#T-cells
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allergy-eaaci.bsky.social
Open Access: Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in Atopic Dermatitis. First author: Takayoshi Komatsu-Fujii; corresponding authors: Ryota Asahina, Toshiaki Kogame, Kenji Kabashima

Read the article: doi.org/10.1111/all.70493

#Allergy_journal
This study demonstrates the role of OX40-OX40 signaling in pathogenic resident memory T cells (TRM) development using an oxazolone (OXA)-induced atopic dermatitis mouse model. Blockade of the OX40 pathway during the initial inflammatory phase suppressed TRM development and attenuated recall dermatitis. Human lesional atopic dermatitis skin showed a transcriptomic profile consistent with Th2/TRM-like features. These findings support further studies targeting the OX40-OX40L axis for the treatment of atopic dermatitis. Watch the video abstract prepared by the authors here: https://youtu.be/jRP3WgCdxVY Read more articles published in #Allergy on #atopicdermatis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease
October 6, 2026 at 4:11 PM
cellbiology-lr.bsky.social
🧪 High mRNA yield but cells acting off? Hidden dsRNA could be the culprit. Learn how to detect, measure & remove it with the MEGAclear dsRNA Removal Kit.

📅 Oct 8 | 9 AM PT / 12 PM ET

👉 Register:

buff.ly/JWLLBlo
https://www.labroots.com/ms/webinar/hidden-trigger-impurity-cells-notice-even-don-t?campaign=LRsocialBS
www.labroots.com
October 6, 2026 at 4:05 PM
shihcheng.bsky.social
New findings reveal that CD8+ T cell immunity boosts tumor susceptibility to cuproptosis, enhancing antitumor effects. Cuproptotic cells trigger immunogenic death, releasing damage-associated factors. This… PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7
https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7
No description available
www.cell.com
October 6, 2026 at 4:00 PM
sigtrans-sttt.bsky.social
Can anti-BCL2 therapy achieve durable clearance of giant congenital melanocytic nevus?

BCL2 inhibition targets senescent and proliferative cells while inducing neutrophil extracellular traps and T-cell responses.

STTT #OpenAccess: doi.org/10.1038/s413...
#Apoptosis #CancerTherapy
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction
October 6, 2026 at 3:45 PM
zimmermanv66.bsky.social
www.sciencedaily.com/releases/202...
Cancer-fighting t cells burn out. Scientists may have found a fix
Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Cent...
www.sciencedaily.com
October 6, 2026 at 3:33 PM
rheumnow.bsky.social
T-cell engager blinatumomab (CD3xCD19 TCE) was used for Deep B-cell depletion in 15 resistant RA pts (MDR-RA). @wk 12 9/15 CDAI LDA, 3/15 CDAI remission. Synovial B cells were depleted (4 of 5 biopsies) but not in lymph nodes. Later, 14/15 flared. No ICANs, 3/15 w/ CRS (gr 1) buff.ly/OUB8fgN
Low-dose blinatumomab in multidrug-resistant rheumatoid arthritis—a case series
T-cell engagers (TCEs) are well-established treatments in haematology; strategies in autoimmune diseases are evolving. As an alternative to high-dose protocols optimising depletion, lower-dose…
buff.ly
October 6, 2026 at 3:01 PM
science.org
How does the body balance immune response and tissue damage during a #parasite infection?

A new Science #Immunology study in helminth-infected mice shows dermal #gdTcells that migrate to the lung activate immune pathways that protect tissues. https://scim.ag/4hrcdvD
Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection
Lung anthelmintic responses during hookworm infection are regulated by skin-derived γδ T cells.
scim.ag
October 6, 2026 at 3:00 PM
cp-cell.bsky.social
Now online! Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis
Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis
A CRISPR screen of solute carriers reveals that T cells depend on SLC52A3 for VB2 uptake, whereas tumors preferentially exploit SLC52A2 to outcompete them, thereby driving T cell ferroptosis. Enforced SLC52A3 overexpression in T cells reverses this metabolic competition and enhances their antitumor activity.
dlvr.it
October 6, 2026 at 2:59 PM
markfortner.bsky.social
Cancer fighting T-Cells burn out. Scientists may have found a fix | #cancer #io #biosky #genesky
Cancer-fighting t cells burn out. Scientists may have found a fix
Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Cent...
www.sciencedaily.com
October 6, 2026 at 2:31 PM
dkfz.bsky.social
Scientists from Heidelberg University Hospital and DKFZ have now developed an innovative approach to CAR-T cell therapies: They are targeting proteins that, while not typical cancer drivers, are present in large quantities on the surface of cancer cells.
t1p.de/ala4u
A Matter of Quantity: A Universal Target for CAR-T Cells Against Cancer
CAR-T cell therapies have proven successful in treating several types of blood and lymphoid cancers. However, their use in treating other tumors is significantly more challenging, in part because suit...
t1p.de
October 6, 2026 at 2:01 PM
thelancetrheum.bsky.social
Read it in full here ➡️bit.ly/4rMqjLy
CAR T cells for autoimmune diseases: 2026 update of the EBMT–ISCT–JACIE practice harmonisation and consensus recommendations
Autoimmune diseases are a heterogeneous group of chronic diseases characterised by loss of immune tolerance with substantial morbidity and mortality. Since 2021, chimeric antigen receptor (CAR) T cell...
bit.ly
October 6, 2026 at 1:49 PM
thelancetrheum.bsky.social
Read the update in full here ➡️bit.ly/4rMqjLy
October 6, 2026 at 1:48 PM
thelancetrheum.bsky.social
NEW—CAR T cells for autoimmune diseases: 2026 update of the EBMT–ISCT–JACIE practice harmonisation and consensus recommendations bit.ly/4rMqjLy
#MedSky #RheumSky #NeuroSky #HaemSky
October 6, 2026 at 1:46 PM
normative.bsky.social
A fun detail: Poirot repeatedly describes the Macho Jesus his leetle grey cells dreamed up as like a “Mustang.” You might think this is merely weird and homoerotic, but it’s actually linked to a bit of misinformation evangelicals like to use to retcon Jesus as a high-T alpha male.
friendlyatheist.com Hemant Mehta @friendlyatheist.com · 3h
Gabe Poirot says he spent 18 days in Heaven and met a Jesus who was six feet tall, made of fire, and overflowing with testosterone.

Fox treated this as news.

There's no evidence of this. Just a deeply manipulative story and a book to promote.

www.friendlyatheist.com/p/a-christia...
A Christian influencer says he went to Heaven and met a testosterone-fueled Jesus
Gabe Poirot says he met a fiery, muscular, intolerant Jesus. Fox News is helping amplify the story.
www.friendlyatheist.com
October 6, 2026 at 1:29 PM
cancer-lr.bsky.social
Gene‑modified CAR T cell therapies are transforming cancer treatment, but variability and manufacturing challenges remain. Discover high‑throughput strategies to characterize CAR T cells—activation, memory, exhaustion, cytokines, and killing. buff.ly/kbahSQo
Phenotypic and Functional Characterization of CAR-T Cells to Support Robust Cell Therapy Research
www.labroots.com
October 6, 2026 at 12:37 PM
inthelab-lr.bsky.social
Gene‑modified CAR T cell therapies are transforming cancer treatment, but variability and manufacturing challenges remain. Discover high‑throughput strategies to characterize CAR T cells—activation, memory, exhaustion, cytokines, and killing. buff.ly/kbahSQo
Phenotypic and Functional Characterization of CAR-T Cells to Support Robust Cell Therapy Research
www.labroots.com
October 6, 2026 at 12:37 PM
drugdiscovery-lr.bsky.social
Gene‑modified CAR T cell therapies are transforming cancer treatment, but variability and manufacturing challenges remain. Discover high‑throughput strategies to characterize CAR T cells—activation, memory, exhaustion, cytokines, and killing. buff.ly/kbahSQo
Phenotypic and Functional Characterization of CAR-T Cells to Support Robust Cell Therapy Research
buff.ly
October 6, 2026 at 12:37 PM
biotech-lr.bsky.social
Gene‑modified CAR T cell therapies are transforming cancer treatment, but variability and manufacturing challenges remain. Discover high‑throughput strategies to characterize CAR T cells—activation, memory, exhaustion, cytokines, and killing. buff.ly/kbahSQo
Phenotypic and Functional Characterization of CAR-T Cells to Support Robust Cell Therapy Research
www.labroots.com
October 6, 2026 at 12:37 PM
labroots.bsky.social
Gene‑modified CAR T cell therapies are transforming cancer treatment, but variability and manufacturing challenges remain. Discover high‑throughput strategies to characterize CAR T cells—activation, memory, exhaustion, cytokines, and killing. buff.ly/kbahSQo
Phenotypic and Functional Characterization of CAR-T Cells to Support Robust Cell Therapy Research
buff.ly
October 6, 2026 at 12:37 PM
diagnostics-lr.bsky.social
Gene‑modified CAR T cell therapies are transforming cancer treatment, but variability and manufacturing challenges remain. Discover high‑throughput strategies to characterize CAR T cells—activation, memory, exhaustion, cytokines, and killing. buff.ly/kbahSQo
Phenotypic and Functional Characterization of CAR-T Cells to Support Robust Cell Therapy Research
www.labroots.com
October 6, 2026 at 12:37 PM
yokoyama-ryo.bsky.social
Sensitive detection of chloroplast movements through changes in leaf cross-polarized reflectance academic.oup.com/plphys/artic... @plantphys.bsky.social
Sensitive detection of chloroplast movements through changes in leaf cross-polarized reflectance
Abstract. We show that the positioning of chloroplasts in plant cells affects the ability of photosynthetic organs to depolarize linearly polarized light t
academic.oup.com
October 6, 2026 at 12:29 PM
mid-citiesmedical.bsky.social
The thymus acts as a training center for T cells, helping the immune system protect us from infections and disease. Researchers are continuing to uncover just how important this small organ may be throughout life. #health #wellness #midcitiesmed
Professor Thymus
The thymus may not be a well-known organ, but it plays a big role in helping keep you healthy. Studies suggest that boosting its activity may help the body fight disease.
newsinhealth.nih.gov
October 6, 2026 at 11:48 AM
ibgunduz.bsky.social
🔬Across 147 immune cell methylomes, it found CEBP and ETS activity in myeloid cells, resolved the naive-to-memory trajectory in CD4+ T cells (AP-1 as memory regulators), and works on sparse single-cell methylomes too.
October 6, 2026 at 11:31 AM
acir-org.bsky.social
Malinconico et al. engineered T cells with both a CAR targeting CD176 (expressed in NSCLC and other tumors), and an inducible cassette encoding either IL-18 or IL-12 that would be expressed following CAR activation of NF-κB.   @aacrjournals.bsky.social
bit.ly/4rFOStG
October 6, 2026 at 11:30 AM
teamevozilla.bsky.social
Nice:

The measles virus infects and destroys memory T and B cells, wiping out 11% to 75% of a person's pre-existing immunological memory pool.

MAGAts will have a hard time...
October 6, 2026 at 11:28 AM