@ironark.bsky.social et al. measured transcript abundance, ribosome-associated RNA, and protein abundance in bacterial endosymbionts, suggesting a mechanism for aberrant pseudogene-derived protein removal.
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
July 13, 2026 at 9:01 AM
@ironark.bsky.social et al. measured transcript abundance, ribosome-associated RNA, and protein abundance in bacterial endosymbionts, suggesting a mechanism for aberrant pseudogene-derived protein removal.
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
🔗 doi.org/10.1093/molbev/msag153
#societyjournal #evobio #molbio
A review on pseudogene-derived lncRNAs signaling in cancer stem cell regulation, their classification & functions, and their dysregulation in CSC development, highlighting their potential as #Biomarkers. @TehUofMed
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 10, 2025 at 4:34 PM
A review on pseudogene-derived lncRNAs signaling in cancer stem cell regulation, their classification & functions, and their dysregulation in CSC development, highlighting their potential as #Biomarkers. @TehUofMed
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Can pseudogene‑derived #lncRNAs unlock new #cancer therapies?
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
July 15, 2026 at 1:31 PM
Can pseudogene‑derived #lncRNAs unlock new #cancer therapies?
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
By sponging miRNAs, they regulate CSC generation and resistance, revealing hidden mechanisms and opening paths to novel diagnostics and treatments. @tumscvdri.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
The lack of pseudogene-derived products in the proteomes suggests that the ribosome-rescue system works well to prevent production of aberrant peptides from pseudogenes.
August 4, 2026 at 5:25 PM
The lack of pseudogene-derived products in the proteomes suggests that the ribosome-rescue system works well to prevent production of aberrant peptides from pseudogenes.
This review explores various #cancer #DrugResistance mechanisms, the structure and functions of #Pseudogenes, and the role of pseudogene-derived lncRNAs in promoting drug-resistance in different cancers. #medsky
#OpenAccess:
#OpenAccess:
www.sciencedirect.com
August 2, 2025 at 1:18 AM
This review explores various #cancer #DrugResistance mechanisms, the structure and functions of #Pseudogenes, and the role of pseudogene-derived lncRNAs in promoting drug-resistance in different cancers. #medsky
#OpenAccess:
#OpenAccess:
This review highlights how #pseudogene‑derived #lncRNAs drive #cancer #DrugResistance through diverse molecular functions, offering new therapeutic strategies to overcome resistance and improve treatment outcomes. #apoptosis
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
July 3, 2026 at 3:19 PM
This review highlights how #pseudogene‑derived #lncRNAs drive #cancer #DrugResistance through diverse molecular functions, offering new therapeutic strategies to overcome resistance and improve treatment outcomes. #apoptosis
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation.
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
May 19, 2026 at 3:38 PM
Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation.
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
This review explores various #cancer #DrugResistance mechanisms, the structure and functions of #Pseudogenes, and the role of pseudogene-derived lncRNAs in promoting drug-resistance in different cancers. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#OpenAccess:
www.sciencedirect.com/science/arti...
June 29, 2025 at 5:18 AM
This review explores various #cancer #DrugResistance mechanisms, the structure and functions of #Pseudogenes, and the role of pseudogene-derived lncRNAs in promoting drug-resistance in different cancers. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#OpenAccess:
www.sciencedirect.com/science/arti...
#ArticleinPress: Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
April 2, 2026 at 8:56 PM
#ArticleinPress: Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
We find that pseudogenes remain broadly transcribed and can still associate with ribosomes even after losing function. Yet, they rarely produce stable proteins, suggesting that bacterial cells rely on some sort of mechanism to prevent pseudogene-derived products from mucking up the proteome
February 8, 2026 at 2:08 AM
We find that pseudogenes remain broadly transcribed and can still associate with ribosomes even after losing function. Yet, they rarely produce stable proteins, suggesting that bacterial cells rely on some sort of mechanism to prevent pseudogene-derived products from mucking up the proteome
RRID:Addgene_12259, was just reported to be used in "Genome‐wide profiling of N6‐methyladenosine‐modified pseudogene‐derived long noncoding RNAs reveals the tumour‐promoting and innate immune‐restraining function of RPS15AP12 in …". Thank you for making your methods matter! #ReproducibleResearch
doi.org
March 31, 2025 at 7:00 AM
RRID:Addgene_12259, was just reported to be used in "Genome‐wide profiling of N6‐methyladenosine‐modified pseudogene‐derived long noncoding RNAs reveals the tumour‐promoting and innate immune‐restraining function of RPS15AP12 in …". Thank you for making your methods matter! #ReproducibleResearch
It seems like the concept of pseudogenes is becoming more accepted and they are apparently more than just non-functional frame shifts or nonsense mutations involved in mitophagy ? www.eurekalert.org/news-release...
Pseudogene-derived lncRNAs in cancer stem cells
Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and...
www.eurekalert.org
April 12, 2026 at 2:04 PM
It seems like the concept of pseudogenes is becoming more accepted and they are apparently more than just non-functional frame shifts or nonsense mutations involved in mitophagy ? www.eurekalert.org/news-release...
Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
May 1, 2026 at 1:09 PM
Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext
🧬 Pseudogene-derived variant (UbKEKS) looks like #ubiquitin—but behaves differently
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/6UPR50YHJFN
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/6UPR50YHJFN
April 13, 2026 at 12:01 PM
🧬 Pseudogene-derived variant (UbKEKS) looks like #ubiquitin—but behaves differently
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/6UPR50YHJFN
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/6UPR50YHJFN
New PaperCast episode: BRCA1P1, a BRCA1-derived pseudogene, suppresses antiviral responses in cancer—targeting it boosts ISGs, apoptosis and immune infiltration. Listen
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
May 15, 2026 at 10:56 AM
New PaperCast episode: BRCA1P1, a BRCA1-derived pseudogene, suppresses antiviral responses in cancer—targeting it boosts ISGs, apoptosis and immune infiltration. Listen
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
https://basebybase.com/episodes/brca1p1-pseudogene-antiviral-immunity
@pnas.org
🧬 Pseudogene-derived variant (UbKEKS) looks like #ubiquitin—but behaves differently
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/Gnts50YHJFO
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/Gnts50YHJFO
April 13, 2026 at 12:01 PM
🧬 Pseudogene-derived variant (UbKEKS) looks like #ubiquitin—but behaves differently
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/Gnts50YHJFO
🔄 binds different set of targets
🧠 shifts protein interactions due to structural changes
🚫 can’t signal proteasomal degradation
👉 Tiny sequence change = major rewiring
https://ow.ly/Gnts50YHJFO
Researchers show that #pseudogene-derived #lncRNA SERHL restrains #GastricCancer progression by promoting KLF16 degradation and blocking PLCB1/PRKCA signaling, revealing new opportunities for diagnosis and targeted therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
June 12, 2026 at 4:48 PM
Researchers show that #pseudogene-derived #lncRNA SERHL restrains #GastricCancer progression by promoting KLF16 degradation and blocking PLCB1/PRKCA signaling, revealing new opportunities for diagnosis and targeted therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Recent review reveals how regulatory #Pseudogene-derived #lncRNAs shape #Cancer #DrugResistance and outlines therapeutic opportunities to overcome treatment failure. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 29, 2025 at 4:34 PM
Recent review reveals how regulatory #Pseudogene-derived #lncRNAs shape #Cancer #DrugResistance and outlines therapeutic opportunities to overcome treatment failure. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
This review explores the roles of pseudogene-derived #lncRNAs in modulating #CancerStemCells across multiple #Cancers and their #Clinical potential as #Biomarkers, #Diagnostics and #therapeutic targets. @tumscvdri.bsky.social #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#OpenAccess:
www.sciencedirect.com/science/arti...
September 23, 2025 at 1:01 PM
This review explores the roles of pseudogene-derived #lncRNAs in modulating #CancerStemCells across multiple #Cancers and their #Clinical potential as #Biomarkers, #Diagnostics and #therapeutic targets. @tumscvdri.bsky.social #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#OpenAccess:
www.sciencedirect.com/science/arti...
This review discuss recent findings on the dysregulated roles of pseudogene-derived lncRNAs in driving and developing #CancerStemCells in various #Cancers. @tumscvdri.bsky.social #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
August 21, 2025 at 12:15 PM
This review discuss recent findings on the dysregulated roles of pseudogene-derived lncRNAs in driving and developing #CancerStemCells in various #Cancers. @tumscvdri.bsky.social #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...