Super excited to see the work of @maikbischoff.bsky.social and team revealing a new role for Plexin/Semaphorin signaling in collective cell migration now out in Science Advances 1/2
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance
An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.
www.science.org
June 19, 2025 at 4:55 AM
Super excited to see the work of @maikbischoff.bsky.social and team revealing a new role for Plexin/Semaphorin signaling in collective cell migration now out in Science Advances 1/2
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#CellBio2024 If you like collective cell migration, organogenesis, or very cool movies check out @maikbischoff.bsky.social's poster this morning (Tuesday, Dec 17 11:15 AM) Semaphorin/Plexin Antagonism regulates Collective Cell Migration and Gap Closure in vivo [P2780- Board B397]
December 17, 2024 at 4:00 PM
#CellBio2024 If you like collective cell migration, organogenesis, or very cool movies check out @maikbischoff.bsky.social's poster this morning (Tuesday, Dec 17 11:15 AM) Semaphorin/Plexin Antagonism regulates Collective Cell Migration and Gap Closure in vivo [P2780- Board B397]
Bischoff, M. C., Norton, J. E., & Peifer, M. (2024). Plexin/Semaphorin Antagonism Orchestrates Collective Cell Migration, Gap Closure and Organ sculpting by Contact-Mesenchymalization. bioRxiv. 2024.10.10.617649. #EpithelialMechanics
buff.ly/OzrQWTr
buff.ly/OzrQWTr
April 16, 2025 at 11:02 AM
Bischoff, M. C., Norton, J. E., & Peifer, M. (2024). Plexin/Semaphorin Antagonism Orchestrates Collective Cell Migration, Gap Closure and Organ sculpting by Contact-Mesenchymalization. bioRxiv. 2024.10.10.617649. #EpithelialMechanics
buff.ly/OzrQWTr
buff.ly/OzrQWTr
Sharing our latest paper in Molecular Metabolism, led by Jake Willows w our dental school collaborator Sarah Peters. A semaphorin 7a KO had altered adipose innervation, especially across development, showing Sema acts on the nerves, not just adipocytes. tinyurl.com/3x8x6yy2 🧪🧪
Semaphorin 7A Regulates Axon Outgrowth in Subcutaneous White Adipose Tissue
Adipose tissue innervation is critical for regulating lipolysis, adipogenesis, and thermogenesis, yet the mechanisms that establish and maintain these…
tinyurl.com
February 5, 2026 at 7:52 PM
Sharing our latest paper in Molecular Metabolism, led by Jake Willows w our dental school collaborator Sarah Peters. A semaphorin 7a KO had altered adipose innervation, especially across development, showing Sema acts on the nerves, not just adipocytes. tinyurl.com/3x8x6yy2 🧪🧪
Our new paper uncovering the role of Plexin/Semaphorin signaling in collective cell migration using testis nascent myotubes in flies is out! This work is from my time with @peiferlabunc.bsky.social led by @maikbischoff.bsky.social. As always, I am so thankful and proud to be a part of this story!
Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance
An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.
www.science.org
June 18, 2025 at 6:23 PM
Our new paper uncovering the role of Plexin/Semaphorin signaling in collective cell migration using testis nascent myotubes in flies is out! This work is from my time with @peiferlabunc.bsky.social led by @maikbischoff.bsky.social. As always, I am so thankful and proud to be a part of this story!
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
@natureaging.bsky.social
www.nature.com/articles/s43...
@natureaging.bsky.social
www.nature.com/articles/s43...
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells - Nature Aging
Toghani, Gupte et al. identify semaphorin 4A as a cell-extrinsic factor that protects myeloid-biased hematopoietic stem cells from inflammaging, mainly produced by their progeny—neutrophils—and acting...
www.nature.com
January 29, 2025 at 9:22 PM
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
@natureaging.bsky.social
www.nature.com/articles/s43...
@natureaging.bsky.social
www.nature.com/articles/s43...
Spectacular work by @maikbischoff.bsky.social @peiferlabunc.bsky.social showing how Plexin/Semaphorin-guided collective cell migration of muscle precursor cells shapes the developing testis. Look at the movies! 😱
| Science Advances www.science.org/doi/10.1126/...
| Science Advances www.science.org/doi/10.1126/...
Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance
An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.
www.science.org
June 19, 2025 at 10:06 AM
Spectacular work by @maikbischoff.bsky.social @peiferlabunc.bsky.social showing how Plexin/Semaphorin-guided collective cell migration of muscle precursor cells shapes the developing testis. Look at the movies! 😱
| Science Advances www.science.org/doi/10.1126/...
| Science Advances www.science.org/doi/10.1126/...
New paper out in Cardiovascular Research! DNMT3A-driven clonal haematopoiesis promotes endothelial activation in heart failure through a semaphorin 4A–dependent mechanism 💃🏻💃🏻
Congratulations to the first author @Mariana Shumliakivska for leading this exciting work!
academic.oup.com/cardiovascre...
Congratulations to the first author @Mariana Shumliakivska for leading this exciting work!
academic.oup.com/cardiovascre...
DNMT3A-driven clonal haematopoiesis induces semaphorin 4A-dependent endothelial activation in heart failure
Mariana Shumliakivska, Inga Hemmerling, Sebastian Cremer, Klara Kirschbaum, Marina Scheller, Xue Li, Carsten Müller-Tidow, Florian Leuschner, David John, W
academic.oup.com
September 8, 2026 at 12:04 PM
New paper out in Cardiovascular Research! DNMT3A-driven clonal haematopoiesis promotes endothelial activation in heart failure through a semaphorin 4A–dependent mechanism 💃🏻💃🏻
Congratulations to the first author @Mariana Shumliakivska for leading this exciting work!
academic.oup.com/cardiovascre...
Congratulations to the first author @Mariana Shumliakivska for leading this exciting work!
academic.oup.com/cardiovascre...
Bischoff, M. C., Norton, J. E., Clark, S. E., Peifer, M. (2025). Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance. Sci Adv, 11(25):eadu3741 www.science.org/doi/10.1126/...
Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance
An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.
www.science.org
October 10, 2025 at 4:38 PM
Bischoff, M. C., Norton, J. E., Clark, S. E., Peifer, M. (2025). Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance. Sci Adv, 11(25):eadu3741 www.science.org/doi/10.1126/...
#DBfeature #Avian
Semaphorin 3A repulsion directs the caudal projection of pioneer longitudinal axons in the developing chicken brain
by Kerry-lyn Riley, Susanne Dietrich, Frank Schubert
www.sciencedirect.com/science/arti...
Semaphorin 3A repulsion directs the caudal projection of pioneer longitudinal axons in the developing chicken brain
by Kerry-lyn Riley, Susanne Dietrich, Frank Schubert
www.sciencedirect.com/science/arti...
July 1, 2025 at 12:27 PM
#DBfeature #Avian
Semaphorin 3A repulsion directs the caudal projection of pioneer longitudinal axons in the developing chicken brain
by Kerry-lyn Riley, Susanne Dietrich, Frank Schubert
www.sciencedirect.com/science/arti...
Semaphorin 3A repulsion directs the caudal projection of pioneer longitudinal axons in the developing chicken brain
by Kerry-lyn Riley, Susanne Dietrich, Frank Schubert
www.sciencedirect.com/science/arti...
He’s already followed one set of leads, revealing exciting and surprising roles for Plexin/Semaphorin signaling in collective cell migration, but that’s the subject for another thread 18/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 1, 2024 at 2:16 PM
He’s already followed one set of leads, revealing exciting and surprising roles for Plexin/Semaphorin signaling in collective cell migration, but that’s the subject for another thread 18/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #accelerateopenscience
The Cappuccino interactome reveals an intracellular role for Semaphorin-2a in Drosophila oogenesis
Read the full paper: The Cappuccino interactome reveals an intracellular role for Semaphorin-2a in Drosophila oogenesis
doi.org
September 27, 2026 at 7:00 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #accelerateopenscience
Endothelial Cell Competition in #VenousMalformation
Hyper-proliferative Tie2-L914F mutant ECs secret Semaphorin 3A & 3F to repel wild-type counterparts
Evidence from
1⃣mixed EC xenograft🐭
2⃣mixed ECs in 3D fibrin #Lumenogenesis
@boscololab.bsky.social #ATVB 2025
www.ahajournals.org/doi/10.1161/...
Hyper-proliferative Tie2-L914F mutant ECs secret Semaphorin 3A & 3F to repel wild-type counterparts
Evidence from
1⃣mixed EC xenograft🐭
2⃣mixed ECs in 3D fibrin #Lumenogenesis
@boscololab.bsky.social #ATVB 2025
www.ahajournals.org/doi/10.1161/...
December 15, 2025 at 8:18 PM
Endothelial Cell Competition in #VenousMalformation
Hyper-proliferative Tie2-L914F mutant ECs secret Semaphorin 3A & 3F to repel wild-type counterparts
Evidence from
1⃣mixed EC xenograft🐭
2⃣mixed ECs in 3D fibrin #Lumenogenesis
@boscololab.bsky.social #ATVB 2025
www.ahajournals.org/doi/10.1161/...
Hyper-proliferative Tie2-L914F mutant ECs secret Semaphorin 3A & 3F to repel wild-type counterparts
Evidence from
1⃣mixed EC xenograft🐭
2⃣mixed ECs in 3D fibrin #Lumenogenesis
@boscololab.bsky.social #ATVB 2025
www.ahajournals.org/doi/10.1161/...
Maik was especially interested to see that several ligands or receptors involve in axon guidance in the nervous system were involved. He chose to focus on the axon guidance receptor PlexA. PlexA & its Semaphorin ligands are famous for their roles regulating neuron axon-axon repulsion 12/n
December 7, 2024 at 2:25 PM
Maik was especially interested to see that several ligands or receptors involve in axon guidance in the nervous system were involved. He chose to focus on the axon guidance receptor PlexA. PlexA & its Semaphorin ligands are famous for their roles regulating neuron axon-axon repulsion 12/n
Next to my talk (12/16 4 pm room 33B), I will present a poster: "Semaphorin/Plexin Antagonism Orchestrates Collective Cell Migration in vivo". Tuesday, Dec 17 11:15 AM.
P2780/Board No. B397
I am so excited. I just love ASCB meetings!
#cellbio2024 #cellbio #devcell @ascbiology.bsky.social #ASCB
P2780/Board No. B397
I am so excited. I just love ASCB meetings!
#cellbio2024 #cellbio #devcell @ascbiology.bsky.social #ASCB
December 12, 2024 at 3:05 PM
Next to my talk (12/16 4 pm room 33B), I will present a poster: "Semaphorin/Plexin Antagonism Orchestrates Collective Cell Migration in vivo". Tuesday, Dec 17 11:15 AM.
P2780/Board No. B397
I am so excited. I just love ASCB meetings!
#cellbio2024 #cellbio #devcell @ascbiology.bsky.social #ASCB
P2780/Board No. B397
I am so excited. I just love ASCB meetings!
#cellbio2024 #cellbio #devcell @ascbiology.bsky.social #ASCB
6/14 A similar mechanism drives Drosophila follicle cell migration around the egg chamber. In 2024, Sally Horne-Badovinac’s group showed that planar polarity depends on Fat2, which polarizes Semaphorin 5b and the RTK Lar.
👉 bsky.app/profile/epim...
👉 bsky.app/profile/epim...
April 20, 2025 at 7:32 AM
6/14 A similar mechanism drives Drosophila follicle cell migration around the egg chamber. In 2024, Sally Horne-Badovinac’s group showed that planar polarity depends on Fat2, which polarizes Semaphorin 5b and the RTK Lar.
👉 bsky.app/profile/epim...
👉 bsky.app/profile/epim...
#cellbio2024: sorry to miss you all this year (Final Exam & grading), but our lab will be well represented. Postdoc @maikbischoff.bsky.social will be giving a talk Monday 12/16 4:00 PM in the "Welcome to the Zellenstaat" session. He'll describe his exciting work on regulation of cell migration 1/3
December 14, 2024 at 3:41 PM
#cellbio2024: sorry to miss you all this year (Final Exam & grading), but our lab will be well represented. Postdoc @maikbischoff.bsky.social will be giving a talk Monday 12/16 4:00 PM in the "Welcome to the Zellenstaat" session. He'll describe his exciting work on regulation of cell migration 1/3
This is cool! The link from Plexin/Semaphorin to R-RAS signaling raises interesting questions about mechanism of action underlying clinical manifestations of human germline gain of function variants in #Noonansyndrome. (🔼bleeding, 🔼lymphatic dysplasia, CNS 🔼oligod 🔼myelination, muscle hypotonia)
For today's #FluorescenceFriday I'm thrilled to share that
ScienceAdvances was so nice to pick my picture as this week's featured image!
It's actually a still of a video😊
Check out the paper to learn more
science.org/doi/10.1126/...
#cellbio #devbio #cellmigration #science
Thank you @aaas.org
ScienceAdvances was so nice to pick my picture as this week's featured image!
It's actually a still of a video😊
Check out the paper to learn more
science.org/doi/10.1126/...
#cellbio #devbio #cellmigration #science
Thank you @aaas.org
June 20, 2025 at 6:07 PM
This is cool! The link from Plexin/Semaphorin to R-RAS signaling raises interesting questions about mechanism of action underlying clinical manifestations of human germline gain of function variants in #Noonansyndrome. (🔼bleeding, 🔼lymphatic dysplasia, CNS 🔼oligod 🔼myelination, muscle hypotonia)
I'll be giving and grading my Final Exam but look for a cool talk Monday (and a poster) by postdoc @maikbischoff.bsky.social and a poster by postbac Sarah Clark!
![Maik's poster: P2780 Semaphorin/Plexin Antagonism regulates Collective Cell Migration and Gap Closure in vivo [Board No. B397]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:r3avzdjyhu6jm7vxia265ncu/bafkreieqqi325ppjq46ahpwepusn4fnjm746gycrhmrfaogch4rfksckhy)
December 7, 2024 at 6:54 PM
I'll be giving and grading my Final Exam but look for a cool talk Monday (and a poster) by postdoc @maikbischoff.bsky.social and a poster by postbac Sarah Clark!
Tuesday postdoc @maikbischoff.bsky.social will present a talk about his exciting work defining novel roles for Plexus-Semaphorin signaling in cellective cell migration. if you're in Europe and hiring this year--Maik is a rising star 2/n
January 12, 2025 at 2:29 PM
Tuesday postdoc @maikbischoff.bsky.social will present a talk about his exciting work defining novel roles for Plexus-Semaphorin signaling in cellective cell migration. if you're in Europe and hiring this year--Maik is a rising star 2/n
Downregulating Piezo1 in the developing brain strongly reduces the expression of long-range chemical guidance cues, such as Semaphorin 3A (Sema3A) and Slit 1.
Piezo 1 isn’t just mechanical - it shapes the chemical landscape essential for long-range axon navigation.
Piezo 1 isn’t just mechanical - it shapes the chemical landscape essential for long-range axon navigation.
January 19, 2026 at 4:39 PM
Downregulating Piezo1 in the developing brain strongly reduces the expression of long-range chemical guidance cues, such as Semaphorin 3A (Sema3A) and Slit 1.
Piezo 1 isn’t just mechanical - it shapes the chemical landscape essential for long-range axon navigation.
Piezo 1 isn’t just mechanical - it shapes the chemical landscape essential for long-range axon navigation.
Hao's Preprint Reading List
July 24th 2025
Anatomy of human Intermediate Leptomeningeal Layer
Blood-glioma barrier in organoids
Endothelial Trauma
Macrophage in 3D construct
Plasma membrane repair machinery
Semaphorin, Luminal disorder and Venous malformation
docs.google.com/document/d/e...
July 24th 2025
Anatomy of human Intermediate Leptomeningeal Layer
Blood-glioma barrier in organoids
Endothelial Trauma
Macrophage in 3D construct
Plasma membrane repair machinery
Semaphorin, Luminal disorder and Venous malformation
docs.google.com/document/d/e...
July 24, 2025 at 7:05 PM
Hao's Preprint Reading List
July 24th 2025
Anatomy of human Intermediate Leptomeningeal Layer
Blood-glioma barrier in organoids
Endothelial Trauma
Macrophage in 3D construct
Plasma membrane repair machinery
Semaphorin, Luminal disorder and Venous malformation
docs.google.com/document/d/e...
July 24th 2025
Anatomy of human Intermediate Leptomeningeal Layer
Blood-glioma barrier in organoids
Endothelial Trauma
Macrophage in 3D construct
Plasma membrane repair machinery
Semaphorin, Luminal disorder and Venous malformation
docs.google.com/document/d/e...
Somite Semaphorin 3A- Endothelial Neuropilin 1 cascade restricts developmental Angiogenesis in Zebrafish
Ectopic intersomitic vessel sprouting in mosaic nrp1a/b MO🐟 or nrp1a/b KO🐟
⏫EC mitosis
⏬EC migration from aorta/vein
sFlt1-independent
#Angiogenesis 2026
link.springer.com/article/10.1...
Ectopic intersomitic vessel sprouting in mosaic nrp1a/b MO🐟 or nrp1a/b KO🐟
⏫EC mitosis
⏬EC migration from aorta/vein
sFlt1-independent
#Angiogenesis 2026
link.springer.com/article/10.1...
May 6, 2026 at 11:09 AM
Somite Semaphorin 3A- Endothelial Neuropilin 1 cascade restricts developmental Angiogenesis in Zebrafish
Ectopic intersomitic vessel sprouting in mosaic nrp1a/b MO🐟 or nrp1a/b KO🐟
⏫EC mitosis
⏬EC migration from aorta/vein
sFlt1-independent
#Angiogenesis 2026
link.springer.com/article/10.1...
Ectopic intersomitic vessel sprouting in mosaic nrp1a/b MO🐟 or nrp1a/b KO🐟
⏫EC mitosis
⏬EC migration from aorta/vein
sFlt1-independent
#Angiogenesis 2026
link.springer.com/article/10.1...
Look for these two great posters from our lab TODAY, & learn about a novel role for Plexin-Semaphorin signaling in collective cell migration, & the possible Rho family GEFs/GAPs that may also be involved
Maik is 12:15 - 1:45 PM B517 & Jenna is 1:45 to 3:15pm B520!! #cellbio23
Maik is 12:15 - 1:45 PM B517 & Jenna is 1:45 to 3:15pm B520!! #cellbio23
December 5, 2023 at 3:54 PM
Look for these two great posters from our lab TODAY, & learn about a novel role for Plexin-Semaphorin signaling in collective cell migration, & the possible Rho family GEFs/GAPs that may also be involved
Maik is 12:15 - 1:45 PM B517 & Jenna is 1:45 to 3:15pm B520!! #cellbio23
Maik is 12:15 - 1:45 PM B517 & Jenna is 1:45 to 3:15pm B520!! #cellbio23
BOOM! Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner www.biorxiv.org/content/10.1... absolutely remarkable sex difference reported here, with some neat Semaphorin-Plexin signaling from Menichella lab led by Paola Pacifico
Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner
The interaction between non-neuronal cells and nerve endings in the epidermis significantly influences the development of various diseases, including Painful Diabetic Neuropathy (PDN). PDN is a common...
www.biorxiv.org
February 5, 2025 at 2:29 AM
BOOM! Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner www.biorxiv.org/content/10.1... absolutely remarkable sex difference reported here, with some neat Semaphorin-Plexin signaling from Menichella lab led by Paola Pacifico