Order Human Tau-441 (2N4R) P301S Mutant PFFs (SPR-329) from StressMarq. High-quality reagents for neurodegenerative disease research.

The circadian clock protein REV-ERBα has been implicated in neuroinflammation but mechanisms are poorly understood. Here, the authors show that microglial REV-ERBα regulates inflammatory signaling and...

Recombinant Tau-441 from rPeptide. High quality, >90% purity, batch to batch consistency. In stock and ready to ship - order online today.

FITC Tau-441 Preformed Fibrils from rPeptide. In stock and ready to ship. High purity, batch to batch consistency. Order online today.

Recombinant FITC Tau-441 from rPeptide. High quality, >90% purity, batch to batch consistency. In stock and ready to ship - order online today.

StressMarq's Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils expressed in Baculovirus can be used for Alzheimer's and Parkinson's disease research.

Misfolded neurotoxic proteins, such as Tau protein, spread within the brain in many neurodegenerative diseases. Receptors play an important role in th…

Aggregation of the protein tau is a key pathological hallmark of tauopathies such as Alzheimer’s Disease. Tau dissociates from microtubules and diffuses from the axon into the soma-dendritic compartment, where it aggregates firstly into oligomers ...

Park et al. demonstrate in tauopathy models that tau disrupts the interaction between neuronal nitric oxide synthase and PSD95, uncoupling glutamatergic synaptic activity from nitric oxide production ...

Tauopathy, including Alzheimer’s disease, is the most prevalent neurodegenerative disorder, yet current therapies fail to halt disease progression, partly because of limited understanding of early tau...

Sleep disturbances frequently occur early in dementias such as Alzheimer's disease (AD) and potentially arise from many factors including cortico-thal…

The circadian clock protein REV-ERBα has been implicated in neuroinflammation but mechanisms are poorly understood. Here, the authors show that microglial REV-ERBα regulates inflammatory signaling and...

Read the full paper: The truncated Tau fragment 315-441 produced by Caspase-2 translocates to the nucleus and alters the proteome of neuroblastoma cells

Buy high-quality Tau-441 recombinant protein from rPeptide for Alzheimer’s and neurodegenerative research. Reliable purity for laboratory research and in-vitro studies.

Misfolded neurotoxic proteins, such as Tau protein, spread within the brain in many neurodegenerative diseases. Receptors play an important role in th…

Recombinant Tau-441, P301L Mutant from rPeptide. High quality, >90% purity, batch to batch consistency. In stock and ready to ship - order online today.

Tau protein, a microtubule-binding protein, is an important biomarker of Alzheimer’s disease (AD). Sensitive and accurate detection of Tau is crucial for the diagnosis and treatment of AD. Even though both immunoassays and mass spectrometry have revealed their advantages in biofluid Tau measurement, significant variation exists among results from different assays due to variability in selectivity or calibrators, which underlines the importance of establishing a traceability chain for Tau measurements. The development of Tau-related certified reference material (CRM) and the establishment of traceability could help to standardize clinical result variation, which could further provide an opportunity for unifying clinical diagnosis interval and cutoff values. In this study, Tau-441 solution CRM (NIM-RM 2901) with the certified value and uncertainty of (74.1 ± 3.6) μg g–1 was developed with high-purity Tau-441 as the raw material. After purity and structure confirmation, three independent isotope dilution mass spectrometry strategies based on amino acids, signature peptides, and sulfur were employed to certify the candidate Tau-441 solution CRM. The candidate Tau-441 CRM showed good homogeneity, and satisfying stability was also demonstrated for at least 7 days at −20 °C and 13 months at −70 °C. The Tau-441 solution CRM (NIM-RM 2901) is primarily intended to be used for value assignment to secondary calibrators or CRMs with clinical matrix, which will help the early diagnosis of AD in the clinic.