What makes CLDN7 lose its #TumorSuppressive power?
This study shows that APT1-driven #depalmitoylation destabilizes CLDN7, promoting #ccRCC invasion and revealing APT1 inhibition as a potential therapy. @pku1898.bsky.social
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This study shows that APT1-driven #depalmitoylation destabilizes CLDN7, promoting #ccRCC invasion and revealing APT1 inhibition as a potential therapy. @pku1898.bsky.social
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
October 8, 2026 at 4:20 PM
What makes CLDN7 lose its #TumorSuppressive power?
This study shows that APT1-driven #depalmitoylation destabilizes CLDN7, promoting #ccRCC invasion and revealing APT1 inhibition as a potential therapy. @pku1898.bsky.social
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This study shows that APT1-driven #depalmitoylation destabilizes CLDN7, promoting #ccRCC invasion and revealing APT1 inhibition as a potential therapy. @pku1898.bsky.social
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This review highlights miR-23b as a versatile post-transcriptional regulator in #cancer, influencing #oncogenic and #TumorSuppressive pathways, affecting prognosis across multiple tumor types, and emerging as a promising therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
May 16, 2026 at 6:01 PM
This review highlights miR-23b as a versatile post-transcriptional regulator in #cancer, influencing #oncogenic and #TumorSuppressive pathways, affecting prognosis across multiple tumor types, and emerging as a promising therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review examines the roles of #LKB1/STK11 in #cancer, detailing its #TumorSuppressive functions, regulation via #AMPK signaling and #AdaptorProteins, and discusses the challenges of developing LKB1-targeted inhibitors. @westernu.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 24, 2025 at 4:34 PM
This review examines the roles of #LKB1/STK11 in #cancer, detailing its #TumorSuppressive functions, regulation via #AMPK signaling and #AdaptorProteins, and discusses the challenges of developing LKB1-targeted inhibitors. @westernu.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
“PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression”
PGC1 represses HIF signaling via ERR-driven EGLN1 transcriptional induction, expanding its #TumorSuppressive role in #PCa ⤵️
nature.com/articles/s41...
PGC1 represses HIF signaling via ERR-driven EGLN1 transcriptional induction, expanding its #TumorSuppressive role in #PCa ⤵️
nature.com/articles/s41...
PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression - Cell Death & Differentiation
Cell Death & Differentiation - PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression
nature.com
September 22, 2026 at 1:20 PM
“PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression”
PGC1 represses HIF signaling via ERR-driven EGLN1 transcriptional induction, expanding its #TumorSuppressive role in #PCa ⤵️
nature.com/articles/s41...
PGC1 represses HIF signaling via ERR-driven EGLN1 transcriptional induction, expanding its #TumorSuppressive role in #PCa ⤵️
nature.com/articles/s41...
This review highlights FTO as a key #m6A demethylase shaping #cancer biology, outlining its dual #oncogenic and #TumorSuppressive roles and emphasizing its emerging potential as a therapeutic target across malignancies.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
April 29, 2026 at 3:31 PM
This review highlights FTO as a key #m6A demethylase shaping #cancer biology, outlining its dual #oncogenic and #TumorSuppressive roles and emphasizing its emerging potential as a therapeutic target across malignancies.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...