Postacute sequelae of COVID-19 or “PASC” is a common but heterogeneous condition associated with significant morbidity. Although its pathogenesis remains poorly understood, proposed underlying mechan...

Postacute sequelae of COVID-19 or “PASC” is a common but heterogeneous condition associated with significant morbidity. Although its pathogenesis remains poorly understood, proposed underlying mechan...

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...

This cohort study analyzes the rate of paid claims for Transforming Episode Accountability Model procedures coded as having increased operative services and their associated payments to evaluate the need for operative complexity risk adjustment.

Autonomic nervous system (ANS) dysfunction is a central feature of long coronavirus disease syndrome, yet little is known about how it develops during and after severe acute respiratory syndrome coron...

Background: There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC). Objective: To investigate clinical laboratory markers of SARS-CoV-2 and PASC. Des...

To investigate the extent of PM order heterogeneity in suboptimal health conditions, we first compared the PM order in primary peripheral blood mononuclear cells (PBMCs) isolated from healthy donors (n = 14) and persons affected by chronic inflammation, namely chronic lymphocytic leukemia (CLL; n = 5) and postacute sequelae of COVID-19 infection (long COVID, LC; n = 14) (Fig. 1a). Characterization of PM order required several key optimization steps, which are described in detail in Supplementary Figs. 2 and 3 and Supplementary Notes 1 and 2. After optimizing protocols for sample preparation40 and flow cytometry settings, we maximized the sensitivity of Pro12A in detecting minute differences in PM order across a wide range of membrane compositions while ensuring its compatibility with live-cell analysis. Next, we designed a panel of cell surface markers to identify cell lineages that was compatible with our probe for PM order (that is, minimal spectral overlap) and enabled us to identify 12 different immune cell subsets in combination with PM order measurements using Pro12A (Supplementary Fig. 4). The intensities of Pro12A, measured in two different channels, were used to calculate PM order—as normalized generalized polarization (ΔGP)—for individual cells (Eqs. 1 and 2 in Supplementary Note 1),...

Postacute IRF discharge is associated with a lower 1-year MACE risk after AIS, highlighting the postacute care setting as a potentially modifiable system-level target for secondary prevention of long-term vascular outcomes.

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...

A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range of long COVID compli...

This Special Communication aims to identify and summarize the most recently published evidence evaluating the effectiveness and safety of US-licensed COVID-19 vaccines and report on the epidemiology o...

Scientific Reports - Medical invalidation is associated with structural barriers in postacute immune mediated syndromes based on patient perspectives in Germany

A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range of long COVID compli...

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...