⚕️ 𝗧𝗵𝗼𝗿𝗮𝗰𝗶𝗰 𝗦𝗠𝗔𝗥𝗖𝗔𝟰-𝗗𝗲𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝗨𝗻𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗲𝗱 𝗧𝘂𝗺𝗼𝘂𝗿 (𝗦𝗗𝗨𝗧)⚕️
As discussion below:
www.linkedin.com/posts/trista...
#Pathtwitter #Pulmpath #BSTpath
As discussion below:
www.linkedin.com/posts/trista...
#Pathtwitter #Pulmpath #BSTpath
Tristan Rutland on LinkedIn: #oncology #pathology #smarca4 #thoracictumours #medicine…
⚕️ 𝗧𝗵𝗼𝗿𝗮𝗰𝗶𝗰 𝗦𝗠𝗔𝗥𝗖𝗔𝟰-𝗗𝗲𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝗨𝗻𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗲𝗱 𝗧𝘂𝗺𝗼𝘂𝗿 (𝗦𝗗𝗨𝗧)⚕️
🕑 5 min learning
Thoracic SMARCA4-deficient…
www.linkedin.com
December 17, 2024 at 11:58 PM
⚕️ 𝗧𝗵𝗼𝗿𝗮𝗰𝗶𝗰 𝗦𝗠𝗔𝗥𝗖𝗔𝟰-𝗗𝗲𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝗨𝗻𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗲𝗱 𝗧𝘂𝗺𝗼𝘂𝗿 (𝗦𝗗𝗨𝗧)⚕️
As discussion below:
www.linkedin.com/posts/trista...
#Pathtwitter #Pulmpath #BSTpath
As discussion below:
www.linkedin.com/posts/trista...
#Pathtwitter #Pulmpath #BSTpath
#PathSky 67M, long smoking hx, LN met. Keratin negative outside- “?sarcoma?” The hx suggests an undifferentiated pulmonary carcinoma with SMARCA4 loss. Our keratin was a bit positive and SMARCA4 is gone. These were originally thought to be thoracic sarcomas but have smoking related mutations.
December 24, 2024 at 7:24 PM
#PathSky 67M, long smoking hx, LN met. Keratin negative outside- “?sarcoma?” The hx suggests an undifferentiated pulmonary carcinoma with SMARCA4 loss. Our keratin was a bit positive and SMARCA4 is gone. These were originally thought to be thoracic sarcomas but have smoking related mutations.
💨☕👩💻Excited to share our recent discovery. Tumour suppressors LKB1 and SMARCA4 working together to regulate gene expression, acting as a nexus between metabolism and chromatin remodelling. #LungCancer #CancerResearch #Epigenetics #Metabolism #LKB1 #SMARCA4 www.frontiersin.org/journals/cel...
Frontiers | Tumor suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression across diverse biological processes in lung cancer
IntroductionThe tumor suppressor kinase liver kinase B1 (LKB1) is known to regulate the activity of the metabolic sensor AMP-activated protein kinase (AMPK),...
www.frontiersin.org
March 17, 2026 at 10:28 AM
💨☕👩💻Excited to share our recent discovery. Tumour suppressors LKB1 and SMARCA4 working together to regulate gene expression, acting as a nexus between metabolism and chromatin remodelling. #LungCancer #CancerResearch #Epigenetics #Metabolism #LKB1 #SMARCA4 www.frontiersin.org/journals/cel...
@alison-harrod.bsky.social has her wonderful project on SMARCA4 and G quadruplex stability out now in Genome Biology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
April 21, 2026 at 4:13 PM
@alison-harrod.bsky.social has her wonderful project on SMARCA4 and G quadruplex stability out now in Genome Biology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
July 18, 2025 at 5:39 AM
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
Happy to share this work on SMARCA4 and SCCOHT with Adela Rodríguez Hernández, Huma Rana, Judy Garber, Colin Young, Carolyn Horton, Linda Polfus, Brittany Borden, Miki Horiguchi, Magan Trottier, Jessica St. Laurent, and Jamie Weyandt. www.sciencedirect.com/science/arti...
SMARCA4 pathogenic variants: Gynecological cancer histories from a laboratory tested cohort
To describe the cancer histories of individuals with a SMARCA4 germline pathogenic/likely pathogenic variant (gPV) obtained through clinical laborator…
www.sciencedirect.com
October 13, 2025 at 9:27 PM
Happy to share this work on SMARCA4 and SCCOHT with Adela Rodríguez Hernández, Huma Rana, Judy Garber, Colin Young, Carolyn Horton, Linda Polfus, Brittany Borden, Miki Horiguchi, Magan Trottier, Jessica St. Laurent, and Jamie Weyandt. www.sciencedirect.com/science/arti...
Case Report: Thoracic SMARCA4-Deficient Undifferentiated Tumor in a 40-Year-Old Male Welder With No Smoking History
www.cureus.com/articles/328...
www.cureus.com/articles/328...
Thoracic SMARCA4-Deficient Undifferentiated Tumor in a 40-Year-Old Male Welder With No Smoking History
Thoracic SMARCA4-deficient undifferentiated tumor (TSDUT) is a rare and quite new classification of primary pulmonary malignancy. It is classified as a non-small cell lung cancer, typically associated...
www.cureus.com
February 4, 2025 at 9:31 PM
Case Report: Thoracic SMARCA4-Deficient Undifferentiated Tumor in a 40-Year-Old Male Welder With No Smoking History
www.cureus.com/articles/328...
www.cureus.com/articles/328...
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
July 4, 2025 at 2:09 PM
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
Maneeth Ellendula @yaleschoolofmed.bsky.social presented a Quick Pitch presentation today #ASTRO26: "Association of SMARCA4 Primary Tumor Mutations with Brain Metastases in Initially Non-Metastatic Non-Small Cell Lung Cancer."
amportal.astro.org/sessions/qp-12…
@astro-org.bsky.social
amportal.astro.org/sessions/qp-12…
@astro-org.bsky.social
September 29, 2026 at 2:11 AM
Maneeth Ellendula @yaleschoolofmed.bsky.social presented a Quick Pitch presentation today #ASTRO26: "Association of SMARCA4 Primary Tumor Mutations with Brain Metastases in Initially Non-Metastatic Non-Small Cell Lung Cancer."
amportal.astro.org/sessions/qp-12…
@astro-org.bsky.social
amportal.astro.org/sessions/qp-12…
@astro-org.bsky.social
New Case report: SMARCA4-deficient NSCLC with ALK fusion.
Applied Immunohistochemistry & Molecular Morphology describes a rare & interesting case - a non-smoking woman with non-small cell #lungcancer that was SMARCA4-deficient, yet still harboured an ALK fusion.
#ALKPositive #LCSM
Applied Immunohistochemistry & Molecular Morphology describes a rare & interesting case - a non-smoking woman with non-small cell #lungcancer that was SMARCA4-deficient, yet still harboured an ALK fusion.
#ALKPositive #LCSM
October 11, 2025 at 9:52 PM
New Case report: SMARCA4-deficient NSCLC with ALK fusion.
Applied Immunohistochemistry & Molecular Morphology describes a rare & interesting case - a non-smoking woman with non-small cell #lungcancer that was SMARCA4-deficient, yet still harboured an ALK fusion.
#ALKPositive #LCSM
Applied Immunohistochemistry & Molecular Morphology describes a rare & interesting case - a non-smoking woman with non-small cell #lungcancer that was SMARCA4-deficient, yet still harboured an ALK fusion.
#ALKPositive #LCSM
A recent study showed that SMARCA4-mutant lung cancer cells reprogram the tumor microenvironment by reducing chromatin accessibility at key enhancers of immune-related genes.
How these findings suggest potential therapeutic strategies: brnw.ch/21wRqXg #EndCancer
How these findings suggest potential therapeutic strategies: brnw.ch/21wRqXg #EndCancer
Study provides genomic insights into treatment resistance in SMARCA4-mutant lung cancer
Study provides genomic insights into treatment resistance in SMARCA4-mutant lung cancer
brnw.ch
March 19, 2025 at 2:12 PM
A recent study showed that SMARCA4-mutant lung cancer cells reprogram the tumor microenvironment by reducing chromatin accessibility at key enhancers of immune-related genes.
How these findings suggest potential therapeutic strategies: brnw.ch/21wRqXg #EndCancer
How these findings suggest potential therapeutic strategies: brnw.ch/21wRqXg #EndCancer
New Journal for ImmunoTherapy of Cancer review: Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1, SMARCA4, and PTEN mutations bit.ly/3Hzc6yO
#JITC #MedSky #OncSky 🧪
#JITC #MedSky #OncSky 🧪
August 18, 2025 at 4:02 PM
New Journal for ImmunoTherapy of Cancer review: Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1, SMARCA4, and PTEN mutations bit.ly/3Hzc6yO
#JITC #MedSky #OncSky 🧪
#JITC #MedSky #OncSky 🧪
Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC
www.nature.com/articles/s4...
www.nature.com/articles/s4...
September 13, 2025 at 2:15 PM
Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Talented PhD student Natisha Field presenting her work on Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) @ the SCCOHT-SMARCA4 mtg in Canada. Very happy to be travelling Natisha's PhD journey with her. A 1st for me - 2 conferences on opposite sides of the world in one day/night! 🥰 🧪
May 26, 2025 at 1:12 AM
Talented PhD student Natisha Field presenting her work on Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) @ the SCCOHT-SMARCA4 mtg in Canada. Very happy to be travelling Natisha's PhD journey with her. A 1st for me - 2 conferences on opposite sides of the world in one day/night! 🥰 🧪
I’m excited to share our new paper in Genome Biology, where we show SMARCA4 protects against genome instability at G4 sites, using analysis of double-strand break mapping and whole genome sequencing. It has been a really interesting and collaborative project!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes - Genome Biology
Background G-quadruplex (G4) structures are secondary structures that can form in guanine-rich single stranded DNA sequences. These play important roles in biological processes such as regulation of g...
link.springer.com
April 23, 2026 at 11:41 AM
I’m excited to share our new paper in Genome Biology, where we show SMARCA4 protects against genome instability at G4 sites, using analysis of double-strand break mapping and whole genome sequencing. It has been a really interesting and collaborative project!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Also thank you to @naghamg.bsky.social for her work showing that we find evidence for an increase in S-phase ssDNA in SMARCA4 deficient cells, especially with G4 stabilising ligand, pyridosatin.
April 23, 2026 at 11:41 AM
Also thank you to @naghamg.bsky.social for her work showing that we find evidence for an increase in S-phase ssDNA in SMARCA4 deficient cells, especially with G4 stabilising ligand, pyridosatin.
Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer https://www.biorxiv.org/content/10.64898/2026.01.26.699134v1
January 28, 2026 at 10:47 PM
Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer https://www.biorxiv.org/content/10.64898/2026.01.26.699134v1
🧬Chromatin / DDR co-mutations drive high-TMB in SMARCA4-DNSCLC, enabling immunotherapy success despite PD-L1 negativity. Tailored precision therapy yielded a 15-month survival, doubling the typical prognosis.
Study: doi.org/10.3389/fonc...
Study: doi.org/10.3389/fonc...
Frontiers | Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways
SMARCA4 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) is the core ATPase subunit of SWI/SNF chromatin remod...
doi.org
January 12, 2026 at 8:47 AM
🧬Chromatin / DDR co-mutations drive high-TMB in SMARCA4-DNSCLC, enabling immunotherapy success despite PD-L1 negativity. Tailored precision therapy yielded a 15-month survival, doubling the typical prognosis.
Study: doi.org/10.3389/fonc...
Study: doi.org/10.3389/fonc...
doi.org/10.1126/scia... very happy to have contributed with @bryonyleeke.bsky.social to this fascinating study from Jesus Gil’s lab @mrc-lms.bsky.social. SMARCA4 inhibition leads to repeat element dysregulation, cGAS/STING activation and enhances immune cell clearance of senescent cells
January 16, 2025 at 6:00 PM
doi.org/10.1126/scia... very happy to have contributed with @bryonyleeke.bsky.social to this fascinating study from Jesus Gil’s lab @mrc-lms.bsky.social. SMARCA4 inhibition leads to repeat element dysregulation, cGAS/STING activation and enhances immune cell clearance of senescent cells
SMARCA4 loss reprograms p300 chromatin occupancy to subvert p53-mediated transcriptional repression in ovarian small cell carcinoma www.nature.com/articles/s4...
June 15, 2026 at 2:15 PM
SMARCA4 loss reprograms p300 chromatin occupancy to subvert p53-mediated transcriptional repression in ovarian small cell carcinoma www.nature.com/articles/s4...
Online now: c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors
c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors
Balke-Want et al. show that B7-H3 is an actionable CAR target in SCLC and thoracic SMARCA4-deficient UTs. However, in thoracic SMARCA4-deficient UTs, TGF-β1 suppresses their activity. By engineering CRISPR knockin c-JUN+B7-H3 CAR T cells with combined expression of type I/II cytokines, the authors overcome TGF-β1-mediated suppression.
dlvr.it
January 21, 2026 at 1:28 PM
Online now: c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors
New PAPER alert! Led by Yano, our latest study presents how PARPi-induced heterochromatin boosts replication stress and ATRi sensitivity, revealing a new strategy for targeting SMARCA4-deficient tumors.
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells - Cell Death Discovery
Cell Death Discovery - PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells
www.nature.com
January 29, 2025 at 6:45 AM
New PAPER alert! Led by Yano, our latest study presents how PARPi-induced heterochromatin boosts replication stress and ATRi sensitivity, revealing a new strategy for targeting SMARCA4-deficient tumors.
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
Beatrice Katsnelson shared analysis of 2,186 patients with #NSCLC, noting KEAP1 & SMARCA4 tumor mutations predicted development of bone mets. Findings suggest molecular profiling could identify high-risk pts and increase surveillance strategies. #ASTRO26
@astro-org.bsky.social @oncoalert.bsky.social
@astro-org.bsky.social @oncoalert.bsky.social
September 30, 2026 at 2:37 PM
Beatrice Katsnelson shared analysis of 2,186 patients with #NSCLC, noting KEAP1 & SMARCA4 tumor mutations predicted development of bone mets. Findings suggest molecular profiling could identify high-risk pts and increase surveillance strategies. #ASTRO26
@astro-org.bsky.social @oncoalert.bsky.social
@astro-org.bsky.social @oncoalert.bsky.social