#ClonalEvolution
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lambalastair.bsky.social
Really enjoyed this deep dive into intratumoural immune archetypes from Matt Krummel
#AACR25 @TheAACR.bsky.social

Loved this video on T Cell vs Dendritic Cell interacting

#IntratumouralHeterogeity
#ClonalEvolution
#ReactiveImmunity
April 29, 2025 at 1:57 PM
lambalastair.bsky.social
Great work from @maxbeesley.bsky.social in his first #WhiteboardPresentation to assembled @qmbci.bsky.social #CEV!!

#ClonalEvolution
#SpatialBiology
#SPACE_Study #ProstateCancer

@mcclellandlab.bsky.social @ciccarellilab.bsky.social
November 7, 2025 at 6:14 PM
lscourzic.bsky.social
#Immunology #Lymphoma #CancerResearch #Lymphoidmalignancies #Epigenetics #Chromatin #SingleCell #ClonalEvolution #PrecisionMedicine #Hematology
April 30, 2026 at 2:33 PM
alicefrolov.bsky.social
Sharing a new data visualization from our ongoing work on clonal dynamics in therapy-resistant malignancies.

#CancerStemCells #ClonalEvolution #TumorHeterogeneity #TherapyResistance #MinimalResidualDisease #CancerModeling #TumorPlasticity #SingleCellGenomics
Sharing a new data visualization from our ongoing work on clonal dynamics in therapy-resistant malignancies. Figure title: "Subclonal expansion and cancer stem cell enrichment across therapy phases" Subtitle: "Simulated clonal trajectories: therapy-resistant subclones expand as CSC fraction rises through relapse" The visualization employs a clonal fan slopegraph, in which branching subclone trajectories are tracked across four discrete treatment phases (diagnosis, induction response, minimal residual disease, and relapse). Each terminal branch corresponds to a genetically distinct subclone, with vertical position encoding its relative population frequency and branch width scaled to absolute clone size. Superimposed CSC-fraction ribbons quantify the proportion of cells within each subclone bearing a cancer stem cell (CSC) phenotype, operationally defined here by a composite stemness signature. I want to emphasize that the underlying data are simulated. The trajectories are generated from a stochastic branching model parameterized to reproduce a well-documented, literature-grounded trend rather than to represent a specific empirical cohort. The intent is illustrative and hypothesis-clarifying. The central pattern is instructive. Under cytotoxic pressure, dominant treatment-sensitive subclones contract sharply during induction, producing an apparent response, while minor subclones harboring resistance-conferring lesions persist through the MRD bottleneck. Critically, these persistent subclones exhibit disproportionately elevated CSC fractions, consistent with the notion that quiescent, stemness-associated states underwrite drug tolerance and subsequent regrowth. During relapse, the resistant subclones undergo expansion, and the population-level CSC fraction rises accordingly, reflecting both selection and plasticity-driven state transitions.
August 27, 2026 at 5:00 PM
alicefrolov.bsky.social
Sharing a visualization from ongoing work on cancer stem cell (CSC) clonal dynamics under therapeutic pressure.

#CancerStemCells #TumorHeterogeneity #ClonalEvolution #MinimalResidualDisease #TumorPlasticity #DrugTolerantPersisters #SingleCellGenomics #PhylogeneticReconstruction
Sharing a visualization from ongoing work on cancer stem cell (CSC) clonal dynamics under therapeutic pressure. Figure: "Therapy reshapes clonal hierarchy via stem-like subclone selection" Subtitle: "Ranked clonal fraction of tumor subclones across treatment phases; stem-marked clones rise under selective pressure" The chart is a phylogenetic bump plot (Muller-style ranked clonal flow) tracking the relative clonal fraction of individual subclones across sequential treatment phases: baseline, on-treatment, minimal residual disease (MRD), and relapse. Each ribbon corresponds to a distinct subclone, with vertical band thickness encoding clonal fraction and vertical ordering encoding rank. Subclones carrying stem-associated marker states (e.g., high ALDH activity, CD133/CD44 enrichment, quiescence-linked transcriptional programs) are highlighted to distinguish them from bulk proliferative lineages. The illustrated trajectory recapitulates a well-documented pattern: cytotoxic selection preferentially depletes proliferative, differentiation-committed subclones while sparing slow-cycling, stem-marked populations. During the MRD window, stem-like ribbons ascend in rank despite overall tumor contraction, consistent with therapy-tolerant persister states buffered by quiescence, enhanced drug efflux, and reinforced self-renewal signaling (WNT, NOTCH, Hedgehog). At relapse, these ascended subclones seed the reconstituted hierarchy, producing a repopulated tumor with an altered clonal architecture rather than a faithful reconstruction of the baseline composition. I want to emphasize that the underlying data here are simulated. The intent is to render a literature-grounded trend in an interpretable topological format, not to present empirical measurements. The parameterization draws on reported CSC plasticity and selection dynamics, but ribbon values are synthetic.
September 10, 2026 at 5:07 PM
hemehub.bsky.social
🩸 Further insights on treatment options for CMML

#CMML #MyeloidMalignancies #Hematology #LeukemiaResearch #RASMutations #KRASInhibitors #TargetedTherapy #PanRAS #Immunotherapy #TIM3 #LILRB4 #MDSMPN #ClonalEvolution #MedicalEducation #HemeOnc #HEMEHUB
April 27, 2026 at 7:47 PM
hemehub.bsky.social
🩸More insights on emerging therapies & future directions in Inherited Bone Marrow Failure Syndromes

#AndrogenTherapy #Danazol #Telomeres #BoneMarrowFailure #IBMFS #Eltrombopag #ClonalEvolution #CD117 #Hematopoiesis #StemCellTherapy #Hematology #ClinicalUpdates #MedEd #HEMEHUB
January 27, 2026 at 10:11 PM
imm.ox.ac.uk
#WIMMSpotlight #WIMMCommunity #LeukaemiaResearch #CancerGenomics #ClonalEvolution #GlobalHealth #MRCWIMM
April 7, 2026 at 9:41 AM
msklibrary.bsky.social
Synapse: Your Connection to our MSK Authors
Meet: Michelle Wu
Research Focus: SKI Epidemiology/Biostatistics; Senior Project Manager

Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA
synapse.mskcc.org/synapse/peop...

#OvarianCancer #ClonalEvolution
#CellFreeDNA
January 22, 2026 at 3:38 PM
df-antoran.bsky.social
We believe human #epithelioids could serve as a new experimental #platform to study epithelial #biology, #clonalevolution, #cellcompetition, tissue responses to #clinical #therapies, and molecular #cancerprevention.
June 10, 2026 at 1:43 PM
df-antoran.bsky.social
Using this approach, we followed human #epithelioids for 8 months in continuous culture. #Mutationburden, #mutationalsignatures and #clonalcomposition remained remarkably stable over time, opening the door to #longitudinal studies of #clonalevolution in human tissues in vitro.
June 10, 2026 at 1:43 PM