Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...

Learn how senolytic drugs target zombie cells and SASP to fight aging. From fisetin to DNA aptamers, explore the science of longevity medicine in 2026.

Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.

Despite incomplete evidence, longevity enthusiasts are experimenting with SGLT2 inhibitors in their quest to live healthier for longer.

Impaired vaccination responses leave older adults more vulnerable to severe influenza (flu) infections. Pretreatment with senolytic Dasatinib and Quercertin (D + Q) did not improve vaccine responses ...

D’Ambrosio et al. screen 10,480 electrophilic compounds for senolytic effects and show that senolytic chloroacetamides or GPX4 inhibitors selectively kill senescent cells by ferroptosis.

A new research paper was published in Volume 18 of Aging on July 13, 2026, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteo...

D’Ambrosio et al. screen 10,480 electrophilic compounds for senolytic effects and show that senolytic chloroacetamides or GPX4 inhibitors selectively kill senescent cells by ferroptosis.

Radiotherapy (RT) efficacy is limited by RT-induced immune resistance. Here we show that RT upregulates programmed death ligand 1 (PD-L1) on senescent tumor cells (STCs) via bromodomain-containing protein 4 (BRD4) signaling, thereby promoting immune evasion. To counter this, we develop POLY-Senolytic, a polymeric senolytic nanoparticle formed by conjugating an acid-responsive polymer to a peptide-based BRD4 PROteolysis-TArgeting Chimera via a reduction-cleavable disulfide bond. The POLY-Senolytic is activated in the acidic and reductive intracellular environment of tumor cells, leading to BRD4 degradation, suppression of RT-induced PD-L1 expression and enhanced immune clearance of STCs. Combined with RT, the POLY-Senolytic suppresses tumor growth and metastasis in orthotopic mouse models of pancreatic and breast tumors. We further engineer a β-galactosidase-responsive POLY-Tracker for real-time monitoring of senolytic therapy. Together, this study identifies an RT-driven BRD4-PD-L1 axi

Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age...

Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targe...

Medical News: A new experimental study has revealed that a drug designed to remove damaged aging cells may significantly protect the brain after a stroke. Scientists discovered that the senolytic drug navitoclax reduced brain injury and improved neurological recovery in laboratory stroke models, highlighting a promising new direction for stroke therapy. A senolytic drug that removes harmful agin...

Through binding mitochondrial ATP synthase, engineered nanomedicines rejuvenate aged bone stem cells and restore osteogenesis, reversing osteoporosis in mice and offering a potential senolytic therapy...