Transgenerational epigenetic inheritance without RdRP...!
Lack of RdRP was one reason people argued epigenetic phenomena in nematodes (which do have RdRP) are fascinating but maybe not relevant to other animals (which don't have RdRP). But now....
Lack of RdRP was one reason people argued epigenetic phenomena in nematodes (which do have RdRP) are fascinating but maybe not relevant to other animals (which don't have RdRP). But now....
In this new work we show that planarians establish long-lasting and heritable small RNA–based gene regulatory states despite lacking canonical RNA-dependent RNA polymerases and nuclear RNAi machinery.
www.biorxiv.org
March 14, 2026 at 12:34 AM
Transgenerational epigenetic inheritance without RdRP...!
Lack of RdRP was one reason people argued epigenetic phenomena in nematodes (which do have RdRP) are fascinating but maybe not relevant to other animals (which don't have RdRP). But now....
Lack of RdRP was one reason people argued epigenetic phenomena in nematodes (which do have RdRP) are fascinating but maybe not relevant to other animals (which don't have RdRP). But now....
A nice little busking script starting to come together.
#redm #redmroleplay #redmrp #RDRP #RDR2 #twitch #twitchstreamer #streamer
#redm #redmroleplay #redmrp #RDRP #RDR2 #twitch #twitchstreamer #streamer
September 24, 2026 at 7:59 PM
A nice little busking script starting to come together.
#redm #redmroleplay #redmrp #RDRP #RDR2 #twitch #twitchstreamer #streamer
#redm #redmroleplay #redmrp #RDRP #RDR2 #twitch #twitchstreamer #streamer
Introducing RdRpCATCH- mining RNA viruses using RdRp HMMs!
Dimitris Karapliafis is here to talk about the community project we took up during the 2023 RdRp Summit!
#RdRpSummit2025
Dimitris Karapliafis is here to talk about the community project we took up during the 2023 RdRp Summit!
#RdRpSummit2025
May 11, 2025 at 4:49 PM
Introducing RdRpCATCH- mining RNA viruses using RdRp HMMs!
Dimitris Karapliafis is here to talk about the community project we took up during the 2023 RdRp Summit!
#RdRpSummit2025
Dimitris Karapliafis is here to talk about the community project we took up during the 2023 RdRp Summit!
#RdRpSummit2025
My paper is out! Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterised sequences in public protein databases. doi.org/10.1093/ve/v... 💻🧬 1/5 🧵
October 28, 2025 at 1:27 PM
My paper is out! Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterised sequences in public protein databases. doi.org/10.1093/ve/v... 💻🧬 1/5 🧵
PB2 is one of 3 subunits (with PA and PB1) that make up the viral RNA-dependent RNA polymerase (RdRp). The RdRp both makes mRNA that’s translated into viral proteins and copies the viral genome segments in the process of virus replication to package into progeny virus particles.
February 27, 2025 at 12:36 PM
PB2 is one of 3 subunits (with PA and PB1) that make up the viral RNA-dependent RNA polymerase (RdRp). The RdRp both makes mRNA that’s translated into viral proteins and copies the viral genome segments in the process of virus replication to package into progeny virus particles.
Lunch breaks are for good food and even better (RdRp) conversations! ❣️💃🏻
#RdRpSummit2025
#RdRpSummit2025
May 11, 2025 at 1:08 PM
Lunch breaks are for good food and even better (RdRp) conversations! ❣️💃🏻
#RdRpSummit2025
#RdRpSummit2025
The previous RdRp summit manifested in the consensus statement. What the second @rdrpsummit.bsky.social brings us?:)
We just published a consensus statement (with 47 institutes) on advancing #RdRp-based RNA virus discovery! We sum up the challenges identified at the 1st #RdRpSummit and propose solutions to ensure greater interoperability. Here’s a summary-
t.ly/Uwqge
t.ly/Uwqge
Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities
Improved RNA virus understanding is critical to studying animal and plant health, and environmental processes. However, the continuous and rapid RNA virus evolution makes their identification and char...
t.ly
May 2, 2025 at 6:28 PM
The previous RdRp summit manifested in the consensus statement. What the second @rdrpsummit.bsky.social brings us?:)
Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social
October 31, 2025 at 12:44 PM
Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social
May 12, 2025 at 3:39 PM
There has been enough opportunity for this substitution to occur, though (same for rdrp adaptation btw). I suspect that there is some other biological precondition we only poorly understand.
Contrary to what many people think we know very little of why one virus turns pandemic while others do not.
Contrary to what many people think we know very little of why one virus turns pandemic while others do not.
After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bovine H5N1 binds poorly to human-type sialic acid receptors - Nature
Nature - Bovine H5N1 binds poorly to human-type sialic acid receptors
www.nature.com
April 21, 2025 at 7:47 AM
There has been enough opportunity for this substitution to occur, though (same for rdrp adaptation btw). I suspect that there is some other biological precondition we only poorly understand.
Contrary to what many people think we know very little of why one virus turns pandemic while others do not.
Contrary to what many people think we know very little of why one virus turns pandemic while others do not.
(1) we need to see what the german intelligence agency has, but the inferrence is that they may have a copy of Ping Yu's masters thesis documenting diverse partial RdRp sequences from bat samples of diverse SARSr sarbecoviruses.
Got it, thanks. If this what they are basing their intelligence on then they are not very smart. A paper describing this work was submitting in 2018.
March 13, 2025 at 11:58 PM
(1) we need to see what the german intelligence agency has, but the inferrence is that they may have a copy of Ping Yu's masters thesis documenting diverse partial RdRp sequences from bat samples of diverse SARSr sarbecoviruses.
What’s more is that glycoprotein usage is not congruent with our Nidovirales polymerase (RdRp) phylogeny, suggesting a complex history of glycoprotein switching throughout this order.
December 17, 2024 at 4:10 AM
What’s more is that glycoprotein usage is not congruent with our Nidovirales polymerase (RdRp) phylogeny, suggesting a complex history of glycoprotein switching throughout this order.
May 21, 2026 at 6:34 AM
So what do these mutations do? Well, because they are in the PB2 subunit of the RdRp, they change how the RdRp works.
D701N increases polymerase (RNA copying) activity & enhances viral replication, as shown by virology legend Hans-Dieter Klenk et al.
journals.asm.org/doi/10.1128/...
D701N increases polymerase (RNA copying) activity & enhances viral replication, as shown by virology legend Hans-Dieter Klenk et al.
journals.asm.org/doi/10.1128/...
PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host | Journal of Virology
ABSTRACT Mutation D701N in the PB2 protein is known to play a prominent role in the adaptation
of avian influenza A viruses to mammalian hosts. In contrast, little is known about
the nearby mutations ...
journals.asm.org
February 27, 2025 at 12:36 PM
So what do these mutations do? Well, because they are in the PB2 subunit of the RdRp, they change how the RdRp works.
D701N increases polymerase (RNA copying) activity & enhances viral replication, as shown by virology legend Hans-Dieter Klenk et al.
journals.asm.org/doi/10.1128/...
D701N increases polymerase (RNA copying) activity & enhances viral replication, as shown by virology legend Hans-Dieter Klenk et al.
journals.asm.org/doi/10.1128/...
Save the date for phylogenetics!
RNA virus Journal Club returns ( @rdrpsummit.bsky.social ) with @evogytis.bsky.social intro to his "Baltic" - python module to visualise phylogenetic trees.
January 15th (Thu) - EEST Vilnius Time 3:00 PM
Join slack for updates: join.slack.com/t/rdrp-io/sh...
RNA virus Journal Club returns ( @rdrpsummit.bsky.social ) with @evogytis.bsky.social intro to his "Baltic" - python module to visualise phylogenetic trees.
January 15th (Thu) - EEST Vilnius Time 3:00 PM
Join slack for updates: join.slack.com/t/rdrp-io/sh...
January 9, 2026 at 1:31 PM
Save the date for phylogenetics!
RNA virus Journal Club returns ( @rdrpsummit.bsky.social ) with @evogytis.bsky.social intro to his "Baltic" - python module to visualise phylogenetic trees.
January 15th (Thu) - EEST Vilnius Time 3:00 PM
Join slack for updates: join.slack.com/t/rdrp-io/sh...
RNA virus Journal Club returns ( @rdrpsummit.bsky.social ) with @evogytis.bsky.social intro to his "Baltic" - python module to visualise phylogenetic trees.
January 15th (Thu) - EEST Vilnius Time 3:00 PM
Join slack for updates: join.slack.com/t/rdrp-io/sh...
ERDRP-0519, a promising non-nucleoside polymerase inhibitor, showcases differential inhibition, effectively targeting Measles (MeV) and Nipah virus (NiV) RdRp, with potential for optimized interactions. PMID:42061399, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00400-9 #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00400-9
No description available
www.cell.com
September 24, 2026 at 4:00 AM
ERDRP-0519, a promising non-nucleoside polymerase inhibitor, showcases differential inhibition, effectively targeting Measles (MeV) and Nipah virus (NiV) RdRp, with potential for optimized interactions. PMID:42061399, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00400-9 #RNA 🧪
Let's RP #RedM whitelist applications are OPEN!
Join the Home of Cinematic Roleplay and help shape the future of Red Dead Redemption RP!
letsrp.co.uk | #RDRP #RDR2 | discord.gg/lets-rp
Join the Home of Cinematic Roleplay and help shape the future of Red Dead Redemption RP!
letsrp.co.uk | #RDRP #RDR2 | discord.gg/lets-rp
March 28, 2025 at 12:00 PM
Let's RP #RedM whitelist applications are OPEN!
Join the Home of Cinematic Roleplay and help shape the future of Red Dead Redemption RP!
letsrp.co.uk | #RDRP #RDR2 | discord.gg/lets-rp
Join the Home of Cinematic Roleplay and help shape the future of Red Dead Redemption RP!
letsrp.co.uk | #RDRP #RDR2 | discord.gg/lets-rp
Interested in RNA virus discovery? You can still register for the RdRp summit and attend remotely!
We'll have some really nice talks and cutting edge discussions on best practices and new directions in the field.
rdrp.io
#phagesky #virosky #bioinformatics
We'll have some really nice talks and cutting edge discussions on best practices and new directions in the field.
rdrp.io
#phagesky #virosky #bioinformatics
rdrp.io
The official website of the RdRp Summit.
rdrp.io
April 25, 2025 at 11:45 AM
Interested in RNA virus discovery? You can still register for the RdRp summit and attend remotely!
We'll have some really nice talks and cutting edge discussions on best practices and new directions in the field.
rdrp.io
#phagesky #virosky #bioinformatics
We'll have some really nice talks and cutting edge discussions on best practices and new directions in the field.
rdrp.io
#phagesky #virosky #bioinformatics
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
Author summary Flaviviridae viruses—including JEV, CSFV, and HCV—deploy intricate molecular strategies to subvert host innate immune surveillance and establish chronic infections, representing signifi...
journals.plos.org
December 5, 2025 at 2:15 PM
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Dengue virus lacks specific #Antivirals; R18, a #ginsenoside from Panax notoginseng, acts as a dual E/RdRp inhibitor, blocking viral adsorption, entry, and replication while attenuating disease in mouse models. #medsky #Virology
#AMM #OpenAccess: doi.org/10.15212/AMM...
#AMM #OpenAccess: doi.org/10.15212/AMM...
September 24, 2026 at 11:08 AM
Dengue virus lacks specific #Antivirals; R18, a #ginsenoside from Panax notoginseng, acts as a dual E/RdRp inhibitor, blocking viral adsorption, entry, and replication while attenuating disease in mouse models. #medsky #Virology
#AMM #OpenAccess: doi.org/10.15212/AMM...
#AMM #OpenAccess: doi.org/10.15212/AMM...
We just published a consensus statement (with 47 institutes) on advancing #RdRp-based RNA virus discovery! We sum up the challenges identified at the 1st #RdRpSummit and propose solutions to ensure greater interoperability. Here’s a summary-
t.ly/Uwqge
t.ly/Uwqge
Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities
Improved RNA virus understanding is critical to studying animal and plant health, and environmental processes. However, the continuous and rapid RNA virus evolution makes their identification and char...
t.ly
April 30, 2024 at 9:31 AM
We just published a consensus statement (with 47 institutes) on advancing #RdRp-based RNA virus discovery! We sum up the challenges identified at the 1st #RdRpSummit and propose solutions to ensure greater interoperability. Here’s a summary-
t.ly/Uwqge
t.ly/Uwqge
September 24, 2026 at 11:27 AM
Rachid Tahzima presenting the RdRp modulome!
#RdRpSummit2025
#RdRpSummit2025
May 11, 2025 at 11:16 AM
Rachid Tahzima presenting the RdRp modulome!
#RdRpSummit2025
#RdRpSummit2025
Hey! That's me! Check out my latest where I develop a method for pinpointing where mutation spectra change along phylogenies. Striking, nodes with large changes are significantly enriched for protein changes in the RdRp (catalytic domain of the polymerase) suggesting a causal role.
Using ~8M SARS-CoV-2 genomes, a new phylogenetic algorithm by @russcd.bsky.social detects 10 shifts in mutation patterns, some of them linked to changes in viral polymerase. This provides new perspectives on the evolution of mutational processes.
🔗 doi.org/10.1093/molb...
#molbio #evobio #covid
🔗 doi.org/10.1093/molb...
#molbio #evobio #covid
A Phylogenetic Method Identifies Candidate Drivers of the Evolution of the SARS-CoV-2 Mutation Spectrum
Abstract. The molecular processes that generate new mutations evolve, but the causal mechanisms are largely unknown. In particular, the relative rates of m
doi.org
May 1, 2025 at 3:02 AM
Hey! That's me! Check out my latest where I develop a method for pinpointing where mutation spectra change along phylogenies. Striking, nodes with large changes are significantly enriched for protein changes in the RdRp (catalytic domain of the polymerase) suggesting a causal role.