#PCBCommunity |🧬El @cnag-eu.bsky.social identifica una nova variant homozigota en el gen #VLDLR associada a la malaltia rara #CAMRQ1 que contribueix a comprendre-la millor i aporta nous coneixements que podrien ajudar a millorar-ne el diagnòstic i el tractament en el futur. 💜
👉 tinyurl.com/bdu8tyz9
👉 tinyurl.com/bdu8tyz9
November 4, 2026 at 11:50 AM
#PCBCommunity |🧬El @cnag-eu.bsky.social identifica una nova variant homozigota en el gen #VLDLR associada a la malaltia rara #CAMRQ1 que contribueix a comprendre-la millor i aporta nous coneixements que podrien ajudar a millorar-ne el diagnòstic i el tractament en el futur. 💜
👉 tinyurl.com/bdu8tyz9
👉 tinyurl.com/bdu8tyz9
💜 New advances on #RareDiseases
🧬 A study led by Dr Pedro Rodríguez (CNAG) reports the 1st genetically cases of CAMRQ1 in Africa, revealing a novel variant in the VLDLR gene and providing insights that could improve future diagnosis and treatment
📎 www.cnag.eu/news/researc...
🧬 A study led by Dr Pedro Rodríguez (CNAG) reports the 1st genetically cases of CAMRQ1 in Africa, revealing a novel variant in the VLDLR gene and providing insights that could improve future diagnosis and treatment
📎 www.cnag.eu/news/researc...
November 3, 2026 at 8:37 AM
💜 New advances on #RareDiseases
🧬 A study led by Dr Pedro Rodríguez (CNAG) reports the 1st genetically cases of CAMRQ1 in Africa, revealing a novel variant in the VLDLR gene and providing insights that could improve future diagnosis and treatment
📎 www.cnag.eu/news/researc...
🧬 A study led by Dr Pedro Rodríguez (CNAG) reports the 1st genetically cases of CAMRQ1 in Africa, revealing a novel variant in the VLDLR gene and providing insights that could improve future diagnosis and treatment
📎 www.cnag.eu/news/researc...
The authors included RRIDs in their in The FASEB Journal paper! Thanks for making your methods matter! #BetterScience #OpenScience #reproducibility
Ceapin-A7 Suppresses UPR Signaling and Mitigates Retinal Neovascularization in Vldlr−/− Mice
Read the full paper: Ceapin-A7 Suppresses UPR Signaling and Mitigates Retinal Neovascularization in Vldlr−/− Mice
doi.org
October 3, 2026 at 7:00 AM
The authors included RRIDs in their in The FASEB Journal paper! Thanks for making your methods matter! #BetterScience #OpenScience #reproducibility
RRIDs were included in this in Investigative Ophthalmology & Visual Science paper. RRIDs improve reproducibility in scientific research. #OpenResearch #OpenScience #ReproducibleResearch
Single-Nucleus RNA Sequencing Highlights Endothelial and Müller Cell ER Stress During Retinal Neovascularization in Vldlr–/– Mouse
Read the full paper: Single-Nucleus RNA Sequencing Highlights Endothelial and Müller Cell ER Stress During Retinal Neovascularization in Vldlr–/– Mouse
doi.org
September 16, 2026 at 7:41 PM
RRIDs were included in this in Investigative Ophthalmology & Visual Science paper. RRIDs improve reproducibility in scientific research. #OpenResearch #OpenScience #ReproducibleResearch
Jonathan H. Lin et al. from Stanford University use single-nucleus RNA sequencing to highlight endothelial and Müller cell ER stress during retinal neovascularization in Vldlr–/– mice.
doi.org/10.1167/iovs.67.11.21
doi.org/10.1167/iovs.67.11.21
September 11, 2026 at 2:21 PM
Jonathan H. Lin et al. from Stanford University use single-nucleus RNA sequencing to highlight endothelial and Müller cell ER stress during retinal neovascularization in Vldlr–/– mice.
doi.org/10.1167/iovs.67.11.21
doi.org/10.1167/iovs.67.11.21
SIRT6 physically binds to PPARγ & suppress its transcriptional activity on Fatty acid metabolic genes (CD36, caveolin-1, FATP1, FABP3, VLDLR)
⬇️PPARγ occupancy at target gene promoters, independent of H3K9 and H3K56 acetylation
#CellRep 2021
www.sciencedirect.com/science/arti...
⬇️PPARγ occupancy at target gene promoters, independent of H3K9 and H3K56 acetylation
#CellRep 2021
www.sciencedirect.com/science/arti...
August 21, 2026 at 12:27 PM
SIRT6 physically binds to PPARγ & suppress its transcriptional activity on Fatty acid metabolic genes (CD36, caveolin-1, FATP1, FABP3, VLDLR)
⬇️PPARγ occupancy at target gene promoters, independent of H3K9 and H3K56 acetylation
#CellRep 2021
www.sciencedirect.com/science/arti...
⬇️PPARγ occupancy at target gene promoters, independent of H3K9 and H3K56 acetylation
#CellRep 2021
www.sciencedirect.com/science/arti...
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus: www.cell.com/cell/fulltex...
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus
Cryo-electron microscopy and structure-guided mutagenesis experiments show that Western
equine encephalitis virus (WEEV) engages distinct host receptors (VLDLR, PCDH10, and
avian MXRA8) through a shar...
www.cell.com
April 4, 2025 at 5:51 PM
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus: www.cell.com/cell/fulltex...
VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
www.nature.com/articles/s41...
www.nature.com/articles/s41...
VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier - Nature Communications
The authors present that encephalitic Semliki Forest virus uses choroid plexus epithelial cells as neuroinvasion pathway in mice and show that entry is specifically dependent on expression of very low...
www.nature.com
December 23, 2024 at 4:14 PM
VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Now online! Structural basis for plasticity in receptor engagement by an encephalitic alphavirus
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus
Cryo-electron microscopy and structure-guided mutagenesis experiments show that Western equine encephalitis virus (WEEV) engages distinct host receptors (VLDLR, PCDH10, and avian MXRA8) through a shared surface near the fusion loop of E1. Structural and evolutionary analyses facilitate the design of a sparrow PCDH10-Fc decoy that protects against all WEEV strains tested.
dlvr.it
April 4, 2025 at 3:00 PM
Now online! Structural basis for plasticity in receptor engagement by an encephalitic alphavirus
Nature research paper: Multiple LDLR family members act as entry receptors for yellow fever virus
go.nature.com/3L9hquu
go.nature.com/3L9hquu
Multiple LDLR family members act as entry receptors for yellow fever virus - Nature
The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.
go.nature.com
November 4, 2025 at 11:02 AM
Nature research paper: Multiple LDLR family members act as entry receptors for yellow fever virus
go.nature.com/3L9hquu
go.nature.com/3L9hquu
#NatMicroPicks
Cracking the code of Yellow Fever Virus entry! 🔑🧪
YFV uses multiple LDL receptor family members, including LRP4, LRP1, and VLDLR, as entry receptors, offering new targets for antiviral strategies
#MicroSky #VirusSky
www.nature.com/articles/s41...
Cracking the code of Yellow Fever Virus entry! 🔑🧪
YFV uses multiple LDL receptor family members, including LRP4, LRP1, and VLDLR, as entry receptors, offering new targets for antiviral strategies
#MicroSky #VirusSky
www.nature.com/articles/s41...
Multiple LDLR family members act as entry receptors for yellow fever virus - Nature
The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.
www.nature.com
November 20, 2025 at 5:46 PM
#NatMicroPicks
Cracking the code of Yellow Fever Virus entry! 🔑🧪
YFV uses multiple LDL receptor family members, including LRP4, LRP1, and VLDLR, as entry receptors, offering new targets for antiviral strategies
#MicroSky #VirusSky
www.nature.com/articles/s41...
Cracking the code of Yellow Fever Virus entry! 🔑🧪
YFV uses multiple LDL receptor family members, including LRP4, LRP1, and VLDLR, as entry receptors, offering new targets for antiviral strategies
#MicroSky #VirusSky
www.nature.com/articles/s41...
ICYMI: New online! Unlocking entry for yellow fever virus
Unlocking entry for yellow fever virus
Nature Reviews Microbiology, Published online: 11 November 2025; doi:10.1038/s41579-025-01265-9This study identifies multiple low-density lipoprotein receptor family members, including LRP4, LRP1 and VLDLR, as entry receptors for yellow fever virus.
www.nature.com
November 18, 2025 at 9:43 PM
ICYMI: New online! Unlocking entry for yellow fever virus
New online! Unlocking entry for yellow fever virus
Unlocking entry for yellow fever virus
Nature Reviews Microbiology, Published online: 11 November 2025; doi:10.1038/s41579-025-01265-9This study identifies multiple low-density lipoprotein receptor family members, including LRP4, LRP1 and VLDLR, as entry receptors for yellow fever virus.
www.nature.com
November 11, 2025 at 9:42 PM
New online! Unlocking entry for yellow fever virus
#NeovascularAgerelatedMacularDegeneration #nAMD
APEX1 redox-specific inhibitor APX2009 (intravitreal) ⏬🐭👁️pathological #Angiogenesis
Laser-induced #ChoroidNeoVascularization
Vldlr-/- mouse subretinal neovascularization
Timothy Corson lab #Angiogenesis 2025
link.springer.com/article/10.1...
APEX1 redox-specific inhibitor APX2009 (intravitreal) ⏬🐭👁️pathological #Angiogenesis
Laser-induced #ChoroidNeoVascularization
Vldlr-/- mouse subretinal neovascularization
Timothy Corson lab #Angiogenesis 2025
link.springer.com/article/10.1...
May 23, 2025 at 8:17 PM
#NeovascularAgerelatedMacularDegeneration #nAMD
APEX1 redox-specific inhibitor APX2009 (intravitreal) ⏬🐭👁️pathological #Angiogenesis
Laser-induced #ChoroidNeoVascularization
Vldlr-/- mouse subretinal neovascularization
Timothy Corson lab #Angiogenesis 2025
link.springer.com/article/10.1...
APEX1 redox-specific inhibitor APX2009 (intravitreal) ⏬🐭👁️pathological #Angiogenesis
Laser-induced #ChoroidNeoVascularization
Vldlr-/- mouse subretinal neovascularization
Timothy Corson lab #Angiogenesis 2025
link.springer.com/article/10.1...
Previous studies showed that Semliki Forest virus (SFV) binds the human receptor VLDLR on the E1 glycoprotein, leaving the canonical receptor binding clefts conspicuously empty 🤔 We were scratching our heads until we saw that SFV actually uses its clefts to bind the mosquito receptor Lachesin!
July 30, 2026 at 4:06 PM
Previous studies showed that Semliki Forest virus (SFV) binds the human receptor VLDLR on the E1 glycoprotein, leaving the canonical receptor binding clefts conspicuously empty 🤔 We were scratching our heads until we saw that SFV actually uses its clefts to bind the mosquito receptor Lachesin!
Some WEEV strains and EEEV both bind VLDLR at the LA1 and LA2 domains, suggesting that VLDLR LA1-LA2 decoy receptor may have broad activity against them. This molecule protected mice against lethal challenge by a WEEV strain that binds VLDLR.
April 4, 2025 at 7:59 PM
Some WEEV strains and EEEV both bind VLDLR at the LA1 and LA2 domains, suggesting that VLDLR LA1-LA2 decoy receptor may have broad activity against them. This molecule protected mice against lethal challenge by a WEEV strain that binds VLDLR.
Strains isolated during epidemics of the early 20th century bind VLDLR and ApoER2 as additional receptors. Our structure of a 1941 strain bound by VLDLR revealed a distinct binding mode than other alphaviruses that bind LDLR-related proteins, such as EEEV, SFV or VEEV.
April 4, 2025 at 7:59 PM
Strains isolated during epidemics of the early 20th century bind VLDLR and ApoER2 as additional receptors. Our structure of a 1941 strain bound by VLDLR revealed a distinct binding mode than other alphaviruses that bind LDLR-related proteins, such as EEEV, SFV or VEEV.
We also determined structures of an ancestral WEEV strain bound to VLDLR, revealing a distinct binding mode compared to other alphaviruses that bind LDLR-related receptors such as EEEV, SFV, or VEEV, indicating independent evolution of WEEV to bind VLDLR/ApoER2!
January 2, 2025 at 10:25 PM
We also determined structures of an ancestral WEEV strain bound to VLDLR, revealing a distinct binding mode compared to other alphaviruses that bind LDLR-related receptors such as EEEV, SFV, or VEEV, indicating independent evolution of WEEV to bind VLDLR/ApoER2!
One feature that makes EEEV so dangerous is its ability to infect a wide variety organisms--birds, insects, and mammals. This adaptability is thought to be due in part to how it binds to receptors on the cell surface.
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
June 13, 2025 at 4:22 PM
One feature that makes EEEV so dangerous is its ability to infect a wide variety organisms--birds, insects, and mammals. This adaptability is thought to be due in part to how it binds to receptors on the cell surface.
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
model, mice that had been vaccinated had 85% less leakage of blood vessels and 82% less lesion size compared to unvaccinated mice. In the genetic model, the vaccine decreased the area of abnormal vessels by 40% at three weeks and 55% at four weeks. Importantly, treatment also reduced the amount of
March 29, 2026 at 4:08 PM
model, mice that had been vaccinated had 85% less leakage of blood vessels and 82% less lesion size compared to unvaccinated mice. In the genetic model, the vaccine decreased the area of abnormal vessels by 40% at three weeks and 55% at four weeks. Importantly, treatment also reduced the amount of
The receptor VLDLR binds East Equine Encephalitis virus through multiple distinct modes https://www.biorxiv.org/content/10.1101/2023.11.30.569340v1
The receptor VLDLR binds East Equine Encephalitis virus through multiple distinct modes https://www.biorxiv.org/content/10.1101/2023.11.30.569340v1
Eastern Equine Encephalitis virus (EEEV) is an alphavirus that can cause severe diseases in infected
www.biorxiv.org
December 1, 2023 at 2:22 AM
The receptor VLDLR binds East Equine Encephalitis virus through multiple distinct modes https://www.biorxiv.org/content/10.1101/2023.11.30.569340v1
Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus https://www.biorxiv.org/content/10.1101/2023.11.15.567188v1
Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus https://www.biorxiv.org/content/10.1101/2023.11.15.567188v1
The very low-density lipoprotein receptor (VLDLR) is comprised of eight LDLR type A (LA) domains and
www.biorxiv.org
November 16, 2023 at 5:18 AM
Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus https://www.biorxiv.org/content/10.1101/2023.11.15.567188v1
Structural basis for VLDLR recognition by eastern equine encephalitis virus https://www.biorxiv.org/content/10.1101/2023.11.14.567065v1
Structural basis for VLDLR recognition by eastern equine encephalitis virus https://www.biorxiv.org/content/10.1101/2023.11.14.567065v1
Alphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogen
www.biorxiv.org
November 15, 2023 at 4:19 AM
Structural basis for VLDLR recognition by eastern equine encephalitis virus https://www.biorxiv.org/content/10.1101/2023.11.14.567065v1
Structural insights into VLDLR recognition by western equine encephalitis virus
->Nature | #virus | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | #virus | More from Lil Dr Glen EcoChat at BigEarthData.ai
Structural insights into VLDLR recognition by western equine encephalitis virus
Chen, W. et al. Arthritogenic alphaviruses: new insights into arthritis and bone pathology. Trends Microbiol. 23, 35–43 (2015). Powers, A. M. et al. Evolutionary relationships and systematics of the alphaviruses. J. Virol. 75, 10118–10131 (2001). Ronca, S. E., Dineley, K...
www.nature.com
December 6, 2025 at 3:57 PM