Fu et al. showed that point mutations in MmTMC1/2 are localized in plasma membrane, and knockdown of UROD, RGP1, or ARL1 promotes plasma membrane localization of HsTMC1/2 in heterologous cells. HsTMC1/2 are activated by mechanical stimuli and function as pore-forming ion channels, supporting their roles as mechanotransduction channels in hair cells.

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Rab GTPases act as molecular switches to regulate organelle homeostasis and membrane trafficking. Ra

Rab GTPases act as molecular switches to regulate organelle homeostasis and membrane trafficking. Ra

The end of an era is upon us! This is MASKulinity’s series finale episode...maybe just for now. It is Samantha’s farewell episode (Remoy may return), and RGP1  interviews her about MASKulinity Podcast, including a trip down memory lane… Remoy starts out by asking why Samantha wanted to start this podcast. Samantha remembers the inciting incident and the events that followed. She talks about her motivations for engineering the show and what she wanted for her and for you, the listeners, to get out of it. She reveals that her motivations were not just for men. Remoy also asks why Samantha tapped him specifically to do it. She shares the importance of this conversation. She shares her hopes for men and masculinity going forward and how that has changed over the years. For a brief walk down memory lane, Samantha chooses three clips from episodes over the last five seasons as friendly reminders. In Season 4, the hosts got into why Phil Dunphy is the perfect character to explore MASKulinity In Season 3, sex educator Wazina Zondon and reproductive justice advocate Andrew Stern of NIRH (at the time) had stopped by the pod to talk sex education with us Why are folks so afraid to talk to boys about anything, but specifically, about sex? In Season 1, we talked about why men fight… Samantha had to find out whether Remoy had finally been in one. Is men wanting to fight innate or conditioning? Samantha takes a moment to thank you, listeners, for sticking with the podcast all these years. Thank you for giving a shit! Remoy thanks Samantha for spawning this podcast and inviting him along this adventure. Lastly, Samantha may be exiting, but the show may not end! It’s just a see you later for now…. If you know anyone who can support the production of this conversation in any way, please let us know! Samantha will monitor emails - maskulinitypodcast@gmail.com - and socials for a while. You can find us at @maskulinitypod on all platforms. To reach Samantha directly, you can find her on Threads or IG at @samanthal_n. Thank you so much for listening! Referenced on this episode: The Brock Turner case that started it all In TV Dads , we talked about why Phil Dunphy and comedy help us see masculinity in a different light That time we talked about sex education and reproductive justice and how little men and boys know about it Men Got Issues - our episode from Season 1 where we talked about why men fight Report on Homicide of trans women Samantha references our conversation with Trevor Mayoh where he mentions providing on off-ramp out of MASKulinity for men