Finally, an in-depth review #JBC about sialylation in cancer: dual role of sialyltransferases (the “writers”) and siglecs/selectins (the “readers”) in cancer progression. Must-read!
tinyurl.com/yvauu3zj
@mathd34.bsky.social
@siglecdude.bsky.social

#glycotime

New review on fucosylation in cancer and its role in anti-tumor immunity. Not only a tumor-promoting modification, but L-fucose also acts as a central regulator of tumor progression and immune response. Fucosyltransferases, selectins, and C-type lectins discussed!
tinyurl.com/y246zx9b

#glycotime

- E- and P-selectin are the “vascular” selectins as they are expressed on vascular endothelial cells, classically within post-capillary venules. E-selectin is solely expressed by endothelial cells (thus, “E-”),

📚 New Review now online

Interplay of integrins and selectins in metastasis

🔓 buff.ly/TAwbF4l

#Integrins #CellAdhesion #Selectins #CancerMetastasis

Well-known for acute recruitment of immune and inflammatory cells from blood to tissue (via ICAM1, VCAM, selectins), their role in the instruction of immune and inflammatory cells after arrival remains much less understood.

http://ow.ly/VXOk307SSNA

Let's start with some definitions:

🩸 Hyperleukocytosis = WBC >100,000
🩸 Leukostasis = symptomatic hyperleukocytosis

Physiology:
🩸 Increased blasts ➡️ release of cytokines that increase selectins and cell adhesion molecules ➡️ adhesion to endothelial cells ➡️ hyperviscosity ➡️ hypoxia

selectins love me enteritides fear me

www.biorxiv.org/content/10.1...