Electrifying skeletal editing? Our latest work on a tunable electrochemical method that enables divergent N-heterocycle synthesis via N insertion into carbocycles.
#skeletalediting #expansion #electrochemistry #heterocycle
#skeletalediting #expansion #electrochemistry #heterocycle
Now online:
Article by Yu Zhao, Ming Joo Koh & co-workers
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion
www.nature.com/articles/s44... ($)
#Chemsky
Article by Yu Zhao, Ming Joo Koh & co-workers
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion
www.nature.com/articles/s44... ($)
#Chemsky
Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion - Nature Synthesis
A divergent electrochemical nitrogen atom insertion into saturated carbocycles is reported, enabling selective access to either functionalized quinolines or N-alkylated saturated N heterocycles. This ...
www.nature.com
December 18, 2025 at 5:26 PM
Electrifying skeletal editing? Our latest work on a tunable electrochemical method that enables divergent N-heterocycle synthesis via N insertion into carbocycles.
#skeletalediting #expansion #electrochemistry #heterocycle
#skeletalediting #expansion #electrochemistry #heterocycle
The University of Chicago Department of Chemistry is proud to announce that Professor Guangbin Dong has been awarded the 2026 Janssen Prize for Creativity in Organic Synthesis. shorturl.at/SoXIh
#UChicago #UChiChemistry #JanssenPrize #OrganicSynthesis #GuangbinDong #SkeletalEditing #Chemistry
#UChicago #UChiChemistry #JanssenPrize #OrganicSynthesis #GuangbinDong #SkeletalEditing #Chemistry
Guangbin Dong Wins 2026 Janssen Prize for Creativity in Organic Synthesis
University of Chicago chemist recognized for pioneering "Cut & Sew" catalysis and groundbreaking advancements in skeletal editing
shorturl.at
April 15, 2026 at 9:22 PM
The University of Chicago Department of Chemistry is proud to announce that Professor Guangbin Dong has been awarded the 2026 Janssen Prize for Creativity in Organic Synthesis. shorturl.at/SoXIh
#UChicago #UChiChemistry #JanssenPrize #OrganicSynthesis #GuangbinDong #SkeletalEditing #Chemistry
#UChicago #UChiChemistry #JanssenPrize #OrganicSynthesis #GuangbinDong #SkeletalEditing #Chemistry
Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis
👉 buff.ly/XvYGfsW
👉 buff.ly/XvYGfsW
September 8, 2025 at 7:01 AM
Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis
👉 buff.ly/XvYGfsW
👉 buff.ly/XvYGfsW
Don't see chemistry in the news much but really neat article in @theguardian.bsky.social about #SkeletalEditing featuring @SarpongGroup and @LevinChem with @MDSgroup_Oxford and my #PfizerChemistry group director Dave Blakemore
Nice to see a cool write up about cutting edge synthesis in the media
Nice to see a cool write up about cutting edge synthesis in the media
‘Endless possibilities’: the chemists changing molecules atom by atom
A new method called ‘skeletal editing’ offers a hugely simplified way to alter matter, paving the way for world-changing innovations in personalised medicine and sustainable plastics
www.theguardian.com
August 6, 2023 at 12:14 AM
Don't see chemistry in the news much but really neat article in @theguardian.bsky.social about #SkeletalEditing featuring @SarpongGroup and @LevinChem with @MDSgroup_Oxford and my #PfizerChemistry group director Dave Blakemore
Nice to see a cool write up about cutting edge synthesis in the media
Nice to see a cool write up about cutting edge synthesis in the media
Happy to share a new way of promoting dual-atom insertion into oxetanes and azetidines to access multi-heteroatom rings using FLP chemistry, just out in @natsynth.nature.com nature.com/articles/s44... #skeletalediting #ringexpansion #FLP
March 12, 2026 at 11:15 AM
Happy to share a new way of promoting dual-atom insertion into oxetanes and azetidines to access multi-heteroatom rings using FLP chemistry, just out in @natsynth.nature.com nature.com/articles/s44... #skeletalediting #ringexpansion #FLP
#StereoChemistry #Podcast
“ #CE&Nuncovered The Strange Copy & Paste #Chemistry of #SkeletalEditing” @cenmag.bsky.social
🧪
podcasts.apple.com/us/podcast/s...
“ #CE&Nuncovered The Strange Copy & Paste #Chemistry of #SkeletalEditing” @cenmag.bsky.social
🧪
podcasts.apple.com/us/podcast/s...
Uncovered: The Strange Copy and Paste Chemistry of Skeletal Editing
Podcast Episode · Stereo Chemistry · September 26, 2025 · 17m
podcasts.apple.com
May 14, 2026 at 9:25 PM
#StereoChemistry #Podcast
“ #CE&Nuncovered The Strange Copy & Paste #Chemistry of #SkeletalEditing” @cenmag.bsky.social
🧪
podcasts.apple.com/us/podcast/s...
“ #CE&Nuncovered The Strange Copy & Paste #Chemistry of #SkeletalEditing” @cenmag.bsky.social
🧪
podcasts.apple.com/us/podcast/s...
Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks | Organic Letters #SkeletalEditing #Atomswap #OrgLett #Hypervalentiodine @acs.org @pubs.acs.org pubs.acs.org/doi/full/10....
Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks
Herein, we report a practical and efficient carbon-to-nitrogen atom swap in 2-phenylimidazo[2,1-a]isoquinoline and 2-phenylimidazo[1,2-a]quinoline scaffolds, enabling their direct conversion to the corresponding 2-phenyl-[1,2,4]triazolo[5,1-a]isoquinoline and 2-phenyl-[1,2,4]triazolo[1,5-a]quinoline analogues. This transformation exploits the intrinsic reactivity of the parent heterocycles to undergo a cascade sequence involving oxidative cleavage, amination, and cyclization (OCAC) under mild conditions with functional group tolerance.
pubs.acs.org
November 3, 2025 at 7:52 PM
Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks | Organic Letters #SkeletalEditing #Atomswap #OrgLett #Hypervalentiodine @acs.org @pubs.acs.org pubs.acs.org/doi/full/10....
🔔 Research article by Dorian Didier 𝘦𝘵 𝘢𝘭.
Twofold 4-to-6 ring expansion of azetines to bis-halogenated pyridines
🔗 doi.org/10.1039/d6qo...
#SkeletalEditing #RingExpansion #Pyridines #CarbeneChemistry #OrganicSynthesis #Heterocycles
Twofold 4-to-6 ring expansion of azetines to bis-halogenated pyridines
🔗 doi.org/10.1039/d6qo...
#SkeletalEditing #RingExpansion #Pyridines #CarbeneChemistry #OrganicSynthesis #Heterocycles
August 5, 2026 at 3:26 AM
🔔 Research article by Dorian Didier 𝘦𝘵 𝘢𝘭.
Twofold 4-to-6 ring expansion of azetines to bis-halogenated pyridines
🔗 doi.org/10.1039/d6qo...
#SkeletalEditing #RingExpansion #Pyridines #CarbeneChemistry #OrganicSynthesis #Heterocycles
Twofold 4-to-6 ring expansion of azetines to bis-halogenated pyridines
🔗 doi.org/10.1039/d6qo...
#SkeletalEditing #RingExpansion #Pyridines #CarbeneChemistry #OrganicSynthesis #Heterocycles
🧪 Chemists build molecules like adding rooms to a house, never touching the structure.
Nagoya University went inside anyway, cutting a bond deep inside a flat molecule and rebuilding it.
Out came nanocarbons that emit spiraling light.
#SkeletalEditing #Nanocarbon #Chemistry
Nagoya University went inside anyway, cutting a bond deep inside a flat molecule and rebuilding it.
Out came nanocarbons that emit spiraling light.
#SkeletalEditing #Nanocarbon #Chemistry
August 3, 2026 at 9:00 AM
🧪 Chemists build molecules like adding rooms to a house, never touching the structure.
Nagoya University went inside anyway, cutting a bond deep inside a flat molecule and rebuilding it.
Out came nanocarbons that emit spiraling light.
#SkeletalEditing #Nanocarbon #Chemistry
Nagoya University went inside anyway, cutting a bond deep inside a flat molecule and rebuilding it.
Out came nanocarbons that emit spiraling light.
#SkeletalEditing #Nanocarbon #Chemistry
✨Atomic alchemy! Scientists are *rewriting* drug blueprints at the molecular level, forging new medicines from existing ones.🤯 #SkeletalEditing
Source: https://phys.org/news/2025-05-atom-swapping-method-successfully-complex.html
Source: https://phys.org/news/2025-05-atom-swapping-method-successfully-complex.html
Atom-swapping method successfully applied to complex organic structures—new possibilities for drug design
Skeletal editing is a modern approach to chemical synthesis. By making precise alterations at the atomic level, researchers are able to directly convert existing drug scaffolds into new, biologically relevant compounds.
phys.org
May 25, 2025 at 2:09 AM
✨Atomic alchemy! Scientists are *rewriting* drug blueprints at the molecular level, forging new medicines from existing ones.🤯 #SkeletalEditing
Source: https://phys.org/news/2025-05-atom-swapping-method-successfully-complex.html
Source: https://phys.org/news/2025-05-atom-swapping-method-successfully-complex.html
Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...
October 15, 2025 at 3:16 PM
Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...
Excited to share our latest work in #J_A_C_S
, wherein formal carbonyl insertion was efficiently achieved at the para or ortho position of pyridines, enabling access to 1,4- or 1,2-azepinones, which could be smoothly downstreamed into pyrrolidinones.
Link: doi.org/10.1021/jacs...
#SkeletalEditing
, wherein formal carbonyl insertion was efficiently achieved at the para or ortho position of pyridines, enabling access to 1,4- or 1,2-azepinones, which could be smoothly downstreamed into pyrrolidinones.
Link: doi.org/10.1021/jacs...
#SkeletalEditing
Divergent Skeletal Editing of Pyridinium Salts to Azepinones and Pyrrolidinones via Formal Carbonyl Insertion
Skeletal editing offers a powerful strategy for rapid diversification of molecular frameworks without requiring de novo synthesis, yet most existing methods enable only a single, unidirectional scaffo...
doi.org
May 15, 2026 at 9:06 AM
Excited to share our latest work in #J_A_C_S
, wherein formal carbonyl insertion was efficiently achieved at the para or ortho position of pyridines, enabling access to 1,4- or 1,2-azepinones, which could be smoothly downstreamed into pyrrolidinones.
Link: doi.org/10.1021/jacs...
#SkeletalEditing
, wherein formal carbonyl insertion was efficiently achieved at the para or ortho position of pyridines, enabling access to 1,4- or 1,2-azepinones, which could be smoothly downstreamed into pyrrolidinones.
Link: doi.org/10.1021/jacs...
#SkeletalEditing
Skeletal editing targets double bonds #Science #Chemistry #OrganicChemistry #SkeletalEditing #DoubleBonds
Skeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
purescience.news
March 14, 2025 at 6:27 PM
Skeletal editing targets double bonds #Science #Chemistry #OrganicChemistry #SkeletalEditing #DoubleBonds