High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions.
A look into avian antibody evolution: https://bit.ly/45wSe95
A look into avian antibody evolution: https://bit.ly/45wSe95
September 25, 2026 at 11:00 AM
High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions.
A look into avian antibody evolution: https://bit.ly/45wSe95
A look into avian antibody evolution: https://bit.ly/45wSe95
Molecular diagnosis of 21-hydroxylase deficiency is complicated by the high homology between CYP21A2 and its pseudogene CYP21A1P.
#genomics #ClinicalGenetics #RareDisease
#genomics #ClinicalGenetics #RareDisease
Long-read sequencing resolves complex CYP21A2 variants and identifies 2+0 carriers in 21-hydroxylase deficiency.
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency · J Mol Diagn 2026
www.genox-veille.fr
September 22, 2026 at 1:00 PM
Molecular diagnosis of 21-hydroxylase deficiency is complicated by the high homology between CYP21A2 and its pseudogene CYP21A1P.
#genomics #ClinicalGenetics #RareDisease
#genomics #ClinicalGenetics #RareDisease
unfortunately, also a torment nexus
September 18, 2026 at 2:20 AM
unfortunately, also a torment nexus
Also check out our open-source software for pseudogene prediction in bacterial genomes: academic.oup.com/mbe/article/...
Pseudofinder: Detection of Pseudogenes in Prokaryotic Genomes
Abstract. Prokaryotic genomes are usually densely packed with intact and functional genes. However, in certain contexts, such as after recent ecological sh
academic.oup.com
August 4, 2026 at 5:25 PM
Also check out our open-source software for pseudogene prediction in bacterial genomes: academic.oup.com/mbe/article/...
The lack of pseudogene-derived products in the proteomes suggests that the ribosome-rescue system works well to prevent production of aberrant peptides from pseudogenes.
August 4, 2026 at 5:25 PM
The lack of pseudogene-derived products in the proteomes suggests that the ribosome-rescue system works well to prevent production of aberrant peptides from pseudogenes.
eugene levy implies the existence of pseudogene levy
July 27, 2026 at 12:23 PM
eugene levy implies the existence of pseudogene levy
Posting my talk today on the 25th anniversary of the human genome (hosted by @beaborsari.bsky.social) lectures.gersteinlab.org/summary/Chan... Lots of new slides on variant impact models & pseudogene epigenetics across tissues
July 20, 2026 at 8:51 PM
Posting my talk today on the 25th anniversary of the human genome (hosted by @beaborsari.bsky.social) lectures.gersteinlab.org/summary/Chan... Lots of new slides on variant impact models & pseudogene epigenetics across tissues
Can pseudogene‑derived #lncRNAs unlock new #cancer therapies?
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
July 15, 2026 at 1:31 PM
Can pseudogene‑derived #lncRNAs unlock new #cancer therapies?
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions.
A look into avian antibody evolution: vist.ly/5b78n
A look into avian antibody evolution: vist.ly/5b78n
July 14, 2026 at 4:03 PM
High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions.
A look into avian antibody evolution: vist.ly/5b78n
A look into avian antibody evolution: vist.ly/5b78n
The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts
#microbiology #pseudogene #ribosome #proteomics #MicroSky
doi.org/10.1093/molb...
#microbiology #pseudogene #ribosome #proteomics #MicroSky
doi.org/10.1093/molb...
The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts
Abstract. Intracellular bacteria in the early stages of host adaptation often show extraordinarily disrupted genomes, where up to half of their ancestral g
doi.org
July 14, 2026 at 7:40 AM
The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts
#microbiology #pseudogene #ribosome #proteomics #MicroSky
doi.org/10.1093/molb...
#microbiology #pseudogene #ribosome #proteomics #MicroSky
doi.org/10.1093/molb...
@ironark.bsky.social et al. measured transcript abundance, ribosome-associated RNA, and protein abundance in bacterial endosymbionts, suggesting a mechanism for aberrant pseudogene-derived protein removal.
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
July 13, 2026 at 9:01 AM
@ironark.bsky.social et al. measured transcript abundance, ribosome-associated RNA, and protein abundance in bacterial endosymbionts, suggesting a mechanism for aberrant pseudogene-derived protein removal.
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
This review highlights how #pseudogene‑derived #lncRNAs drive #cancer #DrugResistance through diverse molecular functions, offering new therapeutic strategies to overcome resistance and improve treatment outcomes. #apoptosis
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
July 3, 2026 at 3:19 PM
This review highlights how #pseudogene‑derived #lncRNAs drive #cancer #DrugResistance through diverse molecular functions, offering new therapeutic strategies to overcome resistance and improve treatment outcomes. #apoptosis
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Yes, there are def some interesting cases. Some of this we may be able to elucidate more in the bramble paper, but a complete investigation is worth its own paper. It also varies by aligner (e.g. STAR and HISAT have opposite transcribed pseudogene preference policies).
July 3, 2026 at 12:24 PM
Yes, there are def some interesting cases. Some of this we may be able to elucidate more in the bramble paper, but a complete investigation is worth its own paper. It also varies by aligner (e.g. STAR and HISAT have opposite transcribed pseudogene preference policies).
The first adult vertebrate devoid of hemoglobin and red blood cells, an icefish, was described in 1954. www.nature.com/articles/173...
The genetic basis was elucidated 52 years later: deletion of the β-globin gene and retention of a truncated α-globin pseudogene.
academic.oup.com/mbe/article/...
The genetic basis was elucidated 52 years later: deletion of the β-globin gene and retention of a truncated α-globin pseudogene.
academic.oup.com/mbe/article/...
Vertebrates without Erythrocytes and Blood Pigment - Nature
Nature - Vertebrates without Erythrocytes and Blood Pigment
www.nature.com
June 25, 2026 at 7:44 PM
The first adult vertebrate devoid of hemoglobin and red blood cells, an icefish, was described in 1954. www.nature.com/articles/173...
The genetic basis was elucidated 52 years later: deletion of the β-globin gene and retention of a truncated α-globin pseudogene.
academic.oup.com/mbe/article/...
The genetic basis was elucidated 52 years later: deletion of the β-globin gene and retention of a truncated α-globin pseudogene.
academic.oup.com/mbe/article/...
20/ The C. teitelbaumiae strain has accumulated multiple nonsense mutations in CDC10/SEP4, rendering it a pseudogene! This is the septin subunit "missing" in hexamers. Accordingly, the Cdc3/Sep3 homolog, which now must homodimerize in the absence of Sep4, has many changes clustered at that interface
June 23, 2026 at 9:00 PM
20/ The C. teitelbaumiae strain has accumulated multiple nonsense mutations in CDC10/SEP4, rendering it a pseudogene! This is the septin subunit "missing" in hexamers. Accordingly, the Cdc3/Sep3 homolog, which now must homodimerize in the absence of Sep4, has many changes clustered at that interface
Microdeletions in the FAAH-OUT pseudogene which modulates FAAH causes a reduction in FAAH activity and maintains high levels of fatty acid amides in the blood which can eliminate pain (even the FAAs that aren’t endocannabinoids can take the place of those that are in being broken down by FAAH).
June 22, 2026 at 3:33 AM
Microdeletions in the FAAH-OUT pseudogene which modulates FAAH causes a reduction in FAAH activity and maintains high levels of fatty acid amides in the blood which can eliminate pain (even the FAAs that aren’t endocannabinoids can take the place of those that are in being broken down by FAAH).
New in @schizjournal.bsky.social: A pseudogene-mitochondria link in schizophrenia
New study reports that the pseudogene NDUFV2P1 disrupts nuclear export of NDUFV2 mRNA, impairing complex-I function and mitochondrial energy metabolism
@sirsofficial.bsky.social
Read more ⬇️
bit.ly/44jCa8T
New study reports that the pseudogene NDUFV2P1 disrupts nuclear export of NDUFV2 mRNA, impairing complex-I function and mitochondrial energy metabolism
@sirsofficial.bsky.social
Read more ⬇️
bit.ly/44jCa8T
A new mechanism underlying mitochondrial dysfunction in schizophrenia – attenuated mRNA transport of the complex I subunit NDUFV2 by its pseudogene NDUFV2P1 - Schizophrenia
Schizophrenia - A new mechanism underlying mitochondrial dysfunction in schizophrenia – attenuated mRNA transport of the complex I subunit NDUFV2 by its pseudogene NDUFV2P1
bit.ly
June 19, 2026 at 8:26 PM
New in @schizjournal.bsky.social: A pseudogene-mitochondria link in schizophrenia
New study reports that the pseudogene NDUFV2P1 disrupts nuclear export of NDUFV2 mRNA, impairing complex-I function and mitochondrial energy metabolism
@sirsofficial.bsky.social
Read more ⬇️
bit.ly/44jCa8T
New study reports that the pseudogene NDUFV2P1 disrupts nuclear export of NDUFV2 mRNA, impairing complex-I function and mitochondrial energy metabolism
@sirsofficial.bsky.social
Read more ⬇️
bit.ly/44jCa8T
The third gene, PpWOX13LC, was considered a pseudogene as it is truncated and was not detected in RT-PCR in several tissue types. This is where out study kicks off... 4/
June 19, 2026 at 7:18 AM
The third gene, PpWOX13LC, was considered a pseudogene as it is truncated and was not detected in RT-PCR in several tissue types. This is where out study kicks off... 4/
#eshg2026 Day 3: Use it or lose it: example of body symmetry in reproductive organs. Pseudogene prevalence across evolution, here avian and reptiles reflects biological changes, including novel factors CIROP+CIROZ.
June 15, 2026 at 9:29 AM
#eshg2026 Day 3: Use it or lose it: example of body symmetry in reproductive organs. Pseudogene prevalence across evolution, here avian and reptiles reflects biological changes, including novel factors CIROP+CIROZ.
Researchers show that #pseudogene-derived #lncRNA SERHL restrains #GastricCancer progression by promoting KLF16 degradation and blocking PLCB1/PRKCA signaling, revealing new opportunities for diagnosis and targeted therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
June 12, 2026 at 4:48 PM
Researchers show that #pseudogene-derived #lncRNA SERHL restrains #GastricCancer progression by promoting KLF16 degradation and blocking PLCB1/PRKCA signaling, revealing new opportunities for diagnosis and targeted therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Using the great Paraphase tool built by Xiao Chen and @meberle.bsky.social @pacbio.bsky.social - we showcase that clinically relevant variants in paralogous genes (ie gene/pseudogene pairs) can now be identified with ease.
June 4, 2026 at 8:27 PM
Using the great Paraphase tool built by Xiao Chen and @meberle.bsky.social @pacbio.bsky.social - we showcase that clinically relevant variants in paralogous genes (ie gene/pseudogene pairs) can now be identified with ease.
Wu et al. explored the dynamics and genetic basis of repeated evolution by experimentally evolving fission yeast populations, suggesting that pseudogene revival is likely an important mechanism underlying repeated evolution.
🔗 doi.org/10.1093/molbev/msag120
#evobio #molbio #yeast
🔗 doi.org/10.1093/molbev/msag120
#evobio #molbio #yeast
Pseudogene revival drives repeated adaptation in fission yeast
Abstract. Repeated (parallel or convergent) evolution is often taken as evidence of adaptation and is relevant to the predictability of evolution. However,
doi.org
May 29, 2026 at 1:22 PM
Wu et al. explored the dynamics and genetic basis of repeated evolution by experimentally evolving fission yeast populations, suggesting that pseudogene revival is likely an important mechanism underlying repeated evolution.
🔗 doi.org/10.1093/molbev/msag120
#evobio #molbio #yeast
🔗 doi.org/10.1093/molbev/msag120
#evobio #molbio #yeast
Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation.
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
May 19, 2026 at 3:38 PM
Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation.
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
New PaperCast episode: BRCA1P1, a BRCA1-derived pseudogene, suppresses antiviral responses in cancer—targeting it boosts ISGs, apoptosis and immune infiltration. Listen
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
May 15, 2026 at 10:56 AM
New PaperCast episode: BRCA1P1, a BRCA1-derived pseudogene, suppresses antiviral responses in cancer—targeting it boosts ISGs, apoptosis and immune infiltration. Listen
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org