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Regulation of endogenous dsRNA: strategies for self-tolerance

Open biology · Heraud-Farlow et al.
doi.org/10.1098/rsob.260111
#RNAsky #RNAmods
Regulation of endogenous dsRNA: strategies for self-tolerance
Open biology · Heraud-Farlow J, Chan YP, Davidson S, Walkley C.
doi.org
November 4, 2026 at 8:23 PM
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Advances in guide RNA engineering for endogenous ADAR-mediated therapeutic RNA editing

Current opinion in chemical biology · Mok et al.
doi.org/10.1016/j.cbpa.2026.102814
#RNAsky #RNAmods
Advances in guide RNA engineering for endogenous ADAR-mediated therapeutic RNA editing
Current opinion in chemical biology · Mok BY.
doi.org
November 5, 2026 at 1:14 AM
rnamod.bsky.social
Post-transcriptional regulation of FGF signaling: insights from musculoskeletal system

Journal of molecular biology · Lecaudey et al.
doi.org/10.1016/j.jmb.2026.170087
#RNAsky #RNAmods
Post-transcriptional regulation of FGF signaling: insights from musculoskeletal system
Journal of molecular biology · Lecaudey LA, Ghasemishahrestani Z, Saqagandomabadi V, Wesche J, Ahi EP.
doi.org
November 5, 2026 at 1:13 AM
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Multivalent ADAR1 recruitment for precise RNA editing

Nature methods
doi.org/10.1038/s41592-026-03285-6
#RNAsky #RNAmods
Multivalent ADAR1 recruitment for precise RNA editing
Nature methods
doi.org
October 31, 2026 at 5:37 PM
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Proximity-Activated Photocatalytic Pharmacology: From Subcellular Compartments to Neural Circuits

Accounts of chemical research · Zhang et al.
doi.org/10.1021/acs.accounts.6c00470
#RNAsky #RNAmods
Proximity-Activated Photocatalytic Pharmacology: From Subcellular Compartments to Neural Circuits
We establish a high-resolution reaction sphere for photocatalytic bond cleavage to enable precise interrogation of biological microdomains.
doi.org
November 4, 2026 at 8:23 PM
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METTL3-mediated m6A modification of DNMT1 enhances ovarian cancer progression

Science advances · Kumari et al.
doi.org/10.1126/sciadv.aec2297
#RNAsky #RNAmods
METTL3-mediated m6A modification of DNMT1 enhances ovarian cancer progression
In this study, we identify a critical oncogenic role of the RNA methyltransferase METTL3 and the N6-methyladenosine (m6A) RNA modification pathway in HGSOC.
doi.org
November 5, 2026 at 1:14 AM
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NOP2/Sun domain 4-mediated m5C methylation of Janus kinase 1 promotes hepatocellular carcinoma progression

Cell adhesion & migration · Ke et al.
doi.org/10.1080/19336918.2026.2757921
#RNAsky #RNAmods
NOP2/Sun domain 4-mediated m5C methylation of Janus kinase 1 promotes hepatocellular carcinoma progression
Cell adhesion & migration · Ke J, Xu Y, Ding F, Chen Y, Li Z, Chen J.
doi.org
November 5, 2026 at 1:14 AM
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Clarifying the In Vivo Perturbation and Translational Scope of the METTL3-FYN-SLIT2/ROBO1 Axis

Journal of gastroenterology and hepatology · Chen et al.
doi.org/10.1111/jgh.70821
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Clarifying the In Vivo Perturbation and Translational Scope of the METTL3-FYN-SLIT2/ROBO1 Axis
Journal of gastroenterology and hepatology · Chen M, Zhang Z, Fu X.
doi.org
November 4, 2026 at 8:23 PM
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FTO does not function as an m6A eraser in AML: a reassessment using direct RNA nanopore sequencing

bioRxiv · Nicholson et al.
doi.org/10.1101/2025.10.22.681652
#RNAsky #RNAmods
FTO does not function as an m6A eraser in AML: a reassessment using direct RNA nanopore sequencing
We find that m6A stoichiometry, including at MYC-specific sites, remains unaffected by FTO knockdown or pharmacologic inhibition in AML.
doi.org
November 5, 2026 at 1:13 AM
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Small Nucleolar RNAs, Big Impact: Biogenesis, Mechanisms, and Roles in Health and Disease

American journal of physiology. Cell physiology · Natarajaseenivasan et al.
doi.org/10.1152/ajpcell.90164.2026
#RNAsky #RNAmods
Small Nucleolar RNAs, Big Impact: Biogenesis, Mechanisms, and Roles in Health and Disease
American journal of physiology. Cell physiology · Natarajaseenivasan SM, Rai AK, Pierre N, Joseph ME, Lam M, Sharma P, Garikipati VNS.
doi.org
November 4, 2026 at 8:24 PM
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m6A-modified hsa_circ_0010996 regulates ferroptosis in anti-tuberculosis drug-induced liver injury cells by binding to EIF4A3

Toxicology and applied pharmacology · Wang et al.
doi.org/10.1016/j.taap.2026.118100
#RNAsky #RNAmods
m6A-modified hsa_circ_0010996 regulates ferroptosis in anti-tuberculosis drug-induced liver injury cells by binding to EIF4A3
Toxicology and applied pharmacology · Wang Q, Long M, Song T, Yao J, Liu Y, Meng C, Feng F.
doi.org
November 4, 2026 at 8:24 PM
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CircCCNB1 Inhibits Ferroptosis in Glioblastoma Cells via the USP4/IGF2BP1/SLC7A11 Axis

Neurochemical research · Cui et al.
doi.org/10.1007/s11064-026-04943-z
#RNAsky #RNAmods
CircCCNB1 Inhibits Ferroptosis in Glioblastoma Cells via the USP4/IGF2BP1/SLC7A11 Axis
Neurochemical research · Cui S, Zhuang Y, Wei H, Xiong H, He Z.
doi.org
November 2, 2026 at 10:16 PM
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ZC3H13 promotes cervical cancer cell proliferation and stemness and reduces cisplatin sensitivity and apoptosis by stabilizing CTHRC1 mRNA in an m6A-Dependent manner

Gene · Aihemaitijiang et al.
doi.org/10.1016/j.gene.2026.150474
#RNAsky #RNAmods
ZC3H13 promotes cervical cancer cell proliferation and stemness and reduces cisplatin sensitivity and apoptosis by stabilizing CTHRC1 mRNA in an m6A-Dependent manner
Gene · Aihemaitijiang F, Meng X, Yumai A, Muhanmude Y.
doi.org
November 3, 2026 at 8:02 PM
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ADAR-mediated RNA editing of Influenza A virus genomes may be age-dependent and inversely correlates with viral load

Infectious diseases (London, England) · Widström et al.
doi.org/10.1080/23744235.2026.2753489
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ADAR-mediated RNA editing of Influenza A virus genomes may be age-dependent and inversely correlates with viral load
Infectious diseases (London, England) · Widström J, Fingal J, Ringlander J, Lindh M, Andersson M, Wahllöf M, Rydell GE, Bustamante Jaramillo LF, Kann M, Westin
doi.org
November 3, 2026 at 8:02 PM
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Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models

Molecular biology reports · Yıldırım et al.
doi.org/10.1007/s11033-026-13074-1
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Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models
Molecular biology reports · Yıldırım ME, Ayhan B, Çelik H.
doi.org
November 2, 2026 at 12:06 AM
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NUDT21 Promotes Myelodysplastic Syndrome Progression by Regulating SRSF2 Expression via Alternative Polyadenylation

Hematological oncology · Guan et al.
doi.org/10.1002/hon.70255
#RNAsky #RNAmods
NUDT21 Promotes Myelodysplastic Syndrome Progression by Regulating SRSF2 Expression via Alternative Polyadenylation
Hematological oncology · Guan D, Xu W, Li S, Li P, Bian J, Wang H, Ren F.
doi.org
November 1, 2026 at 6:22 PM
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Huashi Runzao Decoction alleviates ferroptosis in salivary gland epithelial cells through RBM15B-associated m6A regulation in Sjögren's disease

Journal of ethnopharmacology · Deng et al.
doi.org/10.1016/j.jep.2026.122583
#RNAsky #RNAmods
Huashi Runzao Decoction alleviates ferroptosis in salivary gland epithelial cells through RBM15B-associated m6A regulation in Sjögren's disease
Journal of ethnopharmacology · Deng T, Zhang H, Wang Y, Jiao Y, Wang Z, Shi T, Xu J, Wen C, Zhang J, Zhang K, Su S, Deng T, Tao Q, Xiao C, Luo J.
doi.org
November 3, 2026 at 8:02 PM
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WTAP-mediated m6A methylation stabilizes pIgR mRNA and attenuates smoke-induced epithelial inflammation and apoptosis

iScience · Li et al.
doi.org/10.1016/j.isci.2026.117958
#RNAsky #RNAmods
WTAP-mediated m6A methylation stabilizes pIgR mRNA and attenuates smoke-induced epithelial inflammation and apoptosis
We show that smoke exposure downregulates the m6A writer-complex component WTAP and reduces global m6A methylation.
doi.org
November 2, 2026 at 12:05 AM
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YTHDF1 promotes radioresistance in nasopharyngeal carcinoma through the SATB1/Wnt/β-catenin pathway

Molecular and cellular probes · Liao et al.
doi.org/10.1016/j.mcp.2026.102092
#RNAsky #RNAmods
YTHDF1 promotes radioresistance in nasopharyngeal carcinoma through the SATB1/Wnt/β-catenin pathway
Molecular and cellular probes · Liao B, Zhang L, Zou Q, Wang M, Liu J, Guo L, Zhou Z, Yi Y.
doi.org
November 2, 2026 at 12:06 AM
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RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA

Science advances · Ganem et al.
doi.org/10.1126/sciadv.aed7314
#RNAsky #RNAmods
RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA
We show that ADARs interfere with the efficacy of exogenous RNAi in vivo, likely to prevent trans-silencing, and provide evidence that ADR-2 binding to dsRNA is required for efficient RNAi suppression.
doi.org
October 31, 2026 at 5:38 PM
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M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2

Molecular and cellular biochemistry · Yan et al.
doi.org/10.1007/s11010-026-05785-7
#RNAsky #RNAmods
M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2
Molecular and cellular biochemistry · Yan WZ, Wang JY, Chen YY, Zhang M, Liu GY, He LY.
doi.org
November 2, 2026 at 10:16 PM
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FTO mediated glycolytic metabolism for papillary renal cell carcinoma immune evasion

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · Guimarães-Teixeira et al.
doi.org/10.1016/j.biopha.2026.120009
#RNAsky #RNAmods
FTO mediated glycolytic metabolism for papillary renal cell carcinoma immune evasion
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · Guimarães-Teixeira C, Nunes SP, Bueno-Costa A, Martinez-Verbo L, Duarte IF, Carriço ÍR, Barros-Silva D, Lobo J, Henrique
doi.org
November 2, 2026 at 12:07 AM
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METTL7B-Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression

Cancer medicine · Lin et al.
doi.org/10.1002/cam4.72373
#RNAsky #RNAmods
METTL7B-Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression
Cancer medicine · Lin W, Wu K, Chen J, Yu Z, Zhang H, Chen X.
doi.org
November 1, 2026 at 6:21 PM
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Melatonin Suppresses Colorectal Cancer Alongside Coordinated Changes in H3K4me3Q5ser and m6A Modifications

Journal of pineal research · Zhang et al.
doi.org/10.1111/jpi.70192
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Melatonin Suppresses Colorectal Cancer Alongside Coordinated Changes in H3K4me3Q5ser and m6A Modifications
Journal of pineal research · Zhang W, Yuan L, Yu D, Qi S, Liu C, Wang D, Wang W, Zhang Y, Zhang S, Lu L, Wu M, Huang Y.
doi.org
November 1, 2026 at 6:21 PM
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ASIC1a promotes liver fibrosis by inhibiting METTL3 SUMOylation

Acta pharmacologica Sinica · Li et al.
doi.org/10.1038/s41401-026-01951-1
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ASIC1a promotes liver fibrosis by inhibiting METTL3 SUMOylation
Acta pharmacologica Sinica · Li ZH, Li MX, Song YH, Ren RH, Zhang TT, Huang WJ, Harry AM, Shah KA, Wang YY, Liu ZJ, Chen HY, Qian SH, Xu Z, Zhang JR,
doi.org
October 30, 2026 at 6:33 PM