#UKBB
LightNews LightNews
finngen.bsky.social
Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals.
Browse scans at: mvp-ukbb.finngen.fi
December 5, 2024 at 12:53 PM
airplane-pictures.net
#Antonov #An-26 (all models), #Ukraine - Air Force (02) by Oleksii Karpenko (#Kyiv - Borispol) #Military #aviation #photography #avgeeks
Ukraine - Air Force Antonov An-26 (all models) 02 at Kyiv - Borispol KBP / UKBB (Photo by Oleksii Karpenko)
Photo of 02 Antonov An-26 (all models) of Ukraine - Air Force at KBP / UKBB Kyiv - Borispol - Ukraine © Oleksii Karpenko Mar 3rd 2021
airplane-pictures.net
June 13, 2026 at 9:44 PM
kcklatt.bsky.social
It is amazing to watch the public dataset mining (NHANES, UKBB) published in pay-to-play journals cover hot topics (e.g., urinary glyphosate measures) that get shared online and fuel the wellness influencer ecosystem (e.g., glyphosate is killing us, support MAHA and buy my detox). Burn it all down
March 16, 2026 at 6:08 PM
kauralasoo.bsky.social
Maybe UKBB Nightingale NMR GWAS from @pietznerm.bsky.social and Claudia Langenberg's labs (www.medrxiv.org/content/10.1...) and our UKBB + EstBB meta-analysis (www.medrxiv.org/content/10.1...)?
February 13, 2025 at 4:26 PM
stairwaytokevin.bsky.social
Wow, the Guardian journalists who just yesterday published about the network of race scientists getting funding from tech CEOs just broke another story that this group has accessed UK Biobank data without authorization. This is seriously bad for the integrity of science & a massive failure by UKBB
‘Race science’ group say they accessed sensitive UK health data
Exclusive: Fringe network recorded boasting of securing data from UK Biobank trove donated by 500,000 volunteers
www.theguardian.com
October 17, 2024 at 3:40 PM
kauralasoo.bsky.social
I would also add UKBB + MVP + FinnGen meta-analysis for a subset of harmonized traits:
mvp-ukbb.finngen.fi
mvp-ukbb.finngen.fi
February 17, 2025 at 5:11 PM
noodisnoo.bsky.social
Grüsse aus der Koje Nr. C17 - Notfall UKBB 🤪

Wurde mit der Sanität aus dem Grossraumbüro abgeholt… Resultate sind noch ausstehend.
October 6, 2023 at 12:30 PM
nate-carter.bsky.social
This #UKFB season has been brutal but Pope has softened the blow and I can’t wait to shift my full sports focus to #UKBB. We’re in for a special season on the hardwood. #BBN
November 24, 2024 at 12:39 AM
airplane-pictures.net
#Boeing #737-800, #Ukraine International Airlines (UR-PSF) by Oleksii Karpenko (#Kyiv - Borispol) #Airliners #aviation #photography #avgeeks
Boeing 737-800 photo by Oleksii Karpenko
Ukraine International Airlines | Boeing | 737-800 | UR-PSF | Ukraine, Kyiv - Borispol (KBP - UKBB) | Photo taken by Oleksii Karpenko
airplane-pictures.net
October 4, 2025 at 2:37 PM
finngen.bsky.social
Kindly note that the URLs for our publicly available meta-analysis result browsers have been updated.

The browsers are now accessible at:

➡️FinnGen + pan-UKBB meta-analysis results: public-metaresults-fg-ukbb.finngen.fi

➡️FinnGen-MVP-UKBB meta-analysis results: public-mvp-ukbb.finngen.fi
finngen.bsky.social FinnGen @finngen.bsky.social · Dec 5
Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals.
Browse scans at: mvp-ukbb.finngen.fi
December 22, 2025 at 9:16 AM
tomayates.bsky.social
There are going to be an awful lot of analyses that need redone when people finally accept that collider bias is a major issue in unweighted analyses of UKBB data
Reweighting UK Biobank corrects for pervasive selection bias due to volunteering
AbstractBackground. Biobanks typically rely on volunteer-based sampling. This results in large samples (power) at the cost of representativeness (bias). Th
share.google
July 15, 2025 at 11:51 AM
dalygene.bsky.social
As @kauralasoo.bsky.social points out rs10305492 (A316T) is a lights out conclusively fine-mapped (PIP>0.99) for lower glucose and HbA1c in UKBB & FinnGen - T2D protective in multi-biobank mvp-ukbb.finngen.fi/variant/6:39...
mvp-ukbb.finngen.fi
January 10, 2025 at 4:30 PM
airplane-pictures.net
From our #eyecatcher archive: #Airbus #A321, #Turkish Airlines (TC-JRF) photographed by Vladyslav Gasianets (#Kyiv - Borispol) #Airliners #aviation #photography #avgeeks #planespotting
Airbus A321 photographed by Vladyslav Gasianets
Turkish Airlines | Airbus | A321 | TC-JRF | Ukraine, Kyiv - Borispol (KBP - UKBB) | Photo taken by Vladyslav Gasianets
airplane-pictures.net
December 26, 2024 at 10:01 PM
goboru.bsky.social
One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX.
Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
We show that the X chromosome, understudied in genome-wide association studies, contributes to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full X inactivation bal...
www.cell.com
June 6, 2025 at 9:32 AM
chundru.bsky.social
Using our DNANexus applet it is fast and not too expensive to QC and convert the entire UK Biobank WGS files to pgens! github.com/chundruv/ukb...

And for All of Us v8, we will provide you with the QC’ed pgen files on publication in a public workspace available to registered users.
GitHub - chundruv/ukbb_pvcf2pgen: UKBB pVCF to plink pgen conversion
UKBB pVCF to plink pgen conversion. Contribute to chundruv/ukbb_pvcf2pgen development by creating an account on GitHub.
github.com
November 8, 2025 at 9:31 AM
natureportfolio.nature.com
A study in Nature Medicine shows that a meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors had superior performance in predicting the 10-year risk of coronary artery disease. go.nature.com/4igXqAJ 🔒
This is figure 1, which gives an overview of cohort construction, model development and performance assessment for 10-year incident CAD risk meta-prediction in the UKBB.
April 21, 2025 at 4:38 PM
bigearthdata.ai
Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization
->Nature | #MachineLearning | More info from EcoSearch
Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization
CDTs were created from the UKBB and an independent clinical validation dataset. The UKBB is an open-access resource accessed under application number 88878. Ethical approval was obtained from the Northwest Research Ethics Committee (REC reference: 11/ NW/0382), and written consent...
www.nature.com
May 17, 2025 at 2:00 AM
klehto.bsky.social
We’re hiring: 1 PhD + 1 postdoc for a new ERC-funded project on ADHD features in adults.

We’ll use rich biobank data (Estonian Biobank, UKBB + partners): symptoms + EHRs + 🧬 to understand what’s driving rising diagnosis rates.

Info: genomics.ut.ee/en/content/p...

📍 Tartu, Estonia — pls share!
PhD positions 2026
We are looking for a motivated PhD candidates to join our institute!
genomics.ut.ee
February 2, 2026 at 12:00 PM
godswrath699.bsky.social
youtube.com/watch?v=uKbB...

Legal AF 🚨🚨🚨🚨
Trump FACES Historical DEMISE as His TERM CRASHES
YouTube video by Legal AF
youtube.com
October 2, 2025 at 1:33 AM
ptenigma.bsky.social
🔥Structural and functional brain maps in people with major depression
🔥Brain maps in multiple independent cohorts suggest regionally specific hypoperfusion in major depressive disorder; a new multivariate index - "ReHo-based RVI" - shows promise in studying MDD:
jamanetwork.com/journals/jam...
In this case-control study including a total of 15 501 participants from 4 datasets, the ReHo/regional cerebral blood flow (RCBF) deficits in individuals with MDD had effect sizes that were 2 to 3 times stronger than those with deficits in regional cortical thickness. The effect sizes for functional regional vulnerability index (RVI) were larger than the effect sizes for any individual regions measured in independent datasets, and the RVI-MDD calculated for ReHo and RCBF data showed similar effect sizes that were stronger than the MDD structural RVI. The pattern of regional effect sizes, represented by Cohen d, of MDD on regional cortical thickness reported by ENIGMA was significantly correlated with that observed in UKBB and ACP cohorts. The main novel finding is that the cortical pattern of reduced ReHo for MDD derived from the UKBB was significantly correlated with the cortical patterns of reduced ReHo and/or reduced RCBF in independent groups, ie, a non–treatment-seeking rural population sample in ACP and a patient sample with MDD seeking specialty treatment in ACI.
April 7, 2025 at 3:50 AM
sashagusevposts.bsky.social
I think this is the first null UKBB GWAS I've ever seen. It's actually pretty impressive in it's own way.
October 7, 2023 at 12:07 PM
kauralasoo.bsky.social
The p-value for obesity is even smaller in the UKBB+FinnGen+MVP meta-analysis!
public-mvp-ukbb.finngen.fi/variant/6-39...
April 8, 2026 at 5:40 PM
kauralasoo.bsky.social
Parquet works really well with R as well. I use it all the time to work with GWAS summary statistics that won't fit into memory (our latest metabolite GWAS tested 95M+ variants in UKBB). Here's a minimal example of how to filter data on the fly while reading into R: gist.github.com/kauralasoo/f...
Filtering parquet files with dplyr
GitHub Gist: instantly share code, notes, and snippets.
gist.github.com
September 3, 2025 at 3:01 PM
obialik.bsky.social
Genetic Attraction might really be a thing, or at least it looks like people have some tendency to choose to partner up with people who are at least somewhat genetically similar to them (at least at the trait level). 🧪

Link: ​https://www.nature.com/articles/s41562-026-02556-8
a. Genetic assortative mating rank in the UK (UKBB) and Estonia (EstBB). b. Genetic assortative mating rank vs. different traits in the two populations.
August 29, 2026 at 1:59 AM
kkumar.bsky.social
"Gene dosage architecture across complex traits".

Excited to share our work led by the excellent @KazemSayeh (joint co-author).

We will post a detailed 🧵 in the coming days. Please reach out if you have any questions.

www.medrxiv.org/content/10.1...

#CNVs #GeneDosage #UKBB
February 27, 2025 at 1:46 PM