There are extensive ongoing efforts to slow or even reverse human aging, such as with epigenetic cellular reprogramming, thymus rejuvenation or senolytics. In parallel, new and diverse metrics—known as biological clocks—have been discovered and shown to track the pace of aging in an individual and their organs, tissues and cells. These clocks have multiple potential use cases, including identifying people at high risk of disease, serving as a foundation for prevention or early detection, and determining whether lifestyle factors or an intervention can modulate the aging process. This review provides a critical appraisal of the progress that is being made with biological clocks and how they might ultimately help understand pathobiology, reduce the burden of disease and extend healthspan. This review outlines the state of the art of biological clocks and how they could help understand pathobiology, reduce the burden of disease and extend healthspan.

Source: Fight Aging!

Could a class of drugs that clear aging cells also help treat Alzheimer's disease? A recent study, featured as the cover for Aging (Volume 17, Issue 3), titled “Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implicatio...

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Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, ...

New GLP-1 trials went from 13 in 2016 to 182 in 2025. Senolytics: 7 to 8. We pulled the trial registry: longevity science follows patents, not aging.

A plain-language longevity science glossary: healthspan, hallmarks of aging, senolytics, epigenetic clocks, NAD+ precursors and peptide bioregulators.

Source: Longevity.Technology

In a double-blind, placebo-controlled trial, intermittent dasatinib and quercetin treatment over 21 weeks improves liver fibrosis in patients with MASH, as shown by paired liver biopsies, and reduces ...

Cellular senescence and chronic low-grade inflammation occupy a central, mechanistically coupled position among the hallmarks of aging. Natural killer (NK) cells decline in per-cell cytotoxicity with ...

Why do we age? Explore the biology of aging, longevity science, epigenetic clocks, senolytics and whether aging can be slowed or reversed.

Middle aged mice (12-months-old) administered senolytics and/or aerobic exercise for 9 months showed a significantly lower accumulation of senescent cardiomyocytes and improved myocardial function co...

Middle aged mice (12-months-old) administered senolytics and/or aerobic exercise for 9 months showed a significantly lower accumulation of senescent cardiomyocytes and improved myocardial function co....

Middle aged mice (12-months-old) administered senolytics and/or aerobic exercise for 9 months showed a significantly lower accumulation of senescent cardiomyocytes and improved myocardial function co...

Nature Metabolism, Published online: 01 October 2026; doi:10.1038/s42255-026-01643-4In a double-blind, placebo-controlled trial, intermittent dasatinib and quercetin treatment over 21 weeks improves liver fibrosis in patients with MASH, as shown by paired liver biopsies, and reduces senescence and fibrotic gene signatures, as demonstrated by single-nucleus transcriptomics.

A small randomized trial found improved liver fibrosis with dasatinib plus quercetin in people with MASH. The disease signal is encouraging, but it does not establish slower human aging or longer l…