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Molecular Medicine article: Germline BRCA1/2-associated multi-omic landscape in High Grade Serous Ovarian Cancer (HGSOC): insights from the PowerOMICS study #MolecularMedicine #BRCA #OvarianCancer #PowerOMICS #multiomics
link.springer.com/article/10.1...
Fig. 1. Study design and MOFA2 model overview for the PowerOMICS HGSOC cohort. A – schematic representation of five omic data layers collected from 76 HGSOC patients: RRBS (n=73), RNASeq (n=61), smallRNA-Seq (n=60), WES somatic (n=72), and WES germline (n=76); multi-omic integration was performed using MOFA2 latent factor analysis alongside identification of germline pathogenic and somatic oncogenic variants in BRCA1/2 and HR genes; B – heatmap of variance explained per MOFA2 latent factor across three omic layers (smallRNA-Seq, RNA-Seq, methylome); color intensity reflects the percentage of variance explained within each layer–factor combination; C – total variance explained across all 16 factors per omic layer. HGSOC – high-grade serous ovarian carcinoma; MOFA2 – Multi-Omics Factor Analysis version 2; RRBS – reduced representation bisulfite sequencing; RNA-Seq – whole transcriptome sequencing; WES – whole exome sequencing; HR – homologous recombination.
August 26, 2026 at 3:07 PM