#RSCChemBio!
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rscchembio.rsc.org
🔥 Don't miss #RSCChemBio Advisory Board member, Luc Brunsveld's, newest manuscript!

✨ Read their report on the stabilisation of Tau/14-3-3 protein-protein interactions using reversible-covalent small-molecule molecular glues!

👉 doi.org/10.1039/d6cb...
September 24, 2026 at 8:34 AM
stephanhacker2.bsky.social
Very excited to be part of the #RSCposter conference over on LinkedIn as one of the subject chairs for #RSCChemBio. Looking forward to all the exciting research that will be presented on March 4th and 5th. Follow #RSCposter and #RSCChemBio over there to not miss anything. www.rsc.org/our-events/r...
January 27, 2025 at 7:51 AM
stephanhacker2.bsky.social
#RSCPoster is happening again on March 3rd and 4th, 2026, here on LinkedIn. I am happy to be involved as subject chair for #RSCChemBio.

If you want to share some exciting research in #Chemistry and especially #ChemBio consider registering for the event:

www.rsc.org/our-events/a...
#ChemSky
December 12, 2025 at 11:50 AM
stephanhacker2.bsky.social
Very excited for the virtual #RSCPoster conference by @rsc.org over on LinkedIn that is happening on March 4th and 5th and to be a subject chair for #RSCChemBio together with Lyn Jones and Ali Tavassoli. (1/2)

www.rsc.org/our-events/r...
March 3, 2025 at 1:25 PM
rscchembio.rsc.org
📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026!

📅 8 - 11th September 2026
📍 EMBL Heidelberg, Germany
🔗 www.embl.org/about/i...

Submit your abstract by 2nd June 2026 to a part of the event!

EMBO #ChemicalBiology
January 9, 2026 at 6:03 PM
stephanhacker2.bsky.social
Do you want to present your research to a global audience?

Then you should check out, #RSCPoster, which will happen on March 4th to 5th. Very excited to chair the #ChemBio part #RSCChemBio together with Lyn Jones and Ali Tavassoli.

Click this link for all information: www.rsc.org/our-events/r...
February 12, 2025 at 3:38 PM
rscchembio.rsc.org
📢 Welcome to issue 4 of RSC Chemical Biology!

🦠 This issue features articles on the roles of lipid droplets in metabolic signalling, siRNA chemical modification strategies, TRK fusion-positive cancer targeting PROTACs and more!

➡️ Read it here pubs.rsc.org/en/Jour...

#RSCChemBio
April 20, 2026 at 7:57 AM
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Interesting contribution to #RSCChemBio at #RSCPoster over on LinkedIn by Atanu Ghosh. An exciting method for the automated synthesis of morpholino oligonucleotides with diverse backbones. pubs.acs.org/doi/full/10....

www.linkedin.com/posts/atanu-...
A Unified Phosphoramidite Platform for the Synthesis of Morpholino Oligonucleotides and Diverse Chimeric Backbones
Phosphorodiamidate Morpholino Oligonucleotides (PMOs) have been well established in the milieu of FDA-approved oligonucleotide-based drugs in the past decade. Given their relevance in antisense therap...
pubs.acs.org
March 4, 2025 at 7:19 PM
rscchembio.rsc.org
Celebrating International Women’s Day 2026 with standout women researchers at the chemistry-biology interface.
Explore our new collection: pubs.rsc.org/en/jour...
Contact us if you have a recent #RSCChemBio publications to add to this collection!
#InternationalWomensDay #WomenInScience #WomenInSTEM
February 27, 2026 at 12:00 PM
rscchembio.rsc.org
✨ Want to know more about RNA modifications and RNA-binding proteins? #RSCChemBio have the manuscript for you!

➡️ Amanda Garner and team present their review on RNA mods and RBPs looking at interactions, regulation and avenues for therapeutic modulation!

👉 doi.org/10.1039/d6cb...
September 22, 2026 at 8:28 AM
rscchembio.rsc.org
✨Research spotlight on targeted protein degraders: from macrocyclic peptides to nanoparticle-based delivery systems, there is a wealth and diversity of PROTACs research published in #RSCChemBio each year.
Find the highlights from 2025 on our blog now:
🔗blogs.rsc.org/cb/202...
#PROTAC #RSCChemBio
February 17, 2026 at 7:41 AM
stephanhacker2.bsky.social
Interesting contribution to #RSCChemBio at #RSCPoster over on LinkedIn by Nicolas Cornelissen. An exciting method for the chemo-enzymatic synthesis of base-modified ATP analogs and their use for making highly modified, polyadenylated RNA. pubs.rsc.org/en/content/a...
www.linkedin.com/posts/nicola...
Chemo-enzymatic production of base-modified ATP analogues for polyadenylation of RNA
Base-modified adenosine-5′-triphosphate (ATP) analogues are highly sought after as building blocks for mRNAs and non-coding RNAs, for genetic code expansion or as inhibitors. Current synthetic strateg...
pubs.rsc.org
March 5, 2025 at 11:59 AM
rscchembio.rsc.org
📢 Out now in #RSCChemBio!

🧪 Danielle Schmitt and her team present iGlo: the newest protein-based optical reporter for the sensitive and precise study of compartmentalized glutamine dynamics!

✨ Read more here: doi.org/10.1039/d6cb...
August 18, 2026 at 3:41 PM
rscchembio.rsc.org
📢 Now out in #RSCChemBio!

✨ Anna Barnard and her team present their affinity-based protein profiling of three classes of α-helix mimetics revealing significant differences in proteome-wide selectivity.

➡️ Read it here: http://doi.org/10.10...
August 11, 2026 at 5:41 PM
rscchembio.rsc.org
📢 Don't miss Toru Komatsu and Yasuteru Urano's newest review in #RSCChemBio where they 'revisit the past to discover the new.'

✨ Their review explores how a century of classical chemistry continues to inspire modern enzyme-responsive fluorescent probes.

Read it here: doi.org/10.1039/d6cb...
July 9, 2026 at 10:11 AM
rscchembio.rsc.org
Zoom in on CXM 🔬

New #RSCChemBio study reveals how chuangxinmycin hits bacterial TrpRS enzymes—but not human ones. 10 crystal structures + MD sims = a blueprint for selective antibiotic design.

#RSCchembio #StructuralBiology #Antibiotics #TrpRS #AMR
doi.org/10.1039/D5CB...
Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin
Chuangxinmycin (CXM) is a promising antimicrobial compound targeting bacterial tryptophanyl-tRNA synthetase (TrpRS), an essential enzyme in protein synthesis. The detailed inhibitory mechanism of CXM, particularly in clinically relevant pathogenic bacteria, is poorly understood. In this study, based on the determin
doi.org
June 18, 2025 at 3:26 PM
rscchembio.rsc.org
On the back cover of RSCChemBio Issue 2: Lina Cui et al. explore "Tuning the efficiency of molecular probes via quinone methide-based in situ labeling" ✨
Read the full story now: doi.org/10.1039/D5CB...
👉 Get the full issue here: pubs.rsc.org/en/jour...
February 12, 2026 at 1:37 PM
rscchembio.rsc.org
📢Issue 8 of RSC Chemical Biology is out now and #OpenAccess!

Find our outstanding reviewers editorial as well as articles on antibiotic symmetry, G4-G4 ligand aggregates, DNA origami-based drug delivery, coiled coil peptides as PPI inhibitors and more!

🔗 pubs.rsc.org/cb/issu...

#RSCChemBio
August 6, 2026 at 3:35 PM
rscchembio.rsc.org
🐜 Fungus-growing ant species make a host defence peptide (abaecin-2) with a copper-binding effect that is either inhibitory or protective!

➡️ Read more about these dual roles of this HDP in the newest publication out now in #RSCChemBio

👉 http://doi.org/10.10...

#HDP
August 4, 2026 at 3:28 PM
rscchembio.rsc.org
✨ From our newest #RSCChemBio themed collection, Zachary Rabinowitz and Seyedeh Alaleh Anvar introduce their hydrolase-targeting probes!

📢 Read more about their use of quinone-methide chemistry towards developing and tuning these probes here: doi.org/10.1039/D5CB...

#FlourescentProbes
Tuning the efficiency of molecular probes via quinone methide-based in situ labeling
Imaging the activities of hydrolases using molecular imaging probes can reveal underlying molecular mechanisms in the context of cells to organisms and their correlation with different pathological conditions can be used in diagnosis. Due to the nature of hydrolases, substrate-based probes can take advantage of the
doi.org
January 22, 2026 at 6:50 PM
rscchembio.rsc.org
📢 Catch Pavel Kielkowski and his team's contribution to our #RSCChemBio 2026 Emerging Investigators collection!

✨ Read about how they are expanding proteomics toolboxes with their development of a bioorthogonal chloroalkane-based probe for HaloTag conjugation!

➡️ http://doi.org/10.10...
A cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis
Chemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on a proteome-wide scale. The strategy relies on the reactivity and specificity of bioorthogonal ‘click reactions’. Although a variety of bioorthogonal reactions have been developed to facilitate chemical
doi.org
April 30, 2026 at 3:26 PM
rscchembio.rsc.org
📢 Stuart Conway and his team are working towards better understanding of the phosphatidylinositol 5-phosphate (PI(5)P) pathway with their novel photoaffinity probe.

👏 Read about how this new molecular tool here! doi.org/10.1039/D6CB...

#RSCChemBio #PhotoaffinityProbes
Synthesis and characterization of a novel phosphatidylinositol 5-phosphate (PI(5)P) photoaffinity probe
Phosphatidylinositol 5-phosphate (PI(5)P) plays a crucial role in cellular signaling, cell proliferation, the DNA damage repair response, and gene transcription. However, the underlying mechanism of PI(5)P function in these cellular pathways is poorly understood. This lack of understanding results at least in part,
doi.org
June 4, 2026 at 12:03 PM
rscchembio.rsc.org
✨ Sugar, lit. ✨

GluRho is a new glucose mimic that uses GLUTs 1–4 to light up sugar transport in live cells (and flies!). Great tool for tracking uptake with no metabolic interference.
New in #RSCChemBio #OpenAccess #advancearticle

doi.org/10.1039/D4CB...
Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms
The direct link between sugar uptake and metabolic diseases highlights the iminent need for molecular tools to detect and evaluate alterations in sugar uptake efficiency as approaches to identify disease-relevant metabolic alterations. However, the strict requirements of facilitative glucose transporters reg
doi.org
June 11, 2025 at 10:22 AM
rscchembio.rsc.org
📢New Advance Article in #RSCChemBio

Chengchao Xu, Jigang Wang, Huan Tang et al. investigate the anti-leukemic potential of Eupalinolide B (EB) using integrated chemoproteomic profiling and functional validation studies.

👉Get the full story here: doi.org/10.1039/D5CB...
graphical abstract of RSC ChemBio article "Covalent targeting of PSMD14 by Eupalinolide B induces oncoprotein degradation and apoptosis in acute promyelocytic leukemia cells"
February 9, 2026 at 4:08 PM
rscjapan.bsky.social
Review | RSC Chemical Biology
東京大学の小松徹先生、浦野泰照先生による、蛍光プローブの分子設計の基本を解説した総説🦠🚨 #biochemistry #FluorogenicProbes #Enzyme #RSCChemBio

Chemical basis of fluorogenic substrate probe design: revisiting the past to discover the new in biochemistry
pubs.rsc.org/cb/article/d...
Chemical basis of fluorogenic substrate probe design: revisiting the past to discover the new in biochemistry
July 15, 2026 at 11:47 PM