's used to treat pneumonia has shown promise against Lyme disease at a dose 100 times lower than the standard antibiotic therapy - and it doesn't seem to harm the gut microbiome.
Read @newscientist.com.
www.newscientist.com/article/2477...
Read @newscientist.com.
www.newscientist.com/article/2477...
Lyme disease treated with antibiotic that doesn't harm gut microbiome
Mice overcame a Lyme disease infection after being given an antibiotic that is often used for pneumonia, and its effect on their gut microbiomes was negligible
www.newscientist.com
April 24, 2025 at 10:29 PM
Just don't give out low doses of piperacillin willy nilly and undermine the ability to treat patients with zosyn when they're really sick.
Cefepime represents an excellent alternative to carbapenems for BSI due to AmpC-producing strains, whereas piperacillin/tazobactam is associated with a higher rate of clinical and microbiological failure
Do we need an RCT? #idsky #medsky #AMSsky
Do we need an RCT? #idsky #medsky #AMSsky
🆕️🔥Systematic review & meta-analysis
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
Piperacillin/tazobactam vs. cefepime or carbapenems for the treatment of bloodstream infections due to bacteria producing chromosomal AmpC beta-lactamase: a systematic review and meta-analysis - Infec...
Background The best treatment for bloodstream infections (BSI) due to chromosomal AmpC (c-AmpC) producing Enterobacterales is not clearly defined. Objectives To describe the clinical and microbiologic...
link.springer.com
December 4, 2024 at 7:27 PM
Congratulations to our outstanding PhD student Alice Fraser, first chapter hot off the press in @microbiologysociety.org JMM! E. coli BLBLI in-patient resistance evolution; genome dynamics, mysterious phenotypes... 🧬🖥️ 🦠🧫 🧪
#IDSky #MicroSky #MedSky www.microbiologyresearch.org/content/jour...
#IDSky #MicroSky #MedSky www.microbiologyresearch.org/content/jour...
A high-resolution genomic and phenotypic analysis of resistance evolution of an Escherichia coli strain from a critically unwell patient treated with piperacillin/tazobactam
Introduction. Resistance to the β-lactam/β-lactamase inhibitor (BL/BLI) combination antibiotic piperacillin/tazobactam (TZP) predominantly occurs via β-lactamase enzymes, also leading to resistance to...
www.microbiologyresearch.org
May 19, 2025 at 7:45 PM
Congratulations to our outstanding PhD student Alice Fraser, first chapter hot off the press in @microbiologysociety.org JMM! E. coli BLBLI in-patient resistance evolution; genome dynamics, mysterious phenotypes... 🧬🖥️ 🦠🧫 🧪
#IDSky #MicroSky #MedSky www.microbiologyresearch.org/content/jour...
#IDSky #MicroSky #MedSky www.microbiologyresearch.org/content/jour...
#OTILT Pip-tazo is not considered a preferred option when treating meningitis. While studies have found piperacillin to have good CNS penetration, tazobactam fails to reach concentrations adequate to protect the former from beta-lactamase producers in the CSF.
October 1, 2026 at 9:46 PM
#OTILT Pip-tazo is not considered a preferred option when treating meningitis. While studies have found piperacillin to have good CNS penetration, tazobactam fails to reach concentrations adequate to protect the former from beta-lactamase producers in the CSF.