Abstract. The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure

AbstractMotivation. The Encyclopedia of Domains (TED) provides domain annotations for proteins in the AlphaFold Protein Structure Database (AFDB) using a c

Protein function inference relies on annotating protein domains via sequence similarity, often modeled through profile Hidden Markov Models (profile HMMs), which capture evolutionary diversity within ...