Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis - Nature Communications
Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown. Here, the authors report the g...
doi.org
July 26, 2025 at 10:34 PM
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
Feeling the pressure of training? 🤔 Uncover the benefits of Rhodiola and Ashwagandha! Both adaptogens enhance performance, yet they function in distinct ways. See which one is the perfect fit for you. Published 9.5 months ago.
Learn more here: https://dixsupps.com/en/rhodiola-vs-ashwagandha/
Learn more here: https://dixsupps.com/en/rhodiola-vs-ashwagandha/
Rhodiola VS ashwagandha: Mental performance or sleep?
rhodiola vs ashwagandha: comparison of adaptogens for stress, energy, sleep, and recovery. Benefits, dosages, active ingredients (rosavins, withanolides).
dixsupps.com
May 18, 2026 at 8:00 AM
Feeling the pressure of training? 🤔 Uncover the benefits of Rhodiola and Ashwagandha! Both adaptogens enhance performance, yet they function in distinct ways. See which one is the perfect fit for you. Published 9.5 months ago.
Learn more here: https://dixsupps.com/en/rhodiola-vs-ashwagandha/
Learn more here: https://dixsupps.com/en/rhodiola-vs-ashwagandha/
ICYMI: We explored the biosynthesis of withanolides 🧪
Here’s the official press release by @unihannover.bsky.social & @unibonn.bsky.social:
🔗 www.uni-bonn.de/en/news/130-...
📄 Original research: doi.org/10.1038/s414...
#Science #NaturalProducts
@frankelab.bsky.social @puckerlab.bsky.social
Here’s the official press release by @unihannover.bsky.social & @unibonn.bsky.social:
🔗 www.uni-bonn.de/en/news/130-...
📄 Original research: doi.org/10.1038/s414...
#Science #NaturalProducts
@frankelab.bsky.social @puckerlab.bsky.social
July 19, 2025 at 4:46 AM
ICYMI: We explored the biosynthesis of withanolides 🧪
Here’s the official press release by @unihannover.bsky.social & @unibonn.bsky.social:
🔗 www.uni-bonn.de/en/news/130-...
📄 Original research: doi.org/10.1038/s414...
#Science #NaturalProducts
@frankelab.bsky.social @puckerlab.bsky.social
Here’s the official press release by @unihannover.bsky.social & @unibonn.bsky.social:
🔗 www.uni-bonn.de/en/news/130-...
📄 Original research: doi.org/10.1038/s414...
#Science #NaturalProducts
@frankelab.bsky.social @puckerlab.bsky.social
Physalis heterophylla, one of the 94 species of Physalis around the world, many of which are native to North America.
Fascinating research on the withanolides in Physalis.
Edible fruit (dry them and they're sweet).
Fascinating research on the withanolides in Physalis.
Edible fruit (dry them and they're sweet).
August 14, 2025 at 10:48 AM
Physalis heterophylla, one of the 94 species of Physalis around the world, many of which are native to North America.
Fascinating research on the withanolides in Physalis.
Edible fruit (dry them and they're sweet).
Fascinating research on the withanolides in Physalis.
Edible fruit (dry them and they're sweet).
Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com rdcu.be/evHOF
Fantastic team effort with the Pucker group @bpucker.bsky.social @puckerlab.bsky.social at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Fantastic team effort with the Pucker group @bpucker.bsky.social @puckerlab.bsky.social at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....
rdcu.be
July 10, 2025 at 5:50 PM
Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com rdcu.be/evHOF
Fantastic team effort with the Pucker group @bpucker.bsky.social @puckerlab.bsky.social at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Fantastic team effort with the Pucker group @bpucker.bsky.social @puckerlab.bsky.social at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Ashwagandha is a powerful adaptogen that regulates cortisol to support healthy mood and stress response. Standardized withanolides are key.
https://blog.ryzolabs.shop/2026/07/ashwagandha-ashwagandha-root-extract.html?utm_source=bluesky&utm_medium=social&utm_campaign=ryzo_bluesky
https://blog.ryzolabs.shop/2026/07/ashwagandha-ashwagandha-root-extract.html?utm_source=bluesky&utm_medium=social&utm_campaign=ryzo_bluesky
September 26, 2026 at 7:01 AM
Ashwagandha is a powerful adaptogen that regulates cortisol to support healthy mood and stress response. Standardized withanolides are key.
https://blog.ryzolabs.shop/2026/07/ashwagandha-ashwagandha-root-extract.html?utm_source=bluesky&utm_medium=social&utm_campaign=ryzo_bluesky
https://blog.ryzolabs.shop/2026/07/ashwagandha-ashwagandha-root-extract.html?utm_source=bluesky&utm_medium=social&utm_campaign=ryzo_bluesky
Radial distribution of withanolides in tuberous roots of Withania somnifera is linked to ethylene-mediated regulation of Ws24ISO (Alka Tripathi , Himanshu Tiwari , Ammar Khan , Abhishek Kumar Rai , C H Ratnasekhar , Pradipto Mukhopadhyay) doi.org/10.1093/plph... #PlantScience @aspbofficial
Radial distribution of withanolides in tuberous roots of Withania somnifera is linked to ethylene-mediated regulation of Ws24ISO2
Differential expression of a sterol Δ24-isomerase gene by ethylene signaling led to the enrichment of withanolides in the region of root outside the vascul
doi.org
December 23, 2025 at 3:15 PM
Radial distribution of withanolides in tuberous roots of Withania somnifera is linked to ethylene-mediated regulation of Ws24ISO (Alka Tripathi , Himanshu Tiwari , Ammar Khan , Abhishek Kumar Rai , C H Ratnasekhar , Pradipto Mukhopadhyay) doi.org/10.1093/plph... #PlantScience @aspbofficial
Plants epigenetically control the production of pharmaceutically relevant active ingredients!🌿 #LMU Researchers led by Claude Becker have discovered a #genecluster that regulates the biosynthesis of withanolides in Physalis grisea - with important implications for alternative pesticides & drugs.
How plants epigenetically regulate their chemical defences
A new study demonstrates how plants of the nightshade family produce pharmaceutically valuable compounds and how this biosynthesis is epigenetically regulated.
www.lmu.de
March 6, 2025 at 12:39 PM
Plants epigenetically control the production of pharmaceutically relevant active ingredients!🌿 #LMU Researchers led by Claude Becker have discovered a #genecluster that regulates the biosynthesis of withanolides in Physalis grisea - with important implications for alternative pesticides & drugs.
Withanolide #biosynthesis from nightshade plants decoded. Withanolide steroids are used as a basis for medications for centuries.
Now published by a team around @frankelab.bsky.social + @puckerlab.bsky.social in @natcomms.nature.com (DOI: 10.1038/s41467-025-61686-1).
Now published by a team around @frankelab.bsky.social + @puckerlab.bsky.social in @natcomms.nature.com (DOI: 10.1038/s41467-025-61686-1).
July 14, 2025 at 4:35 PM
Withanolide #biosynthesis from nightshade plants decoded. Withanolide steroids are used as a basis for medications for centuries.
Now published by a team around @frankelab.bsky.social + @puckerlab.bsky.social in @natcomms.nature.com (DOI: 10.1038/s41467-025-61686-1).
Now published by a team around @frankelab.bsky.social + @puckerlab.bsky.social in @natcomms.nature.com (DOI: 10.1038/s41467-025-61686-1).
Radial distribution of withanolides in tuberous roots of Withania somnifera is linked to ethylene-mediated regulation of Ws24ISO2 (Alka Tripathi , Himanshu Tiwari , Ammar Khan , Abhishek Kumar Rai , C H Ratnasekhar , Pradipto Mukhopadhyay) doi.org/10.1093/plph... #PlantScience @aspbofficial
January 19, 2026 at 1:40 PM
Radial distribution of withanolides in tuberous roots of Withania somnifera is linked to ethylene-mediated regulation of Ws24ISO2 (Alka Tripathi , Himanshu Tiwari , Ammar Khan , Abhishek Kumar Rai , C H Ratnasekhar , Pradipto Mukhopadhyay) doi.org/10.1093/plph... #PlantScience @aspbofficial
Interested in learning more?
Read about our work:
1. Withanolide-associated gene cluster discovery: doi.org/10.1038/s414...
Read about our work:
1. Withanolide-associated gene cluster discovery: doi.org/10.1038/s414...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis - Nature Communications
Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown. Here, the authors report the g...
doi.org
June 14, 2026 at 4:20 PM
Interested in learning more?
Read about our work:
1. Withanolide-associated gene cluster discovery: doi.org/10.1038/s414...
Read about our work:
1. Withanolide-associated gene cluster discovery: doi.org/10.1038/s414...
Rhodiola or ashwagandha, which one to choose based on your goal? We compared the two adaptogens without beating around the bush here: https://dixsupps.com/rhodiola-vs-ashwagandha/.
https://bsky.app/profile/dixsupps.bsky.social/post/3mvsksab3kk2g
https://bsky.app/profile/dixsupps.bsky.social/post/3mvsksab3kk2g
Rhodiola VS ashwagandha : Performance mentale ou sommeil ?
rhodiola vs ashwagandha : comparatif des adaptogènes pour stress, énergie, sommeil et récupération. Bienfaits, dosages, actifs (rosavines, withanolides).
dixsupps.com
September 18, 2026 at 4:14 PM
Rhodiola or ashwagandha, which one to choose based on your goal? We compared the two adaptogens without beating around the bush here: https://dixsupps.com/rhodiola-vs-ashwagandha/.
https://bsky.app/profile/dixsupps.bsky.social/post/3mvsksab3kk2g
https://bsky.app/profile/dixsupps.bsky.social/post/3mvsksab3kk2g
Inspired by nature: Synthetic molecule based on one from a nightshade plant is effective against leukemia. Nightshade plants—potatoes, tomatoes & eggplant—also include toxic family members: belladonna & angel's trumpet. Nightshade toxins have anti-cancer properties phys.org/news/2024-06...
Inspired by nature: Synthetic nightshade molecule effective against leukemia cells
Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly spe...
phys.org
June 23, 2024 at 7:14 PM
Inspired by nature: Synthetic molecule based on one from a nightshade plant is effective against leukemia. Nightshade plants—potatoes, tomatoes & eggplant—also include toxic family members: belladonna & angel's trumpet. Nightshade toxins have anti-cancer properties phys.org/news/2024-06...
Nature’s pharmacy unlocked: a gene cluster conserved in nightshade plants powers withanolide biosynthesis. Engineered yeast + tobacco host the path forward
🌱 doi.org/10.1038/s414...
🌱 doi.org/10.1038/s414...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis - Nature Communications
Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown. Here, the authors report the g...
doi.org
October 19, 2025 at 11:42 AM
Nature’s pharmacy unlocked: a gene cluster conserved in nightshade plants powers withanolide biosynthesis. Engineered yeast + tobacco host the path forward
🌱 doi.org/10.1038/s414...
🌱 doi.org/10.1038/s414...
2/ Comme toute substance, elle peut présenter des risques pour la santé par son caractère potentiellement toxique des withanolides à fortes doses.
Effets secondaires :
- des troubles digestifs et intestinaux plus sévères tels que des nausées, des vomissements et des diarrhées.
Effets secondaires :
- des troubles digestifs et intestinaux plus sévères tels que des nausées, des vomissements et des diarrhées.
May 13, 2025 at 8:59 AM
2/ Comme toute substance, elle peut présenter des risques pour la santé par son caractère potentiellement toxique des withanolides à fortes doses.
Effets secondaires :
- des troubles digestifs et intestinaux plus sévères tels que des nausées, des vomissements et des diarrhées.
Effets secondaires :
- des troubles digestifs et intestinaux plus sévères tels que des nausées, des vomissements et des diarrhées.
Early morning. Coffee. Canadian geese flyover. Rooster crowing. Collared doves cooing. And the world seems to be correcting itself...
Me? I'm delving into ground cherry, Physalis, and the withanolides in it that are in the anticancer literature. I mean, why not?
Me? I'm delving into ground cherry, Physalis, and the withanolides in it that are in the anticancer literature. I mean, why not?
August 22, 2025 at 12:48 PM
Early morning. Coffee. Canadian geese flyover. Rooster crowing. Collared doves cooing. And the world seems to be correcting itself...
Me? I'm delving into ground cherry, Physalis, and the withanolides in it that are in the anticancer literature. I mean, why not?
Me? I'm delving into ground cherry, Physalis, and the withanolides in it that are in the anticancer literature. I mean, why not?
Ashwagandha (Withania somnifera) is another genus in the Solanaceae that has an inflated calyx around its fruit.
Fun fact: tomatillos contain withanolides, similar to Withania.
Withanolides have been found to inhibit many kinds of tumorous cell growth.
Fun fact: tomatillos contain withanolides, similar to Withania.
Withanolides have been found to inhibit many kinds of tumorous cell growth.
August 30, 2025 at 10:34 AM
Ashwagandha (Withania somnifera) is another genus in the Solanaceae that has an inflated calyx around its fruit.
Fun fact: tomatillos contain withanolides, similar to Withania.
Withanolides have been found to inhibit many kinds of tumorous cell growth.
Fun fact: tomatillos contain withanolides, similar to Withania.
Withanolides have been found to inhibit many kinds of tumorous cell growth.
Whole-Genome sequencing of Indigenous Withania somnifera accession and comparative cytochrome P450 phylogenomics
doi.org/10.64898/202...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
doi.org/10.64898/202...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis - Nature Communications
Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown. Here, the authors report the g...
doi.org
May 2, 2026 at 4:56 AM
Whole-Genome sequencing of Indigenous Withania somnifera accession and comparative cytochrome P450 phylogenomics
doi.org/10.64898/202...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
doi.org/10.64898/202...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
Ashwagandha improves sleep quality. Its bioactive compounds, including withanolides, have neuroprotective and anti-inflammatory properties that contribute to overall mental well-being and resilience
timesofindia.indiatimes.com/life-style/f...
timesofindia.indiatimes.com/life-style/f...
What is Ashwagandha? Does it actually help relieve stress? Simple ways to add this herb to daily diet - The Times of India
Ashwagandha, a potent adaptogen, significantly reduces stress and anxiety by lowering cortisol levels, as demonstrated in multiple clinical trials. St
timesofindia.indiatimes.com
November 30, 2025 at 11:41 PM
Ashwagandha improves sleep quality. Its bioactive compounds, including withanolides, have neuroprotective and anti-inflammatory properties that contribute to overall mental well-being and resilience
timesofindia.indiatimes.com/life-style/f...
timesofindia.indiatimes.com/life-style/f...
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis https://www.biorxiv.org/content/10.1101/2024.09.27.614867v1
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis https://www.biorxiv.org/content/10.1101/2024.09.27.614867v1
Withanolides are steroidal lactones from nightshade (Solanaceae) plants. Of the over 1,200 known rep
www.biorxiv.org
September 28, 2024 at 10:02 AM
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis https://www.biorxiv.org/content/10.1101/2024.09.27.614867v1
Type Zero KSM-66 Ashwagandha Root Extract 1,200mg, 60 Servings - High Potency 5% Withanolides - with Turmeric, Rhodiola Rosea and BioPerine Black Pepper Extract - 180 Veggie Caps amzn.to/3uuqsKn #ad #helpYOUgetGAINS #stack #stacks
Type Zero KSM-66 Ashwagandha Root Extract 1,200mg, 60 Servings - High Potency 5% Withanolides - with Turmeric, Rhodiola Rosea and BioPerine Black Pepper Extract - 180 Veggie Caps
Buy Type Zero KSM-66 Ashwagandha Root Extract 1,200mg, 60 Servings - High Potency 5% Withanolides - with Turmeric, Rhodiola Rosea and BioPerine Black Pepper Extract - 180 Veggie Caps on Amazon.com ✓ FREE SHIPPING on qualified orders
amzn.to
December 8, 2025 at 2:32 AM
Type Zero KSM-66 Ashwagandha Root Extract 1,200mg, 60 Servings - High Potency 5% Withanolides - with Turmeric, Rhodiola Rosea and BioPerine Black Pepper Extract - 180 Veggie Caps amzn.to/3uuqsKn #ad #helpYOUgetGAINS #stack #stacks
Plants in the nightshade family epigenetically regulate the production of withanolides, compounds with potential pharmaceutical applications, through specific gene clusters in their genome. doi.org/g85824
How plants epigenetically regulate their chemical defenses
A new study demonstrates how plants of the nightshade family produce pharmaceutically valuable compounds and how this biosynthesis is epigenetically regulated.
phys.org
February 25, 2025 at 1:02 AM
Plants in the nightshade family epigenetically regulate the production of withanolides, compounds with potential pharmaceutical applications, through specific gene clusters in their genome. doi.org/g85824
The cytochrome P450 enzyme WsCYP71B35 from Withania somnifera has a role in withanolides biosynthesis and defense against bacteria https://www.biorxiv.org/content/10.1101/2023.10.27.564345v1
The cytochrome P450 enzyme WsCYP71B35 from Withania somnifera has a role in withanolides biosynthesis and defense against bacteria https://www.biorxiv.org/content/10.1101/2023.10.27.564345v1
The medicinal properties of Ashwagandha (Withania somnifera L. Dunal) are attributed to withanolides
www.biorxiv.org
October 30, 2023 at 3:03 AM
The cytochrome P450 enzyme WsCYP71B35 from Withania somnifera has a role in withanolides biosynthesis and defense against bacteria https://www.biorxiv.org/content/10.1101/2023.10.27.564345v1
Oh look. A 2025 paper "Unraveling the role of withanolides as key modulators in breast cancer mitigation."
Cancer research has been halted by the Trump administration. Why?
Cancer research has been halted by the Trump administration. Why?
April 7, 2025 at 5:07 AM
Oh look. A 2025 paper "Unraveling the role of withanolides as key modulators in breast cancer mitigation."
Cancer research has been halted by the Trump administration. Why?
Cancer research has been halted by the Trump administration. Why?