Comparing single-cell #SpatialTranscriptomics methods on FFPE human tumor #TissueMicroArray

CosMx 1k vs MERFISH 500 vs Xenium-UM/-MM 339
93 common genes

lung adenocarcinoma
pleural mesothelioma

Corr. Bulk RNAseq, GeoMx

#NatureComms 2025
www.nature.com/articles/s41...

#SpatialTranscriptomics 👤 #Cardiomyopathy #HeartFailure
GeoMx
Cardiomyocyte #EndothelialCell Fibroblast segmented
44👤🫀 #TissueMicroArray

#MyocyteDisarray HCMpEF➡️⏬ribosome
#CardicFibrosis➡️⏫ACKR1+PLVAP+CCL14+ endothelium
UCHL1 PFKFB2 for HF progression

#EHJ 2025
academic.oup.com/eurheartj/ad...

Benchmarking Imaging-based #SpatialTranscriptomics on FFPE #TissueMicroArray

7 tumors + 16 normal tissues

#CosMx 1 panel
#Xenium 3 panels
#MERSCOPE 2 panels
>94 genes overlap

"CosMx transcript counts may be slightly inflated by false discoveries"🤕

bioRxiv 2023
www.biorxiv.org/content/10.1...

🔬🧫🇩🇪 Germany drives precision pathology with growing tissue microarray adoption in cancer research.
#TissueMicroarray #CancerDiagnostics #GermanyBiotech

www.marketresearchfuture.com/reports/germ...