Postacute sequelae of COVID-19 or “PASC” is a common but heterogeneous condition associated with significant morbidity. Although its pathogenesis remains poorly understood, proposed underlying mechan...

This cohort study investigates the association of SARS-CoV-2 infection with risk of postacute adverse kidney outcomes among children and adolescents.

Background: There is no proven treatment to alleviate symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), despite its substantial public health burden. Objective: To evaluate the efficacy o...

This randomized clinical trial evaluates the efficacy of oral nirmatrelvir-ritonavir for treatment of moderate to severe postacute sequelae of SARS-CoV-2

This cohort study investigates the risk of gastrointestinal tract symptoms and disorders during the postacute and chronic phases of COVID-19 illness among children and adolescents.

This cohort study evaluates the risk of developing postacute sequelae of COVID-19 in patients with schizophrenia, bipolar, or major depressive disorder.

The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, some experience longer lasting effects. Data regarding the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) in children, or long COVID, are only just emerging in the literature. These symptoms and conditions may reflect persistent symptoms from acute infection (eg, cough, headaches, fatigue, and loss of taste and smell), new symptoms like dizziness, or exacerbation of underlying conditions. Children may develop conditions de novo, including postural orthostatic tachycardia syndrome, myalgic encephalomyelitis/chronic fatigue syndrome, autoimmune conditions and multisystem inflammatory syndrome in children. This state-of-the-art narrative review provides a summary of our current knowledge about PASC in children, including prevalence, epidemiology, risk factors, clinical characteristics, underlying mechanisms, and functional outcomes, as well as a conceptual framework for PASC based on the current National Institutes of Health definition. We highlight the pediatric components of the National Institutes of Health-funded Researching COVID to Enhance Recovery Initiative, which seeks to characterize the natural history, mechanisms, and long-term health effects of PASC in children and young adults to inform future treatment and prevention efforts. These initiatives include electronic health record cohorts, which offer rapid assessments at scale with geographical and demographic diversity, as well as longitudinal prospective observational cohorts, to estimate disease burden, illness trajectory, pathobiology, and clinical manifestations and outcomes.

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...

This randomized clinical trial evaluates the efficacy of oral nirmatrelvir-ritonavir for treatment of moderate to severe postacute sequelae of SARS-CoV-2

Analysis of data from the US Department of Veterans Affairs showed that 2 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, risk for most postacute sequelae remained ...

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...

The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few ...

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of th...

Postacute sequelae of COVID-19 or “PASC” is a common but heterogeneous condition associated with significant morbidity. Although its pathogenesis remains poorly understood, proposed underlying mechan...

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...

This cohort study quantifies the gap between true postacute sequelae of SARS-CoV-2 burden and diagnostic code–based estimates, determines the proportion representing chronic disease, and characterizes...

First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfect...

Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) can affect many organ systems. However, temporal changes during the coronavirus disease 2019 (Cov...

This cohort study investigates the risk of gastrointestinal tract symptoms and disorders during the postacute and chronic phases of COVID-19 illness among children and adolescents.