#SingleCellGenomics
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cdneurogenomics.bsky.social
Flagship in @Nature – Lee et al. mapped 6.3M brain-cell nuclei from 1,494 donors across 8 disorders, revealing vulnerabilities shared across dementias and changes unique to each disease. doi.org/10.1038/s415... #PsychAD #SingleCellGenomics
September 23, 2026 at 3:35 PM
cgue2026.bsky.social
🔬 Invited speaker spotlight: Fabien Burki, Uppsala University:
Single cell genomics and fluorescence microscopy suggest a permanent plastid in a marine centrohelid.
@fburki.bsky.social

👉 comparativegenomics2026.com

#Genomics #SingleCellGenomics #Protistology #Protists #Microscopy #Eukaryotes
July 28, 2026 at 9:30 AM
simonelsasser.bsky.social
#Jobalert 🚨: looking for a #computationalbiology expert with track record in analysis, integration and interpretation of #omics datasets, in particular #epigenomics, #singlecellgenomics, #proteomics data. uni-freiburg.de/stellenangeb... short deadline 30th September!
Universität Freiburg
uni-freiburg.de
September 19, 2025 at 8:08 AM
antoniocafufa.bsky.social
🧩Gathering hobbies: Brain Science + @LEGO_Group ! Thanks to @10xGenomics #LEGO #singlecellgenomics #glioblastoma #research
March 12, 2025 at 6:14 AM
csbj.org
🔗 Cell-type specific single-cell signatures reveal nephrotoxic drug effects. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Nephrotoxicity #CellBiology #Cheminformatics #AcuteKidneyInjury #DrugDiscovery #SingleCellGenomics #DrugDevelopment
Cell-type specific single-cell signatures reveal nephrotoxic drug effects. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.012
November 21, 2025 at 9:11 PM
moorejh.bsky.social
Spatially Resolved Single-Cell Omics: Methods, Challenges, and Future Perspectives www.annualreviews.org/content/jour... #genomics #bioinformatics #singlecellgenomics #spatial
Spatially Resolved Single-Cell Omics: Methods, Challenges, and Future Perspectives | Annual Reviews
Overlaying omics data onto spatial biological dimensions has been a promising technology to provide high-resolution insights into the interactome and cellular heterogeneity relative to the organizatio...
www.annualreviews.org
September 4, 2024 at 5:38 PM
imm.ox.ac.uk
📄 Recent publication 👇

#WIMMSpotlight #WIMMCommunity #CancerResearch #Immunology #TranslationalResearch #TCells #SingleCellGenomics #MRCWIMM
Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis
Pinho et al. show that HR+ breast cancer patients with lymph node metastasis have an impaired antitumor CD8 immune response, with less frequency of tumor-reactive TILs. Yet, early-stage patients exhib...
www.cell.com
June 30, 2026 at 9:11 AM
mscience.bsky.social
Congrats to Shimon Sakaguchi, 2025 Nobel Laureate, for discovering regulatory T cells (Tregs) — immune peacekeepers!
His lab used @10xgenomics.bsky.social single-cell and TCR profiling to reveal T cell states driving autoimmune disease.

#NobelPrize #SingleCellGenomics #10xGenomics
October 9, 2025 at 3:46 AM
alicefrolov.bsky.social
Sharing a new data visualization from our ongoing work on clonal dynamics in therapy-resistant malignancies.

#CancerStemCells #ClonalEvolution #TumorHeterogeneity #TherapyResistance #MinimalResidualDisease #CancerModeling #TumorPlasticity #SingleCellGenomics
Sharing a new data visualization from our ongoing work on clonal dynamics in therapy-resistant malignancies. Figure title: "Subclonal expansion and cancer stem cell enrichment across therapy phases" Subtitle: "Simulated clonal trajectories: therapy-resistant subclones expand as CSC fraction rises through relapse" The visualization employs a clonal fan slopegraph, in which branching subclone trajectories are tracked across four discrete treatment phases (diagnosis, induction response, minimal residual disease, and relapse). Each terminal branch corresponds to a genetically distinct subclone, with vertical position encoding its relative population frequency and branch width scaled to absolute clone size. Superimposed CSC-fraction ribbons quantify the proportion of cells within each subclone bearing a cancer stem cell (CSC) phenotype, operationally defined here by a composite stemness signature. I want to emphasize that the underlying data are simulated. The trajectories are generated from a stochastic branching model parameterized to reproduce a well-documented, literature-grounded trend rather than to represent a specific empirical cohort. The intent is illustrative and hypothesis-clarifying. The central pattern is instructive. Under cytotoxic pressure, dominant treatment-sensitive subclones contract sharply during induction, producing an apparent response, while minor subclones harboring resistance-conferring lesions persist through the MRD bottleneck. Critically, these persistent subclones exhibit disproportionately elevated CSC fractions, consistent with the notion that quiescent, stemness-associated states underwrite drug tolerance and subsequent regrowth. During relapse, the resistant subclones undergo expansion, and the population-level CSC fraction rises accordingly, reflecting both selection and plasticity-driven state transitions.
August 27, 2026 at 5:00 PM
imm.ox.ac.uk
📄 Key paper on single cell RNA sequencing and spatial transcriptomics in fetal intestine:
www.sciencedirect.com/science/arti...

#WIMMSpotlight #WIMMCommunity #PaediatricResearch #IntestinalImmunology #SpatialTranscriptomics #SingleCellGenomics #RareDiseaseResearch #MRCWIMM
Spatiotemporal analysis of human intestinal development at single-cell resolution
Development of the human intestine is not well understood. Here, we link single-cell RNA sequencing and spatial transcriptomics to characterize intest…
www.sciencedirect.com
February 24, 2026 at 10:19 AM
gltch.io
🌍 Scientists unite! ✨ Open Problems unlocks the secrets within *every* cell, launching challenges to decode life’s building blocks. 🧬 #SingleCellGenomics

Source: https://phys.org/news/2025-07-cell-complexity-intelligence.html
Cracking single-cell complexity with collective intelligence
Researchers from more than 50 international institutions have launched Open Problems, a collaborative open-source platform to benchmark, improve, and run competitions for computational methods in single-cell genomics.
phys.org
July 3, 2025 at 3:34 PM
hlsalliance.bsky.social
Meet our new Alliance Fellow Bettina Welz!
For the entire feature head over to our LinkedIn page.
www.linkedin.com/posts/rnaseq...
#rnasequencing #healthlifesciencealliance #postdocfellow #researchspotlight #developmentalgenomics #singlecellgenomics #collaboration | Health + Life Science Alliance
Meet our new Alliance Fellow Bettina Welz! Q: Could you tell us a bit about the work you do? Which field do you work in and who are your PIs? A: I work in developmental genomics, studying how embryos...
www.linkedin.com
May 27, 2026 at 6:32 AM
imm.ox.ac.uk
🔗 Read more about the award:
www.ox.ac.uk/news/2025-09...

#WIMMSpotlight #WIMMCommunity #LeukaemiaResearch #ChildhoodCancer #Haematology #CRISPR #SingleCellGenomics #CancerResearch @emilysn1.bsky.social @paediatrics.ox.ac.uk #AcademicSky
The Kaiya Foundation to fund leukaemia research at University of Oxford
The Kaiya Foundation has awarded one of its first major research grants, which will fund pioneering research into the fundamental cause of a high-risk leukaemia. The grant is being made to Dr Emily Ne...
www.ox.ac.uk
June 2, 2026 at 9:36 AM
alicefrolov.bsky.social
Sharing a visualization from ongoing work on cancer stem cell (CSC) clonal dynamics under therapeutic pressure.

#CancerStemCells #TumorHeterogeneity #ClonalEvolution #MinimalResidualDisease #TumorPlasticity #DrugTolerantPersisters #SingleCellGenomics #PhylogeneticReconstruction
Sharing a visualization from ongoing work on cancer stem cell (CSC) clonal dynamics under therapeutic pressure. Figure: "Therapy reshapes clonal hierarchy via stem-like subclone selection" Subtitle: "Ranked clonal fraction of tumor subclones across treatment phases; stem-marked clones rise under selective pressure" The chart is a phylogenetic bump plot (Muller-style ranked clonal flow) tracking the relative clonal fraction of individual subclones across sequential treatment phases: baseline, on-treatment, minimal residual disease (MRD), and relapse. Each ribbon corresponds to a distinct subclone, with vertical band thickness encoding clonal fraction and vertical ordering encoding rank. Subclones carrying stem-associated marker states (e.g., high ALDH activity, CD133/CD44 enrichment, quiescence-linked transcriptional programs) are highlighted to distinguish them from bulk proliferative lineages. The illustrated trajectory recapitulates a well-documented pattern: cytotoxic selection preferentially depletes proliferative, differentiation-committed subclones while sparing slow-cycling, stem-marked populations. During the MRD window, stem-like ribbons ascend in rank despite overall tumor contraction, consistent with therapy-tolerant persister states buffered by quiescence, enhanced drug efflux, and reinforced self-renewal signaling (WNT, NOTCH, Hedgehog). At relapse, these ascended subclones seed the reconstituted hierarchy, producing a repopulated tumor with an altered clonal architecture rather than a faithful reconstruction of the baseline composition. I want to emphasize that the underlying data here are simulated. The intent is to render a literature-grounded trend in an interpretable topological format, not to present empirical measurements. The parameterization draws on reported CSC plasticity and selection dynamics, but ribbon values are synthetic.
September 10, 2026 at 5:07 PM
graeme.fawcett.social
I just do the platform around here, the smart people do the science.

Be like the smart people, do the science (with us)

Single-cell or spatial transcriptomes from the same lovely folk that brought your iPathwayGuide.

[The platform is cool too :)]

www.linkedin.com/posts/202607...
#singlecellgenomics #bioinformatics #transcriptomics #researchgrant #iscanguide #spatialbiology | AdvaitaBio
Can I trust this platform with my data — and my conclusions?  It's the first question researchers ask before uploading single-cell data to a new platform. And it deserves a direct answer.    With iSC...
www.linkedin.com
July 30, 2026 at 4:00 PM
graeme.fawcett.social
"Your time is better spent exploring discoveries than managing pipelines."

[that's my job]

"Single-cell datasets continue to grow both in size and complexity. As they do, researchers need tools that can scale..."

[scaling things is kind of my jam]

Check it out

www.linkedin.com/posts/advait...
#singlecellgenomics #bioinformatics #transcriptomics #researchgrant #iscanguide #spatialbiology | AdvaitaBio
Your time is better spent exploring discoveries than managing pipelines.  Single-cell datasets continue to grow both in size and complexity. As they do, researchers need tools that can scale without ...
www.linkedin.com
July 24, 2026 at 5:51 PM
carondanielp.genomic.social.ap.brid.gy
My hope for this is to finally curate a feed for myself full of #immunology #humanbiology #singlecellgenomics and #bioinformatics (as well as any/all other #academicchatter). If you end up enabling bridging, let me know!!
November 16, 2024 at 1:56 PM
llms.activitypub.awakari.com.ap.brid.gy
Cheaper Sequencing Means More Single Cells Ultima Genomics, Gilad Almogy, PhD, discusses the momentum surrounding single-cell genomics and his excitement about being a part of it. Ultima Genomics, ...

#General #Medicine #News #singlecellgenomics,AI,ChatGPT

Origin | Interest | Match
Cheaper Sequencing Means More Single Cells
Ultima Genomics, Gilad Almogy, PhD, discusses the momentum surrounding single-cell genomics and his excitement about being a part of it. Read the full article here
www.mashupmd.com
August 8, 2025 at 5:20 AM
imm.ox.ac.uk
This will be an invaluable public resource for future studies investigating biological processes in muscle health and disease.

#WIMMSpotlight #WIMMCommunity #SingleCellGenomics #HumanCellAtlas #ComputationalBiology #MuscleResearch #DataScience #MRCWIMM
April 14, 2026 at 9:08 AM
lifesciences-ge.bsky.social
🎟️ 𝐆𝐫𝐚𝐛 𝐘𝐨𝐮𝐫 𝐅𝐫𝐞𝐞 𝐏𝐚𝐬𝐬 𝐓𝐨𝐝𝐚𝐲!
🔬 Explore cutting-edge advances in #SingleCellGenomics, #Transcriptomics & #Proteomics at the 𝟐𝐧𝐝 𝐒𝐢𝐧𝐠𝐥𝐞 𝐂𝐞𝐥𝐥 𝐂𝐨𝐧𝐠𝐫𝐞𝐬𝐬 𝐀𝐬𝐢𝐚 – 𝐃𝐨𝐧’𝐭 𝐌𝐢𝐬𝐬 𝐎𝐮𝐭!

🔗𝐀𝐩𝐩𝐥𝐲 𝐧𝐨𝐰: lnkd.in/gFA6p5Ai

#SingleCellAsia2025 #MultiOmics #PrecisionMedicine #AIinBiotech #CancerResearch #GlobalEngage
2nd Single Cell Congress: Asia Hong Kong 10 - 11 July 2025
June 16, 2025 at 1:52 AM
svbelleghem.bsky.social
Save the date! 24.01 at 11:00 CET @steinaerts.bsky.social
erga-biodiversity.eu/post/seminar... #SingleCellGenomics #DeepLearning #genomics #ERGA
January 11, 2024 at 6:12 PM