Remarkable collection of papers out today from PsychAD, a consortium studying biological mechanisms in dementias & serious mental illnesses. They created a single-cell brain atlas of 6.3 million nuclei from ~1,500 donors. Datasets, analysis tools & resources freely available to research community.🧪👇
PsychAD Consortium
The PsychAD Consortium investigates the biological mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, and serious mental ...
www.nature.com
September 23, 2026 at 10:11 PM
Remarkable collection of papers out today from PsychAD, a consortium studying biological mechanisms in dementias & serious mental illnesses. They created a single-cell brain atlas of 6.3 million nuclei from ~1,500 donors. Datasets, analysis tools & resources freely available to research community.🧪👇
Thrilled to see the PsychAD package published! 🧠
Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease.
Supported by NIA. Deeply grateful to all donors and families.
psych-ad.org
www.nature.com/collections/...
Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease.
Supported by NIA. Deeply grateful to all donors and families.
psych-ad.org
www.nature.com/collections/...
PsychAD
The PsychAD Consortium builds population-scale, single-cell models of the human brain to uncover the molecular mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, an...
psych-ad.org
September 26, 2026 at 8:15 PM
Thrilled to see the PsychAD package published! 🧠
Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease.
Supported by NIA. Deeply grateful to all donors and families.
psych-ad.org
www.nature.com/collections/...
Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease.
Supported by NIA. Deeply grateful to all donors and families.
psych-ad.org
www.nature.com/collections/...
Today we're publishing nine #PsychAD papers across @NaturePortfolio journals, mapping 6.3M+ brain cells to study aging, disease, genetic regulation and new computational methods. Explore the PsychAD collection: nature.com/collections/... Learn more: psych-ad.org #OpenScience
September 23, 2026 at 3:35 PM
Today we're publishing nine #PsychAD papers across @NaturePortfolio journals, mapping 6.3M+ brain cells to study aging, disease, genetic regulation and new computational methods. Explore the PsychAD collection: nature.com/collections/... Learn more: psych-ad.org #OpenScience
A suite of papers in Nature Portfolio journals analyse more than 6.3 million gene expression profiles from the brains of 1,494 deceased donors from the PsychAD programme. The research offers insights into how the prefrontal cortex region develops across the human lifespan. go.nature.com/4xFOWe8 🧬🧪
September 24, 2026 at 4:39 PM
A suite of papers in Nature Portfolio journals analyse more than 6.3 million gene expression profiles from the brains of 1,494 deceased donors from the PsychAD programme. The research offers insights into how the prefrontal cortex region develops across the human lifespan. go.nature.com/4xFOWe8 🧬🧪
PsychAD Consortium
The PsychAD Consortium investigates the biological mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, and serious mental illnesses using large-scale single-cell and multi-omic data from human brain tissue.
www.nature.com/collections/...
The PsychAD Consortium investigates the biological mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, and serious mental illnesses using large-scale single-cell and multi-omic data from human brain tissue.
www.nature.com/collections/...
PsychAD Consortium
The PsychAD Consortium investigates the biological mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, and serious mental ...
www.nature.com
September 26, 2026 at 7:47 PM
PsychAD Consortium
The PsychAD Consortium investigates the biological mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, and serious mental illnesses using large-scale single-cell and multi-omic data from human brain tissue.
www.nature.com/collections/...
The PsychAD Consortium investigates the biological mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, and serious mental illnesses using large-scale single-cell and multi-omic data from human brain tissue.
www.nature.com/collections/...
Using human dorsolateral prefrontal cortex samples from 1,494 donors, researchers generate a single-cell transcriptomic atlas comprising over 6.3 million individual nuclei. Donors include #Alzheimers & #Parkinsons cases ("the PsychAD cohort")
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 25, 2026 at 9:26 AM
Using human dorsolateral prefrontal cortex samples from 1,494 donors, researchers generate a single-cell transcriptomic atlas comprising over 6.3 million individual nuclei. Donors include #Alzheimers & #Parkinsons cases ("the PsychAD cohort")
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The PsychAD cohort included diffuse Lewy body disease, vascular dementia, tauopathy, FTD, schizophrenia, & bipolar disorder. The study replicated findings that the H1 MAPT haplotype is associated with PD susceptibility, & observed that the H1H1 genotype increases PD risk
September 25, 2026 at 9:28 AM
The PsychAD cohort included diffuse Lewy body disease, vascular dementia, tauopathy, FTD, schizophrenia, & bipolar disorder. The study replicated findings that the H1 MAPT haplotype is associated with PD susceptibility, & observed that the H1H1 genotype increases PD risk
🧪Today, the PsychAD Consortium published EIGHT papers across Nature journals detailing their efforts to create the largest map of the human prefrontal cortex. It's hard to overstate the amount of work here, nor the absolute treasure trove this team has created for researchers.
Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more
The atlas of gene expression in the prefrontal cortex was created using samples from almost 1,500 donors of all ages — from infants to centenarians.
www.nature.com
September 23, 2026 at 4:48 PM
🧪Today, the PsychAD Consortium published EIGHT papers across Nature journals detailing their efforts to create the largest map of the human prefrontal cortex. It's hard to overstate the amount of work here, nor the absolute treasure trove this team has created for researchers.
Fuente: El Mundo
www.elmundo.es/salud/2026/0...
www.elmundo.es/salud/2026/0...
Un atlas cerebral sin precedentes identifica los periodos de mayor vulnerabilidad a enfermedades
El consorcio estadounidense PsychAD despliega en 9 estudios publicados hoy en distintas revistas del grupo Nature un atlas sin precedentes de la arquitectura molecular y celular de...
www.elmundo.es
September 24, 2026 at 9:37 PM
Fuente: El Mundo
www.elmundo.es/salud/2026/0...
www.elmundo.es/salud/2026/0...
Un mapa celular para entender las enfermedades cerebrales
www.dw.com/es/mapa-celu...
www.dw.com/es/mapa-celu...
Un mapa molecular revela las claves de las enfermedades cerebrales
Nueve estudios del programa PsychAD analizan más de 6,3 millones de células de 1.494 cerebros para identificar los mecanismos moleculares vinculados a trastornos neurológicos.
www.dw.com
September 27, 2026 at 12:24 AM
Un mapa celular para entender las enfermedades cerebrales
www.dw.com/es/mapa-celu...
www.dw.com/es/mapa-celu...
Leading the #PsychAD flagship and its eight companion papers has been the privilege of my career, and seeing it on the cover of @nature.com today is surreal.
Huge thanks to the brain donors and their families, our amazing team, and every collaborator who made this possible.
Huge thanks to the brain donors and their families, our amazing team, and every collaborator who made this possible.
Today we're publishing nine #PsychAD papers across @NaturePortfolio journals, mapping 6.3M+ brain cells to study aging, disease, genetic regulation and new computational methods. Explore the PsychAD collection: nature.com/collections/... Learn more: psych-ad.org #OpenScience
September 23, 2026 at 3:42 PM
Leading the #PsychAD flagship and its eight companion papers has been the privilege of my career, and seeing it on the cover of @nature.com today is surreal.
Huge thanks to the brain donors and their families, our amazing team, and every collaborator who made this possible.
Huge thanks to the brain donors and their families, our amazing team, and every collaborator who made this possible.
Flagship in @Nature – Lee et al. mapped 6.3M brain-cell nuclei from 1,494 donors across 8 disorders, revealing vulnerabilities shared across dementias and changes unique to each disease. doi.org/10.1038/s415... #PsychAD #SingleCellGenomics
September 23, 2026 at 3:35 PM
Flagship in @Nature – Lee et al. mapped 6.3M brain-cell nuclei from 1,494 donors across 8 disorders, revealing vulnerabilities shared across dementias and changes unique to each disease. doi.org/10.1038/s415... #PsychAD #SingleCellGenomics
Venkatesh et al. created 94 brain cell-type-specific models that link inherited risk to gene activity, finding thousands of gene–disease associations missed by bulk-tissue analyses. doi.org/10.1038/s415... #PsychAD #Genetics #TWAS
September 23, 2026 at 3:35 PM
Venkatesh et al. created 94 brain cell-type-specific models that link inherited risk to gene activity, finding thousands of gene–disease associations missed by bulk-tissue analyses. doi.org/10.1038/s415... #PsychAD #Genetics #TWAS
PsychAD dataset is openly available – described by Fullard et al., with 6.3M nuclei from about 1,500 donors across neurodegenerative and psychiatric disorders, plus neurotypical controls. doi.org/10.1038/s415... #PsychAD #OpenScience
September 23, 2026 at 3:35 PM
PsychAD dataset is openly available – described by Fullard et al., with 6.3M nuclei from about 1,500 donors across neurodegenerative and psychiatric disorders, plus neurotypical controls. doi.org/10.1038/s415... #PsychAD #OpenScience
Un mapa celular para entender las enfermedades cerebrales
Nueve estudios del programa PsychAD analizan más de 6,3 millones de células de 1.494 cerebros para identificar los mecanismos moleculares vinculados a trastornos neurológicos.
amp-dw-com.cdn.ampproject.org/v/s/amp.dw.c...
Nueve estudios del programa PsychAD analizan más de 6,3 millones de células de 1.494 cerebros para identificar los mecanismos moleculares vinculados a trastornos neurológicos.
amp-dw-com.cdn.ampproject.org/v/s/amp.dw.c...
September 26, 2026 at 7:47 PM
Un mapa celular para entender las enfermedades cerebrales
Nueve estudios del programa PsychAD analizan más de 6,3 millones de células de 1.494 cerebros para identificar los mecanismos moleculares vinculados a trastornos neurológicos.
amp-dw-com.cdn.ampproject.org/v/s/amp.dw.c...
Nueve estudios del programa PsychAD analizan más de 6,3 millones de células de 1.494 cerebros para identificar los mecanismos moleculares vinculados a trastornos neurológicos.
amp-dw-com.cdn.ampproject.org/v/s/amp.dw.c...
He et al. developed PASCode, an AI framework linking AD phenotypes with specific brain cells and gene programs, including features shared with depression. doi.org/10.1038/s415... #PsychAD #AI
September 23, 2026 at 3:35 PM
He et al. developed PASCode, an AI framework linking AD phenotypes with specific brain cells and gene programs, including features shared with depression. doi.org/10.1038/s415... #PsychAD #AI
Chandrashekar et al. developed iBrainMap to create personalized maps of brain-cell communication and gene regulation, revealing molecular differences that may explain Alzheimer's heterogeneity. doi.org/10.1038/s414... #PsychAD #PrecisionMedicine
September 23, 2026 at 3:35 PM
Chandrashekar et al. developed iBrainMap to create personalized maps of brain-cell communication and gene regulation, revealing molecular differences that may explain Alzheimer's heterogeneity. doi.org/10.1038/s414... #PsychAD #PrecisionMedicine
Yang et al. mapped 1.3M cells from 284 donors aged 0–97, revealing early-life remodeling, midlife stability and late-life reactivation. doi.org/10.1038/s415... #PsychAD #HealthyAging
September 23, 2026 at 3:35 PM
Yang et al. mapped 1.3M cells from 284 donors aged 0–97, revealing early-life remodeling, midlife stability and late-life reactivation. doi.org/10.1038/s415... #PsychAD #HealthyAging
Meet crumblr: an open-source method from Hoffman et al. for fast, flexible analysis of cell-type composition. It scales to complex studies while controlling false positives. doi.org/10.1038/s414... #PsychAD #ComputationalBiology
September 23, 2026 at 3:35 PM
Meet crumblr: an open-source method from Hoffman et al. for fast, flexible analysis of cell-type composition. It scales to complex studies while controlling false positives. doi.org/10.1038/s414... #PsychAD #ComputationalBiology
More than 6.3 million brain cell nuclei show that six brain disorders share some molecular patterns, while retaining distinct cellular signatures.
Large-scale studies create one of the world's most comprehensive single-cell atlases of human brain disease
Research led by Mount Sinai scientists within the PsychAD Consortium, a large-scale, multidisciplinary initiative launched in 2019 with support from the National Institute on Aging (NIA), is featured in a collection of nine papers published across the Nature family of journals that maps the molecular mechanisms underlying Alzheimer's disease, Parkinson's disease, schizophrenia and other brain disorders.
medicalxpress.com
September 23, 2026 at 3:01 PM
More than 6.3 million brain cell nuclei show that six brain disorders share some molecular patterns, while retaining distinct cellular signatures.
Meet dreamlet – an open-source tool from Hoffman et al. for differential-expression analysis in population-scale single-cell studies. It is fast, memory-efficient and supports complex models. doi.org/10.1038/s414... #PsychAD #Transcriptomics
September 23, 2026 at 3:35 PM
Meet dreamlet – an open-source tool from Hoffman et al. for differential-expression analysis in population-scale single-cell studies. It is fast, memory-efficient and supports complex models. doi.org/10.1038/s414... #PsychAD #Transcriptomics
Investigadores del consorcio público PsychAD, respaldado por el Instituto Nacional sobre el Envejecimiento de Estados Unidos (NIA, en sus siglas inglesa) han elaborado el mapa...
El mayor atlas genómico de la corteza prefrontal confirma que la juventud termina a los 24 años
www.expansion.com
September 24, 2026 at 12:37 PM
Investigadores del consorcio público PsychAD, respaldado por el Instituto Nacional sobre el Envejecimiento de Estados Unidos (NIA, en sus siglas inglesa) han elaborado el mapa...
Zeng et al. built a multi-ancestry atlas of genetic regulation using 5.6M nuclei from 1,384 donors. It shows where brain-disorder risk acts across specific cell types and 14,000+ genes. doi.org/10.1038/s415... #PsychAD #Neurogenomics #QTL
September 23, 2026 at 3:35 PM
Zeng et al. built a multi-ancestry atlas of genetic regulation using 5.6M nuclei from 1,384 donors. It shows where brain-disorder risk acts across specific cell types and 14,000+ genes. doi.org/10.1038/s415... #PsychAD #Neurogenomics #QTL
Single-Cell Brain Atlas Studies Offer Window Into Neuropsychiatric Conditions
Single-Cell Brain Atlas Studies Offer Window Into Neuropsychiatric Conditions
PsychAD Consortium investigators published nine studies based on some 6 million dorsolateral prefrontal cortex cells analyzed by single-cell transcriptomics and other methods.
ebx.sh
September 24, 2026 at 2:20 AM
Single-Cell Brain Atlas Studies Offer Window Into Neuropsychiatric Conditions