Senomorphic microRNAs (miRNAs) are a class of small regulatory RNAs that selectively suppress the senescence-associated secretory phenotype (SASP) without el...

Senescent cells accumulate with age to drive the onset and progression of age-related disease and loss of function. Over the past decade, a broad range of research and development efforts have emerged...

A recent study investigated senescence in mouse and human skeletal muscle tissue. The authors demonstrated that the antiviral drug maraviroc reduces senescence and improves muscle […]

Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular features ...

A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a […]

The polyphenol procyanidin C1, a compound found in grape seeds, possesses senomorphic or senolytic activity and is shown to extend the healthspan and survival of old mice and in various models of sene...

ISM001-055 was shown to have attenuated cellular senescence through the suppression of various aging processes, thus showing potential as a senomorphic drug.

Senescent cells are known to contribute to aging and age-related diseases. One key way they influence aging is by secreting senescence-associated secretory phenotype (SASP) factors along with several ...

The polyphenol procyanidin C1, a compound found in grape seeds, possesses senomorphic or senolytic activity and is shown to extend the healthspan and survival of old mice and in various models of sene...

Partial reprogramming has emerged as a promising strategy to ameliorate aging phenotypes, yet its cellular targets and mechanisms remain poorly defined. Cellular senescence is a central hallmark of aging and a plausible mediator of reprogramming-induced rejuvenation. Here we show that genetic and chemical partial reprogramming act directly on senescent cells without restoring proliferative capacity. OSKM expression or a reduced two-compound regimen, tranylcypromine and RepSox (2c), attenuates senescence-associated secretory activity, restores mitochondrial homeostasis and apoptotic priming, and improves functional and inflammatory parameters in aged mice, establishing senomorphic, identity-preserving reprogramming as a potentially safer aging intervention. ### Competing Interest Statement The authors have declared no competing interest.

Read the full paper: Senomorphic Small Extracellular Vesicles Delivered by a Tissue-Adhesive α-Lipoic-Acid Hydrogel Enable Immuno-Rejuvenation for Bone-Tendon Interface Regeneration

How are senolytics and senomorphic therapies revolutionizing the science of aging, and what breakthroughs can we expect?

Nature Aging - Saeedi Saravi and colleagues demonstrate an age-related increase in the gut microbial metabolite phenylacetic acid (PAA) in humans and mice, linked to Clostridium bacteria. In mice,...

A recent study investigated senescence in mouse and human skeletal muscle tissue. The authors demonstrated that the antiviral drug maraviroc reduces senescence and […]

Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many […]

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles and 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming 10/17/24 were reported on 4/24/25. See: Scientists Discover a Second Epigenetic DNA Marker Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Epigenetic marks ... Knowing something, or not (1)

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles 4/24/25 “These miRNAs target key aging-related pathways as well as specific genes, such as PCAF, HIPK2, DRAM, IL-18, and MOAP1. This study not only emphasizes the potential of miRNA-based therapies to reduce senescence with its associated inflammatory SASP but also identifies an ... Abhorrent atheistic algorithms (9)