#Polymorphisms
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judithmank.bsky.social
So very, very happy to see this out @plosbiology.org : Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations. Beautiful work by two very clever and talented coauthors, Yuying Lin and @vdbijl.bsky.social . journals.plos.org/plosbiology/... 1/
Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations
Genomic inversions spanning many genes can persist for millions of years. This study of Trinidadian guppy populations reveals how both ecological conditions and mate choice help maintain this hidden l...
journals.plos.org
September 23, 2026 at 6:18 PM
dimitridrekonja.bsky.social
Now asking about cyctokine gene polymorphisms and claims that if you bang different people in the knee with a hammer, some swell more than others and this is due to cytokine g polymorphisms (WTF)
September 19, 2025 at 4:37 PM
borjamila.bsky.social
Successful trip sampling gray white-eyes on Reunion island, investigating speciation mechanisms and the maintenance of genetic polymorphisms 👌 with @cjtheb.bsky.social
April 25, 2025 at 4:07 AM
lauradbertola.bsky.social
Inversion Polymorphisms Carried by Introduced Rainbow Trout Disrupt Hybrid Zones Between Native Species
onlinelibrary.wiley.com/doi/10.1111/...
Inversion Polymorphisms Carried by Introduced Rainbow Trout Disrupt Hybrid Zones Between Native Species
Genomic mechanisms explaining why some hybrid zones remain stable while others collapse into hybrid swarms are poorly understood. In Montana's Kootenai River Basin, native interior redband trout (Onc...
onlinelibrary.wiley.com
September 25, 2026 at 4:09 PM
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings www.nature.com/articles/s41...
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings - Molecular Psychiatry
Molecular Psychiatry - Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings
www.nature.com
July 8, 2025 at 10:23 AM
snickersjaguar.bsky.social
ADHD evolved as an adaptation to living in a hunter-gatherer society, modern diets did not cause heritable dopamine receptor polymorphisms.
beezlover.bsky.social beezlover.bsky.social @beezlover.bsky.social · Dec 18
Stop it. Don't start nothing that is not there. We don't need that drama creating crap here. My son has ADHD. We didn't start having these cases until the bulk of our food ingredients changed. NOBODY would choose to have ADHD or Autism. Or heck, any other issue. So please grow up start drama elsewa
December 18, 2024 at 4:54 PM
jsantoyo.bsky.social
Pangenome analysis of transposable element insertion polymorphisms reveals features underlying cold tolerance in rice. #TransposableElements #TE #Pangenomes #RiceGenomes @natcomms.nature.com
www.nature.com/articles/s41...
August 17, 2025 at 7:05 PM
plosbiology.org
Why do some #bacteria #evolve #antibiotic resistance more readily than others? This study shows that naturally occurring single nucleotide polymorphisms in the PhoQP system change how readily E. coli evolves trimethoprim resistance and which mutations enable it.
🧪 #AcademicSky
plos.io/4qCDXQM
Proposed model for the contribution of polymorphisms towards evolvability of resistance, and the role of fitness cost of TMP resistance in determining the optimal level of PhoQ activity during evolution. A: Polymorphisms influence evolvability under drug pressure if they have epistatic interactions with adaptive mutations. Positive epistasis between pre-existing polymorphisms and adaptive mutations promotes the evolution of resistance, i.e., enhances evolvability of resistance. In contrast, negative epistasis diminishes evolvability. In addition, polymorphisms with negative epistasis can also drive adaptation to antibiotics through novel mutational paths. B: PhoQP signalling pathway across different mutants from the present study. The impact of PhoQ activity on trimethoprim resistance due to DHFR expression is correlated with fitness cost due to RpoS cross-activation. Genetic variation in the pathway is brought about by naturally occurring polymorphisms or drug-selected adaptive mutations. These genetic changes in the pathway activate signalling to different extents at the molecular level, thereby altering global transcriptome to different extents. Scaling of trimethoprim resistance level and fitness cost leads to changes in the concentration of antibiotic required to select for different levels of PhoQ/PhoP pathway activity. The presence of a hypersensitising allele of DHFR drove E. coli towards a high activity, high cost PhoQ mutant demonstrating how polymorphisms can change the mutational landscape of adaptation to antibiotics
August 30, 2026 at 4:02 PM
biorxiv-bioinfo.bsky.social
Identification of transposable element families from pangenome polymorphisms https://www.biorxiv.org/content/10.1101/2024.04.05.588311v1
Identification of transposable element families from pangenome polymorphisms https://www.biorxiv.org/content/10.1101/2024.04.05.588311v1
Background: Transposable Elements (TEs) are fragments of DNA, typically a few hundred base pairs up
www.biorxiv.org
April 6, 2024 at 2:46 AM
rejectresubmit.bsky.social
starting a department of genome efficiency to expose the massive fraud in single nucleotide polymorphisms
February 11, 2025 at 8:18 PM
peiferlabunc.bsky.social
WOW!!! A deep dive into the evolution of butterfly wing patterns, consistent with a model in which hybridization introduces novel regulatory polymorphisms in a key transcription factor 🧪 and a remarkable video primer
evolvwing.bsky.social Arnaud Martin @evolvwing.bsky.social · Apr 14
Awesome new paper by @lucalivraghi.bsky.social et al.
doi.org/10.1016/j.cu...
in @currentbiology.bsky.social
on the evo-devo of a butterfly color variation

enjoy the show!
April 14, 2025 at 11:34 AM
martykardos.bsky.social
The role of inversion polymorphisms in the dynamics of a salmonid hybrid zone. onlinelibrary.wiley.com/doi/10.1111/...
Inversion Polymorphisms Carried by Introduced Rainbow Trout Disrupt Hybrid Zones Between Native Species
Genomic mechanisms explaining why some hybrid zones remain stable while others collapse into hybrid swarms are poorly understood. In Montana's Kootenai River Basin, native interior redband trout (Onc...
onlinelibrary.wiley.com
September 22, 2026 at 4:14 PM
rahaeli.bsky.social
They're looking for "single nucleotide polymorphisms", or SNPs: parts where one base pair out of the sequence is "spelled" differently. Our genome is very forgiving: like the human brain can understand lots of misspelled words, our bodies can still function with many differently spelled SNPs.
June 5, 2024 at 3:48 AM
plosbiology.org
Why do some #bacteria #evolve #antibiotic resistance more readily than others? This study shows that naturally occurring single nucleotide polymorphisms in the PhoQP system change how readily E. coli evolves trimethoprim resistance and which mutations enable it.
🧪 #AcademicSky
plos.io/4qCDXQM
Proposed model for the contribution of polymorphisms towards evolvability of resistance, and the role of fitness cost of TMP resistance in determining the optimal level of PhoQ activity during evolution. A: Polymorphisms influence evolvability under drug pressure if they have epistatic interactions with adaptive mutations. Positive epistasis between pre-existing polymorphisms and adaptive mutations promotes the evolution of resistance, i.e., enhances evolvability of resistance. In contrast, negative epistasis diminishes evolvability. In addition, polymorphisms with negative epistasis can also drive adaptation to antibiotics through novel mutational paths. B: PhoQP signalling pathway across different mutants from the present study. The impact of PhoQ activity on trimethoprim resistance due to DHFR expression is correlated with fitness cost due to RpoS cross-activation. Genetic variation in the pathway is brought about by naturally occurring polymorphisms or drug-selected adaptive mutations. These genetic changes in the pathway activate signalling to different extents at the molecular level, thereby altering global transcriptome to different extents. Scaling of trimethoprim resistance level and fitness cost leads to changes in the concentration of antibiotic required to select for different levels of PhoQ/PhoP pathway activity. The presence of a hypersensitising allele of DHFR drove E. coli towards a high activity, high cost PhoQ mutant demonstrating how polymorphisms can change the mutational landscape of adaptation to antibiotics
August 29, 2026 at 12:00 PM
killgrove.bsky.social
Intriguing new study of red blood cell gene polymorphisms suggests incompatibilities among early humans, Denisovans, and Neanderthals. 🏺🧪
Neanderthals' blood type may help explain their demise, new study finds
Human populations that left Africa evolved quickly whereas Neanderthals stayed the same, according to an analysis of blood group systems.
www.livescience.com
January 23, 2025 at 4:17 PM
johnv-nguyen.bsky.social
Really enjoyed sharing my work on color pattern polymorphisms in female anoles at #SICB2025! Thanks to everyone that came to my talk. 🦎
January 6, 2025 at 3:14 AM
tianshenbio.bsky.social
Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n)
www.science.org/doi/10.1126/...
A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
www.science.org
December 5, 2024 at 9:36 PM
petephilip.bsky.social
Ah, shit. I won't be able to refer to Reform voters as neanderthals anymore 😂
www.nature.com/articles/s41...
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings - Molecular Psychiatry
Molecular Psychiatry - Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings
www.nature.com
July 12, 2025 at 6:58 PM
tomkindlon.bsky.social
From Greece

Clinically confirmed cohort reveals antioxidant genetic polymorphisms as potential susceptibility factors for long COVID after mild or asymptomatic COVID-19

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #COVID19 #PASC
Clinically confirmed cohort reveals antioxidant genetic polymorphisms as potential susceptibility factors for long COVID after mild or asymptomatic COVID-19 — Katsarou et al "SOD2 and EPHX1 variants are associated with Long COVID susceptibility."
April 18, 2026 at 12:29 AM
damienmarieathope.bsky.social
The evolution of cognitive abilities in marine animals: a hypothesis based on insights about cognition gene polymorphisms in Coelocanths and lungfish

www.academia.edu/3064-9765/2/...
The evolution of cognitive abilities in marine animals: a hypothesis based on insights about cognition gene polymorphisms in Coelocanths and lungfish - Academia.edu
www.academia.edu
January 10, 2026 at 5:46 PM
njbbari3.bsky.social
Also, the ANDV/ARG strain, which is a clade 3 Andes virus, has been investigated before using passage techniques. turns out
"Our results indicate that there are single-nucleotide polymorphisms that could be used to predict strain-specific ANDV virulence and/or transmissibility."
May 12, 2026 at 6:54 AM
davidlowry.bsky.social
More solid work out of John Kelly's lab: "Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus)" www.nature.com/articles/s41...
December 2, 2024 at 3:11 PM
grudgingsignup.bsky.social
I don't like to boast, but my polymorphisms are pret-ty explosive, to say the least 😌
July 1, 2025 at 11:11 AM
stairwaytokevin.bsky.social
New — with @joannarifkin.bsky.social, @jotlovell.bsky.social, @spicybotrytis.bsky.social, and many more — we created seven new high-quality genomes and explored pangenomic variation in the emerging oilseed crop pennycress (Thlaspi arvense). 1/
Structure and sequence evolution in the pennycress (Thlaspi arvense) pangenome
Summary · Eukaryotic genomes harbor many forms of variation, including nucleotide diversity and structural polymorphisms, which experience natural selection and contribute to genome evolution and biod...
www.biorxiv.org
September 28, 2025 at 5:25 PM
flopezos.bsky.social
📄 Ancient inversion polymorphisms are locally adaptive in a widespread butterfly species 🦋🧬

⬇️
www.science.org/doi/10.1126/...
Ancient inversion polymorphisms are locally adaptive in a widespread butterfly species
Phenotype-agnostic methods detect inversion polymorphisms involved in cryptic ecological adaptation in Neotropical butterflies.
www.science.org
July 13, 2026 at 7:13 AM