Patrick Murphy
@1patrickmurphy.bsky.social
Associate Professor @ UConn Medical School. Endothelial cells, RNA biology, extracellular matrix, leukocyte-endothelial interactions.
Reposted by Patrick Murphy
The newly redesigned #Matrisome Portal is now live: matrisome.org.
Built to meet #ADA standards, the new site improves accessibility, usability, and overall experience for all.
Big shout-out to Tali for leading this effort!
Take a look and let us know what you think!
#Accessibility #ADACompliance
Built to meet #ADA standards, the new site improves accessibility, usability, and overall experience for all.
Big shout-out to Tali for leading this effort!
Take a look and let us know what you think!
#Accessibility #ADACompliance
April 27, 2026 at 8:22 PM
The newly redesigned #Matrisome Portal is now live: matrisome.org.
Built to meet #ADA standards, the new site improves accessibility, usability, and overall experience for all.
Big shout-out to Tali for leading this effort!
Take a look and let us know what you think!
#Accessibility #ADACompliance
Built to meet #ADA standards, the new site improves accessibility, usability, and overall experience for all.
Big shout-out to Tali for leading this effort!
Take a look and let us know what you think!
#Accessibility #ADACompliance
Newly published work from our lab out now #ATVB @ahajournals.bsky.social showing changes in ribosome associated mRNA in chronic conditions of disturbed flow and circulating blood lipids : www.ahajournals.org/doi/10.1161/...
April 22, 2026 at 1:36 PM
Newly published work from our lab out now #ATVB @ahajournals.bsky.social showing changes in ribosome associated mRNA in chronic conditions of disturbed flow and circulating blood lipids : www.ahajournals.org/doi/10.1161/...
Reposted by Patrick Murphy
@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits
Stable, sustained support can transform your career:
Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits
Stable, sustained support can transform your career:
Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
bit.ly
April 16, 2026 at 5:28 PM
@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits
Stable, sustained support can transform your career:
Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits
Stable, sustained support can transform your career:
Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
Reposted by Patrick Murphy
We’re hiring! Tenure-track faculty position in cancer research at LSU Health Shreveport (Pathology & Translational Pathobiology). Looking for investigators building programs at the interface of cancer, metabolism, inflammation, and vascular biology.
www.lsuhsc.edu/shv/CareerOp...
www.lsuhsc.edu/shv/CareerOp...
LSUHSC Career Opportunities - Assistant/Associate/Full Professor (Tenure-Track) – Cancer Research
www.lsuhsc.edu
April 15, 2026 at 1:34 PM
We’re hiring! Tenure-track faculty position in cancer research at LSU Health Shreveport (Pathology & Translational Pathobiology). Looking for investigators building programs at the interface of cancer, metabolism, inflammation, and vascular biology.
www.lsuhsc.edu/shv/CareerOp...
www.lsuhsc.edu/shv/CareerOp...
Very interesting mouse model of preeclampsia - based on maternal, not fetal loss of KLF4 - where hypertension does not develop after gene deletion, but does with pregnancy: www.biorxiv.org/content/10.6...
www.biorxiv.org
April 4, 2026 at 10:29 AM
Very interesting mouse model of preeclampsia - based on maternal, not fetal loss of KLF4 - where hypertension does not develop after gene deletion, but does with pregnancy: www.biorxiv.org/content/10.6...
Reposted by Patrick Murphy
Today I would like to share a publication that is particularly meaningful to me. Our tribute to my late mentor, Richard Hynes, has just been published in Matrix Biology.
I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor.
doi.org/10.1016/j.ma...
I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor.
doi.org/10.1016/j.ma...
March 20, 2026 at 11:40 AM
Today I would like to share a publication that is particularly meaningful to me. Our tribute to my late mentor, Richard Hynes, has just been published in Matrix Biology.
I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor.
doi.org/10.1016/j.ma...
I hope you will take a moment to read and celebrate the legacy of an extraordinary scientist and mentor.
doi.org/10.1016/j.ma...
Reposted by Patrick Murphy
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...
Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture
YouTube video by Nobel Prize
youtube.com
March 21, 2026 at 6:47 AM
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...
Reposted by Patrick Murphy
A mouse model of Nose bleeding
#HereditaryHemorrhagicTelangiectasia
Bmx+ Endothelial Cell ALK1 KO🐭
+🧠microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
⏬pial/mesenteric arterial tone
@mfnavedo.bsky.social #CircRes 2026
www.ahajournals.org/doi/10.1161/...
#HereditaryHemorrhagicTelangiectasia
Bmx+ Endothelial Cell ALK1 KO🐭
+🧠microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
⏬pial/mesenteric arterial tone
@mfnavedo.bsky.social #CircRes 2026
www.ahajournals.org/doi/10.1161/...
March 15, 2026 at 12:37 PM
A mouse model of Nose bleeding
#HereditaryHemorrhagicTelangiectasia
Bmx+ Endothelial Cell ALK1 KO🐭
+🧠microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
⏬pial/mesenteric arterial tone
@mfnavedo.bsky.social #CircRes 2026
www.ahajournals.org/doi/10.1161/...
#HereditaryHemorrhagicTelangiectasia
Bmx+ Endothelial Cell ALK1 KO🐭
+🧠microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
⏬pial/mesenteric arterial tone
@mfnavedo.bsky.social #CircRes 2026
www.ahajournals.org/doi/10.1161/...
Reposted by Patrick Murphy
Considerations in the Use of Mouse Models of Vascular and Valvular Calcification
Our new article is now published in ATVB @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Our new article is now published in ATVB @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Considerations in the Use of Mouse Models of Vascular and Valvular Calcification | Arteriosclerosis, Thrombosis, and Vascular Biology
CLINICAL PROBLEM: Vascular and valvular calcification significantly contributes to cardiovascular morbidity,
particularly in patients with diabetes, atherosclerosis, advanced age, and chronic
kidney d...
www.ahajournals.org
March 4, 2026 at 12:13 AM
Considerations in the Use of Mouse Models of Vascular and Valvular Calcification
Our new article is now published in ATVB @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Our new article is now published in ATVB @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Reposted by Patrick Murphy
I had to renegotiate my F99/K00 award twice in 6 months, and on both occasions I asked what specifically “DEI activities” means. I didn’t get clear answers, so I was hopeful the person that directive came from could specify (the NIH Director). I asked the on @whyshoulditrustyou.bsky.social podcast
February 26, 2026 at 6:36 PM
I had to renegotiate my F99/K00 award twice in 6 months, and on both occasions I asked what specifically “DEI activities” means. I didn’t get clear answers, so I was hopeful the person that directive came from could specify (the NIH Director). I asked the on @whyshoulditrustyou.bsky.social podcast
Reposted by Patrick Murphy
Excited to share our new preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS www.biorxiv.org/content/10.6...
February 26, 2026 at 4:02 PM
Excited to share our new preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS www.biorxiv.org/content/10.6...
Reposted by Patrick Murphy
Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...
February 22, 2026 at 7:59 PM
Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...
Reposted by Patrick Murphy
Reposted by Patrick Murphy
This is perhaps the most tragic of the consequences of the attack by Trump and colleagues on NIH. Gutting the next generation of American science 🧪
Check this out straight from the NIH website, acknowledging that multiyear funding was likely responsible for a 20% decrease in early stage investigators.
And that it was expected.
A strange approach for someone so committed to the next generation of scientists.
grants.nih.gov/news-events/...
And that it was expected.
A strange approach for someone so committed to the next generation of scientists.
grants.nih.gov/news-events/...
February 21, 2026 at 1:17 AM
This is perhaps the most tragic of the consequences of the attack by Trump and colleagues on NIH. Gutting the next generation of American science 🧪
We are excited to share a new discovery in heart transplant www.biorxiv.org/cgi/content/..., which shows a critical role for the endothelium in organizing long term immune responses, and cardiac allograft vasculopathy.
www.biorxiv.org
February 20, 2026 at 3:58 PM
We are excited to share a new discovery in heart transplant www.biorxiv.org/cgi/content/..., which shows a critical role for the endothelium in organizing long term immune responses, and cardiac allograft vasculopathy.
It was pleasure to host my former lab mate Noor Jailkhani from Matrisome Bio yesterday at The University of Connecticut School of Medicine. Not many can say that they both developed a new technology hands on, and then led this into the market as the CEO of a successful company.
November 14, 2025 at 12:14 AM
It was pleasure to host my former lab mate Noor Jailkhani from Matrisome Bio yesterday at The University of Connecticut School of Medicine. Not many can say that they both developed a new technology hands on, and then led this into the market as the CEO of a successful company.
Reposted by Patrick Murphy
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Happy to share an exciting paper from my former lab mate, Jess Hebert, showing Cas12 efficacy and use in somatic screening. Take a look if you are considering the approach! www.nature.com/articles/s41...
Efficient and multiplexed somatic genome editing with Cas12a mice - Nature Biomedical Engineering
Multiplexed editing using Cas12a transgenic mice facilitates the study of disease models with complex genotypes.
www.nature.com
June 5, 2025 at 1:48 AM
Happy to share an exciting paper from my former lab mate, Jess Hebert, showing Cas12 efficacy and use in somatic screening. Take a look if you are considering the approach! www.nature.com/articles/s41...
Despite strong headwinds, we are continuing to do our work. Congratulations to lead author Ashok Cheemala. Here, Ashok shows that even a single point mutation in TDP-43 leads to large defects in cell-cell junction and barrier www.science.org/doi/10.1126/...
Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects
ALS-FTD–associated TDP-43 point mutation in endothelial cells leads to BBB loss and is replicated by gene deletion.
www.science.org
April 17, 2025 at 1:32 AM
Despite strong headwinds, we are continuing to do our work. Congratulations to lead author Ashok Cheemala. Here, Ashok shows that even a single point mutation in TDP-43 leads to large defects in cell-cell junction and barrier www.science.org/doi/10.1126/...
I'm happy to announce that our paper describing the first in human tissue application of inCITE-seq, to assess nuclear levels of RNA-binding proteins, and key regulators of the blood brain barrier (b-Catenin and NF-kB) is now available online from Nature Neuroscience www.nature.com/articles/s41...
Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration - Nature Neuroscience
Targeting the endothelium across ages and neurodegenerative diseases in 92 donors with single-cell inCITE-seq reveals similar alterations in ~40% of capillaries in AD, ALS and FTD. Endothelial TDP-43 ...
www.nature.com
March 14, 2025 at 1:17 PM
I'm happy to announce that our paper describing the first in human tissue application of inCITE-seq, to assess nuclear levels of RNA-binding proteins, and key regulators of the blood brain barrier (b-Catenin and NF-kB) is now available online from Nature Neuroscience www.nature.com/articles/s41...
Reposted by Patrick Murphy
Reposted by Patrick Murphy
Reposted by Patrick Murphy
Reposted by Patrick Murphy
A source close to the situation confirmed that study sections are continuing to be cancelled. On the chopping block this week: developmental brain disorders, mechanisms of cancer therapy, and neurotoxicology of alcohol. For some labs, this was the last chance to get funding or they’ll shut down.
Trump officials are trying to sneak around federal judges’ orders.
They could be held in civil contempt of court, which can include jail time and can’t be undone with a presidential pardon, according to @sbagen.bsky.social .
My latest for @theguardian.com
www.theguardian.com/us-news/2025...
They could be held in civil contempt of court, which can include jail time and can’t be undone with a presidential pardon, according to @sbagen.bsky.social .
My latest for @theguardian.com
www.theguardian.com/us-news/2025...
Trump halts medical research funding in apparent violation of judge’s order
Health department orders NIH to hold Federal Register submissions – critical step in process for funding studies
www.theguardian.com
February 24, 2025 at 7:48 PM
A source close to the situation confirmed that study sections are continuing to be cancelled. On the chopping block this week: developmental brain disorders, mechanisms of cancer therapy, and neurotoxicology of alcohol. For some labs, this was the last chance to get funding or they’ll shut down.
Reposted by Patrick Murphy
Our latest work on targeting the poison exon in #RNA #splicing factor TRA2B in #cancer reveals a role for this non coding transcript and opportunities for targeting splicing factor levels across multiple tumor types
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social
Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects
Nature Communications - The oncogenic splicing factor TRA2β is reported to be upregulated in human cancers partly by increased TRA2β poison exon (PE) skipping. Here the authors show that...
rdcu.be
February 16, 2025 at 2:37 PM
Our latest work on targeting the poison exon in #RNA #splicing factor TRA2B in #cancer reveals a role for this non coding transcript and opportunities for targeting splicing factor levels across multiple tumor types
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social