New study @biorxivpreprint
We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems!
www.biorxiv.org/content/10.1...
#GNN #MolecularDynamics #StructuralBiology
We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems!
www.biorxiv.org/content/10.1...
#GNN #MolecularDynamics #StructuralBiology
June 19, 2025 at 8:09 PM
New study @biorxivpreprint
We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems!
www.biorxiv.org/content/10.1...
#GNN #MolecularDynamics #StructuralBiology
We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems!
www.biorxiv.org/content/10.1...
#GNN #MolecularDynamics #StructuralBiology
Vai tnsc. Me diz como tem país que só chove praticamente e o gramado é perfeito... cidade como Londres, ahhh vtfd
September 4, 2024 at 11:19 PM
Vai tnsc. Me diz como tem país que só chove praticamente e o gramado é perfeito... cidade como Londres, ahhh vtfd
Ou seja vão rebentar com o TNSC que já andava nas lonas 🤡 Oh PQP ...
O Teatro Nacional de São Carlos, os museus nacionais de Arqueologia e do Traje e o Laboratório José de Figueiredo estão entre os organismos que mais perdem financiamento na reprogramação do Plano de Recuperação e Resiliência (PRR) na Cultura
Reprogramação do PRR retira verbas a museus, laboratórios e teatros nacionais
O Teatro Nacional de São Carlos, os museus nacionais de Arqueologia e do Traje e o Laboratório José de Figueiredo estão entre os organismos que mais perdem financiamento na reprogramação do Plano de Recuperação e Resiliência (PRR) na Cultura. Mas a A ministra da área garante que "nunca ficarão por concluir" as obras e que serão aplicadas "todas as verbas" do Plano de Recuperação e Resiliência
expresso.pt
May 28, 2025 at 4:08 PM
Ou seja vão rebentar com o TNSC que já andava nas lonas 🤡 Oh PQP ...
H3ロケットの発射台の後ろに避雷鉄塔を建てました！
本物とは形が違いますが、雰囲気は出てると思います！👍
もうちょっと改良しようかな🤔
#クリエイティブスペース #クリスペ #PSO2_NGS #pso2 #JAXA #PSO2_NGS_SS #H3ロケット #種子島宇宙センター #TNSC
本物とは形が違いますが、雰囲気は出てると思います！👍
もうちょっと改良しようかな🤔
#クリエイティブスペース #クリスペ #PSO2_NGS #pso2 #JAXA #PSO2_NGS_SS #H3ロケット #種子島宇宙センター #TNSC
February 29, 2024 at 9:01 AM
H3ロケットの発射台の後ろに避雷鉄塔を建てました！
本物とは形が違いますが、雰囲気は出てると思います！👍
もうちょっと改良しようかな🤔
#クリエイティブスペース #クリスペ #PSO2_NGS #pso2 #JAXA #PSO2_NGS_SS #H3ロケット #種子島宇宙センター #TNSC
本物とは形が違いますが、雰囲気は出てると思います！👍
もうちょっと改良しようかな🤔
#クリエイティブスペース #クリスペ #PSO2_NGS #pso2 #JAXA #PSO2_NGS_SS #H3ロケット #種子島宇宙センター #TNSC
Publication by the Jinek lab ( @martinjinek.bsky.social ) w/ 1st author Giada Finocchio "Structural basis of TnsC oligomerization and transposase recruitment in type I-B CRISPR-associated transposons" in Nucleic Acids Research ( @narjournal.bsky.social )
buff.ly/dblniWn
@irmaquerques.bsky.social
buff.ly/dblniWn
@irmaquerques.bsky.social
March 21, 2025 at 8:00 AM
Publication by the Jinek lab ( @martinjinek.bsky.social ) w/ 1st author Giada Finocchio "Structural basis of TnsC oligomerization and transposase recruitment in type I-B CRISPR-associated transposons" in Nucleic Acids Research ( @narjournal.bsky.social )
buff.ly/dblniWn
@irmaquerques.bsky.social
buff.ly/dblniWn
@irmaquerques.bsky.social
Here you can see a cryoEM structure of TnsC from the cyanobacteria Peltigera membranacea in complex to dsDNA and ADP (PDB code: 9G0F)
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #transposon #dna #binding #atp #cyanobacteria #cryoEM
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #transposon #dna #binding #atp #cyanobacteria #cryoEM
November 20, 2025 at 10:11 AM
Here you can see a cryoEM structure of TnsC from the cyanobacteria Peltigera membranacea in complex to dsDNA and ADP (PDB code: 9G0F)
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #transposon #dna #binding #atp #cyanobacteria #cryoEM
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #transposon #dna #binding #atp #cyanobacteria #cryoEM
5/8 This "super-ring" clamps the targeting complex and fixes the integration site 49 nt away. The transposase (TnsAB) arrives next, dangling by tiny C-terminal "hooks" 🪝 off the TnsC ring.
May 21, 2026 at 9:17 PM
5/8 This "super-ring" clamps the targeting complex and fixes the integration site 49 nt away. The transposase (TnsAB) arrives next, dangling by tiny C-terminal "hooks" 🪝 off the TnsC ring.
Vai tnsc kkkkkk😹😹😹
September 2, 2024 at 8:16 PM
Vai tnsc kkkkkk😹😹😹
4/8 The machine operates through a cascade of fidelity checkpoints 🔒🔒🔒. First the Cascade-TniQ complex forms a complete R-loop. The Cas8 subunit rotates ~90° to lock onto the target DNA, only then does TnsC assemble into a heptameric ring 💍 around the downstream DNA, contacting both TniQ and Cas8.
May 21, 2026 at 9:17 PM
4/8 The machine operates through a cascade of fidelity checkpoints 🔒🔒🔒. First the Cascade-TniQ complex forms a complete R-loop. The Cas8 subunit rotates ~90° to lock onto the target DNA, only then does TnsC assemble into a heptameric ring 💍 around the downstream DNA, contacting both TniQ and Cas8.
I have a theory that 67 is part of Jung's collective unconscious because how is it possible a 2013 VN did this to me......
June 10, 2026 at 2:35 AM
I have a theory that 67 is part of Jung's collective unconscious because how is it possible a 2013 VN did this to me......
Don't think Court can do that. Usually up to the state bar association, which like most self-regulated professional associations is reluctant to seriously penalize one of their members.
Unless TNSC finds him in criminal contempt. Then they could jail his ass. But that's not gonna happen.
Unless TNSC finds him in criminal contempt. Then they could jail his ass. But that's not gonna happen.
September 10, 2026 at 8:07 PM
Don't think Court can do that. Usually up to the state bar association, which like most self-regulated professional associations is reluctant to seriously penalize one of their members.
Unless TNSC finds him in criminal contempt. Then they could jail his ass. But that's not gonna happen.
Unless TNSC finds him in criminal contempt. Then they could jail his ass. But that's not gonna happen.
I’m delighted to be at the Centro Cultural de Belém for the Teatro Nacional de São Carlos’ holiday concert or Ponchielli’s Messa. Never heard it before. With d’Eça, Kang, Caoduro, the Coro do TNSC & Orquestra Sinfónica Portuguesa conducted by Pirolli
December 21, 2025 at 4:44 PM
I’m delighted to be at the Centro Cultural de Belém for the Teatro Nacional de São Carlos’ holiday concert or Ponchielli’s Messa. Never heard it before. With d’Eça, Kang, Caoduro, the Coro do TNSC & Orquestra Sinfónica Portuguesa conducted by Pirolli
anyway, I'm a detective www.youtube.com/watch?v=tNSc...
10cc Somewhere In Hollywood
YouTube video by OldMisterTime
www.youtube.com
January 30, 2025 at 6:28 AM
anyway, I'm a detective www.youtube.com/watch?v=tNSc...
This meme has been appropriated for the cause.
Signed,
TNSC
Signed,
TNSC
September 28, 2025 at 1:32 PM
This meme has been appropriated for the cause.
Signed,
TNSC
Signed,
TNSC
I’m delighted to be at the Teatro Camões for the Teatro Nacional de São Carlos concert performance of Britten’s War Requiem. With Sequeira, Dos Santos, Baleiro, the Coro do TNSC, Coro da Escola de Música do Colégio Moderno, Orquestra Sinfónica Portuguesa. Jenkins conducts
January 18, 2025 at 6:20 PM
I’m delighted to be at the Teatro Camões for the Teatro Nacional de São Carlos concert performance of Britten’s War Requiem. With Sequeira, Dos Santos, Baleiro, the Coro do TNSC, Coro da Escola de Música do Colégio Moderno, Orquestra Sinfónica Portuguesa. Jenkins conducts
Structural basis of TnsC oligomerization and transposase recruitment in type I-B CRISPR-associated transposons pubmed.ncbi.nlm.nih.gov/40103227/ #cryoem
March 21, 2025 at 2:20 AM
Structural basis of TnsC oligomerization and transposase recruitment in type I-B CRISPR-associated transposons pubmed.ncbi.nlm.nih.gov/40103227/ #cryoem
SEO ARROMBADO
QUANDO É CONTRA A GENTE "SEM QUERER TAMBÉM É FALTA"
DAI A FAVOR não pq foi sem intenção
VAI TNSC!
QUANDO É CONTRA A GENTE "SEM QUERER TAMBÉM É FALTA"
DAI A FAVOR não pq foi sem intenção
VAI TNSC!
March 23, 2026 at 12:50 AM
SEO ARROMBADO
QUANDO É CONTRA A GENTE "SEM QUERER TAMBÉM É FALTA"
DAI A FAVOR não pq foi sem intenção
VAI TNSC!
QUANDO É CONTRA A GENTE "SEM QUERER TAMBÉM É FALTA"
DAI A FAVOR não pq foi sem intenção
VAI TNSC!
6/8 But hooks alone aren't enough ⚡. TnsB's beta-barrel domain must physically dock onto TnsC and grab the target DNA — triggering an allosteric relay that orders disordered domains, remodels the catalytic site by ~11 Å, and switches TnsB on for DNA integration. No target = no chemistry.
May 21, 2026 at 9:17 PM
6/8 But hooks alone aren't enough ⚡. TnsB's beta-barrel domain must physically dock onto TnsC and grab the target DNA — triggering an allosteric relay that orders disordered domains, remodels the catalytic site by ~11 Å, and switches TnsB on for DNA integration. No target = no chemistry.
Graph Attention Neural Networks Reveal TnsC Filament Assembly in a CRISPR-Associated Transposon https://www.biorxiv.org/content/10.1101/2025.06.17.659969v1
June 18, 2025 at 3:48 AM
Graph Attention Neural Networks Reveal TnsC Filament Assembly in a CRISPR-Associated Transposon https://www.biorxiv.org/content/10.1101/2025.06.17.659969v1
Hi!
I'm a #DeidaraBotchi.
That is the trajectory of the Fifth #H3Rocket ...! 🚀
#TanegashimaSpaceCenter #TNSC #種子島宇宙センター #JAXA #宇宙航空研究開発機構 #H3ロケット
#佐多岬
#Kimotsuki #KimotsukiGun #KimotsukiDistrict #肝属郡
#Kagoshima #鹿児島
#Japan #JapanTravel #日本
#Nuidori #ぬい撮り
#NeedleFelt #NeedleFeltTravel
#Travel
I'm a #DeidaraBotchi.
That is the trajectory of the Fifth #H3Rocket ...! 🚀
#TanegashimaSpaceCenter #TNSC #種子島宇宙センター #JAXA #宇宙航空研究開発機構 #H3ロケット
#佐多岬
#Kimotsuki #KimotsukiGun #KimotsukiDistrict #肝属郡
#Kagoshima #鹿児島
#Japan #JapanTravel #日本
#Nuidori #ぬい撮り
#NeedleFelt #NeedleFeltTravel
#Travel
February 19, 2025 at 10:09 AM
Hi!
I'm a #DeidaraBotchi.
That is the trajectory of the Fifth #H3Rocket ...! 🚀
#TanegashimaSpaceCenter #TNSC #種子島宇宙センター #JAXA #宇宙航空研究開発機構 #H3ロケット
#佐多岬
#Kimotsuki #KimotsukiGun #KimotsukiDistrict #肝属郡
#Kagoshima #鹿児島
#Japan #JapanTravel #日本
#Nuidori #ぬい撮り
#NeedleFelt #NeedleFeltTravel
#Travel
I'm a #DeidaraBotchi.
That is the trajectory of the Fifth #H3Rocket ...! 🚀
#TanegashimaSpaceCenter #TNSC #種子島宇宙センター #JAXA #宇宙航空研究開発機構 #H3ロケット
#佐多岬
#Kimotsuki #KimotsukiGun #KimotsukiDistrict #肝属郡
#Kagoshima #鹿児島
#Japan #JapanTravel #日本
#Nuidori #ぬい撮り
#NeedleFelt #NeedleFeltTravel
#Travel
TNSCさんなんか射場の裏側どんどこ上げてくれて眼福なのでほんと勿体無い......
ボイロ関係ももっときて欲しいですね！
ボイロ関係ももっときて欲しいですね！
June 4, 2026 at 5:10 PM
TNSCさんなんか射場の裏側どんどこ上げてくれて眼福なのでほんと勿体無い......
ボイロ関係ももっときて欲しいですね！
ボイロ関係ももっときて欲しいですね！