November 12, 2026 at 10:28 PM
Behold: The full JUMP Cell Painting chemical dataset preprint!
Images + 1.53 billion single-cell profiles for 115,796 compounds in human cells, made across 12 labs. All freely available 🧵 www.biorxiv.org/content/10.1...
Images + 1.53 billion single-cell profiles for 115,796 compounds in human cells, made across 12 labs. All freely available 🧵 www.biorxiv.org/content/10.1...
November 11, 2026 at 5:01 PM
Behold: The full JUMP Cell Painting chemical dataset preprint!
Images + 1.53 billion single-cell profiles for 115,796 compounds in human cells, made across 12 labs. All freely available 🧵 www.biorxiv.org/content/10.1...
Images + 1.53 billion single-cell profiles for 115,796 compounds in human cells, made across 12 labs. All freely available 🧵 www.biorxiv.org/content/10.1...
I swear to god some of you have but a single brain cell
November 15, 2026 at 3:34 AM
I swear to god some of you have but a single brain cell
Single-cell atlases continue to map the diversity of cell states, but how can we use them to interpret non-coding genetic variants?
Excited to share AlphaGenome 2, our model for predicting cell-type-specific regulatory activity and variant effects from DNA sequence.
deepmind.google/blog/alphage...
Excited to share AlphaGenome 2, our model for predicting cell-type-specific regulatory activity and variant effects from DNA sequence.
deepmind.google/blog/alphage...
AlphaGenome 2: Deciphering how cells read DNA to better understand disease
AlphaGenome 2 is our next-generation DNA sequence model that bridges single-cell biology and human genetics, predicting how variants affect human cell types.
deepmind.google
November 12, 2026 at 9:50 AM
Single-cell atlases continue to map the diversity of cell states, but how can we use them to interpret non-coding genetic variants?
Excited to share AlphaGenome 2, our model for predicting cell-type-specific regulatory activity and variant effects from DNA sequence.
deepmind.google/blog/alphage...
Excited to share AlphaGenome 2, our model for predicting cell-type-specific regulatory activity and variant effects from DNA sequence.
deepmind.google/blog/alphage...
Quantum physics dictates that all orange cats share a single brain cell.
November 12, 2026 at 8:54 AM
Quantum physics dictates that all orange cats share a single brain cell.
no not a typo, everything including the single cell will be played by an exclusively gay cast.
November 14, 2026 at 10:23 PM
no not a typo, everything including the single cell will be played by an exclusively gay cast.
7,000,000,000 part series where we witness the single cell evolve into what would become the homosexual sapien. it’s gonna be dramatic as FUCK.
If time, money and talent were no objects, what historical event or milieu would make an incredible streaming series in your opinion?
November 14, 2026 at 10:22 PM
7,000,000,000 part series where we witness the single cell evolve into what would become the homosexual sapien. it’s gonna be dramatic as FUCK.
every cell in the building has people fucking and in the center of the building is a tower with a single swivel chair
November 15, 2026 at 1:19 AM
every cell in the building has people fucking and in the center of the building is a tower with a single swivel chair
Meet GATO-seq 🐱, now online @Molecular Cell: a cell-free assay that tracks Pol II across 1,000 human genes at single-nucleotide resolution. It uncovered a sequence-encoded “super pause” and a new offline Pol II state we call “sidetracked.” Big congrats @robertovn.bsky.social ! tinyurl.com/GATO-seq2
November 11, 2026 at 3:49 PM
Meet GATO-seq 🐱, now online @Molecular Cell: a cell-free assay that tracks Pol II across 1,000 human genes at single-nucleotide resolution. It uncovered a sequence-encoded “super pause” and a new offline Pol II state we call “sidetracked.” Big congrats @robertovn.bsky.social ! tinyurl.com/GATO-seq2
Single-cell transfer RNA sequencing reveals principles of translational regulation https://www.biorxiv.org/content/10.64898/2026.11.11.765974v1
November 14, 2026 at 3:32 AM
Single-cell transfer RNA sequencing reveals principles of translational regulation https://www.biorxiv.org/content/10.64898/2026.11.11.765974v1
"We generated single-nucleus RNA- and ATAC-seq data from cortex across nine mammalian species and identified cell-type-specific candidate cis-regulatory elements"
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Single-cell multiomics across nine mammals reveals cell-type-specific regulatory conservation in the brain
Anderson et al. compare brain gene regulation across nine mammals, revealing that
enhancer conservation extends beyond DNA sequence to include cell-type specificity
and gene targets. Functional assays...
www.cell.com
November 11, 2026 at 5:44 PM
"We generated single-nucleus RNA- and ATAC-seq data from cortex across nine mammalian species and identified cell-type-specific candidate cis-regulatory elements"
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Markwayne Mullin is the largest single cell organism ever found.
November 14, 2026 at 3:39 PM
Markwayne Mullin is the largest single cell organism ever found.
it's a lot of single cell profiles 🙂
November 11, 2026 at 6:40 PM
it's a lot of single cell profiles 🙂
Our jaxQTL paper is out today in Nature Genetics! 🧬
We developed count-based models that improves single-cell eQTL discovery and reveal cell-type-specific genetic regulation.
www.nature.com/articles/s41...
We developed count-based models that improves single-cell eQTL discovery and reveal cell-type-specific genetic regulation.
www.nature.com/articles/s41...
Efficient count-based models improve power and robustness for large-scale single-cell eQTL mapping - Nature Genetics
This study presents jaxQTL, an efficient count-based pseudobulk single-cell eQTL mapping framework. When applied to OneK1K data, jaxQTL discovers more eGenes than existing methods while running faster...
www.nature.com
November 10, 2026 at 8:18 PM
Our jaxQTL paper is out today in Nature Genetics! 🧬
We developed count-based models that improves single-cell eQTL discovery and reveal cell-type-specific genetic regulation.
www.nature.com/articles/s41...
We developed count-based models that improves single-cell eQTL discovery and reveal cell-type-specific genetic regulation.
www.nature.com/articles/s41...
One more episode built on everyone having not one single brain cell!! (But Durin. The dwarves can do no wrong)
November 14, 2026 at 9:29 PM
One more episode built on everyone having not one single brain cell!! (But Durin. The dwarves can do no wrong)
Single Cell
Glückskind, Darkstates · Single Cell · Song · 2025
open.spotify.com
November 9, 2026 at 3:46 AM
Single Cell Paramecium 2.0
Your real age is 70 minus the number of musicians you recognize playing at Coachella 2027
November 15, 2026 at 5:26 AM
Single Cell Paramecium 2.0
single cell organism protein
November 14, 2026 at 5:00 PM
single cell organism protein
...a multi-modal single-cell human brain epigenomic reference for interpreting regulatory principles and epigenetic memory underlying human brain organization and disease... www.cell.com/cell/fulltex...
Single-cell multimodal atlas reveals regulatory programs in the human brain
A multimodal, integrative framework for understanding gene regulatory mechanisms across
diverse cell types in the adult human brain. This framework helps elucidate how regulatory
programs govern neuro...
www.cell.com
November 12, 2026 at 4:27 PM
...a multi-modal single-cell human brain epigenomic reference for interpreting regulatory principles and epigenetic memory underlying human brain organization and disease... www.cell.com/cell/fulltex...
Throw Biden and Trump in the same cell and let them fight over a single meal, I couldn’t give less of a shit.
November 9, 2026 at 11:15 PM
Throw Biden and Trump in the same cell and let them fight over a single meal, I couldn’t give less of a shit.
Please enjoy this Batsyhead dump in lieu of any actual content that requires a thought (I am cleaning The Kitchen™ today and the single brain cell I share with the other Ginger People is conspicuously absent)
November 14, 2026 at 3:02 AM
Please enjoy this Batsyhead dump in lieu of any actual content that requires a thought (I am cleaning The Kitchen™ today and the single brain cell I share with the other Ginger People is conspicuously absent)
#MusicSky
First time I head this song was in a strip club in Key West back in the day and that's all we'll say about that.
Soft Cell 1981
First time I head this song was in a strip club in Key West back in the day and that's all we'll say about that.
Soft Cell 1981
Soft Cell - Tainted Love / Where Did Our Love Go (1981 12" Single) - Technics 1200G / Hana MH
YouTube video by AudioPhil
youtu.be
November 15, 2026 at 4:20 AM
#MusicSky
First time I head this song was in a strip club in Key West back in the day and that's all we'll say about that.
Soft Cell 1981
First time I head this song was in a strip club in Key West back in the day and that's all we'll say about that.
Soft Cell 1981
Single-cell and spatial multi-omics for studying cell competition in the tumor microenvironment
#Drosophila
#Drosophila
Single-cell and spatial multi-omics for studying cell competition in the tumor microenvironment
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 15, 2026 at 6:23 AM
Single-cell and spatial multi-omics for studying cell competition in the tumor microenvironment
#Drosophila
#Drosophila