The many (more than I knew!) changes in gastrointestinal function that GLP-1 agonists can cause are not uncommon side effects, & may require adaptions in management of certain poisoned patients given anticipated rise in the use of these agents & their potential to alter toxicokinetics of other drugs
GLP-1 drugs such as Wegovy and Mounjaro can cause dramatic changes in GI motility and function, as well as dehydration and malnutrition. Will this change the way we treat poisoned patients on these meds?
journals.lww.com/em-news/full...
journals.lww.com/em-news/full...
journals.lww.com
October 15, 2025 at 8:37 PM
The many (more than I knew!) changes in gastrointestinal function that GLP-1 agonists can cause are not uncommon side effects, & may require adaptions in management of certain poisoned patients given anticipated rise in the use of these agents & their potential to alter toxicokinetics of other drugs
Saw an article title with the word "toxicokinetics" and brain went "tacokinetics" I might want tacos?
September 25, 2026 at 4:03 PM
Saw an article title with the word "toxicokinetics" and brain went "tacokinetics" I might want tacos?
🤖 Can AI help fill the gaps in environmental exposure assessment?
This Review explores AI/ML for predicting toxicokinetic and ADME parameters of environmental chemicals.
⏩ www.oaepublish.com/articles/jee...
#AI #Toxicokinetics #ExposureAssessment
This Review explores AI/ML for predicting toxicokinetic and ADME parameters of environmental chemicals.
⏩ www.oaepublish.com/articles/jee...
#AI #Toxicokinetics #ExposureAssessment
September 28, 2026 at 2:56 AM
🤖 Can AI help fill the gaps in environmental exposure assessment?
This Review explores AI/ML for predicting toxicokinetic and ADME parameters of environmental chemicals.
⏩ www.oaepublish.com/articles/jee...
#AI #Toxicokinetics #ExposureAssessment
This Review explores AI/ML for predicting toxicokinetic and ADME parameters of environmental chemicals.
⏩ www.oaepublish.com/articles/jee...
#AI #Toxicokinetics #ExposureAssessment
Keith LS, Jones DE, Chou CH. Aluminum toxicokinetics regarding infant diet and vaccinations. Vaccine. 2002 May 31;20 Suppl 3:S13-7. doi: 10.1016/s0264-410x(02)00165-2. PMID: 12184359.
January 30, 2025 at 3:06 AM
Keith LS, Jones DE, Chou CH. Aluminum toxicokinetics regarding infant diet and vaccinations. Vaccine. 2002 May 31;20 Suppl 3:S13-7. doi: 10.1016/s0264-410x(02)00165-2. PMID: 12184359.
🌍 Our team had the privilege to showcase our latest advances in developing #NAMs under the equator at #WC13! ✨
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
September 18, 2025 at 12:34 PM
🌍 Our team had the privilege to showcase our latest advances in developing #NAMs under the equator at #WC13! ✨
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
• The vaccine-autism narrative is a decoy. The real driver of population-scale neurodevelopmental disruption is food-linked toxicokinetics; Primarily UMFA and secondarily certain other fortification and chemical exposures.
June 11, 2025 at 5:19 PM
• The vaccine-autism narrative is a decoy. The real driver of population-scale neurodevelopmental disruption is food-linked toxicokinetics; Primarily UMFA and secondarily certain other fortification and chemical exposures.
@georgaichinger.bsky.social & @profshana.bsky.social presented at #ICT2025 in Beijing! 🌏
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
October 29, 2025 at 1:36 PM
@georgaichinger.bsky.social & @profshana.bsky.social presented at #ICT2025 in Beijing! 🌏
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
Our study provides a new window into understanding the toxicokinetics of PFAS and a step towards development of scalable biotechnological solutions for PFAS removal. Thanks to fantastic team members, especially first-author Anna Lindell, and all collaborators for making this possible.
July 2, 2025 at 2:57 PM
Our study provides a new window into understanding the toxicokinetics of PFAS and a step towards development of scalable biotechnological solutions for PFAS removal. Thanks to fantastic team members, especially first-author Anna Lindell, and all collaborators for making this possible.
We welcome a new project to OpenSustain.tech #climate #sustainability #opensource #opensustain #openscience github.com/USEPA/CompTo...
GitHub - USEPA/CompTox-ExpoCast-httk: The R package "httk" provides free, open-source data and models for toxicokinetics. The models are designed to use chemical-specific in vitro (animal free) measur...
The R package "httk" provides free, open-source data and models for toxicokinetics. The models are designed to use chemical-specific in vitro (animal free) measurements. The predictions c...
github.com
June 17, 2025 at 5:43 PM
We welcome a new project to OpenSustain.tech #climate #sustainability #opensource #opensustain #openscience github.com/USEPA/CompTo...
Masson JD, Crépeaux G, Authier FJ, Exley C, Gherardi RK. Critical analysis of reference studies on the toxicokinetics of aluminum-based adjuvants. J Inorg Biochem. 2018 Apr;181:87-95. doi: 10.1016/j.jinorgbio.2017.12.015. Epub 2017 Dec 28. PMID: 29307441.
January 30, 2025 at 3:06 AM
Masson JD, Crépeaux G, Authier FJ, Exley C, Gherardi RK. Critical analysis of reference studies on the toxicokinetics of aluminum-based adjuvants. J Inorg Biochem. 2018 Apr;181:87-95. doi: 10.1016/j.jinorgbio.2017.12.015. Epub 2017 Dec 28. PMID: 29307441.
link.springer.com/article/10.1... New commentary in JMT. Deserves the attention of researchers, clinicians, & policymakers @acmt.bsky.social
The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Pharmacokinetics and Toxicokinetics: Is a New Diagnostic and Therapeutic Framework Needed? - Journal of Medical Toxicology
Journal of Medical Toxicology -
link.springer.com
April 16, 2025 at 9:34 PM
link.springer.com/article/10.1... New commentary in JMT. Deserves the attention of researchers, clinicians, & policymakers @acmt.bsky.social
A very good question.
Max is about 1100 μg/day at 95th percentile (1st reference)
Louie F (2021) doi.org/10.1016/j.fc...
Vicini JL (2021) doi.org/10.1111/1541...
Connolly A (2022) doi.org/10.3390/toxi...
(just a few above) note: toxicokinetics & bioavailability additionally important (below RfD)
Max is about 1100 μg/day at 95th percentile (1st reference)
Louie F (2021) doi.org/10.1016/j.fc...
Vicini JL (2021) doi.org/10.1111/1541...
Connolly A (2022) doi.org/10.3390/toxi...
(just a few above) note: toxicokinetics & bioavailability additionally important (below RfD)
Redirecting
doi.org
December 22, 2024 at 8:05 PM
A very good question.
Max is about 1100 μg/day at 95th percentile (1st reference)
Louie F (2021) doi.org/10.1016/j.fc...
Vicini JL (2021) doi.org/10.1111/1541...
Connolly A (2022) doi.org/10.3390/toxi...
(just a few above) note: toxicokinetics & bioavailability additionally important (below RfD)
Max is about 1100 μg/day at 95th percentile (1st reference)
Louie F (2021) doi.org/10.1016/j.fc...
Vicini JL (2021) doi.org/10.1111/1541...
Connolly A (2022) doi.org/10.3390/toxi...
(just a few above) note: toxicokinetics & bioavailability additionally important (below RfD)
Just finished my post about reduction reactions during biotransformation in toxicokinetics if anyone’s wondering how exciting my night has been.
September 29, 2023 at 4:41 AM
Just finished my post about reduction reactions during biotransformation in toxicokinetics if anyone’s wondering how exciting my night has been.
🧪 How can we better predict PFAS accumulation across a lifetime?
An updated toxicokinetic model incorporates key exposure pathways to simulate serum concentrations of bioaccumulative PFAS.
⏩ doi.org/10.20517/jee...
#PFAS #Toxicokinetics #ExposureScience #Bioaccumulation
An updated toxicokinetic model incorporates key exposure pathways to simulate serum concentrations of bioaccumulative PFAS.
⏩ doi.org/10.20517/jee...
#PFAS #Toxicokinetics #ExposureScience #Bioaccumulation
September 3, 2026 at 2:59 AM
🧪 How can we better predict PFAS accumulation across a lifetime?
An updated toxicokinetic model incorporates key exposure pathways to simulate serum concentrations of bioaccumulative PFAS.
⏩ doi.org/10.20517/jee...
#PFAS #Toxicokinetics #ExposureScience #Bioaccumulation
An updated toxicokinetic model incorporates key exposure pathways to simulate serum concentrations of bioaccumulative PFAS.
⏩ doi.org/10.20517/jee...
#PFAS #Toxicokinetics #ExposureScience #Bioaccumulation
Ummm did she pass out too cuz…
![Toxicokinetics
Go to: V
Absorption: Chloroform is absorbed through the skin, respiratory tract, and gastrointestinal tract. 23]|4]
Distribution: Chloroform is distributed throughout the body via the
bloodstream. Chloroform penetrates various tissues, including the liver, kidneys, lungs, and brain. Distribution is influenced by factors such as blood flow, tissue composition, and lipid solubility.
Metabolism: Chloroform primarily undergoes oxidative or reductive metabolism in the liver.
The cytochrome P450 2E1 enzyme system facilitates this process, breaking chloroform down into phosgene, hydrochloric acid, dichloromethane, and carbon monoxide. Phosgene, a product of oxidative metabolism, can further react with water to generate carbon dioxide and hydrogen chloride or form covalent bonds with tissue macromolecules.[15] These metabolites, exhibiting higher solubility in water than chloroform, are more readily eliminated from the body. In cases where oxygen is unavailable, chloroform undergoes reductive metabolism.[14] The primary metabolite produced via reduction is the dichloromethyl free radical, which causes lipid peroxidation.
Elimination: Chloroform and its metabolites are eliminated from the body through various routes. Although the primary route of elimination is pulmonary exhalation, chloroform can also be eliminated in small amounts through feces and urine. 17] When circulating in the
hloodstroam chloroform and ite anidio mataholitec mnderon filtration hu the Lidnovc and ora](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:dexu6ofbn4sf6xkophj7xmme/bafkreievmkklcllxwqfkvy7iercuplen47ikahfznzgpuymr7wyv4zngki)
November 19, 2025 at 8:40 PM
Ummm did she pass out too cuz…
Pharmacologic & toxicologic confounders in brain death determination
🧠 coma
🧠 BD & death by neurologic criteria
💉 controversies in existing BD declaration guidelines
🚧 PK & PD challenges: hypothermia, organ failure, obesity, prolonged infusions, toxicokinetics
🛟 ancillary testing
🔓 rdcu.be/e0C9u
🧠 coma
🧠 BD & death by neurologic criteria
💉 controversies in existing BD declaration guidelines
🚧 PK & PD challenges: hypothermia, organ failure, obesity, prolonged infusions, toxicokinetics
🛟 ancillary testing
🔓 rdcu.be/e0C9u
January 25, 2026 at 1:00 PM
Pharmacologic & toxicologic confounders in brain death determination
🧠 coma
🧠 BD & death by neurologic criteria
💉 controversies in existing BD declaration guidelines
🚧 PK & PD challenges: hypothermia, organ failure, obesity, prolonged infusions, toxicokinetics
🛟 ancillary testing
🔓 rdcu.be/e0C9u
🧠 coma
🧠 BD & death by neurologic criteria
💉 controversies in existing BD declaration guidelines
🚧 PK & PD challenges: hypothermia, organ failure, obesity, prolonged infusions, toxicokinetics
🛟 ancillary testing
🔓 rdcu.be/e0C9u
Last week, the ARET-SFTG-STCM Colloquium on Perinatal Health & Toxic Environments brought together cutting-edge research at @upjv-univ.bsky.social. Our PhD student Hélène Bigonne took home a best oral presentation award for her talk on toxicokinetics in pediatric populations and female tissues 🏆!
May 26, 2026 at 11:15 AM
Last week, the ARET-SFTG-STCM Colloquium on Perinatal Health & Toxic Environments brought together cutting-edge research at @upjv-univ.bsky.social. Our PhD student Hélène Bigonne took home a best oral presentation award for her talk on toxicokinetics in pediatric populations and female tissues 🏆!
Session 5 of #EnvChem2025 is Chemical Sensing, Bioavailability, and Toxicokinetics in Complex Matrices, chaired by Dr Rowena Fletcher-Wood. The first speaker is Adam Peters with "Metal Bioavailability: The rocky road from academic model to routine regulatory implementation
June 13, 2025 at 10:18 AM
Session 5 of #EnvChem2025 is Chemical Sensing, Bioavailability, and Toxicokinetics in Complex Matrices, chaired by Dr Rowena Fletcher-Wood. The first speaker is Adam Peters with "Metal Bioavailability: The rocky road from academic model to routine regulatory implementation
Not even all doctors have that power, which is why pharmacists exist.
That it’s exactly the same discipline as toxicokinetics is not a new discovery, that the only difference medicine and poison is the dose was common knowledge in ancient Greek writings.
That it’s exactly the same discipline as toxicokinetics is not a new discovery, that the only difference medicine and poison is the dose was common knowledge in ancient Greek writings.
December 9, 2024 at 9:57 PM
Not even all doctors have that power, which is why pharmacists exist.
That it’s exactly the same discipline as toxicokinetics is not a new discovery, that the only difference medicine and poison is the dose was common knowledge in ancient Greek writings.
That it’s exactly the same discipline as toxicokinetics is not a new discovery, that the only difference medicine and poison is the dose was common knowledge in ancient Greek writings.
Chicken or egg?
Do placental features change metal toxicokinetics, or do metal exposures change placental features? Or yes?
Cool paper at the link below. Cell type deconvolutions are the first step in thinking rather than the last step in bias removal.
www.sciencedirect.com/science/arti...
Do placental features change metal toxicokinetics, or do metal exposures change placental features? Or yes?
Cool paper at the link below. Cell type deconvolutions are the first step in thinking rather than the last step in bias removal.
www.sciencedirect.com/science/arti...
Placental cellular composition and umbilical cord tissue metal(loid) concentrations: A descriptive molecular epidemiology study leveraging DNA methylation
The placenta is a mixture of cell types, which may regulate maternal-fetal transfer of exogenous chemicals or become altered in response to exposures.…
www.sciencedirect.com
February 20, 2025 at 5:01 PM
Chicken or egg?
Do placental features change metal toxicokinetics, or do metal exposures change placental features? Or yes?
Cool paper at the link below. Cell type deconvolutions are the first step in thinking rather than the last step in bias removal.
www.sciencedirect.com/science/arti...
Do placental features change metal toxicokinetics, or do metal exposures change placental features? Or yes?
Cool paper at the link below. Cell type deconvolutions are the first step in thinking rather than the last step in bias removal.
www.sciencedirect.com/science/arti...
Correctly mentioning FDA standard for injected aluminum, mentions Flarand rabbit study. Uses a study from a group of people anti-vaccine activists like, rather than other studies: pubmed.ncbi.nlm.nih.gov/29307441/
Critical analysis of reference studies on the toxicokinetics of aluminum-based adjuvants - PubMed
We reviewed the three toxicokinetic reference studies commonly used to suggest that aluminum (Al)-based adjuvants are innocuous. A single experimental study was carried out using isotopic 26Al (Flarend et al., Vaccine, 1997). This study used aluminum salts resembling those used in vaccines but ignor …
pubmed.ncbi.nlm.nih.gov
December 5, 2025 at 8:08 PM
Correctly mentioning FDA standard for injected aluminum, mentions Flarand rabbit study. Uses a study from a group of people anti-vaccine activists like, rather than other studies: pubmed.ncbi.nlm.nih.gov/29307441/
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
On August 10, 2026, the Organisation for Economic Co-operation and Development (OECD) posted a Guidance Document on Toxicokinetics to accommodate...
www.jdsupra.com
September 15, 2026 at 4:07 PM
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
On August 10, 2026, the Organisation for Economic Co-operation and Development (OECD) posted a Guidance Document on Toxicokinetics to accommodate...
www.jdsupra.com
September 15, 2026 at 4:07 PM
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
On August 10, 2026, the Organisation for Economic Co-operation and Development (OECD) posted a Guidance Document on Toxicokinetics to accommodate...
www.jdsupra.com
September 15, 2026 at 4:07 PM
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
B&C's Nano and Other Emerging Chemical Technologies Blog: OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
www.lawbc.com/oecd-posts-g...
#OECD, #toxicokinetics
www.lawbc.com/oecd-posts-g...
#OECD, #toxicokinetics
OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles - Bergeson & Campbell, P.C.
On August 10, 2026, the Organisation for Economic Co-operation and Development (OECD) posted a Guidance Document on Toxicokinetics to accommodate Testing
www.lawbc.com
September 14, 2026 at 9:51 PM
B&C's Nano and Other Emerging Chemical Technologies Blog: OECD Posts Guidance Document on Toxicokinetics to Accommodate Testing of (Nano)particles
www.lawbc.com/oecd-posts-g...
#OECD, #toxicokinetics
www.lawbc.com/oecd-posts-g...
#OECD, #toxicokinetics