#Sphingosine
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davidbsauer.bsky.social
Fun little write-up of the SPNS2 collaboration :)

Also, my first exercise with Blender and Molecular Nodes. Wow, does it make pretty pictures! Thanks for the YouTube tutorials @bradyajohnston.bsky.social.

go.nature.com/41XuE25
Collaborating to study the transport and inhibition of the immunoregulatory sphingosine-1-phosphate exporter SPNS2
Probing the sphingosine-1-phosphate exporter SPNS2 through an international collaboration of academia and industry, with results reporting a novel high-throughput screening assay, small-molecule targe...
go.nature.com
March 25, 2025 at 12:01 AM
microbesinfect.bsky.social
Gut DNA #virome enterotype dictates #inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in #Crohn's disease

www.sciencedirect.com/science/arti... #CrohnsDisease #microbiome #MicroSky
February 11, 2026 at 10:04 AM
asm.org
Sphingosine, found on epithelial cells but undetectable in cystic fibrosis patients, kills P. aeruginosa via degradation of cardiolipin, leading to severe membrane changes; mammalian cells lack membranous cardiolipin & remain unharmed. #IAIJournal: journals.asm.org/doi/10.1128/...
Electron microscopy of P. aeruginosa after treatment with sphingosine. P. aeruginosa ATCC 27853 were treated with 20 µM sphingosine (SPH) for 10 min or 30 min or left untreated, fixed, embedded, and analyzed by electron microscopy. A higher concentration of sphingosine was used because 108 CFU P. aeruginosa were used in these experiments to obtain a pellet, which we were able to process. Shown is each a representative picture from at least 50 visualized cells. The arrows in the images in the upper row indicate some of the membrane blebs, and the arrows in the image in the lower row indicate typical membrane rolls. Scale bar sizes in the images: left column (both images) and middle and right column (upper images), each 200 nm; middle column (lower image), 50 nm; right column (lower image), 100 nm.
March 18, 2025 at 2:47 PM
hlatim.bsky.social
Latest paper from the Hla lab- @elife.bsky.social: Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions doi.org/10.7554/eLif...
Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions
doi.org
September 1, 2026 at 11:01 PM
haoyin.bsky.social
How to build a normal multilayered arterial wall?😎

Activated Sphingosine kinase 1 mediates elastin deficiency-induced arterial hypermuscularization🐭

Both Smooth muscle cell & Endothelial cell contribute

@junichisaito.bsky.social @greiflab.bsky.social #NatCVR 2026
www.nature.com/articles/s44...
January 9, 2026 at 12:20 PM
junbcai.bsky.social
Looking forward to presenting at #ICRS2026 tomorrow. I'll be speaking about our work on the functional role of sphingosine kinase in cnidarian–algal symbiosis during the cell and molecular session at 10:30 AM in Room 516.
July 19, 2026 at 7:43 PM
wargolab.bsky.social
New paper from the lap spearheaded by Jacob Mackinder (not on here): journals.asm.org/doi/10.1128/...
Regulation of an important P. aeruginosa virulence factor by host-derived sphingosine - and look for more sphingolipid-related content from us later this year

#microsky #bacteria
Sphingosine induction of the Pseudomonas aeruginosa hemolytic phospholipase C/sphingomyelinase (PlcH) | Journal of Bacteriology
PlcH is a secreted phospholipase C/sphingomyelinase that is important for the virulence of Pseudomonas aeruginosa. Here, we show that sphingosine, which presents itself or as a product of P. aeruginos...
journals.asm.org
February 27, 2024 at 2:27 PM
hlatim.bsky.social
Latest paper from the lab - CD69 in endothelial cells..Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak - Journal of Biological Chemistry www.jbc.org/article/S002...
Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak
Inflammation disrupts endothelial barrier function and causes vascular leak into the tissue parenchyma. Sphingosine 1-phosphate receptor-1 (S1PR1) in endothelial cells (EC) is a key inducer of endothe...
www.jbc.org
July 4, 2025 at 5:02 PM
microbetv.bsky.social
TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neuro-developmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin.
June 17, 2026 at 2:30 PM
annmemmott.bsky.social
"...the American Psychiatric Association has updated the diagnostic criteria for ASD to include hyper- or hyporeactivity to sensory input, with “apparent indifference to pain and temperature” as a symptom of ASD", the team at pubmed.ncbi.nlm.nih.gov/39497100/ write. But/
Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder - PubMed
S1PR1 may contribute to PAI in the PNS in ASD. The mechanism involves KCNQ/M channels and the MAPK and cAMP/PKA signaling pathways. Targeting S1PR1 in the PNS could offer novel therapeutic strategies ...
pubmed.ncbi.nlm.nih.gov
November 5, 2024 at 9:22 AM
wargolab.bsky.social
Another paper out from the lab led by recent PhD student and current Alonzo Lab postdoc Jacob Mackinder. Sphingosine synergizes with polymyxin antibiotics in both Pseudomonas aeruginosa and Klebsiella pneumoniae

www.microbiologyresearch.org/content/jour...

#microsky #microbiology #bacteria
Sphingosine synergizes with polymyxin antibiotics against Pseudomonas aeruginosa and Klebsiella pneumoniae
Antimicrobial resistance is an increasing threat to global health. However, there is a limited set of antibiotics that are effective against drug-resistant Gram-negative bacteria like Pseudomonas aeru...
www.microbiologyresearch.org
August 4, 2026 at 4:43 PM
nadlerlab.bsky.social
Great lipidtime story by Pia Hempelmann, Denisa Jamecna, Doris Höglinger & friends on sphingosine transport. Check it out!
www.biorxiv.org/content/10.1...
September 22, 2023 at 3:40 PM
exceedhergrasp1.bsky.social
Same here: read the alt!
SLIDE TITLE: Mouse Model of Endometriosis This experiment tested whether dienogest or fingolimod could alter disease outcomes after either one endometriosis-like lesion induction (1× ELL) or six inductions given every two weeks (6× ELL), the latter modeling repeated retrograde menstruation. Dienogest is a synthetic progestin used to treat endometriosis; fingolimod is a sphingosine-1-phosphate receptor modulator and immunosuppressant used for multiple sclerosis. Beginning 21 days after the final induction, groups of six mice received PBS vehicle, oral dienogest at 1 mg/kg body weight, or intraperitoneal fingolimod at 1 mg/kg body weight for three weeks. Behavioral testing occurred before treatment, followed by behavioral testing and sample collection on day 49. The graphs show that repeated induction produced more lesions and greater lesion volume than a single induction. Neither dienogest nor fingolimod significantly reduced lesion number or size. As reported elsewhere in the cited paper, however, both treatments improved abdominal pain sensitivity after repeated induction. The findings therefore distinguish treatment effects on pain and neuroinflammation from effects on the physical lesion burden. REFERENCE: Harvey, Hayashi et al., *Journal of Clinical Investigation*, 2026, “Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis models.”
September 24, 2026 at 2:00 PM
cp-cellhostmicrobe.bsky.social
Virome enterotype dictates inflammation

Gut mucosal virome enterotypes influence intestinal inflammation w/Entero-2 predominant in Crohn’s disease & proinflammatory in mice. E2 enriched in phage that ↑B. theta sphingosine production & alters inflammation
www.cell.com/cell-host-mi...
Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease
Wen et al. identify two gut mucosal virome enterotypes that influence intestinal inflammation susceptibility. They reveal that a bacteriophage alters sphingosine production in B. thetaiotaomicron and ...
www.cell.com
February 17, 2026 at 9:25 PM
evebio.bsky.social
🧪 EvE Bio's biggest public data release (#4) yet!

1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
May 19, 2025 at 3:01 PM
biorxiv-cellbio.bsky.social
The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling https://www.biorxiv.org/content/10.1101/2025.06.10.658872v1
June 11, 2025 at 2:31 PM
New paper alert! Pseudomonas aeruginosa metabolises sphingosine, reducing its inhibitory effect. @microbiologysociety.org @wargolab.bsky.social www.microbiologyresearch.org/content/jour...
The Pseudomonas aeruginosa sphBC genes are important for growth in the presence of sphingosine by promoting sphingosine metabolism
Sphingoid bases, including sphingosine, are important components of the antimicrobial barrier at epithelial surfaces where they can cause growth inhibition and killing of susceptible bacteria. Pseudom...
www.microbiologyresearch.org
January 10, 2025 at 11:47 AM
ewanmacdonald.bsky.social
I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies.
doi.org/10.1111/boc....
Flotillins in membrane trafficking and physiopathology
Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and  endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...
doi.org
January 29, 2025 at 11:21 AM
hlatim.bsky.social
Our recent review on S1PR targeted therapeutic approaches in autoimmune pubmed.ncbi.nlm.nih.gov/35508810/
November 26, 2024 at 2:59 PM
davidbsauer.bsky.social
Our SPNS2 paper is published! A massive collaboration of Resolute, Oxford CMD, Nuvisan, @oxfordbiochemistry.bsky.social, CeMM, Bayer, & Univ. of Zurich

Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others

www.nature.com/articles/s41...
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 - Nature Communications
SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the mechanism...
www.nature.com
January 16, 2025 at 6:17 PM
cryoempapers.bsky.social
Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B pubmed.ncbi.nlm.nih.gov/41648189/ #cryoem
February 8, 2026 at 1:05 AM
wargolab.bsky.social
Our 2nd sphingolipid-related pre-print of the year is now up
If you’re at #Pseudomonas2024, see other sphingosine content at our posters 24 & 27

www.biorxiv.org/content/10.1...
The Pseudomonas aeruginosa sphBC genes are important for growth in the presence of sphingosine by promoting sphingosine metabolism
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 4, 2024 at 5:31 AM
cryoempapers.bsky.social
Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors pubmed.ncbi.nlm.nih.gov/41961881/ #cryoem
April 11, 2026 at 12:10 PM
sweetpapers.proteaglyco.com
Cu(I)-Catalyzed Alkylation of γ-Vinyl-γ-Lactone for the Stereoselective Synthesis of L-threo Sphingosin#glycotimem#CarbohydrateResearchch
Cu(I)-Catalyzed Alkylation of γ-Vinyl-γ-Lactone for the Stereoselective Synthesis of L-<em>threo</em> Sphingosine
S000862152500254X
www.sciencedirect.com
August 6, 2025 at 2:50 PM
embojournal.org
Chemoproteomics and photoaffinity labeling reveals structurally related PP2A scaffold PPP2R1A and importins KPNB1, TNPO1, IPO7, IPO5 as targets of sphingosine-like antineoplastic molecules
Aimee Edinger, Pierre Thibault, Stephen Hanessian et al
www.embopress.org/doi/full/10....
July 1, 2025 at 5:01 PM