Our paper, “Antisense oligonucleotide silencing rescues neurodevelopmental deficits in AMPA receptor gain-of-function mice,” was just published in Neuron. It provides proof of concept for developing personalized RNA therapies for neurodevelopmental disorders caused by AMPA receptor mutations.
November 12, 2026 at 3:04 PM
Our paper, “Antisense oligonucleotide silencing rescues neurodevelopmental deficits in AMPA receptor gain-of-function mice,” was just published in Neuron. It provides proof of concept for developing personalized RNA therapies for neurodevelopmental disorders caused by AMPA receptor mutations.
The last dopamine receptor that's active in my brain, trying to get me hyped for GTA VI
November 12, 2026 at 11:19 PM
The last dopamine receptor that's active in my brain, trying to get me hyped for GTA VI
The vast majority of steroid hormone receptors, like estrogen receptor an and b, progesterone receptor, and androgen receptor are transcription factors. The primary function of these hormones is to literally change which genes your cells express.
Nothing against OP, just my field & a 100 like post.
Nothing against OP, just my field & a 100 like post.
The only thing I can say for reasonably certain it cant change is your actual DNA. That’s it. It can change things in every other aspect of your biology.
November 10, 2026 at 12:46 PM
The vast majority of steroid hormone receptors, like estrogen receptor an and b, progesterone receptor, and androgen receptor are transcription factors. The primary function of these hormones is to literally change which genes your cells express.
Nothing against OP, just my field & a 100 like post.
Nothing against OP, just my field & a 100 like post.
Spanish researchers used unsupervised biomarker clustering to identify two Long COVID groups distinguished by soluble ST2 and TNF receptor 1.
These inflammatory signatures could help identify biological subtypes beyond symptoms alone.
These inflammatory signatures could help identify biological subtypes beyond symptoms alone.
November 15, 2026 at 12:00 AM
Spanish researchers used unsupervised biomarker clustering to identify two Long COVID groups distinguished by soluble ST2 and TNF receptor 1.
These inflammatory signatures could help identify biological subtypes beyond symptoms alone.
These inflammatory signatures could help identify biological subtypes beyond symptoms alone.
Once we solve SSRI ligand-receptor interactions, we can finally give birth to the Terminator
#SfN26 #neuroskyence
#SfN26 #neuroskyence
we will never be forgiven for giving anxiety to sand
November 14, 2026 at 3:37 AM
Once we solve SSRI ligand-receptor interactions, we can finally give birth to the Terminator
#SfN26 #neuroskyence
#SfN26 #neuroskyence
A Japanese research team has identified a cell-surface receptor protein that binds to the rubella virus and allows it to enter human airways and placental cells.
Japan research team identifies rubella virus receptor
Although vaccines for rubella are widely available, identifying the main receptor for the virus may aid the development of antiviral drugs.
ebx.sh
November 11, 2026 at 3:47 PM
A Japanese research team has identified a cell-surface receptor protein that binds to the rubella virus and allows it to enter human airways and placental cells.
Your last dopamine receptor:
November 13, 2026 at 12:01 AM
Your last dopamine receptor:
🧪Historic papers in virology - today, 30 years ago, Trkola and colleagues published a landmark Nature study on HIV-1 interactions with the co-receptor CCR5.
November 14, 2026 at 12:21 PM
🧪Historic papers in virology - today, 30 years ago, Trkola and colleagues published a landmark Nature study on HIV-1 interactions with the co-receptor CCR5.
El receptor tampoco lo va a ver...
November 13, 2026 at 7:35 AM
El receptor tampoco lo va a ver...
New Blender x brainchip plugin lets you import and deform your own homunculus (neural self-model weighted by receptor density) in real time! I sculpted mine into a blob :-)
November 11, 2026 at 3:14 PM
New Blender x brainchip plugin lets you import and deform your own homunculus (neural self-model weighted by receptor density) in real time! I sculpted mine into a blob :-)
CRV Science Wiki
🦠 Receptor Editing — Receptor editing is a central B-cell tolerance mechanism in the bone marrow whereby immature self-reactive B lymphocytes re-induce RAG1 and RAG2 recombinase activity to perform secondary immunoglobulin light-chain…
https://crvscience.com/wiki/receptor-editing
🦠 Receptor Editing — Receptor editing is a central B-cell tolerance mechanism in the bone marrow whereby immature self-reactive B lymphocytes re-induce RAG1 and RAG2 recombinase activity to perform secondary immunoglobulin light-chain…
https://crvscience.com/wiki/receptor-editing
CRV Science Wiki
🦠 Receptor Editing — Receptor editing is a central B-cell tolerance mechanism in the bone marrow whereby immature self-reactive B lymphocytes re-induce RAG1 and RAG2 recombinase activity to perform secondary immunoglobulin light-chain V-J rearrangements that replace autoreactive …
crvscience.com
November 14, 2026 at 8:02 PM
CRV Science Wiki
🦠 Receptor Editing — Receptor editing is a central B-cell tolerance mechanism in the bone marrow whereby immature self-reactive B lymphocytes re-induce RAG1 and RAG2 recombinase activity to perform secondary immunoglobulin light-chain…
https://crvscience.com/wiki/receptor-editing
🦠 Receptor Editing — Receptor editing is a central B-cell tolerance mechanism in the bone marrow whereby immature self-reactive B lymphocytes re-induce RAG1 and RAG2 recombinase activity to perform secondary immunoglobulin light-chain…
https://crvscience.com/wiki/receptor-editing
In mice with and without #diabetes, teriparatide and #abaloparatide increased #bone mass and strength only when DMP1-Cre–marked cells retained the parathyroid #hormone receptor. Both drugs still increased bone remodeling when those cells lacked the receptor.👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 11, 2026 at 10:30 AM
In mice with and without #diabetes, teriparatide and #abaloparatide increased #bone mass and strength only when DMP1-Cre–marked cells retained the parathyroid #hormone receptor. Both drugs still increased bone remodeling when those cells lacked the receptor.👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
That face when a mammal bites into the red part of a chili. Capsaicin triggers the heat pain receptor TRPV1, while birds feel nothing and spread the seeds.
November 9, 2026 at 1:10 PM
That face when a mammal bites into the red part of a chili. Capsaicin triggers the heat pain receptor TRPV1, while birds feel nothing and spread the seeds.
The work helped explain HIV entry into human cells - a mechanism later supported by structural biology and exploited by the HIV drug maraviroc.
doi.org/10.1038/3841... #Virology #hiv
doi.org/10.1038/3841... #Virology #hiv
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5 - Nature
Nature - CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
doi.org
November 14, 2026 at 12:21 PM
The work helped explain HIV entry into human cells - a mechanism later supported by structural biology and exploited by the HIV drug maraviroc.
doi.org/10.1038/3841... #Virology #hiv
doi.org/10.1038/3841... #Virology #hiv
Context resolution matters because assays measure different quantities and ranges. Benchmarking concordance for overlapping receptor–odorant pairs—and flagging concentration and co-receptor mismatches—would help users avoid treating standardized records as directly commensurate.
November 14, 2026 at 5:59 PM
Context resolution matters because assays measure different quantities and ranges. Benchmarking concordance for overlapping receptor–odorant pairs—and flagging concentration and co-receptor mismatches—would help users avoid treating standardized records as directly commensurate.
Estrogen receptor-expressing VMHvl neurons at it again, this time in silver foxes!
Very good @currentbiology.bsky.social study led by @eirenechloe.bsky.social, identifying hypothalamic cell-type differences associated with selection for tameness in the silver fox.
Great finding helping us understand the neurobiological processes underlying domestication 🧪🧬🧠
Great finding helping us understand the neurobiological processes underlying domestication 🧪🧬🧠
Hypothalamic cell-type differences associated with selection for tameness in the silver fox
Silver foxes bred for tameness are a classic model of animal domestication, but the
neural changes underlying selection on behavior are unknown. Klein et al. examined
the fox hypothalamus and found th...
www.cell.com
November 9, 2026 at 7:11 PM
Estrogen receptor-expressing VMHvl neurons at it again, this time in silver foxes!
No “Co” for CD28 in NK cells: CD28-harnessed natural killer cells mediate APC lysis independently of T-cell receptor presence or engagement @jimmunol.bsky.social
academic.oup.com/jimmunol/art...
academic.oup.com/jimmunol/art...
November 14, 2026 at 5:06 PM
No “Co” for CD28 in NK cells: CD28-harnessed natural killer cells mediate APC lysis independently of T-cell receptor presence or engagement @jimmunol.bsky.social
academic.oup.com/jimmunol/art...
academic.oup.com/jimmunol/art...
@biorxivpreprint.bsky.social Dual cellular targeting of complement receptor 2 synergistically suppresses autoreactive germinal center activity and autoimmunity in lupus @bostonchildrens.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
November 14, 2026 at 5:19 PM
@biorxivpreprint.bsky.social Dual cellular targeting of complement receptor 2 synergistically suppresses autoreactive germinal center activity and autoimmunity in lupus @bostonchildrens.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
thoughts floating around until they get close enough to whatever receptor to be typed into bsky or said aloud to no one
November 11, 2026 at 12:31 AM
thoughts floating around until they get close enough to whatever receptor to be typed into bsky or said aloud to no one
By "sitting on" the receptor, mixed agonist/antagonist naltrexone partially but incompletely tickles the opiate system (as do behaviors like alcohol/gambling/oxycontin & morphine etc), thus sending a partial signal blocking craving AND crucially blocking more powerful molecules (eg heroin) from OD.
November 14, 2026 at 2:35 PM
By "sitting on" the receptor, mixed agonist/antagonist naltrexone partially but incompletely tickles the opiate system (as do behaviors like alcohol/gambling/oxycontin & morphine etc), thus sending a partial signal blocking craving AND crucially blocking more powerful molecules (eg heroin) from OD.
Aryl hydrocarbon receptor (AhR) restrains the maintenance and acquisition of the anti-inflammatory identity of monocyte-derived macrophages. https://www.biorxiv.org/content/10.64898/2026.11.11.765994v1
November 13, 2026 at 6:20 PM
Aryl hydrocarbon receptor (AhR) restrains the maintenance and acquisition of the anti-inflammatory identity of monocyte-derived macrophages. https://www.biorxiv.org/content/10.64898/2026.11.11.765994v1
By analyzing a massive collection of T cell receptor chains from 150,000+ patient samples, researchers have developed a pipeline to accelerate the discovery and validation of public T cell receptors for immunotherapeutic design. #ScienceTranslationalMedicine https://scim.ag/4AgXz0y
Cancer-specific T cell receptor discovery using 150,000 clinical genomics samples
RNA sequencing data from ∼150,000 samples reveal prevalent public cancer-specific T cell receptors with therapeutic potential.
scim.ag
November 9, 2026 at 7:00 PM
By analyzing a massive collection of T cell receptor chains from 150,000+ patient samples, researchers have developed a pipeline to accelerate the discovery and validation of public T cell receptors for immunotherapeutic design. #ScienceTranslationalMedicine https://scim.ag/4AgXz0y