The authors included RRIDs in their in EMBO Reports paper! Thanks for making your methods matter! #methodsmatter #reproducibility #BetterScience
SIRT2 mediates integrated stress response by deacetylating and stabilizing 4E-BP1 to suppress translation
Read the full paper: SIRT2 mediates integrated stress response by deacetylating and stabilizing 4E-BP1 to suppress translation
doi.org
October 10, 2026 at 7:00 AM
The authors included RRIDs in their in EMBO Reports paper! Thanks for making your methods matter! #methodsmatter #reproducibility #BetterScience
RRIDs were included in this in ChemMedChem paper. We value the author's support of reproducibility. #OpenResearch #accelerateopenscience #BetterScience
Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors
Read the full paper: Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors
doi.org
October 1, 2026 at 7:00 AM
RRIDs were included in this in ChemMedChem paper. We value the author's support of reproducibility. #OpenResearch #accelerateopenscience #BetterScience
@proteintech.bsky.social's resource, RRID:AB_2879780, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #reproducibility #ReproducibleResearch #accelerateopenscience
Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
Read the full paper: Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
doi.org
September 20, 2026 at 7:00 AM
@proteintech.bsky.social's resource, RRID:AB_2879780, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #reproducibility #ReproducibleResearch #accelerateopenscience
Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
#MASLD #LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.08.015
#MASLD #LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.08.015
Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
Zhang et al. identify SIRT2 as a zonated cholesterol sensor in periportal hepatocytes, where chronic cholesterol overload hyperactivates SIRT2 to suppress CYP7B1‑mediated bile acid synthesis, leading to 27‑hydroxycholesterol accumulation and ultimately driving MASLD‑HCC.
doi.org
September 18, 2026 at 8:17 AM
Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
#MASLD #LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.08.015
#MASLD #LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.08.015
Online now: Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
Zhang et al. identify SIRT2 as a zonated cholesterol sensor in periportal hepatocytes, where chronic cholesterol overload hyperactivates SIRT2 to suppress CYP7B1‑mediated bile acid synthesis, leading to 27‑hydroxycholesterol accumulation and ultimately driving MASLD‑HCC.
dlvr.it
September 17, 2026 at 3:42 PM
Online now: Zonated cholesterol sensing by SIRT2 drives MASLD-HCC
🔓Don't miss #OpenAccess research by Elena Cichero & co. from University of Genoa probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays #medchem
Check it out in full below👇
doi.org/10.1039/d6md...
Check it out in full below👇
doi.org/10.1039/d6md...
September 16, 2026 at 11:03 AM
🔓Don't miss #OpenAccess research by Elena Cichero & co. from University of Genoa probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays #medchem
Check it out in full below👇
doi.org/10.1039/d6md...
Check it out in full below👇
doi.org/10.1039/d6md...
RRIDs were included in this in Proceedings of the National Academy of Sciences paper. Thanks for making your methods matter! #STMpublishing #ReproducibleResearch #BetterScience
SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation
Read the full paper: SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation
doi.org
August 29, 2026 at 7:45 AM
RRIDs were included in this in Proceedings of the National Academy of Sciences paper. Thanks for making your methods matter! #STMpublishing #ReproducibleResearch #BetterScience
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
August 27, 2026 at 3:15 PM
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
August 27, 2026 at 4:01 PM
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
August 27, 2026 at 3:15 PM
Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation https://www.biorxiv.org/content/10.64898/2026.08.23.746508v1
Two cellular enzymes—SerRS and SIRT2—become locked together during times of stress, simultaneously shutting down both of their normal jobs, according to a Scripps Research study in Nature Communications. The findings reveal how cells throttle back protein production when they’re short on energy.
A double “off-switch” helps cells respond to stress - Scripps Research
Scripps Research scientists reveal how cells turn down protein production and conserve energy—a critical mechanism in aging, cancer and neurodegeneration.
www.scripps.edu
August 12, 2026 at 12:05 AM
Two cellular enzymes—SerRS and SIRT2—become locked together during times of stress, simultaneously shutting down both of their normal jobs, according to a Scripps Research study in Nature Communications. The findings reveal how cells throttle back protein production when they’re short on energy.
Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer's disease
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer's disease
Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase, has been implicated in aging and neurodegenerative diseases such as Alzheimer's disease (AD). While global SIRT2 inhibition has shown promise in reduci...
www.biorxiv.org
January 19, 2025 at 5:03 PM
Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer's disease
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
October 15, 2025 at 1:48 PM
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
SIRT2 deacetylates cGAS to keep this DNA-sensing machinery in check. If SIRT2 is depleted or lacks its NAD+ cofactor, the cGAS-STING pathway hyperactivates, leading to the continuous, un-checked interferon and cytokine release characteristic of LC
June 5, 2026 at 6:26 AM
SIRT2 deacetylates cGAS to keep this DNA-sensing machinery in check. If SIRT2 is depleted or lacks its NAD+ cofactor, the cGAS-STING pathway hyperactivates, leading to the continuous, un-checked interferon and cytokine release characteristic of LC
-SIRT2 & the cGAS Pathway: Sirtuin 2 (SIRT2) is a critical NAD+-dependent histone deacetylase that regulates cellular senescence and innate immunity. #COVID infection stresses the cell, triggering mitochondrial DNA (mtDNA) leakage into the cytoplasm. Under normal conditions,
June 5, 2026 at 6:26 AM
-SIRT2 & the cGAS Pathway: Sirtuin 2 (SIRT2) is a critical NAD+-dependent histone deacetylase that regulates cellular senescence and innate immunity. #COVID infection stresses the cell, triggering mitochondrial DNA (mtDNA) leakage into the cytoplasm. Under normal conditions,
The long-term physiological complications of LC are heavily tied to persistent epigenetic memory & chromatin enzyme dysregulation. Enzymes like SIRT2 play a critical role in balancing this post-viral inflammatory landscape.
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors
Severe COVID-19 can reprogram hematopoiesis and establish epigenetic memory in hematopoietic
stem and progenitor cells (HSPC) and progeny myeloid cells for up to 1 year. These
durable alterations, whi...
www.cell.com
June 5, 2026 at 6:26 AM
The long-term physiological complications of LC are heavily tied to persistent epigenetic memory & chromatin enzyme dysregulation. Enzymes like SIRT2 play a critical role in balancing this post-viral inflammatory landscape.
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling https://www.biorxiv.org/content/10.1101/2025.10.22.683887v1
October 23, 2025 at 8:01 PM
SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling https://www.biorxiv.org/content/10.1101/2025.10.22.683887v1
SIRT2 deacetylates MRE11, enhancing its DNA binding and end resection, crucially influencing ATM-dependent DNA damage signaling.
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
March 11, 2026 at 2:48 AM
SIRT2 deacetylates MRE11, enhancing its DNA binding and end resection, crucially influencing ATM-dependent DNA damage signaling.
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
SIRT2 deacetylates MRE11, enhancing DNA binding and signaling to bolster DNA damage repair, linking to tumorigenesis.
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
January 17, 2026 at 4:44 AM
SIRT2 deacetylates MRE11, enhancing DNA binding and signaling to bolster DNA damage repair, linking to tumorigenesis.
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/186711
Congrats Dr. Florian Friedrich for your PhD, Summa cum laude @uni-freiburg.de #45 in the Jung group. Structural biology and biochemistry of Sirt2 and CHD1 inhibitors.
July 30, 2026 at 1:32 PM
Congrats Dr. Florian Friedrich for your PhD, Summa cum laude @uni-freiburg.de #45 in the Jung group. Structural biology and biochemistry of Sirt2 and CHD1 inhibitors.
New preprint from a collaboration with the Schutkowski group @unihalle.bsky.social @uni-freiburg.de . Alkyl branching in acyl lysines slows down deacylation by the NAD+ dependent Sirt2 to result in super potent enzyme inhibitors #sirtuin @chemrxivbot.bsky.social chemrxiv.org/doi/full/10.... 1/
Alkyl-Branched Acyl-Lysine Peptides as Potent Cell-Permeable Slow-Substrate Inhibitors of SIRT2 | ChemRxiv
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylase implicated in cancer and neurodegeneration. Here, we report acyl-lysine peptide inhibitors bearing methyl-branched or cyclopropyl-modified acyl chains with low-...
chemrxiv.org
April 29, 2026 at 6:58 AM
New preprint from a collaboration with the Schutkowski group @unihalle.bsky.social @uni-freiburg.de . Alkyl branching in acyl lysines slows down deacylation by the NAD+ dependent Sirt2 to result in super potent enzyme inhibitors #sirtuin @chemrxivbot.bsky.social chemrxiv.org/doi/full/10.... 1/
So far high quality Sirt2 crystals with an open selectivity pocket suitable for soaking were not accessible. First author Florian Friedrich used microseeding with inhibitor-Sirt2 crystals and could induce crystallization of the desired conformation
June 13, 2025 at 11:18 AM
So far high quality Sirt2 crystals with an open selectivity pocket suitable for soaking were not accessible. First author Florian Friedrich used microseeding with inhibitor-Sirt2 crystals and could induce crystallization of the desired conformation