So excited to do some very cool experiments at Diamond Light Source in the next few days! #XChem #fragments #Ebola
December 10, 2023 at 5:16 PM
So excited to do some very cool experiments at Diamond Light Source in the next few days! #XChem #fragments #Ebola
XChem still blows my mind. Using crystallography for drug discovery?!
Learn all about the fantastic work by colleagues at CMD-Oxford and the Diamond Light Source
Learn all about the fantastic work by colleagues at CMD-Oxford and the Diamond Light Source
onlinelibrary.wiley.com/doi/10.1002/...
Highlighting this work from @instruct-eric.bsky.social -UK centre at Diamond
Highlighting this work from @instruct-eric.bsky.social -UK centre at Diamond
Accelerating Drug Discovery With High‐Throughput Crystallographic Fragment Screening and Structural Enablement
Crystallographic fragment screening has become highly efficient, overcoming previous challenges of low throughput and time consumption, due to advances in synchrotron technology and the establishment...
onlinelibrary.wiley.com
November 28, 2024 at 1:39 PM
XChem still blows my mind. Using crystallography for drug discovery?!
Learn all about the fantastic work by colleagues at CMD-Oxford and the Diamond Light Source
Learn all about the fantastic work by colleagues at CMD-Oxford and the Diamond Light Source
You can access our capabilities at Diamond through the UK Instruct centre @instruct-eric.bsky.social for MX, XChem fragment based drug discovery, BioSAXS, CryoEM (eBIC) and Bioimaging (B24, soft X-ray tomography). Comprehensive details from our Diamond web pages @diamondlightsource.bsky.social also
A few more to add @spcembl.bsky.social @pappteam-embl.bsky.social @cssbhamburg.bsky.social And our research sites @itqbnova.bsky.social
Some I am not sure if they are: @ludocryoem.bsky.social is this one your facility @necen.bsky.social ?
@walshdls.bsky.social is the eBIC in?
Some I am not sure if they are: @ludocryoem.bsky.social is this one your facility @necen.bsky.social ?
@walshdls.bsky.social is the eBIC in?
Bluesky is filling up with more and more Instruct facilities - check them out and follow them here! go.bsky.app/6B2u1Zw
We have 23 facilities across Europe offering access to advanced structural biology technologies through Instruct. Find out more and apply here - instruct-eric.org/centres/inst...
We have 23 facilities across Europe offering access to advanced structural biology technologies through Instruct. Find out more and apply here - instruct-eric.org/centres/inst...
February 2, 2025 at 11:13 AM
You can access our capabilities at Diamond through the UK Instruct centre @instruct-eric.bsky.social for MX, XChem fragment based drug discovery, BioSAXS, CryoEM (eBIC) and Bioimaging (B24, soft X-ray tomography). Comprehensive details from our Diamond web pages @diamondlightsource.bsky.social also
The structure of ASAP-0017445, all 800+ X-ray crystal structures with compounds that enabled its development bound, and the results of the Polaris design challenge are now available in the public domain. fragalysis-legacy.xchem.diamond.ac.uk/viewer/react... (6/10)
XChem @ Diamond
fragalysis-legacy.xchem.diamond.ac.uk
March 25, 2025 at 7:33 PM
The structure of ASAP-0017445, all 800+ X-ray crystal structures with compounds that enabled its development bound, and the results of the Polaris design challenge are now available in the public domain. fragalysis-legacy.xchem.diamond.ac.uk/viewer/react... (6/10)
Opportunity for beamline scientist (XChem) at Diamond Light Source (Harwell Oxfordshire UK) ref: 11716 | closing: 09-Nov-2025 #MX #StructBiol #FBD #FBLD #FBDD #chemsky 🧪
vacancies.diamond.ac.uk/vacancy/prin...
vacancies.diamond.ac.uk/vacancy/prin...
Principal Beamline Scientist - XChem (11716)
vacancies.diamond.ac.uk
October 17, 2025 at 6:50 AM
Opportunity for beamline scientist (XChem) at Diamond Light Source (Harwell Oxfordshire UK) ref: 11716 | closing: 09-Nov-2025 #MX #StructBiol #FBD #FBLD #FBDD #chemsky 🧪
vacancies.diamond.ac.uk/vacancy/prin...
vacancies.diamond.ac.uk/vacancy/prin...
Welcoming our two new team members with a photo shoot to showcase their work. Ole and Shashank will be joining our #MX/#Xchem and #eBIC4i teams to support services for #industry. Great to see them already making an impact! https://loom.ly/gSCzEzc
October 29, 2025 at 12:11 PM
Welcoming our two new team members with a photo shoot to showcase their work. Ole and Shashank will be joining our #MX/#Xchem and #eBIC4i teams to support services for #industry. Great to see them already making an impact! https://loom.ly/gSCzEzc
Summary of xchem from frank von delft and follow on work and the tools being developed to help users to develop these fragment hits into hits and accelerate the drug discovery pipeline ..lots of new tools including fragalysis, fragmentstein, car encapsulated as fas forward fragments or f^3 i guess
January 7, 2025 at 3:42 PM
Summary of xchem from frank von delft and follow on work and the tools being developed to help users to develop these fragment hits into hits and accelerate the drug discovery pipeline ..lots of new tools including fragalysis, fragmentstein, car encapsulated as fas forward fragments or f^3 i guess
The Bertozzi and Ferguson labs have targeted GALE in the early 2000s (references in the paper!), so we knew it could be drugged. Will did a tour de force fragment screen with colleages @crick.ac.uk at XChem @diamondlightsource.bsky.social. Rounds of iteration got him a good non-covalent inhibitor.
October 7, 2025 at 6:10 AM
The Bertozzi and Ferguson labs have targeted GALE in the early 2000s (references in the paper!), so we knew it could be drugged. Will did a tour de force fragment screen with colleages @crick.ac.uk at XChem @diamondlightsource.bsky.social. Rounds of iteration got him a good non-covalent inhibitor.
S4.2. Advances and Challenges in Structure-Based Drug Discovery
📢 Faster, Larger, Better XChem: Fast Forward Fragments for progressing fragment hits - Jasmin Aschenbrenner
#47congresosebbm
📢 Faster, Larger, Better XChem: Fast Forward Fragments for progressing fragment hits - Jasmin Aschenbrenner
#47congresosebbm
September 4, 2025 at 7:40 AM
S4.2. Advances and Challenges in Structure-Based Drug Discovery
📢 Faster, Larger, Better XChem: Fast Forward Fragments for progressing fragment hits - Jasmin Aschenbrenner
#47congresosebbm
📢 Faster, Larger, Better XChem: Fast Forward Fragments for progressing fragment hits - Jasmin Aschenbrenner
#47congresosebbm
Daren Fearon (XChem, Diamond) is the winner of the BSG prize lecture 2025 for his work on fragment based drug discovery.
April 16, 2025 at 12:57 PM
Daren Fearon (XChem, Diamond) is the winner of the BSG prize lecture 2025 for his work on fragment based drug discovery.
Shockingly I have submitted both MX and XChem six month reports / revised science cases at Diamond with over two hours to spare.
I do still need to sort out new sample details for the fresh BAG starting next month.
I do still need to sort out new sample details for the fresh BAG starting next month.
March 19, 2025 at 2:49 PM
Shockingly I have submitted both MX and XChem six month reports / revised science cases at Diamond with over two hours to spare.
I do still need to sort out new sample details for the fresh BAG starting next month.
I do still need to sort out new sample details for the fresh BAG starting next month.
Attending #CCP4? Don’t miss Day 2 at 16:00–16:30! Discover how Diamond’s #FragmentScreening facility accelerates early-stage drug discovery. Hear Ailsa Powell share how XChem speeds structural insights from concept to candidate. https://loom.ly/mZKk5ys
January 7, 2026 at 5:04 PM
Attending #CCP4? Don’t miss Day 2 at 16:00–16:30! Discover how Diamond’s #FragmentScreening facility accelerates early-stage drug discovery. Hear Ailsa Powell share how XChem speeds structural insights from concept to candidate. https://loom.ly/mZKk5ys
At Diamond’s #XChem facility, Syngenta & Centre for Medicines Discovery solved Arabidopsis FatA at 1.5 Å & found 129 fragment hits across key sites - unlocking structure-guided FAT inhibitor design for safer, smarter crop protection. https://loom.ly/mUHm-_A
#HerbicideResistance #Agrochemicals
#HerbicideResistance #Agrochemicals
January 21, 2026 at 12:11 PM
At Diamond’s #XChem facility, Syngenta & Centre for Medicines Discovery solved Arabidopsis FatA at 1.5 Å & found 129 fragment hits across key sites - unlocking structure-guided FAT inhibitor design for safer, smarter crop protection. https://loom.ly/mUHm-_A
#HerbicideResistance #Agrochemicals
#HerbicideResistance #Agrochemicals
First up in today's Antiviral Drug Discovery Open Science Forum is Warren Thompson ASAP @diamondlightsource.bsky.social showing automated fragment progression capabilities that Diamond Light Source users will soon be able to access!
asapdiscovery.org/forum/
www.diamond.ac.uk/Instruments/...
asapdiscovery.org/forum/
www.diamond.ac.uk/Instruments/...
May 21, 2025 at 3:10 PM
First up in today's Antiviral Drug Discovery Open Science Forum is Warren Thompson ASAP @diamondlightsource.bsky.social showing automated fragment progression capabilities that Diamond Light Source users will soon be able to access!
asapdiscovery.org/forum/
www.diamond.ac.uk/Instruments/...
asapdiscovery.org/forum/
www.diamond.ac.uk/Instruments/...
Exciting news for #OpenBind! Ali Ebrahim will be working with the #XChem team at Diamond to help analyse and curate structural data for our data‑release packages and software, boosting the quality and utility of ML training sets. Welcome aboard, Ali! https://loom.ly/Vro7Lo8
January 21, 2026 at 10:27 AM
Exciting news for #OpenBind! Ali Ebrahim will be working with the #XChem team at Diamond to help analyse and curate structural data for our data‑release packages and software, boosting the quality and utility of ML training sets. Welcome aboard, Ali! https://loom.ly/Vro7Lo8
#OpenBind has installed three new Crystal Shifter instruments to support Diamond Light Source’s #XChem #FragmentScreening and help drive the next generation of ML‑powered structure‑based #drug design. https://loom.ly/RRLB3V0),
January 16, 2026 at 12:10 PM
#OpenBind has installed three new Crystal Shifter instruments to support Diamond Light Source’s #XChem #FragmentScreening and help drive the next generation of ML‑powered structure‑based #drug design. https://loom.ly/RRLB3V0),
just modeled as a black market shifty person for xchem, living the dream
January 23, 2025 at 2:18 PM
just modeled as a black market shifty person for xchem, living the dream
An afternoon of fun playing soccer baseball with xchem
January 23, 2025 at 2:18 PM
An afternoon of fun playing soccer baseball with xchem
Doing xchem at my old elementary school till wed and chillin in phk till then!
January 23, 2025 at 2:18 PM
Doing xchem at my old elementary school till wed and chillin in phk till then!
last day of work! hurrah! lunch with mc at 12 then OCL meeting at 3:30, then THE WEEKEND, maybs out with xchem + seeing @ryann_putnam
January 23, 2025 at 2:10 PM
last day of work! hurrah! lunch with mc at 12 then OCL meeting at 3:30, then THE WEEKEND, maybs out with xchem + seeing @ryann_putnam
just woke up from last night, fish bowl friday with xchem = a success! haha we tore up the pub d-floor
January 23, 2025 at 2:09 PM
just woke up from last night, fish bowl friday with xchem = a success! haha we tore up the pub d-floor