The oestrogen receptor (ER or ERα), a nuclear hormone receptor that drives most breast cancer1, is commonly activated by phosphorylation at serine 118 within its intrinsically disordered N-terminal transactivation domain2,3. Although this modification enables oestrogen-independent ER function, its mechanism has remained unclear despite ongoing clinical trials of kinase inhibitors targeting this region4–6. By integration of small-angle X-ray scattering and nuclear magnetic resonance spectroscopy with functional studies, we show that serine 118 phosphorylation triggers an unexpected expansion of the disordered domain and disrupts specific hydrophobic clustering between two aromatic-rich regions. Mutations mimicking this disruption rescue ER transcriptional activity, target-gene expression and cell growth impaired by a phosphorylation-deficient S118A mutation. These findings, driven by hydrophobic interactions, extend beyond electrostatic models and provide mechanistic insights

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The oestrogen receptor (ER or ERα), a nuclear hormone receptor that drives most breast cancer1, is commonly activated by phosphorylation at serine 118 within its intrinsically disordered N-terminal transactivation domain2,3. Although this modification enables oestrogen-independent ER function, its mechanism has remained unclear despite ongoing clinical trials of kinase inhibitors targeting this region4–6. By integration of small-angle X-ray scattering and nuclear magnetic resonance spectroscopy with functional studies, we show that serine 118 phosphorylation triggers an unexpected expansion of the disordered domain and disrupts specific hydrophobic clustering between two aromatic-rich regions. Mutations mimicking this disruption rescue ER transcriptional activity, target-gene expression and cell growth impaired by a phosphorylation-deficient S118A mutation. These findings, driven by hydrophobic interactions, extend beyond electrostatic models and provide mechanistic insights

This was reported by the Russian Defense Ministry.According to them, Russian air defense allegedly intercepted and destroyed 86 drones overnight:23 UAVs over Kursk region16 UAVs over Bryansk region15 UAVs over Tula region12 UAVs over Belgorod region12 UAVs over Oryol region4 UAVs over the Moscow region, including 2 flying toward Moscow2 UAVs over Smolensk region1 UAV over Voronezh region1 UAV over Ryazan regionMoscow Mayor Sergei Sobyanin also confirmed reports about drones allegedly shot down while heading toward the Russian capital.????Loud dawn in the #Moscow region#UkraineRussiaWar #Russiahttps://t.co/jK8GgJ48Q8 pic.twitter.com/RUajL1mhyj— Еспресо Global (@Espresotveng) July 9, 2025 On the night of July 9, Russia launched a record number of drones and missiles at Ukraine. Ukrainian air defenders shot down 718 Russian targets.

The Russian Ministry of Defense provided the breakdown of the drones allegedly destroyed:30 over Bryansk region29 over Kursk region18 over Oryol region17 over Belgorod region13 over Tula region4 over Kaluga region3 over Leningrad region2 over Smolensk region2 over Novgorod region1 over Tver region1 over the Azov SeaAt 12:43 a.m., Andrei Kravchenko, the Kremlin-appointed mayor of Novorossiysk (Kuban, Russia), announced that Russian forces were repelling an attack by unmanned boats.Just four minutes later, the mayor shared more details: "Traffic is blocked on the embankment from Isaeva Street to Suvorovskaya Street! Walking there is also prohibited!"Back in fall 2024, OSINT analysts reported that Russia had already moved key Black Sea Fleet ships out of Novorossiysk, expecting Ukrainian long-range strikes.

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Zelensky confirms Ukraine troops in Russia's Belgorod region4 hours ago Share Save Jaroslav Lukiv...