Starship is go for propellant load ahead of attempt 3 for flight 10 with Booster 16 and Ship 37, weather currently 55% go for launch in just under an hour.
www.youtube.com/watch?v=TpmT...
www.youtube.com/watch?v=TpmT...
August 26, 2025 at 10:32 PM
Starship is go for propellant load ahead of attempt 3 for flight 10 with Booster 16 and Ship 37, weather currently 55% go for launch in just under an hour.
www.youtube.com/watch?v=TpmT...
www.youtube.com/watch?v=TpmT...
C'est pas juste 30€ pour un tpmt ? Et après tarif Taxi classique
September 27, 2026 at 1:31 PM
C'est pas juste 30€ pour un tpmt ? Et après tarif Taxi classique
Third time's a charm, they say. Following two scrubs, join us 🔴LIVE🔴 on Tuesday, August 26th, from 3:30 p.m. CDT / 20:30 UTC as SpaceX attempts to launch Starship Flight 10!
www.youtube.com/watch?v=TpmT...
www.youtube.com/watch?v=TpmT...
SpaceX Starship Flight 10 - Third Attempt
YouTube video by NASASpaceflight
www.youtube.com
August 26, 2025 at 2:06 PM
Third time's a charm, they say. Following two scrubs, join us 🔴LIVE🔴 on Tuesday, August 26th, from 3:30 p.m. CDT / 20:30 UTC as SpaceX attempts to launch Starship Flight 10!
www.youtube.com/watch?v=TpmT...
www.youtube.com/watch?v=TpmT...
New genetic variant affecting chemotherapy metabolism identified, more common in individuals of African ancestry.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Genotype and Phenotype Correlation of the TPMT∗8 Allele in Thiopurine Metabolism
Thiopurine 6-mercaptopurine (6-MP) is metabolized by thiopurine methyl transferase (TPMT). TPMT genetic variation results in some individuals having r…
www.sciencedirect.com
December 10, 2024 at 6:44 PM
New genetic variant affecting chemotherapy metabolism identified, more common in individuals of African ancestry.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Jason Xu (@stjuderesearch.bsky.social) reports on impact of VNTR in TPMT promoter region (beyond coding variants in TPMT). Hypothesis: ↑ VNTR repeats associated w/ ↓ enzymatic activity of TPMT & ↑myelosuppression 2/2 thiopurines. Genotype pipeline below. Allele types vary w/ ancestry. (1/2) #ASH25
December 6, 2025 at 9:22 PM
Jason Xu (@stjuderesearch.bsky.social) reports on impact of VNTR in TPMT promoter region (beyond coding variants in TPMT). Hypothesis: ↑ VNTR repeats associated w/ ↓ enzymatic activity of TPMT & ↑myelosuppression 2/2 thiopurines. Genotype pipeline below. Allele types vary w/ ancestry. (1/2) #ASH25
TPMT (Touche Pas à Ma Tourangelle)!!!
March 2, 2024 at 1:00 PM
TPMT (Touche Pas à Ma Tourangelle)!!!
Come visit us at stand X7 at #Biomedica today! We had a brilliant time yesterday and we're looking forward to the day ahead. We hope to see you there.
#Biomedica2025 #Genseq #Cardiology #singlegenetests #DPYD #TPMT #HFE #TTR #CYP2C19 #Conventioncentredublin #oncology #cardiology#DNA #RNA
#Biomedica2025 #Genseq #Cardiology #singlegenetests #DPYD #TPMT #HFE #TTR #CYP2C19 #Conventioncentredublin #oncology #cardiology#DNA #RNA
March 20, 2025 at 11:47 AM
Come visit us at stand X7 at #Biomedica today! We had a brilliant time yesterday and we're looking forward to the day ahead. We hope to see you there.
#Biomedica2025 #Genseq #Cardiology #singlegenetests #DPYD #TPMT #HFE #TTR #CYP2C19 #Conventioncentredublin #oncology #cardiology#DNA #RNA
#Biomedica2025 #Genseq #Cardiology #singlegenetests #DPYD #TPMT #HFE #TTR #CYP2C19 #Conventioncentredublin #oncology #cardiology#DNA #RNA
Genotype and Phenotype Correlation of the TPMT∗8 Allele in Thiopurine Metabolism
“…a TPMT∗1/∗8 diplotype displayed reduced 6-MP metabolism between that of normal metabolizers and intermediate metabolizers, suggesting that TPMT∗8 is a reduced function allele.”
www.jmdjournal.org/article/S152...
“…a TPMT∗1/∗8 diplotype displayed reduced 6-MP metabolism between that of normal metabolizers and intermediate metabolizers, suggesting that TPMT∗8 is a reduced function allele.”
www.jmdjournal.org/article/S152...
DEFINE_ME
www.jmdjournal.org
November 18, 2024 at 10:39 PM
Genotype and Phenotype Correlation of the TPMT∗8 Allele in Thiopurine Metabolism
“…a TPMT∗1/∗8 diplotype displayed reduced 6-MP metabolism between that of normal metabolizers and intermediate metabolizers, suggesting that TPMT∗8 is a reduced function allele.”
www.jmdjournal.org/article/S152...
“…a TPMT∗1/∗8 diplotype displayed reduced 6-MP metabolism between that of normal metabolizers and intermediate metabolizers, suggesting that TPMT∗8 is a reduced function allele.”
www.jmdjournal.org/article/S152...
TPMT fait toujours de la merde.
September 13, 2023 at 8:46 AM
TPMT fait toujours de la merde.
Check out this brief report from #CTSjournal: bit.ly/43xd9rt
June 11, 2025 at 1:02 PM
Check out this brief report from #CTSjournal: bit.ly/43xd9rt
Genseq is delighted to launch our Single Gene Testing service SoloSEQ!🎉 To find out more go to our website 💻 lnkd.in/eSqasvaJ or email us at
support@genseqgroup.com
#singlegenetesting #singlegenetests #DPYD #TPMT #CYP2C19 #HFE #TTR #singlegenetestingservice #ISO15189 #ISO15189accredited #DNA #RNA
support@genseqgroup.com
#singlegenetesting #singlegenetests #DPYD #TPMT #CYP2C19 #HFE #TTR #singlegenetestingservice #ISO15189 #ISO15189accredited #DNA #RNA
March 13, 2025 at 9:21 AM
Genseq is delighted to launch our Single Gene Testing service SoloSEQ!🎉 To find out more go to our website 💻 lnkd.in/eSqasvaJ or email us at
support@genseqgroup.com
#singlegenetesting #singlegenetests #DPYD #TPMT #CYP2C19 #HFE #TTR #singlegenetestingservice #ISO15189 #ISO15189accredited #DNA #RNA
support@genseqgroup.com
#singlegenetesting #singlegenetests #DPYD #TPMT #CYP2C19 #HFE #TTR #singlegenetestingservice #ISO15189 #ISO15189accredited #DNA #RNA
We are proud to further enhance our ISO15189:2022 Accredited (Certified by INAB) offerings to include a significant enhancement of our Hereditary Cancer Testing Offer and the addition of a range of single gene tests including CYP2C19, DPYD, HFE, TPMT and TTR.
#singlegenetesting #hereditarycancer
#singlegenetesting #hereditarycancer
February 13, 2025 at 9:47 AM
We are proud to further enhance our ISO15189:2022 Accredited (Certified by INAB) offerings to include a significant enhancement of our Hereditary Cancer Testing Offer and the addition of a range of single gene tests including CYP2C19, DPYD, HFE, TPMT and TTR.
#singlegenetesting #hereditarycancer
#singlegenetesting #hereditarycancer
January 8, 2025 at 4:52 PM
Interesting tool: Aldy does exact genotyping of highly polymorphic pharmacogenes (CYP2D6, DPYD, TPMT and 30+ others), including phased star-alleles and copy number variation. Works on BAM/CRAM/VCF. #bioinformatics #pharmacogenomics
github.com/0xTCG/aldy
github.com/0xTCG/aldy
GitHub - 0xTCG/aldy: Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes - 0xTCG/aldy
github.com
June 26, 2026 at 11:50 AM
Interesting tool: Aldy does exact genotyping of highly polymorphic pharmacogenes (CYP2D6, DPYD, TPMT and 30+ others), including phased star-alleles and copy number variation. Works on BAM/CRAM/VCF. #bioinformatics #pharmacogenomics
github.com/0xTCG/aldy
github.com/0xTCG/aldy
The CPIC Pharmacogene Curation Expert Panel re-evaluated the star alleles of TPMT and NUDT15, two genes central to the metabolism of thiopurines used in cancer and autoimmune disease.
#pharmacogenomics #PGx #genomics
#pharmacogenomics #PGx #genomics
Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pha
Thiopurine toxicity and dose adjustment · Clin Pharmacol Ther 2026
www.genox-veille.fr
August 17, 2026 at 10:47 AM
The CPIC Pharmacogene Curation Expert Panel re-evaluated the star alleles of TPMT and NUDT15, two genes central to the metabolism of thiopurines used in cancer and autoimmune disease.
#pharmacogenomics #PGx #genomics
#pharmacogenomics #PGx #genomics
The Making of Matsumoto Jun GOO.N / 松本潤 グ～ン メイキングCM
YouTube video by CM DE ARASHI
m.youtube.com
August 12, 2026 at 2:59 PM
TPMT 與 NUDT15 的族群方向
TPMT 失能等位基因主要好發於歐洲人與非洲人（歐洲人帶因率約 10%）。
NUDT15 變異主要好發於亞洲人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞 —— 寫反就是錯的。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
TPMT 失能等位基因主要好發於歐洲人與非洲人（歐洲人帶因率約 10%）。
NUDT15 變異主要好發於亞洲人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞 —— 寫反就是錯的。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
August 3, 2026 at 2:03 PM
TPMT 與 NUDT15 的族群方向
TPMT 失能等位基因主要好發於歐洲人與非洲人（歐洲人帶因率約 10%）。
NUDT15 變異主要好發於亞洲人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞 —— 寫反就是錯的。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
TPMT 失能等位基因主要好發於歐洲人與非洲人（歐洲人帶因率約 10%）。
NUDT15 變異主要好發於亞洲人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞 —— 寫反就是錯的。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
TPMT 與 NUDT15 的族群分布
TPMT 變異多見於歐洲人與非洲人（異型合子約 10%）。
NUDT15 變異多見於亞洲人，尤其華人與日本人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞。台日已把 NUDT15 檢測納入 ALL 標準流程。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
TPMT 變異多見於歐洲人與非洲人（異型合子約 10%）。
NUDT15 變異多見於亞洲人，尤其華人與日本人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞。台日已把 NUDT15 檢測納入 ALL 標準流程。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
August 3, 2026 at 10:48 AM
TPMT 與 NUDT15 的族群分布
TPMT 變異多見於歐洲人與非洲人（異型合子約 10%）。
NUDT15 變異多見於亞洲人，尤其華人與日本人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞。台日已把 NUDT15 檢測納入 ALL 標準流程。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
TPMT 變異多見於歐洲人與非洲人（異型合子約 10%）。
NUDT15 變異多見於亞洲人，尤其華人與日本人，是東亞族群 thiopurine 骨髓毒性的主因。
記法：TPMT 走西方，NUDT15 守東亞。台日已把 NUDT15 檢測納入 ALL 標準流程。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
6-TGN 濃度是一體兩面
太低沒效、太高中毒 —— 骨髓抑制的本質就是 6-TGN 在骨髓過量。
TPMT 把 6-MP 甲基化成無活性的 6-MMP，是分流解毒路徑；TPMT 或 NUDT15 活性低，更多藥物走向 6-TGN。
骨髓抑制與肝毒性的嚴重度與這兩個基因型直接相關。胰臟炎則不是 6-MP 的常見副作用。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
太低沒效、太高中毒 —— 骨髓抑制的本質就是 6-TGN 在骨髓過量。
TPMT 把 6-MP 甲基化成無活性的 6-MMP，是分流解毒路徑；TPMT 或 NUDT15 活性低，更多藥物走向 6-TGN。
骨髓抑制與肝毒性的嚴重度與這兩個基因型直接相關。胰臟炎則不是 6-MP 的常見副作用。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
August 3, 2026 at 2:04 PM
6-TGN 濃度是一體兩面
太低沒效、太高中毒 —— 骨髓抑制的本質就是 6-TGN 在骨髓過量。
TPMT 把 6-MP 甲基化成無活性的 6-MMP，是分流解毒路徑；TPMT 或 NUDT15 活性低，更多藥物走向 6-TGN。
骨髓抑制與肝毒性的嚴重度與這兩個基因型直接相關。胰臟炎則不是 6-MP 的常見副作用。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
太低沒效、太高中毒 —— 骨髓抑制的本質就是 6-TGN 在骨髓過量。
TPMT 把 6-MP 甲基化成無活性的 6-MMP，是分流解毒路徑；TPMT 或 NUDT15 活性低，更多藥物走向 6-TGN。
骨髓抑制與肝毒性的嚴重度與這兩個基因型直接相關。胰臟炎則不是 6-MP 的常見副作用。
#血液專科
https://hema-2026.hsiehting.com/q/113-074
6-MP 的三條代謝路徑
HGPRT 活化 → 生成 thioguanine nucleotide（TGN），併入 DNA 造成鹼基錯配。
TPMT 甲基化 → 去活化。
黃嘌呤氧化酶（XO）氧化 → 去活化。
去活化路徑失能，TGN 就會積聚而造成骨髓抑制 —— 這也是為什麼併用 allopurinol 要減量。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
HGPRT 活化 → 生成 thioguanine nucleotide（TGN），併入 DNA 造成鹼基錯配。
TPMT 甲基化 → 去活化。
黃嘌呤氧化酶（XO）氧化 → 去活化。
去活化路徑失能，TGN 就會積聚而造成骨髓抑制 —— 這也是為什麼併用 allopurinol 要減量。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
August 3, 2026 at 10:47 AM
6-MP 的三條代謝路徑
HGPRT 活化 → 生成 thioguanine nucleotide（TGN），併入 DNA 造成鹼基錯配。
TPMT 甲基化 → 去活化。
黃嘌呤氧化酶（XO）氧化 → 去活化。
去活化路徑失能，TGN 就會積聚而造成骨髓抑制 —— 這也是為什麼併用 allopurinol 要減量。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
HGPRT 活化 → 生成 thioguanine nucleotide（TGN），併入 DNA 造成鹼基錯配。
TPMT 甲基化 → 去活化。
黃嘌呤氧化酶（XO）氧化 → 去活化。
去活化路徑失能，TGN 就會積聚而造成骨髓抑制 —— 這也是為什麼併用 allopurinol 要減量。
#血液專科
https://hema-2026.hsiehting.com/q/114-098
Y'all Street Physical Gold ETF (TPMT) holds LBMA Good Delivery gold bars in a segregated vault account and charges a 0.24% annual sponsor fee.
Save What Matters
Curate Feeds | Make Collections | Customize Email Briefs
briefly.co
July 17, 2026 at 6:43 PM
Y'all Street Physical Gold ETF (TPMT) holds LBMA Good Delivery gold bars in a segregated vault account and charges a 0.24% annual sponsor fee.
Phantom BC | Postgame Press Conference | 02.22.26
Watch here: www.youtube.com/watch?v=tpMt...
#BallersNewz #Unrivaled
Watch here: www.youtube.com/watch?v=tpMt...
#BallersNewz #Unrivaled
Aliyah Boston & Head Coach Roneeka Hodges: Phantom BC Postgame vs. Hive BC | Unrivaled 02.22.26
YouTube video by The Ballers Magazine
www.youtube.com
February 23, 2026 at 2:44 PM
Phantom BC | Postgame Press Conference | 02.22.26
Watch here: www.youtube.com/watch?v=tpMt...
#BallersNewz #Unrivaled
Watch here: www.youtube.com/watch?v=tpMt...
#BallersNewz #Unrivaled
Third Party Monitoring Team has issued a grave warning that the peace process in the Bangsamoro region has reached a “perilous juncture,” citing a profound breakdown in trust between the government and the Moro Islamic Liberation Front.
mindanaogoldstardaily.com/archives/151...
#GoldStarDailyNews
mindanaogoldstardaily.com/archives/151...
#GoldStarDailyNews
Trust deficit puts Bangsamoro peace at risk, monitors warn
THE Third Party Monitoring Team (TPMT) has issued a grave warning that the peace process in the Bangsamoro region has reached a “perilous juncture,” citing a profound breakdown in trust between the Ph...
mindanaogoldstardaily.com
August 29, 2025 at 6:02 AM
Third Party Monitoring Team has issued a grave warning that the peace process in the Bangsamoro region has reached a “perilous juncture,” citing a profound breakdown in trust between the government and the Moro Islamic Liberation Front.
mindanaogoldstardaily.com/archives/151...
#GoldStarDailyNews
mindanaogoldstardaily.com/archives/151...
#GoldStarDailyNews
ClinPGx Blog: Correction to CPIC Guideline for TPMT, NUDT15 and Thiopurines
Correction to CPIC Guideline for TPMT, NUDT15 and Thiopurines
A correction to Table 1 of the "Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update" was published in Clinical Pharmacology and Therapeutics.
An individual carrying one no function allele plus one decreased function allele is an Intermediate Metabolizer (IM), not a Possible Intermediate Metabolizer as shown in the original table. The therapeutic recommendations for TPMT IMs and Possible IMs are the same. The
blog.clinpgx.org
May 14, 2026 at 6:03 AM
ClinPGx Blog: Correction to CPIC Guideline for TPMT, NUDT15 and Thiopurines