#RNA-based
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bstritt52.bsky.social
RNA based life thinking of the future:
jpbrammer.bsky.social JP @jpbrammer.bsky.social · Apr 11
low key what is a peptide
April 11, 2026 at 10:34 PM
pestilence4all.bsky.social
It’s an RNA world. RNA is posited to be the first genetic material, arising 4 billion years ago. It can store information and act as an enzyme. Eventually, it duplicated its information into a more stable form, DNA.
A four panel comic, from left to right: 1960s LIFE IS BASED ON DNA, WHICH USES RNA TO MAKE PROTEINS THAT DO STUFF. 1980s ALSO, THE RNA DOES SOME STUFF ITSELF, WHICH IS WEIRD. 2000s THERE ARE 50 MANY KINDS OF RNA. IT'S DOING SO MUCH STUFF! 2020s LIFE IS A SEETHING MASS OF RNA THAT SOMETIMES USES DNA TO TAKE NOTES. WHAT DO THE PROTEINS DO? ERRANDS FOR RNA.
February 13, 2026 at 2:17 PM
sailorrooscout.bsky.social
THIS IS HUGE! Researchers at The Jackson Laboratory and UConn Health have successfully discovered a molecular switch that can actually SHUT DOWN cancer growth signals and STOP tumor growth at the RNA LEVEL. The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. 🧪🧵⬇️
March 23, 2025 at 4:00 PM
caleblareau.bsky.social
Out today in @naturegenet.bsky.social -- PERFF-seq! With @tsionabay.bsky.social , @ronanchaligne.bsky.social, Bob Stickels, Meril Takizawa, + Ansu Satpathy, we describe this new assay to study rare populations with programmable nucleic acid cytometry. 1/n
www.nature.com/articles/s41...
Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing - Nature Genetics
Programmable Enrichment via RNA FlowFISH by sequencing (PERFF-seq) isolates rare cells based on RNA marker transcripts for single-cell RNA sequencing profiling of complex tissues, with applicability t...
www.nature.com
January 8, 2025 at 1:30 PM
drjengunter.bsky.social
The effectiveness of propaganda. A friend who is an MD who I have always thought of as evidence based said she isn’t going to get any more RNA based vaccines. She has not had a negative vaccine reaction and she can’t really put into words why she doesn’t trust them.
November 20, 2024 at 6:03 PM
joergstuelke.bsky.social
Identification of a novel RNA-modifying enzyme! RlmS!
#SubtiWiki
www.pnas.org/doi/10.1073/...
Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA | PNAS
RNA modifications play an important role in biological processes. Mapping the diversity of RNA chemistry and studying the biological function of in...
www.pnas.org
September 26, 2026 at 4:43 PM
brettcollins.bsky.social
Not my area at all, but how cool are these cryoEM structures of purely RNA-based assemblies!
www.nature.com/articles/s41...
High resolution CryoEM maps of RNA assemblies
August 6, 2025 at 10:42 PM
dereklowe.bsky.social
More progress in the mRNA cancer vaccine work. It’s taken a long time to get here!
Progress on RNA-Based Cancer Vaccines
www.science.org
March 3, 2025 at 4:59 PM
eigenvectrix.northsky.social
Virtually all life now is based on DNA. But it is generally agreed that the most plausible hypothesis of the emergence of life involves the “RNA world,” a biosphere whose genetic material was based entirely on the more fragile RNA. DNA is a hardened, resilient form of RNA, and was selected for.
September 28, 2026 at 4:17 AM
incarnatolab.bsky.social
A language model-based deep learning approach for #RNA 3D structure prediction www.nature.com/articles/s41...
Accurate RNA 3D structure prediction using a language model-based deep learning approach - Nature Methods
RhoFold+ is an end-to-end language model-based deep learning method to predict RNA three-dimensional structures of single-chain RNAs from sequences.
www.nature.com
November 21, 2024 at 3:15 PM
quantamagazine.org
“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...
Portrait of Rachel Green, an RNA biologist at Johns Hopkins University
August 4, 2025 at 8:04 PM
maddow.bsky.social
Trump canceled: "a grant to Emory University and Georgia State University, where researchers had developed three potential drugs that showed promise against many RNA-based viruses, including coronaviruses, Ebola, avian influenza and measles.."

www.nytimes.com/interactive/...
The Gutting of America’s Medical Research: Here Is Every Canceled or Delayed N.I.H. Grant
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 8, 2025 at 6:16 PM
ralfwittenbrink.bsky.social
Antihistaminika, insbesondere Histaminrezeptor-H1 (HRH1)-Antagonisten, hemmen wirksam die #SARSCoV2-Infektion

In dieser Studie wurde „nachgewiesen, dass HRH1 als alternativer Rezeptor für #SARSCoV2 fungiert, indem er direkt an das virale Spike-Protein bindet.🧵

#COVID19 #Corona
Fig 7 Antihistamine drugs prevented SARS-CoV-2 infection in transgenic hACE2 mice. (A) Acrivastine at serially diluted concentrations was premixed with authentic SARS-CoV-2 D614G viruses, followed by incubation with HEK293T-hACE2 cells. After 48 h, the viral RNA in the supernatants was extracted and quantified via RT-PCR-based detection. The IC50 value was calculated based on the relative number of viral RNA copies within each concentration. (B) The IC50 of triprolidine against the authentic SARS-CoV-2 D614G strain was measured and calculated as described in panel A. (C) Schematic of the animal infection assay. Four transgenic hACE2 mice (C57BL/6) were intravenously administrated with acrivastine at a dosage of 10 mg/kg of body weight. Mice in the control group were administrated with an equal volume of saline. Six hours later, all mice were intranasally challenged with 1 × 105 focus-forming units of the SARS-CoV-2 D614G virus. …
July 6, 2024 at 1:11 PM
kgoepfrich.bsky.social
Hey #RNA world, we are excited to share our RNA design engine #pyFuRNAce - an integrated tool for RNA origami experts and novices alike. Kudos to @monari-luca.bsky.social @floppleton.bsky.social et al! Preprint: www.biorxiv.org/content/10.1... Try it out at pyfurnace.de Feedback welcome!
PyFuRNAce: An integrated design engine for RNA origami
To realize the full potential of RNA nanotechnology and RNA origami, user-friendly design tools are needed. Here, we present pyFuRNAce, an open-source, Python-based software package with a graphical u...
www.biorxiv.org
April 20, 2025 at 12:29 PM
simonbullock11.bsky.social
How are mRNAs linked to molecular motors in mammalian cells?

In our new preprint, we show that FXR1/2 are RNA adaptors for the microtubule motor dynein. Our findings have also prompted us to rethink how activating adaptors contribute to motor-based transport (1/n)
biorxiv-cellbio.bsky.social bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 5d
FXR proteins and BICD2 cooperate to promote dynein-mediated RNP transport and stress granule assembly https://www.biorxiv.org/content/10.64898/2026.09.25.754448v1
September 28, 2026 at 1:23 PM
atranscendedman.bsky.social
Beijing scientists built a $0.10 biosensor that detects SARS-CoV-2 RNA and ASFV DNA in under 1 minute with a simple test tube flip, beating PCR and CRISPR in speed, cost, and sensitivity—no equipment needed

www.science.org/doi/10.1126/...
A tube-based biosensor for DNA and RNA detection
The sensor performs cheap, sensitive, and visual DNA/RNA detection based on target-triggered change of surface wettability.
www.science.org
May 3, 2025 at 9:34 PM
nature.com
A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases

https://go.nature.com/3POiHpJ
A scalable system using mini-organs to test personalized RNA therapy
Platform to accelerate the testing of antisense oligonucleotides.
go.nature.com
January 25, 2025 at 12:06 PM
m1quelag.bsky.social
Hi all! Inspired by how easy ColabFold ( @sokrypton.org ) made prot structure prediction for me, I have started ColabRNA to facilitate making predictions with RNA-based models!

Currently, the following models are available:
- SpliceAI
- Pangolin
- SpliceTransformer
- Borzoi

Happy to get feedback!
GitHub - MiqG/ColabRNA: Making RNA-based models accessible to all.
Making RNA-based models accessible to all. Contribute to MiqG/ColabRNA development by creating an account on GitHub.
github.com
February 15, 2025 at 10:31 PM
sailorrooscout.bsky.social
The revelation by researchers from The Jackson Laboratory and UConn Health could lead to new RNA-based multi-cancer treatments.

The study has been published in Nature Communications. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
TLDR Cancer disrupts RNA splicing by suppressing poison exons, leading to uncontrolled tumor growth. Researchers at JAX and UConn Health found that targeting TRA2B RNA with antisense oligonucleotides (ASOs) restores this natural kill switch, shutting down cancer growth signals. ASOs offer a promising, highly specific approach for treating aggressive cancers. The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. ABSTRACT Upregulated expression of the oncogenic splicing factor TRA2ß occurs in human tumors partly through decreased inclusion of its autoregulatory non-coding poison exon (PE). Here, we reveal that low TRA2ß-PE inclusion negatively impacts patient survival across several tumor types. We demonstrate the ability of splice-switching antisense oligonucleotides (ASOs) to promote TRA2ß-PE inclusion and lower TRA2ß protein levels in pre-clinical cancer models. TRA2ß-PE-targeting ASOs induce anti-cancer phenotypes and widespread transcriptomic alterations with functional impact on RNA processing, mTOR, and p53 signaling pathways. Surprisingly, the effect of TRA2ß-PE-targeting ASOs on cell viability are not phenocopied by TRA2ß knockdown. Mechanistically, we find that the ASO functions by both decreasing TRA2ß protein and inducing the expression of TRA2B-PE-containing transcripts that act as long non-coding RNAs to sequester nuclear proteins. Finally, TRA2B-PE-targeting ASOs are toxic to preclinical 3D organoid and in vivo patient-derived xenograft models. Together, we demonstrate that TRA2ß-PE acts both as a regulator of protein expression and a long-noncoding RNA to control cancer cell growth. Drugging oncogenic splicing factors using PE-targeting ASOs is a promising therapeutic strategy. This research was supported by the National Institutes of Health and the NCI-designated JAX Cancer Center.
March 23, 2025 at 4:01 PM
plantteaching.bsky.social
In a global first, Mexico approves use of RNA-based fungicide.
Oifirax, created by GreenLight Biosciences, uses RNA molecules to kill the fungus responsible for powdery mildew on grapes.
www.science.org/content/arti...
In a global first, Mexico approves use of RNA-based fungicide
Oifirax, created by GreenLight Biosciences, uses RNA molecules to kill the fungus responsible for powdery mildew on grapes
www.science.org
August 27, 2026 at 3:22 PM
warrenoates1.bsky.social
New RNA treatments for things like cancer, dementia & infectious diseases will be possible thanks to a new facility the government has announced today.

The UK RNA Biofoundry, to be based in Darlington & backed by £30m funding, is part of the Life Sciences Sector Plan from the Industrial Strategy.
Next-gen therapies for cancer, dementia and more fast-tracked with new facility
New facility based in Darlington to springboard novel RNA therapies – which could help tackle cancer, heart conditions, infectious diseases, and more.
www.gov.uk
August 28, 2025 at 6:26 PM
docvivileandra.bsky.social
Would also make something made of relatively unstable RNA (like the Proteavirus itself) much more stable, which allows more room for the obscene complexity it possesses for an RNA-based lifeform (yes, unlike Earth viruses, you can consider it "alive")
May 15, 2026 at 3:22 PM
uweohler.bsky.social
#paperalert!
In our new study, we ask the question: Can we predict RNA stability across conditions and protocols, based solely on experimental and/or computationally predicted RNA binding protein target sites?
Read the paper to find out !

www.biorxiv.org/content/10.1...
Cell-type specific prediction of RNA stability from RNA-protein interactions
RNA-binding proteins (RBPs) are important contributors to post-transcriptional regulatory processes. The combinatorial action of expressed RBPs and non-coding factors bound to the same transcript dete...
www.biorxiv.org
December 4, 2024 at 12:48 PM
quantamagazine.org
“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...
Portrait of RNA biologist Rachel Green at John Hopkins University.
July 18, 2025 at 8:04 PM
natbiotech.nature.com
A resource of human RNA-protein associations is produced using a sequencing-based method go.nature.com/4gmf1Ii
rdcu.be/fxFn1
Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology
A resource of human RNA-protein associations is produced using a sequencing-based method.
go.nature.com
August 4, 2026 at 4:07 AM