How does SRSF11 #Succinylation drive #Radioresistance in #LiverCancer?
This study shows that KAT2A promotes RAD52 splicing and RAD51-dependent DNA repair, identifying a potential target for radiosensitization.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerDiagnosis #AIinMedicine
This study shows that KAT2A promotes RAD52 splicing and RAD51-dependent DNA repair, identifying a potential target for radiosensitization.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerDiagnosis #AIinMedicine
October 17, 2026 at 12:01 PM
How does SRSF11 #Succinylation drive #Radioresistance in #LiverCancer?
This study shows that KAT2A promotes RAD52 splicing and RAD51-dependent DNA repair, identifying a potential target for radiosensitization.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerDiagnosis #AIinMedicine
This study shows that KAT2A promotes RAD52 splicing and RAD51-dependent DNA repair, identifying a potential target for radiosensitization.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerDiagnosis #AIinMedicine
7. Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors - Bhat et al. doi.org/10.1093/narc.... A concrete example of emerging therapeutics: identifies and optimizes RAD52 inhibitors with selective toxicity in BRCA-mutant cells. 8/18
Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors
Abstract. RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose polymerase (PARP) inhibitors, pharmacological inhibit
doi.org
October 7, 2026 at 1:44 AM
7. Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors - Bhat et al. doi.org/10.1093/narc.... A concrete example of emerging therapeutics: identifies and optimizes RAD52 inhibitors with selective toxicity in BRCA-mutant cells. 8/18
Very proud of my third year grad student Jamaurie who’s working on our RAD52 project in ovarian cancer cells-he gave a fantastic talk to our department yesterday!
September 19, 2026 at 2:45 PM
Very proud of my third year grad student Jamaurie who’s working on our RAD52 project in ovarian cancer cells-he gave a fantastic talk to our department yesterday!
Even among the two 5’-nicks, the mechanisms by which they cause expansions are different: the 5’-nick near the GAA repeat strand (and much less for the TTC strand) promotes expansions that depend on the Rad52 protein and thus happen via homologous recombination. 16/n
November 25, 2024 at 9:44 PM
Even among the two 5’-nicks, the mechanisms by which they cause expansions are different: the 5’-nick near the GAA repeat strand (and much less for the TTC strand) promotes expansions that depend on the Rad52 protein and thus happen via homologous recombination. 16/n
Nature research paper: The RAD52 double-ring remodels replication forks restricting fork reversal
https://go.nature.com/3QXdjBp
https://go.nature.com/3QXdjBp
The RAD52 double-ring remodels replication forks restricting fork reversal - Nature
A head-to-head double-ring complex of the human multifunctional DNA repair protein RAD52 mediates protection of stalled replication forks during replication stress, protecting them from reversal by SMARCAL1 motor.
go.nature.com
April 3, 2025 at 1:37 PM
Nature research paper: The RAD52 double-ring remodels replication forks restricting fork reversal
https://go.nature.com/3QXdjBp
https://go.nature.com/3QXdjBp
Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101
Oxford Academic
academic.oup.com/nar/article/...
Oxford Academic
academic.oup.com/nar/article/...
Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101
Abstract. RAD52, the primary single-stranded DNA annealing (SSA) protein in humans, forms undecameric rings that bind single-stranded DNA (ssDNA) within a
academic.oup.com
April 28, 2026 at 7:41 AM
Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101
Oxford Academic
academic.oup.com/nar/article/...
Oxford Academic
academic.oup.com/nar/article/...
Sharing our two recent papers on PRIMPOL in ssDNA gap metabolism published in NAR: 1) HELQ and RAD52 regulate ssDNA gap repair doi.org/10.1093/nar/...
CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps
Abstract. Treatment with genotoxic agents, such as platinum compounds, is still the mainstay therapeutical approach for the majority of cancers. Our unders
doi.org
December 18, 2024 at 3:44 PM
Sharing our two recent papers on PRIMPOL in ssDNA gap metabolism published in NAR: 1) HELQ and RAD52 regulate ssDNA gap repair doi.org/10.1093/nar/...
Rôle de chaperon de la protéine Rad52 dans la recombinaison homologue
Rôle de chaperon de la protéine Rad52 dans la recombinaison homologue
La recombinaison homologue est une des voies majeures de réparation des dommages de l'ADN telles que les cassures double brin. Une étape clé de cette voie de réparation consiste en la formation de filaments nucléoprotéiques formés de la protéine Rad51 sur de l'ADN simple brin. Ces nucléofilaments sont responsables de la recherche d'homologie et de l'invasion d'un ADN intact et semblable à l'ADN endommagé afin de l'utiliser comme matrice pour la synthèse réparatrice. La formation de ces nucléofilaments Rad51 est finement régulée. Chez la levure, la formation des filaments Rad51 est régulée par la protéine Rad52 et chez l'homme par la protéine BRCA2.
Dans une étude précédente, des chercheurs de l’UMR Stabilité Génétique, Cellules souches et Radiations - SGCSR/iRCM (UMR 1274 UParis/UPSaclay/INSERM/CEA-Jacob, Fontenay-aux-Roses) et de l’I2BC (CNRS/CEA-Joliot/UPsaclay, Gif-sur-Yvette) avaient démontré que l'association Rad52-Rad51 non seulement favorise la formation des nucléofilaments de Rad51, mais qu'elle est aussi essentielle pour les protéger de l'activité déstabilisatrice d'une autre protéine, Srs2 (Ma et al., 2018).
Dans une nouvelle étude publiée dans Nature Communications, ces deux équipes, en collaboration avec l'Institut Curie et le synchrotron SOLEIL, dévoilent les bases moléculaires de l'interaction Rad51-Rad52.
Lire la suite de l’Actu CEA
-> Contact : eric.coic@cea.fr
sco.lt
August 10, 2025 at 7:54 AM
Rôle de chaperon de la protéine Rad52 dans la recombinaison homologue
Hopeful news for new cancer drugs
phys.org/news/2025-04...
phys.org/news/2025-04...
DNA repair protein's unexpected structure may lead to new cancer treatments
A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and mechani...
phys.org
April 2, 2025 at 8:22 PM
Hopeful news for new cancer drugs
phys.org/news/2025-04...
phys.org/news/2025-04...
New paper alert! 📄
We’re thrilled to share a new publication from our lab:
"Monomers and short oligomers of human RAD52 promote single-strand annealing"
Check it out: www.pnas.org/doi/10.1073/...
#DNARepair #RAD52 #MolecularBiology #SingleMolecule #PhDResearch #MassPhotometry #StructuralBiology
We’re thrilled to share a new publication from our lab:
"Monomers and short oligomers of human RAD52 promote single-strand annealing"
Check it out: www.pnas.org/doi/10.1073/...
#DNARepair #RAD52 #MolecularBiology #SingleMolecule #PhDResearch #MassPhotometry #StructuralBiology
Monomers and short oligomers of human RAD52 promote single-strand annealing | PNAS
Genome maintenance and stability rely on the repair of DNA double-strand breaks. Breaks
can be repaired via the single-strand-annealing pathway med...
www.pnas.org
April 8, 2025 at 8:11 AM
New paper alert! 📄
We’re thrilled to share a new publication from our lab:
"Monomers and short oligomers of human RAD52 promote single-strand annealing"
Check it out: www.pnas.org/doi/10.1073/...
#DNARepair #RAD52 #MolecularBiology #SingleMolecule #PhDResearch #MassPhotometry #StructuralBiology
We’re thrilled to share a new publication from our lab:
"Monomers and short oligomers of human RAD52 promote single-strand annealing"
Check it out: www.pnas.org/doi/10.1073/...
#DNARepair #RAD52 #MolecularBiology #SingleMolecule #PhDResearch #MassPhotometry #StructuralBiology
How are Rad51 filaments formed during Homologous Recombination?
Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2.
urldefense.com/v3/__https:/...
Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2.
urldefense.com/v3/__https:/...
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Nature Communications - The mediator protein Rad52 promotes Rad51 binding onto RPA-coated DNA to initiate homologous recombination. Here, the authors show that Rad52 sorts Rad51 into monomers and...
urldefense.com
July 21, 2025 at 12:34 PM
How are Rad51 filaments formed during Homologous Recombination?
Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2.
urldefense.com/v3/__https:/...
Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2.
urldefense.com/v3/__https:/...
Since there are new followers and a new platform: here is a new study from the group showcasing how mediators promote Rad51 nucleation, not growth, on RPA-coated DNA during homologous Recombination.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rad52 sorts and stacks Rad51 at the DNA junction to promote homologous recombination
Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs). The DSBs are resected to yield single-stranded DNA (ssDNA) that are coated by Replication Protein A (RPA). Rad51 is a recombina...
www.biorxiv.org
November 12, 2024 at 10:44 PM
Since there are new followers and a new platform: here is a new study from the group showcasing how mediators promote Rad51 nucleation, not growth, on RPA-coated DNA during homologous Recombination.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This is finally ready to share. The mechanism of Rad52 (mediator) catalyzed Rad51 (recombinase) engagement onto DNA during HR. Study resolves long standing questions between Rad52 and BRCA2. How do they function the same, but are structurally not related.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 8, 2024 at 6:07 PM
This is finally ready to share. The mechanism of Rad52 (mediator) catalyzed Rad51 (recombinase) engagement onto DNA during HR. Study resolves long standing questions between Rad52 and BRCA2. How do they function the same, but are structurally not related.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Guess, we need to double post until the migration is complete 😀 New paper from the group describing how Rad52-Rad51 interactions are likely similar to BRCA2-RAD51 interactions. rdcu.be/dnOKZ
October 6, 2023 at 2:57 PM
Guess, we need to double post until the migration is complete 😀 New paper from the group describing how Rad52-Rad51 interactions are likely similar to BRCA2-RAD51 interactions. rdcu.be/dnOKZ
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #RRID
Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model
doi.org
November 25, 2025 at 8:01 AM
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #RRID
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #ReproducibleResearch #reproducibility
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
doi.org
August 12, 2025 at 7:00 AM
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #ReproducibleResearch #reproducibility
Authors published a paper in #BioRxiv, they used ImageJ in the study. Including #RRIDs will make this less ambiguous.
SciScore.com made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
SciScore.com made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
The histone chaperone CAF-1 prevents Rad52-mediated instability of the budding yeast ribosomal DNA during replication-coupled DNA double-strand break repair
www.biorxiv.org
February 13, 2025 at 12:23 AM
Authors published a paper in #BioRxiv, they used ImageJ in the study. Including #RRIDs will make this less ambiguous.
SciScore.com made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
SciScore.com made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
The Rad52 superfamily as seen by AlphaFold https://www.biorxiv.org/content/10.1101/2024.08.09.607149v1
The Rad52 superfamily as seen by AlphaFold https://www.biorxiv.org/content/10.1101/2024.08.09.607149v1
Rad52, a highly conserved eukaryotic protein, plays a crucial role in DNA repair, especially in doub
www.biorxiv.org
August 10, 2024 at 5:46 AM
The Rad52 superfamily as seen by AlphaFold https://www.biorxiv.org/content/10.1101/2024.08.09.607149v1
FANCM is a promising cancer therapeutic target due to genetic interactions with BRCA1, SMARCAL1 & RAD52 & in ALT-positive cancers. Moving toward this goal, our work was an amazing collaboration with industry and academic partners across Australia, China and the UK!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Structural basis of Fanconi anemia pathway activation by FANCM | The EMBO Journal
imageimageFANCM employs a sophisticated dual recognition mechanism in genome maintenance, using distinct DNA-binding domains to identify and move around on branched DNA structures. This study reveals how FANCM evolved from an ancient repair motor ...
www.embopress.org
June 2, 2025 at 12:42 AM
FANCM is a promising cancer therapeutic target due to genetic interactions with BRCA1, SMARCAL1 & RAD52 & in ALT-positive cancers. Moving toward this goal, our work was an amazing collaboration with industry and academic partners across Australia, China and the UK!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
I ❤️ this new paper on RAD52 at replication forks, just published @nature.com. Cryo-EM reveals a unique double-ring structure that blocks reversal of replication forks.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The RAD52 double-ring remodels replication forks restricting fork reversal - Nature
A head-to-head double-ring complex of the human multifunctional DNA repair protein RAD52 mediates protection of stalled replication forks during replication stress, protecting them from reversal by SM...
www.nature.com
April 3, 2025 at 11:58 PM
I ❤️ this new paper on RAD52 at replication forks, just published @nature.com. Cryo-EM reveals a unique double-ring structure that blocks reversal of replication forks.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function @PLOSGenetics http://goo.gl/7zZZPC
Goo.gl is sunsetting
goo.gl
November 24, 2024 at 5:19 AM
Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function @PLOSGenetics http://goo.gl/7zZZPC